Abstract
7-Nitro indazole (25-100 mg/kg i.p.), an inhibitor of neuronal nitric oxide (NO) synthase, attenuated the severity of pilocarpine (300 mg/kg i.p.)-induced seizures in mice. This indicates that the decreased neuroexcitability of the central nervous system (CNS) following administration of 7-nitro indazole may be due to inhibition of neuronal NO synthase, implying that NO acts as an excitatory and proconvulsant factor in the CNS.
| Original language | English |
|---|---|
| Pages (from-to) | 211-3 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 287 |
| Issue number | 2 |
| Publication status | Published - 12 Dec 1995 |
Keywords
- Animals
- Dose-Response Relationship, Drug
- Enzyme Inhibitors
- Indazoles
- Male
- Mice
- Mice, Inbred Strains
- Motor Activity
- Nitric Oxide Synthase
- Pilocarpine
- Seizures
- Journal Article