3D-fiber deposition for tissue engineering and organ printing applications

N. E. Fedorovich; L. Moroni; J. Malda; J. Alblas; C. A. Van Blitterswijk; W. J.A. Dhert

doi:10.1007/978-90-481-9145-1_13

3D-fiber deposition for tissue engineering and organ printing applications

N. E. Fedorovich^*, L. Moroni, J. Malda, J. Alblas, C. A. Van Blitterswijk, W. J.A. Dhert

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

14 Citations (Scopus)

Abstract

Scaffold manufacturing technologies are moving towards systems that combine a precise control over scaffold 3-dimensional (3D) architecture with incorporation of cells in the fabrication process. A rapid prototyping technology, termed 3D-fiber deposition, generates 3D scaffolds that can satisfy these requirements, while maintaining a completely open porosity that can reduce nutrient diffusion limitations. This extrusion-based technique is effective in fabrication of porous thermoplastic scaffolds that function as instructive templates for seeded cells and can also be used to build viable tissue equivalents by layered deposition of cell-laden hydrogels. Therefore, this technology could accelerate and improve the assembly and functionality of tissue-engineered constructs.

Original language	English
Title of host publication	Cell and Organ Printing
Publisher	Springer Netherlands
Pages	225-239
Number of pages	15
ISBN (Print)	9789048191444
DOIs	https://doi.org/10.1007/978-90-481-9145-1_13
Publication status	Published - 1 Dec 2010

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AU - Moroni, L.

AU - Malda, J.

AU - Alblas, J.

AU - Van Blitterswijk, C. A.

AU - Dhert, W. J.A.

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AB - Scaffold manufacturing technologies are moving towards systems that combine a precise control over scaffold 3-dimensional (3D) architecture with incorporation of cells in the fabrication process. A rapid prototyping technology, termed 3D-fiber deposition, generates 3D scaffolds that can satisfy these requirements, while maintaining a completely open porosity that can reduce nutrient diffusion limitations. This extrusion-based technique is effective in fabrication of porous thermoplastic scaffolds that function as instructive templates for seeded cells and can also be used to build viable tissue equivalents by layered deposition of cell-laden hydrogels. Therefore, this technology could accelerate and improve the assembly and functionality of tissue-engineered constructs.

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3D-fiber deposition for tissue engineering and organ printing applications

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