(18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review

U T Timur; J A van Herwaarden; D Mihajlovic; P De Jong; W Mali; F L Moll

doi:10.1186/s13550-015-0153-8

(18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review

U T Timur, J A van Herwaarden, D Mihajlovic, P De Jong, W Mali, F L Moll

Research output: Contribution to journal › Literature review › peer-review

1 Downloads (Pure)

Abstract

PURPOSE: The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 ((18)F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on molecular characteristics of the aneurysm wall.

METHODS: MEDLINE, EMBASE, and the Cochrane database were searched for relevant articles. After inclusion and exclusion, we selected 18 relevant articles reporting on (18)F-FDG PET scanning of aortic aneurysms.

RESULTS: The sample size of studies is limited, and there are no standardized imaging protocols and quantification methods. (18)F-FDG PET scanning was shown to display molecular characteristics of the aortic wall. Different studies showed contradictory findings of aortic (18)F-FDG uptake in aneurysm patients compared to controls.

CONCLUSIONS: Non-invasively determining molecular characteristics of aortic wall weakening might lead to better rupture and growth prediction. This might influence the decision of the surgeon between conservative and surgical treatment of aneurysms. To date, there is conflicted evidence regarding the use of (18)F-FDG PET scanning to predict aneurysm rupture and growth. The role of (18)F-FDG PET scanning in rupture risk prediction needs to be further investigated, and standardized imaging protocols and quantification methods need to be implemented.

Original language	English
Pages (from-to)	76
Journal	EJNMMI Research
Volume	5
Issue number	1
DOIs	https://doi.org/10.1186/s13550-015-0153-8
Publication status	Published - Dec 2015

Access to Document

10.1186/s13550-015-0153-8

015-0153-8Final published version, 678 KB

Cite this

@article{1d587786c1aa4fd4a5aea432aaf1395b,

title = "(18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review",

abstract = "PURPOSE: The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 ((18)F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on molecular characteristics of the aneurysm wall.METHODS: MEDLINE, EMBASE, and the Cochrane database were searched for relevant articles. After inclusion and exclusion, we selected 18 relevant articles reporting on (18)F-FDG PET scanning of aortic aneurysms.RESULTS: The sample size of studies is limited, and there are no standardized imaging protocols and quantification methods. (18)F-FDG PET scanning was shown to display molecular characteristics of the aortic wall. Different studies showed contradictory findings of aortic (18)F-FDG uptake in aneurysm patients compared to controls.CONCLUSIONS: Non-invasively determining molecular characteristics of aortic wall weakening might lead to better rupture and growth prediction. This might influence the decision of the surgeon between conservative and surgical treatment of aneurysms. To date, there is conflicted evidence regarding the use of (18)F-FDG PET scanning to predict aneurysm rupture and growth. The role of (18)F-FDG PET scanning in rupture risk prediction needs to be further investigated, and standardized imaging protocols and quantification methods need to be implemented.",

author = "Timur, {U T} and {van Herwaarden}, {J A} and D Mihajlovic and {De Jong}, P and W Mali and Moll, {F L}",

year = "2015",

month = dec,

doi = "10.1186/s13550-015-0153-8",

language = "English",

volume = "5",

pages = "76",

journal = "EJNMMI Research",

issn = "2191-219X",

publisher = "Springer Berlin",

number = "1",

}

TY - JOUR

T1 - (18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics

T2 - a systematic review

AU - Timur, U T

AU - van Herwaarden, J A

AU - Mihajlovic, D

AU - De Jong, P

AU - Mali, W

AU - Moll, F L

PY - 2015/12

Y1 - 2015/12

N2 - PURPOSE: The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 ((18)F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on molecular characteristics of the aneurysm wall.METHODS: MEDLINE, EMBASE, and the Cochrane database were searched for relevant articles. After inclusion and exclusion, we selected 18 relevant articles reporting on (18)F-FDG PET scanning of aortic aneurysms.RESULTS: The sample size of studies is limited, and there are no standardized imaging protocols and quantification methods. (18)F-FDG PET scanning was shown to display molecular characteristics of the aortic wall. Different studies showed contradictory findings of aortic (18)F-FDG uptake in aneurysm patients compared to controls.CONCLUSIONS: Non-invasively determining molecular characteristics of aortic wall weakening might lead to better rupture and growth prediction. This might influence the decision of the surgeon between conservative and surgical treatment of aneurysms. To date, there is conflicted evidence regarding the use of (18)F-FDG PET scanning to predict aneurysm rupture and growth. The role of (18)F-FDG PET scanning in rupture risk prediction needs to be further investigated, and standardized imaging protocols and quantification methods need to be implemented.

AB - PURPOSE: The purpose of this study is to give an overview of studies investigating the role of fludeoxyglucose F18 ((18)F-FDG) positron emission tomography (PET) scanning in patients with aortic aneurysms with a focus on molecular characteristics of the aneurysm wall.METHODS: MEDLINE, EMBASE, and the Cochrane database were searched for relevant articles. After inclusion and exclusion, we selected 18 relevant articles reporting on (18)F-FDG PET scanning of aortic aneurysms.RESULTS: The sample size of studies is limited, and there are no standardized imaging protocols and quantification methods. (18)F-FDG PET scanning was shown to display molecular characteristics of the aortic wall. Different studies showed contradictory findings of aortic (18)F-FDG uptake in aneurysm patients compared to controls.CONCLUSIONS: Non-invasively determining molecular characteristics of aortic wall weakening might lead to better rupture and growth prediction. This might influence the decision of the surgeon between conservative and surgical treatment of aneurysms. To date, there is conflicted evidence regarding the use of (18)F-FDG PET scanning to predict aneurysm rupture and growth. The role of (18)F-FDG PET scanning in rupture risk prediction needs to be further investigated, and standardized imaging protocols and quantification methods need to be implemented.

UR - http://www.scopus.com/inward/record.url?scp=84951267578&partnerID=8YFLogxK

U2 - 10.1186/s13550-015-0153-8

DO - 10.1186/s13550-015-0153-8

M3 - Literature review

C2 - 26695768

SN - 2191-219X

VL - 5

SP - 76

JO - EJNMMI Research

JF - EJNMMI Research

IS - 1

ER -

(18)F-FDG PET scanning of abdominal aortic aneurysms and correlation with molecular characteristics: a systematic review

Abstract

Access to Document

Other files and links

Fingerprint

Cite this