Research output per year
Research output per year
Personal profile
Personal webpage
Biography
Wouter de Laat studied biology at the Utrecht University. During his PhD (1998) at the Erasmus University Rotterdam (Prof. Jan Hoeijmakers) he investigated the molecular mechanism of nucleotide excision repair. He identified one of the nucleases and characterized the interplay between repair factors at the site of the lesion. As a postdoc, he joined the group of Prof. Frank Grosveld to work on beta-globin gene activation. In 2000 he received a career grant (VIDI) to work on long-range gene activation. His group used 3C technology, and later developed 4C technology, to demonstrate chromatin loops between genes and enhancers and to uncover long-range DNA contacts within and between chromosomes.
In 2008 he received an ERC Young Investigator Grant. In September 2008 de Laat moved his group to the Hubrecht Institute, where he continued his work on genome structure and function. In January 2009 he was appointed professor in Biomedical Genomics at the University Medical Center Utrecht. He received a prestigious VICI career grant in 2012.
Fellowship & awards
VIDI (2000)
VICI (2012)
ERC Starting Grant (2008)
EMBO Member
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Characterization of induced cohesin loop extrusion trajectories in living cells
Han, R., Huang, Y., Robers, M. J., Magnitov, M., Vaandrager, I., Allahyar, A., Verstegen, M. J. A. M., Zhang, K., de Wit, E., de Laat, W. & Krijger, P. H. L., 2025, In: Nature genetics. 57, 11, p. 2785–2797 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Identification of a SNAI1 enhancer RNA that drives cancer cell plasticity
Fan, C., Wang, Q., Krijger, P. H. L., Cats, D., Selle, M., Khorosjutina, O., Dhanjal, S., Schmierer, B., Mei, H., de Laat, W. & Ten Dijke, P., 25 Mar 2025, In: Nature Communications. 16, 1, 2890.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations
Tjalsma, S. J. D., Rinzema, N. J., Verstegen, M. J. A. M., Robers, M. J., Nieto-Aliseda, A., Gremmen, R. A., Allahyar, A., Muraro, M. J., Krijger, P. H. L. & de Laat, W., 12 Mar 2025, In: Cell genomics. 5, 3, 100778.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Reactivation of developmentally silenced globin genes through forced linear recruitment of remote enhancers
Felder, A. K., Tjalsma, S. J. D., Verhagen, H. J. M. P., Majied, R., Verstegen, M. J. A. M., Verheul, T. C. J., van Haren, J., Mohnani, R., Gremmen, R., Krijger, P. H. L., Philipsen, S., van den Akker, E. & de Laat, W., 7 Aug 2025, In: Blood. 146, 6, p. 732-744 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain
Huang, Y., Verstegen, M. J. A. M., Tjalsma, S. J. D., Krijger, P. H. L., Gupta, K., Park, M., Boettiger, A. & de Laat, W., 1 Mar 2025, In: Genes and Development. 39, 5-6, p. 348-363 16 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Downloads (Pure)