Personal profile
Biography
Saskia van Mil (PhD) is Professor of Molecular and Translational Metabolism at the University Medical Center Utrecht, and Director of the Center for Molecular Medicine (www.cmmutrecht.eu). She is a member of the governing board and scientific committee of the European Association for the Study of the Liver (www.easl.eu).
She received her PhD from the University of Utrecht in 2004, on the topic of genetic disorders of pediatric cholestasis. As a post-doc at Imperial College London, United Kingdom, she studied the role of the bile salt sensor farnesoid X receptor (FXR) in intrahepatic cholestasis of pregnancy.
Since then, she has been intrigued by the versatility in molecular mechanisms of transcription by the nuclear receptor FXR and its therapeutic potential. Having received funding from the Netherlands’ Organisation of Scientific Research (Veni, Vidi, Vici), European Commission, Dutch Digestive Disease Foundation and DSM, her group studies the molecular and translational aspects of energy metabolism in the liver and the intestine. Amongst other projects, her group studies the molecular mechanisms of FXR function in metabolic disorders (e.g. NASH) and disorders of intestinal integrity (e.g. IBD). For more information on her research, please visit www.vanmil-lab.org.
External positions
Voorzitter Herenboerderij Nieuw Bureveld - Voorzitter Herenboerderij Nieuw Bureveld, KVK 75883074 - Herenboeren Utrecht Oost Cooperatie U.A.
21 May 2025 → 20 May 2028
Vidi beoordelingscommissie - Jaarlijks beoordelen en priotiriseren van aanvragen - ZonMW
1 Sept 2022 → 31 Dec 3999
Wetenschappelijke Adviesraad van de MLDS - jaarlijkse beoordeling en prioritering van ingediende grant proposals - MLDS
1 Sept 2020 → 31 Dec 3999
Keywords
- QP Physiology
- bile acids
- farnesoid X receptor
- nuclear receptor biology
- liver disease
- gut health
Collaborations and top research areas from the last five years
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The farnesoid X receptor activates transcription independently of RXR at non-canonical response elements
van der Veen, S. W., Dijkstra, J. J., Willemsen, E. C. L., Houtman, R., Milona, A., Marchet, N., Spit, M., Hollman, D., Zwartkruis, F. J. T., Vermeulen, M., Ramos Pittol, J. M. & van Mil, S. W. C., 8 Feb 2025, In: Nucleic acids research. 53, 4, 13 p., gkae1214.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile20 Downloads (Pure) -
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)
The LITMUS Investigators, Jun 2024, In: Nature metabolism. 6, 6, p. 1178-1196 19 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
Dietary cystine restriction increases the proliferative capacity of the small intestine of mice
de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., Van Mil, S. W. C. & Ijssennagger, N., Jan 2024, In: PLoS ONE. 19, 1 January, e0290493.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile17 Downloads (Pure) -
EASL Clinical Practice Guidelines on genetic cholestatic liver diseases
European Association for the Study of the Liver, Aug 2024, In: Journal of Hepatology. 81, 2, p. 303-325 23 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Human liver organoids: From generation to applications
Afonso, M. B., Marques, V., van Mil, S. W. C. & Rodrigues, C. M. P., 1 Jun 2024, In: Hepatology (Baltimore, Md.). 79, 6, p. 1432-1451 20 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile14 Downloads (Pure)
Activities
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NWO ZonMW VIDI committee (External organisation)
van Mil, S. (Chair)
1 Mar 2023 → 1 Mar 2026Activity: Membership › Membership of committee › Academic
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Wetenschappelijke raad Maag, Lever, Darm stichting (External organisation)
van Mil, S. (Chair)
2021 → 2026Activity: Membership › Membership of committee › Academic
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Three research projects receive money to enhance collaboration - Centaur
van Baal, J. (Contributor), van der Hee, B. (Contributor), van den Boom, R. (Contributor), van Doorn, D. A. (Contributor), Penning, L. C. (Contributor), Spee, B. (Contributor), Fuchs, S. A. (Contributor) & van Mil, S. (Contributor)
2021Activity: Other › Types of Public engagement and outreach - Media article or participation
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Governing Board and Scientific Committee member European Association for the Study of the Liver
van Mil, S. (Consultant)
1 Jun 2020 → 1 Jun 2023Activity: Consultancy › Professional
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ZonMw (Netherlands Organisation for Health Research and Development (External organisation)
van Mil, S. (Chair)
1 Jan 2018 → 1 Jan 2020Activity: Membership › Membership of committee › Academic
Press/Media
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Selective healing, bile acid therapy for inflammatory bowel disease
1/09/13
1 Media contribution
Press/Media: Public Engagement Activities