Stefan Willems

2014

CORRELATION OF MGMT PROMOTER METHYLATION STATUS ANALYSIS USING 6 MS-MLPA PROBES AND CLINICAL RESPONSE OF TEMOZOLOMIDE IN GLIOBLASTOMA PATIENTS

Fakkert, M., de Leng, W., de Weger, R., Willems, S., Spliet, W. G. M., van Hecke, W. & de Vos, F., Nov 2014, In: Neuro-Oncology. 16, 1 p.

Research output: Contribution to journal › Meeting Abstract › Other research output

Differences in methylation profiles between HPV-positive and HPV-negative oropharynx squamous cell carcinoma: A systematic review

van Kempen, P. M. W., Noorlag, R., Braunius, W. W., Stegeman, I., Willems, S. M. & Grolman, W., 1 Jan 2014, In: Epigenetics. 9, 2, p. 194-203 10 p.

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Energy-dispersive X-ray microanalysis of poststapedotomy reparative granuloma.

Translated title of the contribution: Energy-dispersive X-ray microanalysis of poststapedotomy reparative granuloma.Topsakal, V., Willems, S. M. & Tange, R. A., 2014, In: Otology & Neurotology. 35, 1, p. e62-e63 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Fibroblast growth factor receptor 2 overexpression is differently regulated in oral and oropharyngeal cancer

Koole, K., Noorlag, R., van Kempen, P., Ebbers, L., Peeters, T., van Diest, P. J., Koole, R., Grolman, W., van Es, R. & Willems, S. M., Aug 2014, In: Virchows Archives. 465, p. S32-S32 1 p.

Research output: Contribution to journal › Meeting Abstract › Other research output

HPV-positive oropharyngeal squamous cell carcinoma is associated with TIMP3 and CADM1 promoter hypermethylation

van Kempen, P. M. W., van Bockel, L., Braunius, W. W., Moelans, C. B., van Olst, M., de Jong, R., Stegeman, I., van Diest, P. J., Grolman, W. & Willems, S. M., 2014, In: Cancer Medicine. 3, 5, p. 1185-1196 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Moleculaire pathologie bij tumorclassificatie: heden en toekomst van de moleculaire revolutie.

Translated title of the contribution: Moleculaire pathologie bij tumorclassificatie: heden en toekomst van de moleculaire revolutie.Willems, S. M., Engelsman-Theelen, W. & Blaauwgeers, J. L. G., 2014, In: Nederlands Tijdschrift voor Geneeskunde. 158, p. A7364 1 p.

Research output: Contribution to journal › Article › Professional

Nodal metastasis and survival in oral cancer: Association with protein expression of SLPI, not with LCN2, TACSTD2, or THBS2.

Noorlag, R., van der Groep, P., Leusink, F. K. J., van Hooff, S. R., Frank, M. H., Willems, S. M. & van Es, R. J. J., 25 Apr 2014, In: Head and Neck.

Research output: Contribution to journal › Article › Academic › peer-review

p16INK4A and p14ARF gene promoter hypermethylation as prognostic biomarker in oral and oropharyngeal squamous cell carcinoma: a review.

Translated title of the contribution: p16INK4A and p14ARF gene promoter hypermethylation as prognostic biomarker in oral and oropharyngeal squamous cell carcinoma: a review.Al-Kaabi, A., van Bockel, L. W., Pothen, A. J. & Willems, S. M., 2014, In: Disease markers. 2014, p. 260549 1 p., 260549.

Research output: Contribution to journal › Article › Academic › peer-review

Promoter hypermethylation using 24-gene array in early head and neck cancer: better outcome in oral than in oropharyngeal cancer

Noorlag, R., van Kempen, P. M. W., Moelans, C. B., de Jong, R., Blok, L. E. R., Koole, R., Grolman, W., van Diest, P. J., van Es, R. J. J. & Willems, S. M., Sept 2014, In: Epigenetics. 9, 9, p. 1220-1227 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Pseudogout in the middle ear.

Translated title of the contribution: Pseudogout in the middle ear.Shamil, E., Willems, S. M., Grolman, W. & Topsakal, V., 2014, In: Otology & Neurotology. 35, 5, p. e202-e203 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Resection of early oral squamous cell carcinoma with positive or close margins: relevance of adjuvant treatment in relation to local recurrence: margins of 3 mm as safe as 5 mm

Dik, E. A., Willems, S. M., Ipenburg, N. A., Adriaansens, S. O., Rosenberg, A. J. W. P. & van Es, R. J. J., Jun 2014, In: Oral Oncology. 50, 6, p. 611-615 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.

Translated title of the contribution: Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma.Sun, C., Wang, L., Huang, S., Heynen, G., Prahallad, A. C., Robert, C., Haanen, J., Blank, C., Wesseling, J., Willems, S. M., Zecchin, D., Hobor, S., Bajpe, P. K., Lieftink, C., Mateus, C., Vagner, S., Grernrum, W., Hofland, I., Schlicker, A. & Wessels, L. F. A. & 5 others, Beijersbergen, R. L., Bardelli, A., Di Nicolantonio, F., Eggermont, A. M. M. & Bernards, R., 2014, In: Nature. 508, 7494, p. 118-122 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

The estimation of tumor cell percentage for molecular testing by pathologists is not accurate

Smits, A. J. J., Kummer, J. A., de Bruin, P. C., Bol, M., van den Tweel, J. G., Seldenrijk, K. A., Willems, S. M., Offerhaus, G. J. A., de Weger, R. A., van Diest, P. J. & Vink, A., Feb 2014, In: Modern Pathology. 27, 2, p. 168-174 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Tumor heterogeneity and personalized cancer medicine: Are we being outnumbered?

Cirkel, G. A., drs. Gadellaa-van Hooijdonk, C. G. M., Koudijs, M. J., Willems, S. M. & Voest, E. E., 1 Feb 2014, In: Future Oncology. 10, 3, p. 417-428 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Use of the 2-μm continuous wave thulium laser for the resection of oral squamous cell carcinomas does not impair pathological assessment

Pothen, A. J., Evenboer, J., Swartz, J. E., Willems, S. M., van Cann, E. M., Janssen, L. M., van der Heijden, G. J. M. G. & Grolman, W., 2014, In: Lasers in Surgery and Medicine. 46, 8, p. 608-613 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

2013

De moleculaire revolutie in de pathologie.

Translated title of the contribution: De moleculaire revolutie in de pathologie.Hinrichs, J. W. J. & Willems, S. M., 2013, In: Analyse. 9, p. 267-270 4 p.

Research output: Contribution to journal › Article › Professional

De rol van de pathologie in de kankerdiagnostiek.

Translated title of the contribution: De rol van de pathologie in de kankerdiagnostiek.van Diest, P. J. & Willems, S. M., 2013, In: Kanker Breed. 5, 1, p. 2 1 p.

Research output: Contribution to journal › Article › Professional

Discrepancy between routine and expert pathologists' assessment of non-palpable breast cancer and its impact on locoregional and systemic treatment

Postma, E. L., Verkooijen, H. M., van Diest, P. J., Willems, S. M., van den Bosch, M. A. A. J. & van Hillegersberg, R., 2013, In: European Journal of Pharmacology. 717, 1-3, p. 31-35 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice.

Translated title of the contribution: Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice.Gautier, T., de Haan, W., Grober, J., Ye, D., Bahr, M. J., Claudel, T., Nijstad, N., van Berkel, T. J. C., Havekes, L. M., Manns, M. P., Willems, S. M., Hogendoorn, P. C. W., Lagrost, L., Kuipers, F., van Eck, M., Rensen, P. C. N. & Tietge, U. J. F., 2013, In: Journal of Lipid Research. 54, 8, p. 2195-2205 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.

Translated title of the contribution: Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing.Majewski, I. J., Mittempergher, L., Davidson, N. M., Bosma, A., Willems, S. M., Horlings, H. M., de Rink, I., Greger, L., Hooijer, G. K. J., Peters, D., Nederlof, P. M., Hofland, I., de Jong, J., Wesseling, J., Kluin, R. J. C., Brugman, W., Kerkhoven, R., Nieboer, F., Roepman, P. & Broeks, A. & 8 others, Muley, T. R., Jassem, J., Niklinski, J., van Zandwijk, N., Brazma, A., Oshlack, A., van den Heuvel, M. & Bernards, R., 2013, In: Journal of Pathology. 230, 3, p. 270-276 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

Rol van patholoog in de diagnostiek van erfelijke tumoren.

Translated title of the contribution: Rol van patholoog in de diagnostiek van erfelijke tumoren.Willems, S. M. & Morreau, H., 2013, In: Kanker Breed. 5, 1, p. 11-14 4 p.

Research output: Contribution to journal › Article › Professional

TGF-β: an emerging player in drug resistance.

Translated title of the contribution: TGF-β: an emerging player in drug resistance.Brunen, D., Willems, S. M., Kellner, U., Midgley, R., Simon, I. & Bernards, R., 2013, In: Cell Cycle. 15, 18, p. 2960-2968 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Waarde van eiwitdetectie in tumoren voor de patholoog: immuunhistochemie en proteomics.

Translated title of the contribution: Waarde van eiwitdetectie in tumoren voor de patholoog: immuunhistochemie en proteomics.Nguyen, T. Q., Willems, S. M. & van Diest, P. J., 2013, In: Kanker Breed. 5, 1, p. 7-10 4 p.

Research output: Contribution to journal › Article › Professional

2012

Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review.

Translated title of the contribution: Diagnosis of breast lesions: fine-needle aspiration cytology or core needle biopsy? A review.Willems, S. M., van Deurzen, C. H. M. & van Diest, P. J., 2012, In: Journal of Clinical Pathology. 65, 4, p. 287-292 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

Digital slide images for primary diagnostics in breast pathology: a feasibility study.

Translated title of the contribution: Digital slide images for primary diagnostics in breast pathology: a feasibility study.Al-Janabi, S., Huisman, A., Willems, S. M. & van Diest, P. J., 2012, In: Human Pathology. 43, 12, p. 2318-2325 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

Efficacy of 'radioguided occult lesion localisation' (ROLL) versus 'wire-guided localisation' (WGL) in breast conserving surgery for non-palpable breast cancer: a randomised controlled multicentre trial

Postma, E. L., Verkooijen, H. M., van Esser, S., Hobbelink, M. G. G., van der Schelling, G. P., Koelemij, R., Witkamp, A. J., Contant, C., van Diest, P. J., Willems, S. M., Borel Rinkes, I. H. M., van den Bosch, M. A. A. J., Mali, W. P. T. M., ROLL Study Group, X. & van Hillegersberg, R., Nov 2012, In: Breast Cancer Research and Treatment. 136, 2, p. 469-478 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

2011

Chewing khat and chronic liver disease.

Translated title of the contribution: Chewing khat and chronic liver disease.Stuyt, R. J. L., Willems, S. M., Wagtmans, M. J. & van Hoek, B., 2011, In: Liver International. 31, 3, p. 434-436 3 p.

Research output: Contribution to journal › Article › Academic › peer-review

2010

Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity.

Translated title of the contribution: Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity.Willems, S. M., van Remoortere, A., van Zeijl, R., Deelder, A. M., McDonnell, L. A. & Hogendoorn, P. C. W., 2010, In: Journal of Pathology. 222, 4, p. 400-409 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.

Translated title of the contribution: Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option.Willems, S. M., Schrage, Y. M., Briaire-de Bruijn, I. H., Szuhai, K., Hogendoorn, P. C. W. & Bovee, J., 2010, In: Molecular Cancer. 9, p. 257 1 p.

Research output: Contribution to journal › Article › Academic › peer-review

Peptide and protein imaging mass spectrometry in cancer research.

Translated title of the contribution: Peptide and protein imaging mass spectrometry in cancer research.McDonnell, L. A., Corthals, G. L., Willems, S. M., van Remoortere, A., van Zeijl, R. & Deelder, A. M., 2010, In: Journal of Proteomics. 73, 10, p. 1921-1944 24 p.

Research output: Contribution to journal › Article › Academic › peer-review

Running GAGs: Myxoid matrix in tumor pathology revisited: What's in it for the pathologist

Willems, S. M., Wiweger, M., Van Roggen, J. F. G. & Hogendoorn, P. C. W., 1 Feb 2010, In: Virchows Archiv. 456, 2, p. 181-192 12 p.

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Running GAGs: myxoid matrix in tumor pathology revisited: what's in it for the pathologist?

Translated title of the contribution: Running GAGs: myxoid matrix in tumor pathology revisited: what's in it for the pathologist?Willems, S. M., Wiweger, M., Graadt van Roggen, J. F. & Hogendoorn, P. C. W., 2010, In: Virchows Archives. 456, 2, p. 181-192 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

2009

Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix

Willems, S. M., Mohseny, A. B., Balog, C., Sewrajsing, R., Briaire-de Bruijn, I. H., Knijnenburg, J., Cleton-Jansen, A.-M., Sciot, R., Fletcher, C. D. M., Deelder, A. M., Szuhai, K., Hensbergen, P. J. & Hogendoorn, P. C. W., Jul 2009, In: Journal of Cellular and Molecular Medicine. 13, 7, p. 1291-1301 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2008

Liver transplantation in a patient with encapsulating peritoneal sclerosis

Cappel, W. H. D. V. T. N., Dubbeld, J., Willems, S. M., Ringers, J. & van Hoek, B., 2008, In: Netherlands Journal of Medicine. 66, 7, p. 280-282 3 p.

Research output: Contribution to journal › Article › Academic › peer-review

Macroscopic hematuria in patient with myelofibrosis caused by extramedullary hematopoiesis of bladder

Willems, S., Beck, J. & von der Thusen, J., Oct 2008, In: Urology. 72, 4, 2 p., ARTN 948.e13.

Research output: Contribution to journal › Article › Academic › peer-review

Myxoid tumours of soft tissue: the so-called myxoid extracellular matrix is heterogeneous in composition

Willems, S. M., Schrage, Y. M., Baelde, J. J., Bruijn, I.B.-D., Mohseny, A., Sciot, R., Bovee, J. V. M. G. & Hogendoorn, P. C. W., Mar 2008, In: Histopathology. 52, 4, p. 465-474 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Reduced leucocyte cholesteryl ester transfer protein expression in acute coronary syndromes

Ye, D., Kraaijeveld, A. O., Grauss, R. W., Willems, S. M., van Vark-van der Zee, L. C., de Jager, S. C. A., Jauhiainen, M., Kuivenhoven, J. A., Dallinga-Thie, G. M., Atsma, D. E., Hogendoorn, P. C. W., Biessen, E. A. L., Van Berkel, T. J. C., Jukema, J. W. & van Eck, M., Dec 2008, In: Journal of Internal Medicine. 264, 6, p. 571-585 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

2007

Congenital disorder of glycosylation type Ia presenting with hydrops fetalis

van de Kamp, J. M., Lefeber, D. J., Ruijter, G. J. G., Steggerda, S. J., den Hollander, N. S., Willems, S. M., Matthijs, G., Poorthuis, B. J. H. M. & Wevers, R. A., Apr 2007, In: Journal of Medical Genetics. 44, 4, p. 277-280 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

CT-guided, COBRA-FISH-assisted diagnosis of well-differentiated liposarcoma (inflammatory subtype) of the retroperitoneum

Willems, S. M., Szuhai, K., Hartgrink, H., Bovee, J. V. M. G., De Schepper, A. & Hogendoorn, P. C. W., Sept 2007, In: Histopathology. 51, 3, p. 422-426 5 p.

Research output: Contribution to journal › Letter › Academic › peer-review

The number of pelvic lymph nodes in the quality control and prognosis of radical hysterectomy for the treatment of cervical cancer

Pieterse, Q. D., Kenter, G. G., Gaarenstroom, K. N., Peters, A. A. W., Willems, S. M., Fleuren, G. J. & Trimbos, J. B. M. Z., Mar 2007, In: European Journal of Surgical Oncology. 33, 2, p. 216-221 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

2006

Local recurrence of myxofibrosarcoma is associated with increase in tumour grade and cytogenetic aberrations, suggesting a multistep tumour progression model

Willems, S., Debiec-Rychter, M., Szuhai, K., Hogendoorn, P. & Sciot, R., Mar 2006, In: Modern Pathology. 19, 3, p. 407-416 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

2005

An unexpected cause of a recurrent cerebral hemorrhage

Thijs, R., Hazekamp, M., Rijlaarsdam, M., Willems, S., Schutte, P. & Laan, L., Oct 2005, In: Neuropediatrics. 36, 5, p. 324-327 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

Gastric carcinoma with osteoclast-like giant cells and lymphoepithelioma- like carcinoma of the stomach: Two of a kind? [7]

Willems, S., Carneiro, F. & Geboes, K., 1 Sept 2005, In: Histopathology. 47, 3, p. 331-333 3 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

14 Citations (Scopus)

2004

Pericardial synovial sarcoma: 14-Year survival with multimodality therapy

Van Der Mieren, G., Willems, S., Sciot, R., Dumez, H., Van Oosterom, A., Flameng, W. & Herijgers, P., 1 Sept 2004, In: Annals of Thoracic Surgery. 78, 3

Research output: Contribution to journal › Article › Academic › peer-review

31 Citations (Scopus)

Stefan Willems

Research output

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