Research output per year
Research output per year
Personal profile
Personal webpage
nl.linkedin.com/pub/stefan-nierkens/16/89/912/en
Nierkens Group - Prinses Máxima Centrum - Research (prinsesmaximacentrum.nl)
Biography
Dr. Stefan Nierkens (PhD) is Associate Professor and Medical Immunologist, accredited according to guidelines of the College of Medical Immunologists of the Dutch Society of Immunology, in the UMC Utrecht and Princess Máxima Center for Pediatric Oncology. Within the ISO15189-accredited laboratory his focus areas are Hemato-oncology, Immune monitoring, Cell and functional diagnostics, and Serology.
Dr. Nierkens is Associate Professor Pediatric Tumor Immunology and HCT and focusses on the development of innovative immunotherapy treatment strategies (based on dendritic cells and gene-engineered T cells) to improve the outcome of pediatric cancers (e.g. acute leukemia and neuroblastoma). Furthermore, his lab (12 fte) focuses on the combination of advanced immune monitoring and PK-PD modeling to provide predictable immune reconstitution after hematopoietic cell transplantation.
Fellowship & awards
KWF fellowship
Kika
ZonMW-TAS
VillaJoep
Ammodo
Side activities
Advisory Board / Consultancy / Speaker: Sobi, Medimmune, GamidaCell, Olink
External positions
Medische Immunologie - Overeenkomstige taken als Medisch Immunoloog bij LTI UMCU - Prinses Maxima Centrum voor Kinderoncologie
23 Aug 2018 → 31 Dec 3999
commissie - expertise medische immunologie - NVVI
1 Jan 2018 → 31 Dec 3999
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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B-cell precursor acute lymphoblastic leukemia elicits an interferon-α/b response in bone marrow-derived mesenchymal stroma
Smeets, M. W. E., Steeghs, E. M. P., Orsel, J., Stalpers, F., Vermeeren, M. M. P., Veltman, C. H. J., Slenders, L., Nierkens, S., Van de Ven, C. & Den Boer, M. L., Jul 2024, In: Haematologica. 109, 7, p. 2073-2084 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response
Alieva, M., Barrera Román, M., de Blank, S., Petcu, D., Zeeman, A. L., Dautzenberg, N. M. M., Cornel, A. M., van de Ven, C., Pieters, R., den Boer, M. L., Nierkens, S., Calkoen, F. G. J., Clevers, H., Kuball, J., Sebestyén, Z., Wehrens, E. J., Dekkers, J. F. & Rios, A. C., Jul 2024, In: Nature protocols. 19, 7, p. 2052-2084 33 p.Research output: Contribution to journal › Article › Academic › peer-review
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Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior
Jansen, S. A., Cutilli, A., de Koning, C., van Hoesel, M., Frederiks, C. L., Saiz Sierra, L., Nierkens, S., Mokry, M., Nieuwenhuis, E. E. S., Hanash, A. M., Mocholi, E., Coffer, P. J. & Lindemans, C. A., 21 Jun 2024, In: iScience. 27, 6, p. 1-19 19 p., 110072.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Combining CRISPR-Cas9 and TCR exchange to generate a safe and efficient cord blood-derived T cell product for pediatric relapsed AML
Lo Presti, V., Meringa, A., Dunnebach, E., van Velzen, A., Moreira, A. V., Stam, R. W., Kotecha, R. S., Krippner-Heidenreich, A., Heidenreich, O. T., Plantinga, M., Cornel, A., Sebestyen, Z., Kuball, J., van Til, N. P. & Nierkens, S., 5 Apr 2024, In: Journal for ImmunoTherapy of Cancer. 12, 4, 15 p., e008174.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure) -
Corrigendum: Therapeutic drug monitoring of anti-thymocyte globulin in allogeneic stem cell transplantation: proof of concept (Front. Pharmacol., (2022), 13, (828094), 10.3389/fphar.2022.828094)
Meesters-Ensing, J. I., Admiraal, R., Ebskamp, L., Lacna, A., Boelens, J. J., Lindemans, C. A. & Nierkens, S., 2024, In: Frontiers in Pharmacology. 15, 1444228.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Open AccessFile
Activities
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Immune monitoring for solid tumors
Stefan Nierkens (Speaker)
23 Mar 2023 → 24 Mar 2023Activity: Talk or presentation › Invited talk › Academic
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Measureable residual disease in AML & Post-transplantation therapies
Stefan Nierkens (Speaker)
14 Mar 2023 → 15 Mar 2023Activity: Talk or presentation › Oral presentation › Academic
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Make CAR-T cells feel at home
Stefan Nierkens (Speaker)
27 Feb 2023Activity: Talk or presentation › Invited talk › Academic
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Immune Monitoring in pediatric BCP-ALL patients treated with CAR-T therapy
Stefan Nierkens (Speaker)
21 Nov 2022Activity: Talk or presentation › Invited talk › Professional
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The use of liquid biopsy approaches in immunology
Stefan Nierkens (Speaker)
11 Oct 2022Activity: Talk or presentation › Invited talk › Academic
Prizes
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Joos Kerckhaert Award
Nierkens, Stefan (Recipient), 5 Oct 2023
Prize: Prize (including medals and awards)
Press/Media
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Burgemeester op bezoek voor gezamenlijk project WKZ-PMC - Connect
Jaap-Jan Boelens, Max van Noesel & Stefan Nierkens
23/05/16
1 Media contribution
Press/Media: Public Engagement Activities
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Immunologie onderzoek versnellen en verbeteren’
7/12/12
1 Media contribution
Press/Media: Public Engagement Activities