Personal profile
Biography
Dr. Simon C. Mastbergen is an associate professor and director of research at the department Rheumatology & Clinical Immunology of the University Medical Center Utrecht, The Netherlands. He studied Medical Biology and obtained his MSc in 1998. In 2005 he obtained his PhD which was focused on the role of COX-2 in osteoarthritis. He has a strong interest in translational rheumatology research with a focus on tissue-regeneration in joint diseases, especially osteoarthritis, though not limited to. Central theme of his research is modulation of cartilage, synovium, and bone to prevent and when possible, cure joint damage. Within this theme he is involved in several research lines including “Joint distraction in treatment of severe osteoarthritis", “Causes of development and progression of osteoarthritis”, and “DMOADS in treatment of osteoarthritis” amongst other. Within these research lines he pushes for innovation and translation to the clinic.
Collaborations and top research areas from the last five years
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Disentangling patient, disease, and treatment effects: proteomic and metabolomic differences in early versus established psoriatic arthritis
Bentvelzen, M. L. M., El Bouhaddani, S., Spierings, J., Vonkeman, H. E., Mooij, S. C., Schipper, L. G., Herman, A., Mastbergen, S. C., Uh, H.-W. & Welsing, P. M. J., 2026, In: Rheumatology advances in practice. 10, 1, 8 p., rkaf136.Research output: Contribution to journal › Article › Academic › peer-review
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How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort
Jansen, M. P., Mastbergen, S. C., Wirth, W., Roemer, F. W., Bacardit, J., Bay-Jensen, A. C., Kloppenburg, M., Blanco, F. J., Haugen, I. K., Berenbaum, F., Eijkelkamp, N. & Jarraya, M., Mar 2026, In: Osteoarthritis and Cartilage Open. 8, 1, 5 p., 100726.Research output: Contribution to journal › Article › Academic › peer-review
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Progression of bone and joint space deformity in patients with mild knee osteoarthritis: Data from the IMI-APPROACH cohort
Nguyen, H. C., Bax, E., Custers, R. J. H., van Egmond, N., Kuiper, R. J. A., Arbabi, V., Rayegan, H., Gielis, W. P., Sakkers, R. J. B., Kloppenburg, M., Blanco, F. J., Haugen, I. K., Berenbaum, F., Jansen, M. P., Mastbergen, S. C., Lindner, C., Cootes, T. F. & Weinans, H., Jun 2026, In: Osteoarthritis and Cartilage Open. 8, 2, 7 p., 100762.Research output: Contribution to journal › Article › Academic › peer-review
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Sex-related differences in femorotibial cartilage thickness: A matched pair analysis
Spoelder, N., Turmezei, T. D., Kessler, D. A., Mackay, J. W., Mastbergen, S. C., Karperien, M., Jansen, M. P. & Eckstein, F., Jun 2026, In: Annals of Anatomy. 266, 7 p., 152824.Research output: Contribution to journal › Article › Academic › peer-review
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Unicompartmental versus bicompartmental joint space width measures: Which reflect whole joint structural damage better? Data from IMI-APPROACH
Bax, E. A., Custers, R. J. H., van Egmond, N., Kruyt, M. C., Rayegan, H., Kloppenburg, M., Blanco, F. J., Haugen, I. K., Berenbaum, F., Roemer, F. W., Weinans, H., Mastbergen, S. C. & Jansen, M. P., Feb 2026, In: Osteoarthritis and Cartilage. 34, 2, p. 297-303 7 p.Research output: Contribution to journal › Article › Academic › peer-review
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