Sabine Linn

Prof.dr., prof. dr.

    1995 …2025

    Research activity per year

    Personal profile

    Side activities

    Neven activiteiten van Sabine Linn

     

     

    Family Name:                   

    Linn

    Christian names:             

    Sabine Charlotte

    BIG number:                     

    99032942301

    Working address:             

    Dept. of Medical Oncology

    Netherlands Cancer Institute

    Plesmanlaan 121

    1066 CX  Amsterdam

    The Netherlands

    Telephone:                       

    +31 20 5129111

    Fax:                                   

    +31 20 5122572                                               

     

     

     

     

    Advisory boards and consultancies

     

    2012 – present                

    Function: Member Scientific Advisory Board

    Organization: Cergentis, a spin-off company for targeted amplification of complete genes, The Netherlands

    Personal income: No

     

    2016                                      

    Function: Member Lynparza (Olaparib) AstraZeneca Global Advisory Board

    Organization: AstraZeneca

    Personal income: No

     

    2016 – 2017                     

    Function: Member IBM Watson Health Oncology Global Advisory Board

    Organization: IBM, Boston, MA, USA

    Personal income: No

                                                   

     

    Educational and scientific committees

     

    2003 – 2020                       

    Function: Member of the NKI-AVL Organizing Committee for Continuing Medical Education Program for Dutch Medical Oncologists “DONAMO (DOorlopende NAscholing Medische Oncologie)”

    Organization: Netherlands Cancer Institute, Amsterdam, Netherlands

    Personal income: No

     

    2007 – 2015                       

    Function: Member of the Dutch Society for Medical Oncology (NVMO) Advisory Board for the Dutch Institute for Healthcare Improvement (CBO) Breast Cancer Guidelines

    Organization: Dutch Institute for Healthcare Improvement (CBO)

    Personal income: No

     

    2008 – 2013                       

    Function: Chair Working Group (neo)adjuvant systemic therapy of Borstkanker Onderzoek Groep (BOOG) (Dutch Breast Cancer Trialists’ Group)

    Organization: Dutch Breast Cancer Trialists’ Group

    Personal income: No

     

    2013 – 2019                      

    Function: Member of Program Committee of Dutch and Flemish Annual Oncology Days (NVMO Oncologiedagen Nederland en Vlaanderen)

    Organization: NVMO (Nederlandse Vereniging voor Medische Oncologie)

    Personal income: No

     

    2014 – present                

    Function: Member Committee on Personalised Medicine

    Organization: ZonMw, The Netherlands

    Personal income: No

     

    2015 - present                 

    Member Editorial Board of Breast Cancer Research

    Organization: Springer Nature

    Personal income: No

     

    2015                                      

    Function: Member Scientific Advisory Group

    Organization: European Medicines Agency (EMA) London, UK

    Personal income: No

     

    2016 – 2017                      

    Function: Member RiskAp Expert Group on breast cancer screening

    Organization: German Federal Ministry of Education and Research

    Personal income: No

     

    2016 – 2017                    

    Function: Member Scientific Evaluation Committee Institut National du Cancer, France

    Organization: Institut National du Cancer (INCA), Paris, France

    Personal income: No

     

    2016 – 2017                       

    Function: Member Expert Review Panel CRUK and EPSRC Cancer Imaging Centres (Oxford University, Cambridge University, King’s College London/University College London, The Institute of Cancer Research)

    Organization: Cancer Research United Kingdom (CRUK)

    Personal income: No

     

    2016 – 2017                       

    Function: Member IMPAKT 2017 Scientific Committee, Brussels, Belgium

    Organization: ESMO (European Society of Medical Oncology) and BIG (Breast International Group)

    Personal income: No

     

    2016 – 2018                       

    Function: Member ESMO 2018 scientific subcommittee breast cancer, early

    Organization: ESMO (European Society of Medical Oncology)

    Personal income: No

     

    2017 – 2019                       

    Function: Co-chair (with Alberto Bardelli) ESMO-EACR 2019 scientific subcommittee Translational Research

    Organization: ESMO (European Society of Medical Oncology)

    Personal income: No

     

    2017 – 2020                       

    Function: Member evaluation board of the panel LS4 “Physiology, Pathophysiology and Endocrinology” for European Research Council  Consolidator Grants (CoG) in 2018, and 2020

    Organization: European Commission

    Personal income: Yes, > 2,200 Euro/year

     

    2018 - present                  

    Faculty ENDEAVOR workshops for European future breast cancer leaders in the field

     

    2021 – present                

    Function: Member VIDI committee Dutch Research Council (NWO)

    Organisation: Dutch Research Council (NWO)

    Personal income: yes, < 2,200 euro/year

     

    2022 – present                 

    Member Health Council of the Netherlands – Independent scientific advisory body for government and parliament

    Biography

    Dr. Sabine Linn is a professor of translational oncology focusing on breast cancer at Utrecht University, The Netherlands. Linn received her medical degree (1991, cum laude) at the State University Leiden, The Netherlands, and her internal medicine board certification (2000) at the University Medical Center Utrecht, The Netherlands. She earned her PhD (1998) on the subject of multidrug resistance in solid tumors from the Free University of Amsterdam under supervision of prof. Dr H.M. Pinedo.
    She was awarded a Dutch Cancer Society Research Fellowship in 2000 and developed two conditional knock-out mouse models, one for non-small cell lung cancer and one for small cell lung cancer, respectively, in close collaboration with Dr Ralph Meuwissen in the laboratory of prof. Dr A.J. Berns at the Netherlands Cancer Institute, Amsterdam, The Netherlands. From 2001 to 2002 she was a postdoctoral research fellow in the laboratories of prof. Dr P.O. Brown, and prof. Dr M. van de Rijn, at Stanford University Medical School, Stanford, CA, where she contributed to the development of a molecular classification for soft tissue sarcomas. She returned to the Netherlands Cancer Institute in Amsterdam, where she earned her medical oncology certification (2002-2005) and became a senior staff member of the Division of Medical Oncology (2003).
    Since 2005 she has also been a group leader at the Division of Molecular Pathology at the Netherlands Cancer Institute where she and her research group focus on the molecular dissection of breast cancer by differential drug sensitivity. To further develop this research line Dr. Linn was awarded a Dutch Cancer Society Clinical Research Award in 2006. From 2008-2012, Dr Linn served as chair of the Working Group on (neo)adjuvant systemic therapy of the Dutch Breast Cancer Trialists' Group (BOOG).

     

    Collaborations and top research areas from the last five years

    Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
    • Genetic Alterations, Therapy Response, and Survival Among Patients With Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial

      Richters, L., Gluz, O., Weber-Lassalle, N., Christgen, M., Haverkamp, H., Kuemmel, S., Kayali, M., Kates, R. E., Grischke, E. M., Altmüller, J., Forstbauer, H., Thiele, H., Braun, M., Warm, M., Ossowski, A., Wuerstlein, R., Ernst, C., Graeser, M., Linn, S. C. & Nitz, U. & 5 others, Hauke, J., Kreipe, H. H., Schmutzler, R. K., Hahnen, E. & Harbeck, N., 3 Feb 2025, In: JAMA network open. 8, 2, e2461639.

      Research output: Contribution to journalArticleAcademicpeer-review

      Open Access
      File
    • Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer

      Hoppe, R., Winter, S., Lo, W. Y., Michailidou, K., Bolla, M. K., Keeman, R., Wang, Q., Dennis, J., Lush, M., Kalari, K. R., Goetz, M. P., Wang, L., Cairns, J., Weinshilboum, R., Shepherd, L., Chen, B. E., Häberle, L., Ruebner, M., Beckmann, M. W. & He, W. & 54 others, Larson, N. L., Armasu, S. M., Schroth, W., Chowbay, B., Khor, C. C., Abubakar, M., Antoniou, A. C., Brüning, T., Castelao, J. E., Chang-Claude, J., NBCS Collaborators, C., Dörk, T., Eccles, D. M., Figueroa, J. D., Gago-Dominguez, M., García-Sáenz, J. A., Gündert, M., Hack, C. C., Hamann, U., Han, S., Hooning, M. J., Huebner, H., ABCTB Investigators, I., John, E. M., Ko, Y. D., Kristensen, V. N., Linn, S., Margolin, S., Mavroudis, D., Nevanlinna, H., Neven, P., Obi, N., Park-Simon, T. W., Pylkäs, K., Rashid, M. U., Romero, A., Saloustros, E., Sawyer, E. J., Tapper, W. J., Tomlinson, I., Wendt, C., Winqvist, R., Dunning, A. M., Simard, J., Hall, P., Pharoah, P. D. P., Schwab, M., Couch, F. J., Czene, K., Fasching, P. A., Easton, D. F., Schmidt, M. K., Ingle, J. N. & Brauch, H., 19 Feb 2025, In: npj Breast Cancer. 11, 1, 18.

      Research output: Contribution to journalArticleAcademicpeer-review

      Open Access
      File
    • The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

      Bornes, L., van Winden, L. J., Geurts, V. C. M., de Bruijn, B., Azarang, L., Lanfermeijer, M., Caruso, M., Proost, N., Boeije, M., Lohuis, J. O., Belthier, G., Noguera Delgado, E., de Gruil, N., Kroep, J. R., van de Ven, M., Menezes, R., Wesseling, J., Kok, M., Linn, S. & Broeks, A. & 3 others, van Rossum, H. H., Scheele, C. L. G. J. & van Rheenen, J., Jan 2025, In: Nature. 637, 8044, p. 195-204 10 p., 8487.

      Research output: Contribution to journalArticleAcademicpeer-review

      Open Access
      File
    • The prognostic and predictive value of the luminal-like subtype in hormone receptor-positive breast cancer: an analysis of the DATA trial

      Lammers, S. W. M., Geurts, S. M. E., Hermans, K. E. P. E., Kooreman, L. F. S., Swinkels, A. C. P., Smorenburg, C. H., van der Sangen, M. J. C., Kroep, J. R., Honkoop, A. H., van den Berkmortel, F. W. P. J., de Roos, W. K., Linn, S. C., Imholz, A. L. T., Vriens, I. J. H. & Tjan-Heijnen, V. C. G., Feb 2025, In: ESMO open. 10, 2, 104154.

      Research output: Contribution to journalArticleAcademicpeer-review

      Open Access
      File
    • Academic Uphill Battle to Personalize Treatment for Patients With Stage II/III Triple-Negative Breast Cancer

      Kok, M., Gielen, R. J., Adams, S., Lennerz, J. K., Sharma, P., Loibl, S., Reardon, E., Sonke, G., Linn, S., Delaloge, S., Lacombe, D., Robinson, T., Badve, S., Martin, M., Balko, J. M., Ignatiadis, M., Curigliano, G., Wolff, A. C., Mittendorf, E. A. & Loi, S. & 3 others, Pusztai, L., Tolaney, S. M. & Salgado, R., 20 Oct 2024, In: Journal of Clinical Oncology. 42, 30, p. 3523-3529 7 p.

      Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review