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Roger Damoiseaux started his medical career in Africa. He worked for 4 years as a medical officer in a mission hospital in Malawi (Central Africa). Since 1995 he works as a general practitioner. In 2000 he finished his PhD thesis ‘acute otitis media in infancy in general practice, a therapeutic and prognostic study’. In 2011 he became a teacher at the specialty training in general practice at the University Medical Center in Utrecht. In 2013 he was appointed as head of the GP specialty training in Utrecht. In 2014 he was appointed as professor of General Practice at the University Medical Center in Utrecht.

His research focuses on the treatment of otitis media and upper respiratory tract infections in children. Further there is an ongoing search for prognostic factors for these medical problems. He also is involved in research on medical education.

He is co-author of professional guidelines and Cochrane reviews on otitis media and colorectal blood loss. He is member of the editorial board of the Cochrane group ‘acute respiratory infections’. From 2003 until 2007 he was member of the editorial board of ‘Huisarts en Wetenschap’ and from 2012 until 2020 he was member of the editorial board of 'het Nederlands Tijdschrift voor Geneeskunde'. From 2007 until 2011 he was member of the Commission Pharmaceutical Help (CFH) of the Health Care Insurance Board (CVZ). From 2014 to 2016 he was a member of the Registration Board of Medical Specialists (RGS). From 2016 to 2024 he was a member of the Legislative Board of Medical Specialists (CGS).