Personal profile
Biography
Robin H. van der Weide is an Assistant Professor in computational and single-cell genomics at the Center for Molecular Medicine, UMC Utrecht. His research focuses on understanding how the many regulatory layers of the (epi)genome control cell identity in development and disease.
Robin combines cutting-edge experimental techniques with computational analysis to reveal hidden patterns in gene regulation. During his PhD at the Netherlands Cancer Institute, he showed how the Cohesin protein complex creates physical loops in DNA, fundamentally shaping how the genome is organized in three dimensions.
As a postdoctoral researcher at the Hubrecht Institute, he co-developed MAbID, a technology that measures multiple features of gene regulation simultaneously in thousands of individual cells. This innovation opened new ways to study how cells make decisions and led to a biotechnology spin-off.
His lab takes a holistic approach to studying what turns genes on or off in healthy and diseased cells: single-cell chromatin systems biology. Robin is passionate about training the next generation of scientists and building a collaborative, transparent research environment.
Fellowship & awards
2024 - UitZicht Pilot Grant
2023 - NWO VENI Fellowship
2021 - GOA Young Investigator Award
Collaborations and top research areas from the last five years
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A computational framework to dissect imputation strategies for single-cell histone modification data
Moreno-González, M., de Ridder, J., Kind, J. & van der Weide, R. H., Dec 2025, In: NAR genomics and bioinformatics. 7, 4, lqaf192.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Combinatorial single-cell profiling of major chromatin types with MAbID
Lochs, S. J. A., van der Weide, R. H., de Luca, K. L., Korthout, T., van Beek, R. E., Kimura, H. & Kind, J., Jan 2024, In: Nature Methods. 21, 1, p. 72-82 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
A Mediator-cohesin axis controls heterochromatin domain formation
Haarhuis, J. H. I., van der Weide, R. H., Blomen, V. A., Flach, K. D., Teunissen, H., Willems, L., Brummelkamp, T. R., Rowland, B. D. & de Wit, E., 8 Feb 2022, In: Nature Communications. 13, 1, p. 754Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Distinct roles for CKM–Mediator in controlling Polycomb-dependent chromosomal interactions and priming genes for induction
Dimitrova, E., Feldmann, A., van der Weide, R. H., Flach, K. D., Lastuvkova, A., de Wit, E. & Klose, R. J., Oct 2022, In: Nature Structural and Molecular Biology. 29, 10, p. 1000-1010 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access -
Hi-C analyses with GENOVA: a case study with cohesin variants
van der Weide, R. H., van den Brand, T., Haarhuis, J. H. I., Teunissen, H., Rowland, B. D. & de Wit, E., Jun 2021, In: NAR genomics and bioinformatics. 3, 2, lqab040.Research output: Contribution to journal › Article › Academic › peer-review
Open Access