Personal profile
Personal webpage
http://www.nanomedicinelab.eu/
https://www.linkedin.com/pub/raymond-schiffelers/13/247/487
https://scholar.google.nl/citations?user=7OLnPLIAAAAJ&hl=nl
Biography
Raymond Schiffelers studied Bio-Pharmaceutical Sciences at Leiden University (1990-1995). After an industrial traineeship at SmithKline Beecham Pharmaceuticals (UK) he did his PhD in medical microbiology at Erasmus University Rotterdam on liposomal targeting of antimicrobial agents (1996-2001). Subsequently he became post-doc at Utrecht University working on liposomes targeting tumor vasculature. In 2002-2003, at Intradigm Co (USA) he expanded his tumor vasculature-targeting work with polymers for delivery of siRNA. After his return to Utrecht University he became assistant and then associate professor. He co-invented OncoCort® a nanomedicine formulation of corticosteroids that will enter clinical trials in 2015. In 2011, he moved to the Laboratory for Clinical Chemistry & Hematology of the University Medical Center Utrecht to work on nanomedicines, both for diagnosis and therapy. In particularly, he focuses on extracellular vesicles in the circulation as inspiration for new drug delivery systems and diagnostic readouts. He is founding member of the International Society for Extracellular Vesicles (ISEV) founding member and member organizing committee for the ISEV2014-annual meeting, Associate Editor of the Journal Extracellular Vesicles and editor of the International Journal of Pharmaceutics and the Journal of Controlled Release. He is Founder of EXCYTEX-an extracellular vesicle-based company and member of the Scientific Advisory Board for a number of start-up companies.
Fellowship & awards
Vidi 2007 ‘Targeting inflammation to fight cancer’
Galenus Research Award 2009
ERC Consolidator grant 2010 260627 ‘Microvesicle-inspired drug delivery systems’
ERC Proof of Concept grant 2012 29744 ‘TargetMV’
Education/Academic qualification
PhD Liposomal Targeting of Antimicrobial Agents to Bacterial Infections, Erasmus University Rotterdam
15 Jan 1996 → 7 Feb 2001
Award Date: 7 Feb 2001
MSc Bio-Pharmaceutical Sciences, Leiden University
1 Sept 1989 → 25 Sept 1995
Award Date: 25 Sept 1995
External positions
Scientist - Projectadvies - Hospital del Mar Research Inistitute Barcelona
15 Mar 2026 → 31 Dec 3999
Binnen Nanocell Therapeutics heb ik de functie van VP Preclinical R&D - supervisie onderzoekers op het gebied van preklinische R&D van nanomedicines - Nanocell Therapeutics
1 Jun 2021 → 31 Dec 3999
Scientific Advisory Board - bedrijf ontwikkelt producten op mijn vakgebied - SentryX bv
1 Jun 2019 → 31 Dec 3999
associate editor - publicatie op mijn vakgebied - Drug Delivery & Translational Research
1 Aug 2018 → 31 Dec 3999
Chief Scientific Officer - Wetenschappelijke ontwikkelingen signaleren en onderzoeksstrategie bepalen - Excytex bv
15 Jan 2014 → 31 Dec 3999
Collaborations and top research areas from the last five years
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Efficiency and immunogenicity of lipid nanoparticle-mediated cardiac mRNA delivery are lipid composition-dependent
Labonia, M. C. I., Martinez de Castilla, P. E., van der Kraak, P. H., Brans, M. A. D., Yang, Q., Lei, Z., de Jager, S. C. A., de Voogt, W. S., Schiffelers, R. M., Sluijter, J. P. G. & Vader, P., 16 Jun 2026, In: Molecular Therapy Nucleic Acids. 37, 2, 102939.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Impaired placental vascular remodeling and persistent uNK cells in the RUPP model: A time-dependent perspective
van Kammen, C. M., Al Darwish, F. M., Strijkers, G. J., Coolen, B. F., Alles, L. K., Faas, M. M., Schiffelers, R., Lely, A. T. & Terstappen, F., Feb 2026, In: Placenta. 174, p. 1-8 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Downloads (Pure) -
LAH5-mediated delivery of prime editor ribonucleoprotein complexes for genome editing
Yao, B., Öktem, M., Yang, G., Wang, Q., Daniels, M. A., Dokter, I., Lefferts, J. W., Gonçalves, M. A. F. V., Doevendans, P. A., van Mil, A., Sluijter, J. P. G., Schiffelers, R., Mastrobattista, E. & Lei, Z., 10 Mar 2026, In: International Journal of Pharmaceutics. 692, 10 p., 126622.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Liposomal encapsulation of L-arginine and L-citrulline enhances pharmacokinetics and therapeutic effects in a model of preeclampsia and fetal growth restriction
van Kammen, C., Brink, M., Minnion, M., Feelisch, M., Schiffelers, R., Lely, T. & Terstappen, F., 18 Mar 2026, In: Scientific Reports. 16, 1, 13970.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Longitudinal 3D-DCE MRI Assessment of Placental Perfusion Under Reduced Uterine Perfusion Pressure in Pregnant Rats
Al Darwish, F. M., van Kammen, C., Terstappen, F., Alles, L., Schiffelers, R., Lely, A. ., Strijkers, G. & Coolen, B., Apr 2026, In: NMR in Biomedicine. 39, 4, e70251.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure)
Activities
- 1 Examination
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Lipid Nanoparticle-Mediated Delivery of CRISPR-Cas9 for Therapeutic Gene Correction
Mastrobattista, E. (Examiner), Bosma, P. J. (Examiner), Fuchs, S. (Examiner), Geijsen, N. (Examiner), Merkel, O. (Examiner), Schiffelers, R. (Examiner) & Vermonden, T. (Examiner)
4 Dec 2023Activity: Examination › Academic
File
Prizes
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NWA-ORC: Nanospresso-NL: Local preparation of high-quality, personalized nucleic acid nanomedicines
Schiffelers, R. (Recipient), Estapé Sentí, M. (Recipient), Saber, N. (Recipient), Zwart, B. (Recipient) & Fuchs, S. (Recipient), 2022
Prize: Prize (including medals and awards)
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NWA-ORC: NANOSPRESSO-NL: op maat gemaakte gepersonaliseerde geneesmiddelen versus grootschalige industriële productie van geneesmiddelen
Schiffelers, R. (Recipient), Vermes, A. (Recipient), Dekker, J. (Recipient), Fuchs, S. A. (Recipient) & van Hasselt, P. (Recipient), 2021
Prize: Prize (including medals and awards)