Research output per year
Research output per year
Personal profile
Biography
Pieter Vader graduated in Chemistry (B.Sc., 2005) and Drug Innovation (M.Sc., 2007) from the University of Utrecht. He earned his PhD degree in 2012 from the University of Utrecht on the subject of targeted delivery of siRNA to inhibit tumor angiogenesis.
From 2012 to 2014, Pieter was employed as a (senior) postdoctoral fellow at the University of Oxford, UK, in the lab of Prof. Matthew Wood, supported by a NWO Rubicon fellowship. The research topic was development of small RNA-loaded extracellular vesicles for targeted delivery.
In 2014 he moved back to The Netherlands to continue his work at the University Medical Center Utrecht. Currently, he is Associate Professor at CDL Research and at the Department of Experimental Cardiology. His main research interests are in the field of therapeutic applications of extracellular vesicles, including unraveling the mechanisms underlying extracellular vesicle-mediated cargo transfer. His research has been supported by a NWO Veni Grant (2014), ERC Starting Grant (2019), Dutch Heart Foundation Dekker Senior Scientist Grant (2019), NWO Vidi Grant (2020) and ERC Consolidator Grant (2023). In 2021, Pieter was awarded the Prix Galien Research Award for his work on drug delivery.
Fellowship & awards
- 2023 ERC Consolidator Grant for the project: "Unravelling extracellular vesicle heterogeneity to inspire improved therapeutic RNA delivery systems"
- 2020 NWO Vidi grant for the project: "Molecular drivers of extracellular vesicle targeting and RNA transfer – towards improved delivery"
- 2019 ERC Starting grant for the project: "Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles"
- 2019 Dutch Heart Foundation Dekker Senior Scientist grant for the project: "Therapeutic mRNA delivery to the myocardium for cardiac regeneration"
- 2014 NWO Veni grant for the project: “Inspired by nature: Extracellular vesicles as potent RNA delivery platforms”
- 2011 NWO Rubicon grant for the project: "Cell-derived microvesicles for delivery of small RNAs to tumours"
External positions
Member of Scientific Advisory Board
1 Apr 2019 → …
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration
Labonia, M. C. I., Estapé Senti, M., van der Kraak, P. H., Brans, M. A. D., Dokter, I., Streef, T. J., Smits, A. M., Deshantri, A. K., de Jager, S. C. A., Schiffelers, R. M., Sluijter, J. P. G. & Vader, P., May 2024, In: Journal of controlled release : official journal of the Controlled Release Society. 369, p. 734-745 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes
Ilahibaks, N. F., Kluiver, T. A., de Jong, O. G., de Jager, S. C. A., Schiffelers, R. M., Vader, P., Peng, W. C., Lei, Z. & Sluijter, J. P. G., Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, e12389.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
Inter-laboratory multiplex bead-based surface protein profiling of MSC-derived EV preparations identifies MSC-EV surface marker signatures
Nguyen, V. V. T., Welsh, J. A., Tertel, T., Choo, A., van de Wakker, S. I., Defourny, K. A. Y., Giebel, B., Vader, P., Padmanabhan, J., Lim, S. K., Nolte-'t Hoen, E. N. M., Verhaar, M. C., Bostancioglu, R. B., Zickler, A. M., Hong, J. M., Jones, J. C., EL Andaloussi, S., van Balkom, B. W. M. & Görgens, A., Jun 2024, In: Journal of Extracellular Vesicles. 13, 6, e12463.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., M˜y, G. M., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., & 20 others, 7 Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses
van de Wakker, S., Bauzá-Martinez, J., Rios Arceo, C., Manjikian, H., Snijders Blok, C. J. B., Roefs, M., Maas, R. G., Willms, E., Pronker, M. F., de Jong, O., Wu, W., Görgens, A., Andaloussi, S. E. L., Sluijter, J. & Vader, P., 13 Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, 21 p., 12396.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure)
Activities
- 1 Consultancy