1993 …2024

Research activity per year

Personal profile

Personal webpage

Biography

Pieter A. Doevendans became a cardiologist in Maastricht (trained by H. Wellens) after his medical training at the Leiden University. In 1993-1994 he had the opportunity to work with Ken Chien at the University of California San Diego, where the work on embryonic stem cells started. The work was completed in Maastricht and provided the basis for a thesis on the function of the promoter of the atrial Myosin Light Chain gene. Upon return in The Netherlands he worked with Christine Mummery and Hans Clevers on both human Embryonic as well as human Cardiac stem cells. In the meantime he remained active as an interventional cardiologist initially in Maastricht, but from 2002 on in Utrecht at the UMC Utrecht. Here he was appointed full professor in Translational Cardiology in 2004 and head of the department in 2005. The focus of the department of cardiology is on Cardiac Failure, Stem Cells and Genetics. He was funded by various national and international foundations. Thus far (2017) he published more than 700 peer reviewed papers and 11 books

Fellowship & awards

 

Honors

  • Fellow of the European Society of Cardiology, 2000
  • Honorary Professor Yantai Yuhuangding Hospital, China, 2007
  • Visiting Professor Harvard University, USA, 2007-2009
  • Romanian Academy of Medical Sciences (Honorary Foreign Fellow), 2009
  • Visiting Professor Rose Weiss Lahey Hospital & Medical Center, USA, 2014

 

Research grants obtained 

  • NATO Collaborative Research Grant. 1996-1997. Travel grant for collaboration with Robert S. Kass, University of Columbia, New York USA. "Expression of min K channels in heart".
  • The Netherlands Heart Foundation: 1997-1999. "The characterization of the regulatory sequence of the atrial myosin light chain 2 gene".

  • NIH: "The role of the min K gene". Grant with R.S. Kass.

  • The Netherlands Heart Foundation: “Hypertrophic cardiomyopathy: early non-invasive identification of altered myocardial mechanics and coronary flow” (nr. 99.203) with A.C. van Rossum, VU Amsterdam.

  • The Netherlands Heart Foundation: “Characterization of the effects of estrogen on cardiac function under pathophysiologic conditions” (nr. 99.114)

  • The Netherlands Heart Foundation: “Elucidation of pathogenic genetic pathways in the hypertrophic and failing heart by micro-array-technology” (nr. 99.122) with H. Smeets, University Maastricht.

  • Jan Dekkerstichting en dr. Ludgardine Bouwmanstichting: “Adenovirale gentherapie voor boezemfibrilleren” (nr. 99-04)

  • The Netherlands Heart Foundation: “Inhibition of myocardial hypertrophy and dilatation by viral mediated blockade of intracellular signaling pathways” (nr. 2000.160)

  • ICIN: Molecular genetic basis of cardiovascular disease (2000)

  • ICIN: Human genetics and cardiovascular developement (2000)

  • NHS: Dekker program: Vanessa van Empel (2001-2004)

  • STW: Stem cell based cardiomyocyte differentiation and classification in 3 D cultures (2003)

  • BSIK: Weefsel op maat (2003)

  • Bekales Research Grant – Cardiology 2004, candidature.

  • Bekales Research Grant (2005)

  • NHS: Translational medicine: stem cell applications (2006)

  • ICIN: Stem cells from patients with genetic cardiac disease (2007)

  • BMM: SMARTCARE: cardiac repair with microtissues (2008)

  • NIRM: Stem cells as disease models (2009)

  • ZonMw: TAS (Translationeel Adult Stamcelonderzoek) Cardiomyocyte progenitor cells for clinical application in cardiac repair (2011-2015)
    Phase A1 preclinical PL €300.000 (total project  €2.0M)

  • CVON: HUSTCARE: HUman STem cells for CArdiac Repair (2012-2017)
    (Total project 0,5M)

  • CAS-NW Program: Cardiac cell therapy in a preclinical animal model for hereditary cardiomyopathie (Total project 450K)

  • Leducq (Total project 6 M€) (2018)

  • RegMed: Cardiovascular Moonshot (4 M€) (2018)

Side activities

                                   

  • Member of the Scientific Board, Netherlands Heart Institute                                                                                         
  • Chairman Steering committee Heart and Vascular Center  
  • Advisor AMT Utrecht
  • Advisor and shareholder HeartEye                                                                          

External positions

adviesraad - aandeelhouder in HeartEye - HeartEye

1 Jan 202231 Dec 3999

Aansturen Netherlands Heart Institute - Letten op belangen van beide organisaties omdat het beide over cardiologie gaat. - Netherlands Heart Institute

1 Jan 202131 Dec 3999

Advies medisch inhoudelijk en funding - Geen Chirurgische technieken Inkomsten voor afd cardiologie - AMT

1 Sept 202031 Dec 3999

Keywords

  • R Medicine (General)

Collaborations and top research areas from the last five years

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