Research output per year
Research output per year
Personal profile
Biography
I am an associate professor in clinical trial methodology and statistics working within the Department of Data Science and Biostatistics of the Julius Center where I lead the Clinical Trial Methodology & Statistical Consultation team. My interests lie in innovative clinical trial methodology (both development and application) and adaptive methods, trials-within cohorts and trials in rare diseases in particular. I am the Trial Methodology Lead for U-TRIAL and workpackage leader for the Adaptive Trial Platform WP in the ONCODE-ACCELERATOR growthfund project. I am the chair of the UMC Utrecht's internal DSMB. I also act as a methodology assessor (seconded) for the Dutch Medicines Evaluation Board (College ter Beoordeling van Geneesmiddelen: CBG-MEB).
From July 2009 until April 2021 I worked at the Amsterdam UMC location VUmc as a researcher, a statistical consultant and methodology member of the hospital's institutional review board (METc).
I hold a PhD degree in Statistics from Eindhoven University of Technology (2007), a M.A. degree in Health Psychology from Tilburg University (2003) and a M.Sc. degree in Engineering Mathematics from Eindhoven University of Technology (2001). I have held postdoctoral research positions at the Southampton Statistical Sciences Research Institute S3RI (2007-2008) and TNO Quality of Life (2008-2009).
Side activities
Member of the Internal Grant Review Committee Development (since 2022) and PIPELINE Committee (since 2024) of the Dutch Cancer Society
Expert statistical reviewer for Diabetologia (since 2020)
Member of several external Data Safety and Monitoring Boards (since 2017)
Member of the Statistical Expert Panel of the Dutch Oncology Research Platform DORP (2019 - 2022)
External positions
Member of the grant review board of the Dutch Cancer Society (KWF)
1 Jan 2022 → …
Methodology asssessor (seconded), Dutch Medicines Evaluation Board (MEB), Utrecht
1 May 2021 → …
Statistical reviewer (paid) for Diabetologia
1 Oct 2020 → …
Keywords
- HA Statistics
- Clinical trials
- Adaptive methods
- Bayesian methods
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Breaking the chains of lipoprotein lipase deficiency: A pediatric perspective on the efficacy and safety of Volanesorsen
den Hollander, B., Brands, M. M., Nijhuis, I. J. M., Doude van Troostwijk, L. J. A. E., van Essen, P., Hofsteenge, A. H., Koot, B. G., Müller, A. R., Tseng, L. A., Stroes, E. S. G., van de Ven, P. M., Wiegman, A. & van Karnebeek, C. D. M., May 2024, In: Molecular Genetics and Metabolism. 142, 1, 108347.Research output: Contribution to journal › Article › Academic › peer-review
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Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials
Müller, A. R., den Hollander, B., van de Ven, P. M., Roes, K. C. B., Geertjens, L., Bruining, H., van Karnebeek, C. D. M., Jansen, F. E., de Wit, M. C. Y., ten Hoopen, L. W., Rietman, A. B., Dierckx, B., Wijburg, F. A., Boot, E., Brands, M. M. G. & van Eeghen, A. M., 4 Jan 2024, In: BMC Psychiatry. 24, 1, 23.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Corrigendum to “Effectiveness of L-serine supplementation in children with a GRIN2B loss-of-function mutation: Rationale and protocol for single patient (n-of-1) multiple cross-over trials” [Contemp. Clin. Trials Commun. 36 (2023)/ DOI: 10.1016/j.conctc.2023.101233] (Contemporary Clinical Trials Communications (2023) 36, (S2451865423001795), (10.1016/j.conctc.2023.101233))
Hollander, B. D., Rothuizen-Lindenschot, M., Geertjens, L., Vaz, F. M., Brands, M. M., Le, H. L., van Eeghen, A. M., van de Ven, P. M., Cornel, M. C., Jacobs, B. A. W., Bruining, H. & van Karnebeek, C. D., Apr 2024, In: Contemporary Clinical Trials Communications. 38, 101264.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
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Hyperbaric Oxygen Therapy and Late Local Toxic Effects in Patients With Irradiated Breast Cancer: A Randomized Clinical Trial
Mink van der Molen, D. R., Batenburg, M. C. T., Maarse, W., van den Bongard, D. H. J. G., Doeksen, A., de Lange, M. Y., van der Pol, C. C., Evers, D. J., Lansdorp, C. A., van der Laan, J., van de Ven, P. M., van der Leij, F. & Verkooijen, H. M., 1 Apr 2024, In: JAMA Oncology. 10, 4, p. 464-474 11 p.Research output: Contribution to journal › Article › Academic › peer-review
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Rationale and design for the randomized placebo-controlled double-blind trial studying the effect of single antiplatelet therapy (clopidogrel) versus dual antiplatelet therapy (clopidogrel/acetylsalicylic acid) on the occurrence of atherothrombotic events following lower extremity peripheral transluminal angioplasty (CLEAR-PATH)
Wegerif, E. C. J., Ünlü, Ç., Generaal, M. I., van den Bor, R. M., van de Ven, P. M., Bots, M. L. & de Borst, G. J., Jul 2024, In: American Heart Journal. 273, p. 121-129 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure)