Research output per year
Research output per year
Personal profile
Personal webpage
Biography
Patrick Derksen (1970) obtained his PhD at the department of Pathology, Academic Medical Center, Amsterdam, The Netherlands. Following his graduation in 2003, he moved to the Netherlands Cancer Institute to study the consequences inactivation of cell-cell adhesion in breast cancer development and progression. Here he developed two mouse models for human invasive lobular carcinoma (ILC), by conditional and mammary-specific knockout of E-cadherin and p53. In 2005 he was awarded an independent researcher grant from the Dutch organization for scientific research (NWO-VENI) in 2005. In 2007, he joined the Medical Oncology department as an independent researcher and head of the UMCU Mouse Cancer Clinic. He received a NWO-VIDI award in 2008. In 2010 his position was tenured as an Associate Professor at the Department of Pathology.
His group is aiming at combining expertise on adhesion molecules, cell signaling and clinically relevant mouse models to study the downstream effectors of the adherens junction complex that propel breast cancer development and progression.
Research in the Derksen laboratory is currently sponsored by grants from NWO, KWF, H2020, STW and Breast Cancer Now.
Fellowship & awards
NWO-VENI 916.56.135. (2006)
AICR 07-585. (2007)
Pink Ribbon Award (2008)
NWO-VIDI 016.096.318. (2009)
KWF-UU 2011-5230 (2011)
Stichting Vrienden UMC Utrecht (2011)
KWF UU 2013-5801 (2013)
KWF-UU 2014-7201 (2015)
Side activities
Chair European Lobular Breast Cancer Consortium (ELBCC)
Side activities
Chair COST Action #19138 LOBSTERPOT
Side activities
Scientific Advisory Board Member of the Lobular Breast Cancer Alliance (LBCA)
Side activities
co-investigator POSEIDON-2-Lobular Clinical intervention trial
External positions
Clinical Trial Manager/Coordinator - borstkanker - NKI/AvL
1 Apr 2022 → 31 Dec 3999
Chair - borstkanker - COST
29 Oct 2020 → 31 Dec 3999
scientific advisory board member - borstkanker - LBCA
1 Apr 2019 → 31 Dec 3999
Chair - borstkanker - European Lobular Breast Cancer Consortium
1 Nov 2018 → 31 Dec 3999
Keywords
- RB Pathology
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S., Fortier, A-M., & 6 others, 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Combined spatial Keratin expression profiles at the invasive front represent a prognostic classifier for head and neck cancer
Haughton, P. D., Haakma, W. E., van Kempen, S., de Ruiter, E. J., Willems, S. M. & Derksen, P. W. B., Jun 2024, In: Oral Oncology Reports. 10, 11 p., 100394.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Differential transcriptional invasion signatures from patient derived organoid models define a functional prognostic tool for head and neck cancer
Haughton, P. D., Haakma, W., Chalkiadakis, T., Breimer, G. E., Driehuis, E., Clevers, H., Willems, S., Prekovic, S. & Derksen, P. W. B., 2 Aug 2024, In: Oncogene. 43, 32, p. 2463-2474 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Integration of pathological criteria and immunohistochemical evaluation for invasive lobular carcinoma diagnosis: recommendations from the European Lobular Breast Cancer Consortium
Jul 2024, In: Modern Pathology. 37, 7, 100497.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
International survey on invasive lobular breast cancer identifies priority research questions
Oesterreich, S., Pate, L., Lee, A. V., Chen, F., Jankowitz, R. C., Mukhtar, R., Metzger, O., Sikora, M. J., Li, C. I., Sotiriou, C., Shah, O. S., Koorman, T., Ulaner, G., Reis-Filho, J. S., Davidson, N. M., Van Baelen, K., Hutcheson, L., Freeney, S., Migyanka, F., Turner, C., & 3 others, 20 Jul 2024, In: npj Breast Cancer. 10, 1, p. 1-7 7 p., 61.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile
Prizes
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De Achilleshiel van uitzaaiende kankercellen
Derksen, Patrick (Recipient), 2008
Prize: Prize (including medals and awards)