Personal profile
Biography
Dr Patricia Olofsen is a postdoc in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. She obtained her PhD in 2021 at the Erasmus University on the molecular and cellular defects driving the leukemic progression of severe congenital neutropenia. Intrigued by neutrophils, cytokines and cancer, she joined the Leusen lab in 2021 to study the role of cytokines in attracting and activating neutrophils to kill tumor cells using IgA monoclonal antibodies.
Collaborations and top research areas from the last five years
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Germline LCP1 mutations cause immunodeficiency with neutropenia, monocytopenia, lymphopenia and defective cytokinesis
van Bergen, T., Bosch, D., Bellanné-Chantelot, C., Mulet-Lazaro, R., Bledsoe, J. R., Chen, L., de Looper, H. W. J., van Dijk, C., Ter Borg, M., Bindels, E., Hoogenboezem, R., Roovers, O., Olofsen, P. A., Bartels, M., van Montfrans, J. M., Breed, P., Salzer, E., Holierhoek, M. G., Nelken, B. & Beaupain, B. & 7 others, , 10 Feb 2026, In: Blood Advances. 10, 3, p. 627-641 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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Quantification of Signal Transduction Pathway Activity in Pancreatic Ductal Adenocarcinoma
Raymakers, L., Daamen, L. A., Intven, M. P. W., Leusen, J. H. W., Olofsen, P. A., van de Stolpe, A. & Raymakers, R. A. P., 25 Nov 2025, In: International Journal of Molecular Sciences. 26, 23, 18 p., 11385.Research output: Contribution to journal › Article › Academic › peer-review
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The Efficacy of Targeted Monoclonal IgA Antibodies Against Pancreatic Ductal Adenocarcinoma
Raymakers, L., Passchier, E. M., Verdonschot, M. E. L., Evers, M., Chan, C., Kuijpers, K. C., Raicu, G. M., Molenaar, I. Q., van Santvoort, H. C., Strijbis, K., Intven, M. P. W., Daamen, L. A., Leusen, J. H. W. & Olofsen, P. A., 24 Apr 2025, In: Cells. 14, 9, 21 p., 632.Research output: Contribution to journal › Article › Academic › peer-review
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Enhancing neutrophil cytotoxicity of a panel of clinical EGFR antibodies by Fc engineering to IgA3.0
Chan, C., Jansen, J. H. M., Hendriks, I. S. T., van der Peet, I. C., Verdonschot, M. E. L., Passchier, E. M., Tsioumpekou, M., Nederend, M., Klomp, S. A., Valerius, T., Peipp, M., Leusen, J. H. W. & Olofsen, P. A., 4 Sept 2024, In: MOLECULAR CANCER THERAPEUTICS. 23, 9, p. 1317-1331 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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The Effect of Radiation Treatment of Solid Tumors on Neutrophil Infiltration and Function: A Systematic Review
Raymakers, L., Demmers, T. J., Meijer, G. J., Molenaar, I. Q., Santvoort, H. C. V., Intven, M. P. W., Leusen, J. H. W., Olofsen, P. A. & Daamen, L. A., 1 Nov 2024, In: International journal of radiation oncology, biology, physics. 120, 3, p. 845-861 17 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Downloads (Pure)