Nico Wulffraat

prof. dr.

    1985 …2024

    Research activity per year

    Personal profile

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    Biography

    Nico Wulffraat is professor of pediatric Rheumatology at the department of pediatrics, University Medical Center, Utrecht, The Netherlands. He obtained his MD and PhD (1987) at the Free University Hospital Amsterdam. He trained as a paediatrician from 1988 untill 1993 in Utrecht. He was fellow pediatric immunology and rheumatology from 1993 to 1995 in the WKZ. Since 1995 he worked as a consultant in pediatric immunology-rheumatology. Since 2010 he is the head of this subunit. From 1997-2004 he was also coordinator of the pediatric allogeneic and autologous stem cell transplantations for immune deficiencies, metabolic disorders and autoimmune diseases. He is PI of several investigator initiated trials of immunisations in children with rheumatic diseases including MMR, HPV and Men C, prevention of MTX side effects, and application of Mesenchymal Stem cells in refractory GvHD and JIA. He is coordinator of a FP7 consortium for pharmacovigilance of biologics used in JIA (PHARMACHILD). Also he leads the EHHC project SHARE that aims at documenting standards of care and treatment recommendations for pediatric rheumatic diseases throughout Europe.

    Since 2008 he became supervisor of the postgraduate clinical fellowship pediatric rheumatology and since 2009 head of pediatric immunology and rheumatology. In 2014, he was appointed as head of pediatric Rheumatology, Immunology, hematology and infectious diseases.

    He has co-authored 220 Pubmed cited papers in international journals on pediatric rheumatology and immunology and 12 chapters in books.

    Side activities

    Committees:

    Gezondheidsraad advies CVS

    ZonMW commissie programma translationeel onderzoek en adulte stamcellen, adviesgroep medische producten (2009-2016)

    Evaluatie beoordeling NFU expertise centra

    Council PRES (2004-2010)

    Council PRINTO National representative for NL (2001-2014)

    ERN RITA HCP Member Representative (2017) and since 2019 ERN RITA coordinator

    Reviewer for all major rheumatology Journals, Blood, Lancet, NEJM

    Memberships:

    Member of EBMT working party for autoimmune diseases (Chair R Saccardi, Florence Italy)

    Member of the ZONWM programme committee Translational Adult Stem cell research

    Member of Advisory working group consisting of external experts for RIVM (Corona related) (2021- )

    Member of the European Medicines Agency (EMA) expert group for pediatric rheumatology

    Member of the ZONMW programme committee Priority medicines for children

    Member of the advisory council Ter Meulen Fonds

    Member of the Drug Safety Monitoring board of the adalumimab trial for uveitis (NHS, England)

    Member of the board for the Dutch pediatric rheumatology society, for education and research (2001-2010)

    Member of the board for Utrecht pediatric postgraduate courses (1999-2010)

    Member of the Scientific Advisory Council of the Dutch League for Rheumatology (Nationaal Reumafonds, 2006-2009)

    Member of the Utrecht study group for the development of the electronic patient file into clinical paractise (2005-2009)

    Member of the EBMT working party for inborn errors and immunodeficiencies (1996-2008)

    Potential Conflicts of Interest

    Dr. Wulffraat has regular interaction with pharmaceutical and other industrial partners. These activities were continued until 2018 . Since then he is the chair of the European rare Diseases Network (RITA) and receives grants from the EU to sustain this network. As per may 2022 he will receive a part time salary for this. ERN RITA has supported international clinical practice guidelines. UMCU has received incidental funding (up to €10,000 as multi sponsoring per event as  support for research and educational activities deployed by the Pediatric Rheumatology European Society. This is a non-for profit organization. He has received support from the Dutch medical Insurance company het Zilveren Kruis for a study on the use of an App (as a medical device) specifically for patients with chronic arthritis

    Fellowship & awards

    FP7 Grant Pharmachild

    AEMC Grant SHARE

    Div. ZON MW Grants

    UCAN CANDU

    Foreum

    AbbVie (bijdrage Reuma2Go)

    Roche (bijdrage Reuma2Go)

    ERN coordinator RITA

    ZonMW grant Chronic Fatique QFS and JIA

    External positions

    chair of the European rare Diseases Network (RITA) - Clinical & Research expertise - The European Reference Network

    1 May 202231 Dec 3999

    Collaborations and top research areas from the last five years

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