Personal profile
Biography
Michiel was trained as a medical doctor (2002) and pediatrician (2010) and as a clinical epidemiologist (2009) at the UMC Utrecht. In 2011 he obtained his PhD on his thesis entitled: RSV Bronchiolitis in Healthy Term Infants, Pathogenesis and Prediction. Since 2010 he works as a general pediatrician in the Wilhelmina Children’s Hospital (UMC Utrecht) and since 2014 he is head of the section of general en social pediatrics. He is the pediatrician and coordinator of the 22q11.2 deletion syndrome childhood outward patient clinic and studies the heterogeneity and prognostic factors of this syndrome, in close collaboration with colleagues of other pediatric, surgery, psychiatric, psychology and genetics specialties. He is also involved in several further studies on the healthy term birth (amniotic fluid) cohort from his PhD trajectory.
Fellowship & awards
- 2011-12 PhD Curriculum of Training Upcoming Leaders in Pediatric Science (TULIPS), competitive selection
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2011 NVK Masterclass, Prof Dr B Prakken, Prof Dr HJ Verkade, competitive selection
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2007 NVK Young Investigators, award best poster presentation
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2005 ESPID Fellowship Award
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2000 UMC Utrecht Students’ Scientific meeting, 2nd price for oral presentation
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1992 Theoretical Mathematics Olympiads, team competition, national winner
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1992 Applied Mathematics Olympiads, team competition, national winner
External positions
Bestuurslid NVK-sectie Erfelijke en Aangeboren Aandoeningen (EAA) - Algemeen kinderarts met dit aandachtsgebied - Ned. Ver. Kindergeneeskunde
1 May 2022 → 31 Dec 3999
Member of the Multidisciplinary advisory board of the Dutch patient support group “Steun 22Q11" - Kinderarts & medisch coordinator van 22q11-polikliniek WKZ / UMCU - Dutch patient support group “Steun 22Q11"
1 Nov 2017 → 31 Dec 3999
Collaborations and top research areas from the last five years
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Natural history study of scoliosis in patients with 22q11.2 deletion syndrome, starting before disease onset
Lafranca, P. P. G., de Reuver, S., Abdi, A., Houben, M. L., Kruyt, M. C., Ito, K., Castelein, R. M. & Schlösser, T. P. C., Jan 2026, In: Spine Deformity. 14, 1, p. 227-235 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
A comprehensive overview of neuropsychiatric symptoms in adolescents with 22q11.2 deletion syndrome
Selten, I., Blok, J., Boerma, T., Djelantik, A. A. A. M. J., Houben, M., Wijnen, F., Zinkstok, J., Vorstman, J. A. S. & Fiksinski, A. M., Feb 2025, In: Journal of Intellectual Disability Research. 69, 2, p. 113-126 14 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile12 Downloads (Pure) -
EARLYBIRD: catching the earliest changes of the bone and intervertebral discs in children at increased risk for scoliosis development with MRI – study protocol of a prospective observational cohort study
Lafranca, P. P. G., Stempels, H. W., Reuver, S. D., Houben, M. L., Kok, J., Kruyt, M. C., Castelein, R. M., Seevinck, P. R., van der Velden, T., Shcherbakova, Y. M., Ito, K. & Schlösser, T. P. C., 26 Jun 2025, In: BMJ Open. 15, 6, 7 p., e098929.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile13 Downloads (Pure) -
Genotype–Phenotype Correlations, Treatment, and Prognosis of Children With Early-Onset (Neonatal) Marfan Syndrome
van der Leest, E. C., van der Hulst, A. E., Pals, G., Zhytnik, L., Lai, L., Jacquemart, C., Mills, L., Houben, M., Jira, P., Lunshof, B. L., Warnink-Kavelaars, J., de Waard, V. & Menke, L. A., Aug 2025, In: Clinical Genetics. 108, 2, p. 134-145 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile21 Downloads (Pure) -
Early Sagittal Shape of the Spine Predicts Scoliosis Development in a Syndromic (22q11.2DS) Population A Prospective Longitudinal Study
de Reuver, S., Homans, J. F., Houben, M. L., Schlösser, T. P. C., Ito, K., Kruyt, M. C. & Castelein, R. M., 4 Dec 2024, In: Journal of Bone and Joint Surgery. 106, 23, p. 2256-2263 8 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile4 Downloads (Pure)
Activities
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Refereeravond Jeugdgezondheidszorg | 22q11.2 deletiesyndroom vanuit het perspectief van de jeugdarts
Houben, M. (Speaker)
9 Dec 2024Activity: Talk or presentation › Oral presentation › Academic
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22q11.2 Society - Conference Portugal 2024
Houben, M. (Invited speaker)
15 Jul 2024 → 18 Jul 2024Activity: Participating in or organising an event › Participation in conference › Academic
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Medisch Contact (Journal)
Houben, M. (Editor)
24 May 2024Activity: Publication peer-review and editorial work › Editorial activity › Academic
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Voorjaarssymposium Sectie EAA NVK 12-04-2024
Houben, M. (Organiser) & Houben, M. (Invited speaker)
12 Apr 2024Activity: Participating in or organising an event › Participation in conference › Academic
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Organisation of outpatient clinical care for patients with 22q11.2 deletion and duplication syndrome, across Europe
Houben, M. (Speaker)
19 Nov 2023Activity: Talk or presentation › Oral presentation › Academic
File
Prizes
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Uitreiking cheque €150.00 aan ML Houben, voor onderzoek naar Predictors van Neurocognitieve Achteruitgang bij Kinderen met 22q11.2 Deletiesyndroom (door Stichting Steun 22q11)
Houben, M. (Recipient), 24 Nov 2018
Prize: Other distinction
Press/Media
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Opnames voor RTL4 programma: Het Kinderziekenhuis
Houben, M. & Fiksinski, A.
1/06/24
1 Media contribution
Press/Media: Expert Comment
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Na Down is dit het meest voorkomende syndroom, toch heb je er waarschijnlijk nog nooit van gehoord
7/05/24
1 Media contribution
Press/Media: Expert Comment
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Jasper (15) heeft 22q11: een syndroom dat veel voorkomt, maar bijna niemand kent
26/01/22
1 Media contribution
Press/Media: Expert Comment
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Jasper (15) heeft 22q11: een syndroom dat veel voorkomt, maar bijna niemand kent
24/01/22
1 Media contribution
Press/Media: Public Engagement Activities