Michiel Flier van der

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Michiel van der Flier

dr.

    • Heidelberglaan 100, UMC Utrecht

      3584 CX Utrecht

      Netherlands

    1995 …2025

    Research activity per year

    Personal profile

    Biography

    Michiel van der Flier (Utrecht, 1970) studied medicine at Utrecht University. As a student he was a guest investigator at the Rockefeller University, New York, US. He trained as a paediatrician at the Wilhelmina Children's Hospital/UMC Utrecht and St Antonius Hospital Nieuwegein. He earned his PhD  in 2003 at Utrecht University on the thesis “VEGF in sepsis and meningitis”.  He did his subspecialty training in Paediatric Infectious Diseases and Immunology at the  Sophia Children's Hospital-ErasmusMC in Rotterdam and at the Great Ormond Street Hospital for Sick Children in Londen. From 2009 to 2018 he worked as a consultant  in Paediatric Infectious Diseases and Immunology at the Amalia Children's Hospital-Radboudumc in Nijmegen and from 2014 to 2018 he served as program manager of the subspecialty .  In 2017-2018 he worked half a year as Honorary Clinical Senior Lecturer in St Mary’s Hospital, Imperial College, in Londen. Starting November 2018 he returned to the UMC Utrecht. He combines the care for children with infections and immunodeficiencies  in the Wilhelmina Children's Hospital and the Princess Maxima Centre for Paediatric Oncology with research and teaching.  

    Fellowship & awards

    2020         Wilhelmina Research Fund Grant 2019-2020

    2006         ESPID Fellowship

    1998         AGIKO Stipendium ZonMw

    1995         WKZ Award “Best student researchproject"

    1993         Free-Mover Stipendium STIR-fund

    Research Grants (selection)

    2023-present             Effect of Anti-Group B streptococcus (GBS) monoclonal antibodies in human (preterm) neonatal anti-GBS host defense assays. Minervax.  PI

    2021-present             RUBY (Rna umbilical cord blood sepsis diagnosis in newborn baby’s) Elisabeth von Freyburg Fund  PI

    2021-2023                        Boosting host-defence to protect against neonatal GBS sepsis. Vaillant Fund 

    2020-present                    DIAMONDS (Diagnosis and Management Of febrile illness using RNA Personalized Molecular Signature Diagnosis) EU H2020 project PI UMCUtrecht Co-lead Clinical working Party Immunocompromised patients.

    2020-2024                PEARLS       (Boosting host-defence to prevent and treat neonatal sepsis) WKZ Research fund 

    2017-present           Exhaled breath analysis to distinguish viral from bacterial aetiology of lower respiratory tract infections in children. ESPID Fellowship, European Society for Paediatric Infectious Diseases. Supervisor of recipient (Koen van Aerde).

    2016-2019           PERFORM Personalised Risk assessment in febrile illness to Optimise Rela-life Management across the European Union. EU H2020 Project  Co-PI Radboudumc.

    2012-2016           EUCLIDS European Childhood Life-threatening Infectious Disease Study . EU FP7  Investigator Radboudumc coordinator Dutch patient inclusion.

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    • A 5-transcript signature for discriminating viral and bacterial etiology in pediatric pneumonia

      Viz-Lasheras, S., Gómez-Carballa, A., Pardo-Seco, J., Bello, X., Rivero-Calle, I., Dacosta, A. I., Kaforou, M., Habgood-Coote, D., Cunnington, A. J., Emonts, M., Herberg, J. A., Wright, V. J., Carrol, E. D., Paulus, S. C., Zenz, W., Kohlfürst, D. S., Van der Flier, M., de Groot, R., Schlapbach, L. J. & Agyeman, P. & 24 others, Pollard, A. J., Fink, C., Kuijpers, T. T., Anderson, S., Calvo, C., Martínez-Padilla, M. D. C., Pérez-Aragón, A., Gómez-Sánchez, E., Valencia-Ramos, J., Giménez-Sánchez, F., Alonso-Quintela, P., Moreno-Galarraga, L., von Both, U., Pokorn, M., Zavadska, D., Tsolia, M., Vermont, C. L., Moll, H. A., Levin, M., Martinón-Torres, F., Salas, A., DIAMONDS, GENDRES and & PERFORM consortia, 21 Feb 2025, In: iScience. 28, 2, 111747.

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    • A diagnostic host-specific transcriptome response for Mycoplasma pneumoniae pneumonia to guide pediatric patient treatment

      Viz-Lasheras, S., Gómez-Carballa, A., Bello, X., Rivero-Calle, I., Dacosta, A. I., Kaforou, M., Habgood-Coote, D., Cunnington, A. J., Emonts, M., Herberg, J. A., Wright, V. J., Carrol, E. D., Paulus, S. C., Zenz, W., Kohlfürst, D. S., Schweintzger, N., Van der Flier, M., de Groot, R., Schlapbach, L. J. & Agyeman, P. & 14 others, Pollard, A. J., Fink, C., Kuijpers, T. T., Anderson, S., Von Both, U., Pokorn, M., Zavadska, D., Tsolia, M., Moll, H. A., Vermont, C., Levin, M., Martinón-Torres, F., Salas, A. & EUCLIDS, PERFORM, and DIAMONDS consortia, 15 Jan 2025, In: Nature Communications. 16, 1, 13 p., 673.

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    • Antibody dependent complement activation is critical for boosting opsonophagocytosis of Staphylococcus epidermidis in an extremely preterm human whole blood model

      Beudeker, C. R., van Dalen, R., Ruyken, M., de Haas, C. J. C., Scheepmaker, L. M., Vijlbrief, D., Lely, A. T., van Kessel, K. P. M., van der Bruggen, J.-T., Rooijakkers, S. H. M., Salazar, L. A. & van der Flier, M., 25 Aug 2025, In: Scientific Reports. 15, 1, 13 p., 31243.

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    • Immunity to Streptococcus pyogenes and Common Respiratory Viruses at Age 0 to 4 Years After COVID-19 Restrictions

      Dokal, K., Channon-Wells, S., Davis, C., Estrada-Rivadeneyra, D., Huse, K. K., Lias, A., Hamilton, S., Guy, R. L., Lamagni, T., Nichols, S., Taylor, A., Agyeman, P. K. A., Anpananthar, A., Basmaci, R., Carrol, E. D., Carter, M. J., De, T., de Jonge, M. I., Emonts, M. & Elorrieta, L. E. & 31 others, Fidler, K., Kolnik, M., Kuijpers, T. W., Martinon-Torres, F., Moll, H., Mommert-Tripon, M., Neshat, S., Nyirenda-Nyang'wa, M., O'Riordan, S., Owens, D. R., Pathan, N., Paulus, S., Peters, M. J., Pokorn, M., Pollard, A. J., Rivero-Calle, I., Rojo, P., Romani, L., Rughani, P., Schlapbach, L. J., Schweintzger, N. A., Shen, C. F., Sulik, A., Tsolia, M., Usuf, E., van der Flier, M., Vermont, C., von Both, U., Wellman, P., Wright, V. J. & PERFORM and DIAMONDS consortiums, 15 Oct 2025, In: JAMA network open. 8, 10, p. 1-16 16 p., e2537808.

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    • Procalcitonin use in febrile children attending European emergency departments: a prospective multicenter study

      Borensztajn, D. M., Zachariasse, J. M., Carrol, E. D., Nijman, R. G., von Both, U., Emonts, M., Herberg, J., Kohlmaier, B., Levin, M., Lim, E., Maconochie, I. K., Martinón-Torres, F., Pokorn, M., Rivero-Calle, I., Rudzāte, A., Tan, C. D., Tsolia, M., Vermont, C., Zavadska, D. & Zenz, W. & 31 others, Moll, H. A., Willems, E., Philipsen, R., Huijnen, M., Henriet, S., van Gool, A. J., Gloerich, J., van den Broek, B., Alkema, W., van Aerde, K., de Jonge, M. I., van der Flier, M., de Groot, R., Syggelou, K., Xagorari, M., Marmarinos, A., Tambouratzi, M., Nora Urbāne, U., Svile, D., Sidorova, A., Selecka, K., Pučuka, Z., Pavāre, J., Nokalna, I., Meiere, A., Grope, I., Grāvele, D., Gardovska, D., Deksne, D., Bārzdiņa, A. & On behalf of PERFORM consortium: Personalised Risk assessment in febrile children to optimise Real-life Management across the European Union, 1 Mar 2025, In: BMC Pediatrics. 25, 1, 157.

      Research output: Contribution to journal › Article › Academic › peer-review

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    • 6 Participation in conference
    • 4 Editorial activity
    • 4 Publication peer-review
    • 2 Participation in workshop, seminar, course
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