Research output per year
Research output per year
Personal profile
Biography
Maarten Huismans studied biomedical sciences and medicine in Groningen, where he got his medical degree in 2019. After working as a medical resident in the St. Antonius hospital he started to work full time on his PhD research in 2020. He now works at the center for molecular medicine and the strategic program cancer under supervision of dr. Hugo Snippert and dr. Jeanine Roodhart
Research interests
My research is centered on a new promising treatment for colorectal cancer patients called the RASTRIC phase I/II clinical trial. In addition to coordinating this trial, I have established organoid cultures from metastatic lesions of our patients. These organoids are used to assess the tumor-specific sensitivity of these organoids to our new combination treatment.
Techniques and expertise:
- Coordination of the RASTRIC clinical trial
- Organoid culture and drug screens
- Data-analysis in R and Python
- Several techniques for image analysis of drug screen images and immunohistochemistry slides.
Side activities
No side activities
Keywords
- RC0254 Neoplasms. Tumors. Oncology (including Cancer)
- Colorectal cancer
- organoids
- drug screens
- phase I clinical trial
- phase II clinical trial
- RASTRIC
- lapatinib
- binimetinib
- vinorelbine
- RAS
- RAS-targetting
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
- 4 Article
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DNA damage induces p53-independent apoptosis through ribosome stalling
Boon, N. J., Oliveira, R. A., Körner, P.-R., Kochavi, A., Mertens, S., Malka, Y., Voogd, R., van der Horst, S. E. M., Huismans, M. A., Smabers, L. P., Draper, J. M., Wessels, L. F. A., Haahr, P., Roodhart, J. M. L., Schumacher, T. N. M., Snippert, H. J., Agami, R. & Brummelkamp, T. R., 17 May 2024, In: Science. 384, 6697, p. 785-792 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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Efficacy and safety in early-phase clinical trials for refractory colorectal cancer: A meta-analysis
Smabers, L. P., Huismans, M. A., van Nieuwenhuijzen, N., Minnema, M. C., Kranenburg, O., Koopman, M., Snippert, H. J. G., May, A. M. & Roodhart, J. M. L., Nov 2024, In: European Journal of Cancer. 212, 115059.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response
Smabers, L. P., Wensink, E., Verissimo, C. S., Koedoot, E., Pitsa, K.-C., Huismans, M. A., Higuera Barón, C., Doorn, M., Valkenburg-van Iersel, L. B., Cirkel, G. A., Brousali, A., Overmeer, R., Koopman, M., Braat, M. N., Penning de Vries, B., Elias, S. G., Vries, R. G., Kranenburg, O., Boj, S. F. & Roodhart, J. M., 27 Feb 2024, In: Journal of experimental & clinical cancer research. 43, 1, p. 1-16 16 p., 61.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
Mertens, S., Huismans, M. A., Verissimo, C. S., Ponsioen, B., Overmeer, R., Proost, N., van Tellingen, O., van de Ven, M., Begthel, H., Boj, S. F., Clevers, H., Roodhart, J. M. L., Bos, J. L. & Snippert, H. J. G., 25 Apr 2023, In: Cell Reports. 42, 4, 112324.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile31 Downloads (Pure)