Research output

Research output per year 2013 2014 2015 2016 2017 2018 2022 2023 2024

• 32 Article
• 2 Review article
• 1 Comment/Letter to the editor

Research output per year

Research output per year

Search results

• 2024

  A multipurpose, adolescent idiopathic scoliosis-specific, short MRI protocol: A feasibility study in volunteers

  Shcherbakova, Y. M., Lafranca, P. P. G., Foppen, W., van der Velden, T. A., Nievelstein, R. A. J., Castelein, R. M., Ito, K., Seevinck, P. R. & Schlosser, T. P. C., Aug 2024, In: European Journal of Radiology. 177, 7 p., 111542.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Scoliosis 100%
  • Feasibility Studies 96%
  • Volunteers 77%
  • Nucleus Pulposus 30%
  • Intervertebral Disc 26%
  1 Downloads (Pure)
• 2023

  Automatic generation of subject-specific finite element models of the spine from magnetic resonance images

  Kok, J., Shcherbakova, Y. M., Schlösser, T. P. C., Seevinck, P. R., van der Velden, T. A., Castelein, R. M., Ito, K. & van Rietbergen, B., 5 Sept 2023, In: Frontiers in bioengineering and biotechnology. 11, 1244291.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Magnetic Resonance 100%
  • Magnetic resonance 99%
  • Magnetic Resonance Spectroscopy 80%
  • Spine 74%
  • Tomography 69%
  3 Downloads (Pure)

• Enzymatic Isolation of Articular Chondrons: Is It Much Different Than That of Chondrocytes?

  Van Mourik, M., Schuiringa, G. H., Varion-Verhagen, L. P., Vonk, L. A., Van Donkelaar, C. C., Ito, K. & Foolen, J., 1 Jan 2023, In: Tissue Engineering - Part C: Methods. 29, 1, p. 30-40 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cartilage 100%
  • Collagen 80%
  • Collagen Type VI 78%
  • Chondrocytes 77%
  • Cells 74%

• NOTOCHORDAL CELL-DERIVED MATRIX INHIBITS MAPK SIGNALING IN THE DEGENERATIVE DISC ENVIRONMENT

  Laagland, L. T., Bach, F. C., Riemers, F. M., Erdmann, G., Braun, T. S., van den Akker, G. G. H., Schmitz, T. C., Creemers, L. B., Sachse, C., Maitre, C. L. L., Welting, T. J. M., Ito, K., Templin, M. F. & Tryfonidou, M. A., 1 Jul 2023, In: European Cells and Materials. 46, p. 57-90 34 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nucleus Pulposus 100%
  • Mitogen-Activated Protein Kinases 88%
  • Proteins 81%
  • Environment 50%
  • Protein 36%
  15 Downloads (Pure)
• 2022

  The Spring Distraction System for Growth-Friendly Surgical Treatment of Early Onset Scoliosis: A Preliminary Report on Clinical Results and Safety after Design Iterations in a Prospective Clinical Trial

  Tabeling, C. S., Lemans, J. V. C., Top, A., Scholten, E. P., Stempels, H. W., Schlösser, T. P. C., Ito, K., Castelein, R. M. & Kruyt, M. C., 1 Jul 2022, In: Journal of Clinical medicine. 11, 13, 3747.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Scoliosis 100%
  • Operating Rooms 71%
  • Clinical Trials 60%
  • Safety 53%
  • Growth 46%
  10 Downloads (Pure)

• Viscoelastic Chondroitin Sulfate and Hyaluronic Acid Double-Network Hydrogels with Reversible Cross-Links

  Mihajlovic, M., Rikkers, M., Mihajlovic, M., Viola, M., Schuiringa, G., Ilochonwu, B. C., Masereeuw, R., Vonk, L., Malda, J., Ito, K. & Vermonden, T., 14 Mar 2022, In: Biomacromolecules. 23, 3, p. 1350-1365 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hyaluronic acid 100%
  • Hydrogels 75%
  • Chondroitin Sulfate 71%
  • Hyaluronic Acid 67%
  • Sulfates 65%
  7 Downloads (Pure)
• 2021

  Comparison of annulus fibrosus cell collagen remodeling rates in a microtissue system

  Tromp, I. N., Foolen, J., van Doeselaar, M., Zhang, Y., Chan, D., Kruyt, M. C., Creemers, L. B., Castelein, R. M. & Ito, K., Sept 2021, In: Journal of Orthopaedic Research. 39, 9, p. 1955-1964 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Annulus Fibrosus 100%
  • Collagen 53%
  • Inbred C57BL Mouse 18%
  • Intervertebral Disc 11%
  • Scoliosis 10%
  7 Downloads (Pure)
• 2020

  T2* mapping in an equine articular groove model: Visualizing changes in collagen orientation

  Brinkhof, S., Te Moller, N., Froeling, M., Brommer, H., van Weeren, R., Ito, K. & Klomp, D., 1 Nov 2020, In: Journal of Orthopaedic Research. 38, 11, p. 2383-2389 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Horses 100%
  • Collagen 79%
  • Polarization Microscopy 76%
  • Carpal Bones 75%
  • Joints 74%
  9 Downloads (Pure)
• 2019

  Bi-layered micro-fibre reinforced hydrogels for articular cartilage regeneration

  Castilho, M., Mouser, V., Chen, M., Malda, J. & Ito, K., 1 Sept 2019, In: Acta Biomaterialia. 95, p. 297-306 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cartilage 100%
  • Hydrogels 98%
  • Articular Cartilage 81%
  • Implant 75%
  • Regeneration 64%

• Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI

  Brinkhof, S., Ali Haghnejad, A., Ito, K., Markenroth Bloch, K. & Klomp, D. W. J., 1 Nov 2019, In: NMR in Biomedicine. 32, 11, p. e4173 e4173.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Protons 100%
  • Coil 94%
  • Cartilage 85%
  • Sodium 81%
  • Knee 78%
  1 Downloads (Pure)
• 2018

  Biologic canine and human intervertebral disc repair by notochordal cell-derived matrix: From bench towards bedside

  Bach, F. C., Tellegen, A. R., Beukers, M., Miranda-Bedate, A., Teunissen, M., de Jong, W. A. M., de Vries, S. A. H., Creemers, L. B., Benz, K., Meij, B. P., Ito, K. & Tryfonidou, M. A., 29 May 2018, In: Oncotarget. 9, 41, p. 26507-26526 20 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intervertebral Disc 100%
  • Canidae 75%
  • Mesenchymal Stem Cells 48%
  • Chondrocytes 32%
  • Intervertebral disc disease 31%

• Mechanical behavior of a soft hydrogel reinforced with three-dimensional printed microfibre scaffolds

  Castilho, M., Hochleitner, G., Wilson, W., van Rietbergen, B., Dalton, P. D., Groll, J., Malda, J. & Ito, K., 19 Jan 2018, In: Scientific Reports. 8, 1, p. 1245 1245.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hydrogels 100%
  • Gels 19%

• Melt Electrowriting Allows Tailored Microstructural and Mechanical Design of Scaffolds to Advance Functional Human Myocardial Tissue Formation

  Castilho, M., van Mil, A., Maher, M., Metz, C. H. G., Hochleitner, G., Groll, J., Doevendans, P. A., Ito, K., Sluijter, J. P. G. & Malda, J., 4 Oct 2018, In: Advanced Functional Materials. 28, 40, 10 p., 1803151.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Scaffolds 100%
  • stem cells 87%
  • Tissue 71%
  • Stem cells 59%
  • Fiber 54%

• Notochordal cell matrix as a bioactive lubricant for the osteoarthritic joint

  De Vries, S. A. H., Van Doeselaar, M., Kaper, H. J., Sharma, P. K. & Ito, K., 1 Dec 2018, In: Scientific Reports. 8, 1, 8875.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • lubricants 100%
  • interleukin-1 30%
  • cells 29%
  • chondrocytes 29%
  • hyaluronic acid 19%
• 2017

  Bone Morphogenetic Protein-2, but Not Mesenchymal Stromal Cells, Exert Regenerative Effects on Canine and Human Nucleus Pulposus Cells

  Bach, F. C., Miranda-Bedate, A., Van Heel, F. W. M., Riemers, F. M., Müller, M. C. M. E., Creemers, L. B., Ito, K., Benz, K., Meij, B. P. & Tryfonidou, M. A., 1 Mar 2017, In: Tissue Engineering. Part A. 23, 5-6, p. 233-242 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Nucleus Pulposus 100%
  • Bone Morphogenetic Protein 2 96%
  • Intercellular Signaling Peptides and Proteins 86%
  • Bone 73%
  • Proteins 69%

• Link-N: The missing link towards intervertebral disc repair is species-specific

  Bach, F. C., Laagland, L. T., Grant, M. P., Creemers, L. B., Ito, K., Meij, B. P., Mwale, F. & Tryfonidou, M. A., 1 Nov 2017, In: PLoS ONE [E]. 12, 11, e0187831.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • intervertebral disks 100%
  • Glycosaminoglycan 80%
  • Intervertebral Disc 79%
  • dogs 52%
  • Canidae 51%

• Melt Electrospinning Writing of Poly-Hydroxymethylglycolide-co-ε-Caprolactone-Based Scaffolds for Cardiac Tissue Engineering

  Castilho, M., Feyen, D., Flandes-Iparraguirre, M., Hochleitner, G., Groll, J., Doevendans, P. A. F., Vermonden, T., Ito, K., Sluijter, J. P. G. & Malda, J., Sept 2017, In: Advanced Healthcare Materials. 6, 18, 1700311.

  Research output: Contribution to journal › Article › Academic › peer-review

  • caprolactone 100%
  • Electrospinning 83%
  • Tissue engineering 77%
  • Scaffolds 73%
  • Tissue Engineering 60%

• Notochordal-cell derived extracellular vesicles exert regenerative effects on canine and human nucleus pulposus cells

  Bach, F., Libregts, S., Creemers, L., Meij, B. P., Ito, K., Wauben, M. H. M. & Tryfonidou, M. A., 2017, In: Oncotarget. 8, 51, p. 88845-88856 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nucleus Pulposus 100%
  • Extracellular Vesicles 90%
  • Conditioned Culture Medium 73%
  • Canidae 66%
  • Chondrocytes 36%

• Osteogenic protein 1 does not stimulate a regenerative effect in cultured human degenerated nucleus pulposus tissue

  van Dijk, B. G. M., Potier, E., van Dijk, M., Creemers, L. B. & Ito, K., 1 Jul 2017, In: Journal of Tissue Engineering and Regenerative Medicine. 11, 7, p. 2127-2135 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Bone Morphogenetic Protein 7 100%
  • Nucleus Pulposus 91%
  • Osteogenic 89%
  • Proteins 64%
  • Tissue 59%
  1 Citation (Scopus)
• 2016

  Increased caveolin-1 in intervertebral disc degeneration facilitates repair

  Bach, FC., Zhang, Y., Miranda-Bedate, A., Verdonschot, L. C., Bergknut, N., Creemers, L. B., Ito, K., Sakai, D., Chan, D., Meij, B. P. & Tryfonidou, M. A., 2016, In: Arthritis Research & Therapy. 18, 18:59.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Caveolin 1 100%
  • Intervertebral Disc Degeneration 96%
  • Chondrocytes 32%
  • Transforming Growth Factors 23%
  • Nucleus Pulposus 17%
  1 Downloads (Pure)

• Soluble and pelletable factors in porcine, canine and human notochordal cell-conditioned medium: Implications for IVD regeneration

  Bach, F. C., de Vries, S. A. H., Riemers, F. M., Boere, J., van Heel, F. W. M., Goerdayal, S. S., van Doeselaar, M., Nikkels, P. G. J., Benz, K., Creemers, L. B., Maarten Altelaar, A. F., Meij, B. P., Ito, K. & Tryfonidou, M. A., 1 Jul 2016, In: European Cells & Materials. 32, p. 163-180 18 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intervertebral Disc 100%
  • Conditioned Culture Medium 88%
  • Proteins 79%
  • Canidae 75%
  • Regeneration 72%

• The Stimulatory Effect of Notochordal Cell-Conditioned Medium in a Nucleus Pulposus Explant Culture

  de Vries, S. A. H., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A. & Ito, K., 1 Jan 2016, In: Tissue Engineering. Part A. 22, 1-2, p. 103-110 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Nucleus Pulposus 100%
  • Conditioned Culture Medium 78%
  • Bone 73%
  • Glycosaminoglycan 59%
  • Environment 43%
• 2015

  Biomaterials for intervertebral disc regeneration: Past performance and possible future strategies

  Schutgens, E. M., Tryfonidou, M. A., Smit, T. H., Cumhur Öner, F., Krouwels, A., Ito, K. & Creemers, L. B., 2015, In: European Cells & Materials. 30, p. 210-231 22 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Biomaterials 100%
  • Intervertebral Disc 94%
  • Biocompatible Materials 83%
  • Biomaterial 69%
  • Regeneration 68%
  1 Citation (Scopus)

• Conditioned medium derived from notochordal cell-rich nucleus pulposus tissue stimulates matrix production by canine nucleus pulposus cells and bone marrow-derived stromal cells.

  de Vries, S. A. H., Potier, E., van Doeselaar, M., Meij, B. P., Tryfonidou, M. A. & Ito, K., 1 Mar 2015, In: Tissue engineering Part C, Methods. 21, 5-6, p. 1077-1084 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Conditioned Culture Medium 100%
  • Nucleus Pulposus 87%
  • Proteoglycan 83%
  • Cell Nucleus 68%
  • Bone 64%

• Effect of coculturing canine notochordal, nucleus pulposus and mesenchymal stromal cells for intervertebral disc regeneration.

  Arkesteijn, I. TM., Smolders, L. A., Spillekom, S., Riemers, F. M., Potier, E., Meij, B. P., Ito, K. & Tryfonidou, M. A., 2015, In: Arthritis Research & Therapy. 17, 60, 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nucleus Pulposus 100%
  • Intervertebral Disc 88%
  • Mesenchymal Stem Cells 68%
  • Canidae 66%
  • Regeneration 64%

• Reduced tonicity stimulates an inflammatory response in nucleus pulposus tissue that can be limited by a COX-2-specific inhibitor.

  van Dijk, B., Potier, E., van Dijk, M., Langelaan, M., Papen-Botterhuis, N. & Ito, K., 1 Nov 2015, In: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 33, 11, p. 1724-1731 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • prostaglandin synthase 100%
  • inflammation 81%
  • explants 78%
  • pain 71%
  • interleukin-6 49%

• The species-specific regenerative effects of notochordal cell-conditioned medium on chondrocyte-like cells derived from degenerated human intervertebral discs.

  Bach, FC., de Vries, S. A. H., Krouwels, A., Creemers, L. B., Ito, K., Meij, B. P. & Tryfonidou, M. A., 2015, In: European Cells & Materials. 30, p. 132-147 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Glycosaminoglycans 100%
  • Glycosaminoglycan 65%
  • Intervertebral Disc 65%
  • Conditioned Culture Medium 57%
  • Chondrocytes 57%
• 2014

  Flow-perfusion interferes with chondrogenic and hypertrophic matrix production by mesenchymal stem cells

  Kock, L. M., Malda, J., Dhert, W. J. A., Ito, K. & Gawlitta, D., 2014, In: Journal of Biomechanics. 47, 9, p. 2122-2129 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Increased Osmolarity and Cell Clustering Preserve Canine Notochordal Cell Phenotype in Culture.

  Spillekom, S., Smolders, L. A., Grinwis, G. C. M., Arkesteijn, I. T. M., Ito, K., Meij, B. P. & Tryfonidou, M. A., 1 Aug 2014, In: Tissue engineering Part C, Methods. 20, 8, p. 652-662 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Potential regenerative treatment strategies for intervertebral disc degeneration in dogs.

  Bach, F. C., Willems, N., Penning, L. C., Ito, K., Meij, B. P. & Tryfonidou, M. A., 1 Jan 2014, In: BMC Veterinary Research [E]. 10, 3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• The Effect of a Cyclooxygenase 2 Inhibitor on Early Degenerated Human Nucleus Pulposus Explants

  van Dijk, B., Potier, E., Licht, R., Creemers, LB. & Ito, K., 1 Jan 2014, In: Global Spine Journal. 04, 01, p. 033-040 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review
• 2013

  Mechanisms of intervertebral disk degeneration/injury and pain: a review

  Ito, K. & Creemers, L., Jun 2013, In: Global Spine Journal. 3, 3, p. 145-52 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Intervertebral Disc Degeneration 100%
  • Back Pain 54%
  • Pain 45%
  • Wounds and Injuries 38%
  • Annulus Fibrosus 37%