Personal profile
Biography
Dr. J.M. Beekman obtained a PhD in molecular immunology in 2004, and performed multiple post docs in molecular and cell biology within various immunological settings. In October 2010, he became principle investigator at the UMC Utrecht, and started a novel translational research line focusing on developing novel therapeutic strategies for cystic fibrosis, a genetic disease characterized by aberrant ion and fluid homeostasis at mucosal surfaces leading to chronic infection and inflammation and early death around the 3rd to 4th decade of life.
‘People with chronic diseases living healthy lives: I strive to create breakthrough solutions for clinical needs of people with chronic diseases by scientific research that focuses on the development of novel diagnostic or therapeutic approaches. This requires a multidisciplinary approach in which basic and clinical research is aligned, and integrated with needs of patients, the private sector and regulatory authorities. Currently, I am particularly proud of leading a team that developed a highly innovative diagnostic assay that enables individualized therapy for people with cystic fibrosis that lead to direct clinical impact for people within 4 years after the initial discovery.’
External positions
Professor Cellulaire Ziektemodellen - Sporadische activiteiten als consultant voor FAIR therapeutics - FAIR Therapeutics
19 Aug 2024 → 31 Dec 3999
Board member - Organisatie congres en activiteiten van de Dutch Society for Stem Cell Research - Dutch Society for Stem Cell Research
1 May 2024 → 31 Dec 3999
Keywords
- RJ101 Child Health. Child health services
- cystic fibrosis
- human disease modeling
- human stem cells
- organoids
- CFTR-targeting drugs
Collaborations and top research areas from the last five years
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Functional, Cohort-Level Assessment of CFTR Modulator Responses Using Biobanked Nasal Epithelial Cells from Individuals with Cystic Fibrosis
Aalbers, B. L., Amatngalim, G. D., Aarts, E. M., Rodenburg, L. W., den Hertog-Oosterhoff, L. A., Heijerman, H. G. M. & Beekman, J. M., Jan 2026, In: Journal of Personalized Medicine. 16, 1, 51.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Patient-Derived Intestinal Organoids in the Global Cystic Fibrosis Landscape
Kroes, S., Taylor-Cousar, J. L., Zampoli, M., Karadag, B., van der Ent, C. K., de Winter-de Groot, K. M., Beekman, J. M. & Spelier, S., Apr 2026, In: Pediatric Pulmonology. 61, 4, 9 p., e71584.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Reply: Lung organoids: a new frontier in neonatology and paediatric respiratory medicine
Zanetto, L., Bonadies, L., Moll-Diaz, R., Beekman, J., Muraca, M., Pozzobon, M. & Baraldi, E., 2026, In: European Respiratory Review. 35, 179, 260009.Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Open AccessFile -
ACE-tRNAs are a platform technology for suppressing nonsense mutations that cause cystic fibrosis
Ko, W., Porter, J. J., Spelier, S., Sorensen, E. G., Bhatt, P., Gabell, J. T., van der Windt, I., Couch, T., Coote, K., Mense, M., Beekman, J. M. & Lueck, J. D., 22 Jul 2025, In: Nucleic acids research. 53, 13, gkaf675.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile10 Downloads (Pure) -
Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids
Pleguezuelos-Manzano, C., Beenker, W. A. G., van Son, G. J. F., Begthel, H., Amatngalim, G. D., Beekman, J. M., Clevers, H. & den Hertog, J., 17 Jan 2025, In: Scientific Reports. 15, 1, 14 p., 2222.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile7 Downloads (Pure)
Prizes
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Elisabeth von Freyburg Stichting: Better Care for the Rare – testing new treatments in mini-organs with genetic diseases
Fuchs, S. (Recipient) & Beekman, J. (Recipient), 2019
Prize: Prize (including medals and awards)
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