Jan van de Winkel

Complement is activated by IgG hexamers assembled at the cell surface.

Diebolder, C. A., Beurskens, F. J. M., de Jong, R. N., Koning, R. I., Strumane, K., Lindorfer, M. A., Voorhorst, M. M., Ugurlar, D., Rosati, S., Heck, A. J. R., van de Winkel, J. G. J., Wilson, I. A., Koster, A. J., Taylor, R. P., Saphire, E. O., Burton, D. R., Schuurman, J., Gros, P. & Parren, P. W. H. I., 2014, In: Science. 343, 6176, p. 1260-1263 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

Efficient generation of stable bispecific IgG1 by controlled Fab-arm exchange.

Labrijn, A. F., Meesters, J., Goeij, B. E., van den Bremer, E. T. J., Neijssen, J., van Kampen, M. D., Strumane, K., Verploegen, S., Kundu, A., Gramer, M. J., van Berkel, P. H. C., van de Winkel, J. G. J., Schuurman, J. & Parren, P. W. H. I., 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 13, p. 5145-5150 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

IgA EGFR antibodies mediate tumour killing in vivo.

Boross, P., Lohse, S., Nederend, M., Jansen, J. H. M., van Tetering, G., Dechant, M., Peipp, M., Royle, L., Liew, L. P., Boon, L., van Rooijen, N., Bleeker, W. K., Parren, P., van de Winkel, J. G. J., Valerius, T. & Leusen, J. H. W., 2013, In: Embo Molecular Medicine. 5, 8, p. 1213-1216 4 p.

Research output: Contribution to journal › Article › Academic › peer-review

Staphylococcus aureus formyl peptide receptor-like 1 inhibitor (FLIPr) and its homologue FLIPr-like are potent FcγR antagonists that inhibit IgG-mediated effector functions

Stemerding, A. M., Kohl, J., Pandey, M. K., Kuipers, A., Leusen, J. H. W., Boross, P., Nederend, M., Vidarsson, G., Weersink, A. J. L., van de Winkel, J. G. J., van Kessel, C. P. M. & van Strijp, J. A. G., 2013, In: Journal of Immunology. 191, 1, p. 353-362 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

The novel tribody [(CD20)(2)xCD16] efficiently triggers effector cell-mediated lysis of malignant B cells.

Glorius, P., Baerenwaldt, A., Kellner, C., Staudinger, M., Dechant, M., Stauch, M., Beurskens, F. J., Parren, P. W. H. I., van de Winkel, J. G. J., Valerius, T., Humpe, A., Repp, R., Gramatzki, M., Nimmerjahn, F. & Peipp, M., 2013, In: Leukemia. 27, 1, p. 190-201 12 p.

Research output: Contribution to journal › Article › Academic › peer-review