Jaap Kappelle

2025

Sex differences in cognitive functioning in patients with heart failure

1 Jan 2025, In: International Journal of Cardiology. 418, 132603.

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2024

Alzheimer's Disease and Cognitive Decline in Patients with Cardiovascular Diseases Along the Heart-Brain Axis

Trieu, C., van Harten, A. C., Leeuwis, A. E., Exalto, L. G., Hooghiemstra, A. M., Verberk, I. M. W., Allaart, C. P., Brunner-La Rocca, H. P., Kappelle, L. J., van Oostenbrugge, R. J., Biessels, G. J., Teunissen, C. E., van der Flier, W. M., 2 Apr 2024, In: Journal of Alzheimer's Disease. 98, 3, p. 987-1000 14 p.

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Association between lower extremity arterial calcification and coronary arterial calcification in a population at increased risk of cardiovascular disease

8 Feb 2024, In: BMJ Open Diabetes Research and Care. 12, 1, e003811.

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Association of body mass index and waist circumference with long-term mortality risk in 10,370 coronary patients and potential modification by lifestyle and health determinants

May 2024, In: PLoS ONE. 19, 5 May, e0303329.

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Decompressive craniectomy plus best medical treatment versus best medical treatment alone for spontaneous severe deep supratentorial intracerebral haemorrhage: a randomised controlled clinical trial

Beck, J., Fung, C., Strbian, D., Bütikofer, L., Z'Graggen, W. J., Lang, M. F., Beyeler, S., Gralla, J., Ringel, F., Schaller, K., Plesnila, N., Arnold, M., Hacke, W., Jüni, P., Mendelow, A. D., Stapf, C., Al-Shahi Salman, R., Bressan, J., Lerch, S. & Hakim, A. & 31 others, Martinez-Majander, N., Piippo-Karjalainen, A., Vajkoczy, P., Wolf, S., Schubert, G. A., Höllig, A., Veldeman, M., Roelz, R., Gruber, A., Rauch, P., Mielke, D., Rohde, V., Kerz, T., Uhl, E., Thanasi, E., Huttner, H. B., Kallmünzer, B., Jaap Kappelle, L., Deinsberger, W., Roth, C., Lemmens, R., Leppert, J., Sanmillan, J. L., Coutinho, J. M., Hackenberg, K. A. M., Reimann, G., Mazighi, M., Bassetti, C. L. A., Mattle, H. P., Raabe, A., 1 Jun 2024, In: The Lancet. 403, 10442, p. 2395-2404 10 p.

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Henry J.M. Barnett (1922–2016)

van Gijn, J. & Kappelle, L. J., Oct 2024, In: Journal of Neurology. 271, 10, p. 7057-7058 2 p.

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Orthostatic hypotension, cognition and structural brain imaging in hemodynamically impaired patients

Starmans, N. L. P., Wolters, F. J., Leeuwis, A. E., Bron, E. E., de Bresser, J., Brunner-La Rocca, H. P., Staals, J., Muller, M., Biessels, G. J., Kappelle, L. J., 15 Jun 2024, In: Journal of the Neurological Sciences. 461, 8 p., 123026.

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Prediction of Severe Baseline Asymptomatic Carotid Stenosis and Subsequent Risk of Stroke and Cardiovascular Disease

Poorthuis, M. H. F., Hageman, S. H. J., Fiolet, A. T. L., Kappelle, L. J., Bots, M. L., Steg, P. G., Visseren, F. L. J., Bhatt, D. L. & De Borst, G. J., Nov 2024, In: Stroke. 55, 11, p. 2632-2640 9 p.

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Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Zonneveld, T. P., Vermeer, S. E., van Zwet, E. W., Groot, A. E. D., Algra, A., Aerden, L. A. M., Alblas, K. C. L., de Beer, F., Brouwers, P. J. A. M., de Gans, K., van Gemert, H. M. A., van Ginneken, B. C. A. M., Grooters, G. S., Halkes, P. H. A., van der Heijden-Montfroy, T. A. M. H. G., Jellema, K., de Jong, S. W., Lövenich-Ciccarello, H., van der Meulen, W. D. M. & Peters, E. W. & 24 others, van der Ree, T. C., Remmers, M. J. M., Richard, E., Rovers, J. M. P., Saxena, R., van Schaik, S. M., Schonewille, W. J., Schreuder, T. A. H. C. M. L., de Schryver, E. L. L. M., Schuiling, W. J., Spaander, F. H., van Tuijl, J. H., Visser, M. C., Zinkstok, S. M., Zock, E., Dippel, D. W. J., Kappelle, L. J., van Oostenbrugge, R. J., Roos, Y. B. W. E. M., Vermeij, F. H., Wermer, M. J. H., van der Worp, H. B., Nederkoorn, P. J. & Kruyt, N. D., Aug 2024, In: The Lancet Neurology. 23, 8, p. 807-815 9 p., doi.org/10.1016/S1474-4422(24)00177-7.

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2023

A cluster of blood-based protein biomarkers associated with decreased cerebral blood flow relates to future cardiovascular events in patients with cardiovascular disease

Dec 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 12, p. 2060-2071 12 p.

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Cerebrospinal fluid volume improves prediction of malignant edema after endovascular treatment of stroke

Kauw, F., Bernsen, M. L., Dankbaar, J. W., de Jong, H., Kappelle, J., Velthuis, B. K., Van der Worp, H. B., van der Lugt, A., Roos, Y. B., Yo, L., van Walderveen, M. A., Hofmeijer, J. & Bennink, E., Feb 2023, In: International Journal of Stroke. 18, 2, p. 187-192 6 p.

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Cohort profile: the Utrecht Cardiovascular Cohort-Second Manifestations of Arterial Disease (UCC-SMART) Study-an ongoing prospective cohort study of patients at high cardiovascular risk in the Netherlands

Castelijns, M. C., Helmink, M. A. G., Hageman, S. H. J., Asselbergs, F. W., De Borst, G. J., Bots, M. L., Cramer, M. J., Dorresteijn, J. A. N., Emmelot-Vonk, M. H., Geerlings, M. I., De Jong, P. A., Van Der Kaaij, N. P., Kappelle, L. J., Lely, A. T., Van Der Meer, M. G., Mol, B. M., Nathoe, H. M., Onland-Moret, N. C., Van Petersen, R. B. & Ruigrok, Y. M. & 6 others, Van Smeden, M., Teraa, M., Vandersteen, A., Verhaar, M. C., Westerink, J. & Visseren, F. L. J., 20 Feb 2023, In: BMJ Open. 13, 2, e066952.

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Detection of Cardioembolic Sources With Nongated Cardiac Computed Tomography Angiography in Acute Stroke: Results From the ENCLOSE Study

Kauw, F., Velthuis, B. K., Takx, R. A. P., Guglielmo, M., Cramer, M. J., van Ommen, F., Bos, A., Bennink, E., Marquering, H. A., Kappelle, L. J., de Jong, H. W. A. M. & Dankbaar, J. W., 1 Mar 2023, In: Stroke. 54, 3, p. 821-830 10 p.

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Drivers of healthcare costs in patients with ischaemic stroke: a hospital-based retrospective cohort study

Mensing, L. A., Kappelle, L. J., Koffijberg, H. & Ruigrok, Y. M., 3 Jan 2023, In: BMJ Open. 13, 1, e064445.

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Effects of oral anticoagulation in people with atrial fibrillation after spontaneous intracranial haemorrhage (COCROACH): prospective, individual participant data meta-analysis of randomised trials

Dec 2023, In: The Lancet Neurology. 22, 12, p. 1140-1149 10 p.

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Iatrogenic Cerebral Amyloid Angiopathy Post Neurosurgery: Frequency, Clinical Profile, Radiological Features, and Outcome

Kaushik, K., Van Etten, E. S., Siegerink, B., Kappelle, L. J., Lemstra, A. W., Schreuder, F. H. B. M., Klijn, C. J. M., Peul, W. C., Terwindt, G. M., Van Walderveen, M. A. A. & Wermer, M. J. H., 1 May 2023, In: Stroke. 54, 5, p. 1214-1223 10 p.

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Impact of Cerebral Microbleeds in Stroke Patients with Atrial Fibrillation

Jul 2023, In: Annals of Neurology. 94, 1, p. 61-74 14 p.

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Ischemic stroke recurrence and mortality in different imaging phenotypes of ischemic cerebrovascular disease: The SMART-MR Study

Lucci, C., Rissanen, I., de Jong, P. A., Kappelle, L. J., Hendrikse, J. & Geerlings, M. I., Jun 2023, In: European Stroke Journal. 8, 2, p. 522-531 10 p.

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Lower haemoglobin concentrations are associated with impaired cognition in patients with carotid artery occlusion

24 Jun 2023, In: Cerebral Circulation - Cognition and Behavior. 5, p. 1-5 5 p., 100169.

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Neighbourhood walkability in relation to cognitive functioning in patients with disorders along the heart-brain axis

Jan 2023, In: Health & place. 79, p. 1-10 102956.

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Safety and technical efficacy of early minimally invasive endoscopy-guided surgery for intracerebral haemorrhage: the Dutch Intracerebral haemorrhage Surgery Trial pilot study

Jun 2023, In: Acta Neurochirurgica. 165, 6, p. 1585-1596 12 p.

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Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke

Exalto, L. G., Weaver, N. A., Kuijf, H. J., Aben, H. P., Bae, H.-J., Best, J. G., Bordet, R., Chen, C. P. L. H., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kim, J., Kappelle, L. J., Kim, B. J., Köhler, S., de Kort, P. L. M. & Koudstaal, P. J. & 16 others, Lim, J.-S., Makin, S. D. J., Mok, V. C. T., van Oostenbrugge, R. J., Roussel, M., Staals, J., Valdés-Hernández, M. D. C., Venketasubramanian, N., Verhey, F. R. J., Wardlaw, J. M., Werring, D. J., Xu, X., van Zandvoort, M. J. E., Biesbroek, J. M., Chappell, F. M. & Biessels, G. J., 1 Sept 2023, In: Stroke. 54, 9, p. 2296-2303 8 p.

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Temporal Trends and Determinants of Stroke Risk in Patients With Medically Treated Asymptomatic Carotid Stenosis

Poorthuis, M. H. F., Solomon, Y., Herings, R. A. R., Visseren, F. L. J., Kappelle, L. J., Bots, M. L., Rissanen, I. & de Borst, G. J., 1 Jul 2023, In: Stroke. 54, 7, p. 1735-1749 15 p.

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Twenty-four hour blood pressure variability and the prevalence and the progression of cerebral white matter hyperintensities

May 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 5, p. 801-811 11 p.

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2022

A cluster of blood-based protein biomarkers reflecting coagulation relates to the burden of cerebral small vessel disease

Kuipers, S., Overmars, L. M., van Es, B., de Bresser, J., Bron, E. E., Hoefer, I. E., Kappelle, L. J., Teunissen, C. E., Biessels, G. J. & Haitjema, S., 1 Jul 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 7, p. 1282-1293 12 p.

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Antitrombotica ter preventie van cardiovasculaire complicaties: De voor- en nadelen van ‘dual pathway inhibition’

Translated title of the contribution: Recent developments in secondary cardiovascular prevention: the pros and cons of dual pathway inhibitionNugteren, M. J., de Borst, G. J., van den Broek, W. W. A., Ten Berg, J. M., Kappelle, L. J. & Ünlü, Ç., 22 Jun 2022, In: Nederlands Tijdschrift voor Geneeskunde. 166, p. 1-8 D6145.

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Delay in patients suspected of transient ischaemic attack: a cross-sectional study

Dolmans, F., Kappelle, J., Bartelink, M.-L., Hoes, A. W. & Rutten, F. H., 10 Jan 2022, In: BMJ open [E]. 9, 2, e027161.

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Detection of Early Ischemic Changes with Virtual Noncontrast Dual-Energy CT in Acute Ischemic Stroke: A Noninferiority Analysis

Kauw, F., Ding, V. Y., Dankbaar, J. W., Ommen, F. V., Zhu, G., Boothroyd, D. B., Wolman, D. N., Molvin, L., de Jong, H. W. A. M., Kappelle, L. J., Velthuis, B. K., Heit, J. J. & Wintermark, M., 1 Sept 2022, In: American Journal of Neuroradiology. 43, 9, p. 1259-1264 6 p.

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Lifestyle changes and kidney function: A 10-year follow-up study in patients with manifest cardiovascular disease

Sept 2022, In: European Journal of Clinical Investigation. 52, 9, e13814.

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Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke

Biesbroek, J. M., Weaver, N. A., Aben, H. P., Kuijf, H. J., Abrigo, J., Bae, H.-J., Barbay, M., Best, J. G., Bordet, R., Chappell, F. M., Chen, C. P. L. H., Dondaine, T., van der Giessen, R. S., Godefroy, O., Gyanwali, B., Hamilton, O. K. L., Hilal, S., Huenges Wajer, I. M. C., Kang, Y. & Kappelle, L. J. & 28 others, Kim, B. J., Köhler, S., de Kort, P. L. M., Koudstaal, P. J., Kuchcinski, G., Lam, B. Y. K., Lee, B.-C., Lee, K.-J., Lim, J.-S., Lopes, R., Makin, S. D. J., Mendyk, A.-M., Mok, V. C. T., Oh, M. S., van Oostenbrugge, R. J., Roussel, M., Shi, L., Staals, J., Valdés-Hernández, M. D. C., Venketasubramanian, N., Verhey, F. R. J., Wardlaw, J. M., Werring, D. J., Xin, X., Yu, K.-H., van Zandvoort, M. J. E., Zhao, L. & Biessels, G. J., 2022, In: NeuroImage. Clinical. 34, p. 1-7 103018.

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Non-Invasive Assessment of Damping of Blood Flow Velocity Pulsatility in Cerebral Arteries With MRI

Jun 2022, In: Journal of Magnetic Resonance Imaging. 55, 6, p. 1785-1794 10 p.

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Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Harlianto, N. I., Westerink, J., Hol, M. E., Wittenberg, R., Foppen, W., Van Der Veen, P. H., Van Ginneken, B., Verlaan, J. J., De Jong, P. A., Mohamed Hoesein, F. A. A., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T. & Van Der Kaaij, N. P. & 4 others, Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C. & Visseren, F. L. J., 2022, In: Rheumatology advances in practice. 6, 2, p. rkac060 rkac060.

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Perforating artery flow velocity and pulsatility in patients with carotid occlusive disease. A 7 tesla MRI study

2022, In: Cerebral Circulation - Cognition and Behavior. 3, p. 1-7 100143.

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Residual cardiovascular risk reduction guided by lifetime benefit estimation in patients with symptomatic atherosclerotic disease: Effectiveness and cost-effectiveness

Hageman, S. H. J., Dorresteijn, J. A. N., Bots, M. L., Asselbergs, F. W., Westerink, J., Van Der Meulen, M. P., Mosterd, A., Visseren, F. L. J., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J. & Ruigrok, Y. M. & 18 others, Verhaar, M. C., Visseren, F. L. J., Westerink, J., Asselbergs, F. W., Nathoe, H. M., De Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., De Jong, P. A., Leiner, T., Lely, A. T., Van Der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J. & Westerink, J., 1 Mar 2022, In: European Journal of Preventive Cardiology. 29, 4, p. 635-644 10 p.

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2 Citations (Scopus)

Risk evaluation of cognitive impairment in patients with heart failure: A call for action

Dec 2022, In: IJC Heart and Vasculature. 43, 101133.

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Screen-detected abnormal ankle brachial index: A risk indicator for future cardiovascular morbidity and mortality in patients with manifest cardiovascular disease

Jagt, V. L., Hazenberg, C. E. V. B., Kapelle, J., Cramer, M. J., Visseren, F. L. J. & Westerink, J., 10 Mar 2022, In: PLoS ONE. 17, 3, p. 1-17 e0265050.

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2021

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial

Nov 2021, In: The Lancet. Neurology. 20, 11, p. 907-916 10 p.

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Apparent treatment resistant hypertension and the risk of recurrent cardiovascular events and mortality in patients with established vascular disease

1 Jul 2021, In: International Journal of Cardiology. 334, p. 135-141 7 p.

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Applicability of Blood Pressure-Lowering Drug Trials to Real-World Patients With Cardiovascular Disease

Bonekamp, N. E., Spiering, W., Nathoe, H. M., Kappelle, L. J., de Borst, G. J., Visseren, F. L. J., Westerink, J., Feb 2021, In: Hypertension (Dallas, Tex. : 1979). 77, 2, p. 357-366 10 p.

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Are visual working memory and episodic memory distinct processes? Insight from stroke patients by lesion-symptom mapping

Jul 2021, In: Brain Structure and Function. 226, 6, p. 1713-1726 14 p.

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Association of Ischemic Imaging Phenotype With Progression of Brain Atrophy and Cerebrovascular Lesions on MRI: The SMART-MR Study

Rissanen, I., Lucci, C., Ghaznawi, R., Hendrikse, J., Kappelle, L. J., Geerlings, M. I., 14 Sept 2021, In: Neurology. 97, 11, p. e1063-e1074

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Balancing Benefits and Risks of Long-Term Antiplatelet Therapy in Noncardioembolic Transient Ischemic Attack or Stroke

Hilkens, N. A., Algra, A., Diener, H. C., Bath, P. M., Csiba, L., Hacke, W., Kappelle, L. J., Koudstaal, P. J., Leys, D., Mas, J. L., Sacco, R. L. & Greving, J. P., Oct 2021, In: Stroke. 52, 10, p. 3258-3265 8 p.

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