Research output per year
Research output per year
Personal profile
Personal webpage
http://www.cellbiology-utrecht.nl/research/klumperman.html
https://nl.linkedin.com/pub/judith-klumperman/28/98/472
http://www.umcutrecht.nl/nl/Ziekenhuis/Zorgverleners/Klumperman-J
Biography
Since 2001 Judith Klumperman is professor of Cell Biology and since 2008 chair of the Department of Cell Biology at the UMC Utrecht. She is also head of the Cell Microscopy Core of the UMC Utrecht, which is widely recognized as one of the best expertise centers in the world for immuno-electron microscopy. On a yearly basis the UMC Utrechts trains and assist over 40 scientists from the Netherlands and 15-20 international guests.She is often asked for expert microscopy advise and participate(d) in a large number of international collaborations.
Her research focus on understanding the molecular basis of human diseases, with an emphasis on diseases of the endo-lysosomal system. Diseases specifically addressed in my work are: Lysosomal storage disorders (Pompe disease; Mucolipidosis II/I-Cell disease) – Alzheimer disease – Hermansky Pudlak Syndrome (pigmentation bleeding disorder) - Cancer – virus and bacterial infections – ARC syndrome –Microvillar inclusion Disease. In addition, her work has elucidated fundamental concepts of endosome and lysosome biogenesis, of which the most recent finding is a novel pathway for the delivery of lysosomal membrane proteins to the lysosomes.
Fellowship & awards
2007: 20th Foundation lecture, Center for Cell and Molecular Biology, Hyderabad, India.
2004: VICI Award (1.25M€) from the Netherlands Organisation for Scientific Research.
1998: UMC Utrecht award: Attraction and maintenance of female talent.
External positions
Voorzitter van bestuur - Organisatie Elektronen Microscopie in Nederland - NEMI - Netherlands Electron Microscopy Infrastructure
1 Oct 2015 → 31 Dec 3999
Organisatie Elektronen Microscopie in Utrecht - Onderzoeken m.b.v. elektronen microscopie - Utrecht University, Steering Committee EM Square
1 Jan 2015 → 31 Dec 3999
Bestuurslid. - Toekomst Electronen Microscopie in Utrecht veilig stellen. - Steering Committee EM Square, UU
1 Jan 2015 → 31 Dec 2026
Geven van lezingen op congressen - Kennisoverdracht eigen onderzoeken - Diversen
1 Jan 2013 → 31 Dec 3999
Review voor wetenschappelijke tijdschriften - kennis op gebied van Celbiologie, microscopie etc. - Diversen
1 Jan 2013 → 31 Dec 3999
Als 'gaste' editor van het tijdschrift - Celbiologie - Scientific Journal 'Cell Biology'
1 Jan 2013 → 31 Dec 3999
Deelnemen aan PhD promotie commissies als voorzitter of commissielid - kennisoverdracht, niveau academici bewaken. - Nationale en internationale universiteiten
1 Jan 2013 → 31 Dec 3999
Lid van Bestuur - opleidings gerelateerd - UU IB – Institute and graduate school of Biomembranes
1 Jan 2013 → 31 Dec 3999
Board member of Biomembranes - Stimulate the Phd program - Institute of 'Biomembranes'
1 Jan 2013 → 31 Dec 3999
Grant reviewer - Voor diverse bladen (NWO, KWF, EMBO, Wellcome Trust, Medical Researh Council, KNAW, Telethon) - Grant reviewer voor diverse bladen: NWO, EMBO, KWF, Well
1 Jan 2013 → 31 Dec 3999
Reviewer for different Scientific magazines - Assess whether the articles can be published. - Science organisations in general
1 Jan 2013 → 31 Dec 3999
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A nonenzymatic dependency on inositol-requiring enzyme 1 controls cancer cell cycle progression and tumor growth
Zuazo-Gaztelu, I., Lawrence, D., Oikonomidi, I., Marsters, S., Pechuan-Jorge, X., Gaspar, C. J., Kan, D., Segal, E., Clark, K., Beresini, M., Braun, M. G., Rudolph, J., Modrusan, Z., Choi, M., Sandoval, W., Reichelt, M., DeWitt, D. C., Kujala, P., van Dijk, S. & Klumperman, J. & 1 others, , Apr 2025, In: PLoS Biology. 23, 4, e3003086.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Downloads (Pure) -
ATG9A and ARFIP2 cooperate to control PI4P levels for lysosomal repair
De Tito, S., Almacellas, E., Dai Yu, D., Millard, E., Zhang, W., de Heus, C., Queval, C., Hervás, J. H., Pellegrino, E., Panagi, I., Fogde, D., Thurston, T. L. M., Klumperman, J., Gutierrez, M. & Tooze, S. A., 20 Oct 2025, In: Developmental Cell. 60, 20, p. 2744-2760.e9Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Identification of a RAB32-LRMDA-Commander membrane trafficking complex reveals the molecular mechanism of human oculocutaneous albinism type 7
Butkovič, R., Healy, M. D., de Heus, C., Walker, A. P., Beyers, W., McNally, K. E., Lewis, P. A., Heesom, K. J., Liv, N., Klumperman, J., Di Pietro, S., Collins, B. M. & Cullen, P. J., Dec 2025, In: Nature Communications. 16, 1, 8794.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile3 Downloads (Pure) -
Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection
Mukherjee, R., Bhattacharya, A., Tomaskovic, I., Mello-Vieira, J., Brunstein, M. E., Başoğlu, M., Veenendaal, T., Bailey, H., Colby, T., Misra, M., Eimer, S., Klumperman, J., Münch, C., Matic, I. & Dikic, I., 1 Aug 2025, In: EMBO Journal. 44, 15, p. 4252-4279 28 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Trafficking to the lysosome: HOPS paves the way
van der Beek, J. & Klumperman, J., Jun 2025, In: Current Opinion in Cell Biology. 94, 9 p., 102515.Research output: Contribution to journal › Review article › peer-review
Open AccessFile13 Downloads (Pure)
Activities
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8th Asian EM meeting (Kanasawa, Japan)
Klumperman, J. (Invited speaker)
9 Jun 2004Activity: Participating in or organising an event › Participation in conference › Academic
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Invited lecture 3th international congress on Electron Tomography (Albany, USA)
Klumperman, J. (Invited speaker)
15 Apr 2004Activity: Participating in or organising an event › Participation in conference › Academic
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Invited lecture Keystone Meeting (Coldspring Harbor, USA)
Klumperman, J. (Invited speaker)
15 Jan 2004Activity: Participating in or organising an event › Participation in conference › Academic
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Anterograde and retrograde traffic to and through the Golgi
Klumperman, J. (Speaker)
14 Dec 2000Activity: Talk or presentation › Oral presentation › Academic
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Leica Cryoworkshop (Utrecht)
Klumperman, J. (Invited speaker)
15 Nov 2000Activity: Participating in or organising an event › Participation in workshop, seminar, course › Academic