Helen Leavis

2025

Disseminated histoplasmosis induced hemophagocytic lymphohistiocytosis in an immunocompromised patient

Bardai, N. E., Vos, L. M., Leavis, H. L., Jak, M., Bruns, A. H. W. & Limper, M., Apr 2025, In: Clinical Infection In Practice. 26, 6 p., 100488.

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Gut microbial dysbiosis, IgA, and Enterococcus in common variable immunodeficiency with immune dysregulation

Berbers, R.-M., Paganelli, F. L., van Montfrans, J. M., Ellerbroek, P. M., Viveen, M. C., Rogers, M. R. C., Salomons, M., Schuurmans, J., van Stigt Thans, M., Vanmaris, R. M. M., Brosens, L. A. A., van der Wal, M. M., Dalm, V. A. S. H., van Hagen, P. M., van de Ven, A. A. J. M., Uh, H.-W., van Wijk, F., Willems, R. J. L. & Leavis, H. L., 16 Jan 2025, In: Microbiome. 13, 1, 1 p., 12.

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2024

Abatacept bij de behandeling van monogenetische en refractaire inflammatoire ziekte

Translated title of the contribution: Abatacept as treatment for monogenetic and refractory inflammatory diseaseLeavis, H., van den Berg, J. M., Berghuis, D., de Bree, G. J., Buddingh, E. P., Bulatovic-Calasan, M., Dalm, V. A. S. H., van Hagen, P. M., Hamann, D., Henriet, S. S. V., Hoppenreijs, E. P. A. H., Jansen, M., Kuijpers, T. W., Legger, G., van Montfrans, J., Mulders-Manders, K., Potjewijd, J., Rutgers, A., Scholvinck, E. H. & van de Veerdonk, F. L. & 2 others, Vermont, C. L. & van Well, G. T. J., Aug 2024, In: Nederlands tijdschrift voor allergie, astma en klinische immunologie. 24, 3, p. 102-105

Research output: Contribution to journal › Article › Academic › peer-review

Association of autoantibodies with the IFN signature and NETosis in patients with systemic lupus erythematosus

Kaan, E. D., Brunekreef, T. E., Drylewicz, J., van den Hoogen, L. L., van der Linden, M., Leavis, H. L., van Laar, J. M., van der Vlist, M., Otten, H. G. & Limper, M., Dec 2024, In: Journal of translational autoimmunity. 9, 100246.

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Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

Demidov, G., Yaldiz, B., Garcia-Pelaez, J., de Boer, E., Schuermans, N., Van de Vondel, L., Paramonov, I., Johansson, L. F., Musacchia, F., Benetti, E., Bullich, G., Sablauskas, K., Beltran, S., Gilissen, C., Hoischen, A., Ossowski, S., de Voer, R., Lohmann, K., Oliveira, C. & Topf, A. & 3 others, Vissers, L. E. L. M., Solve-RD Consortium & Laurie, S., 26 Oct 2024, In: npj Genomic Medicine. 9, 1, 49.

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JAK-remmers in de behandeling van zeldzame afweerstoornissen en autoinflammatoire aandoeningen

Translated title of the contribution: JAK inhibitors to treat rare inborn errors of immunity and (auto-)inflammatory conditionsBuddingh, E. P., van den Berg, J. M., Berghuis, D., de Bree, G. J., Bulatovic-Calasan, M., Dalm, V. A. S. H., Van Hagen, P. M., Hamann, D., Henriet, S. S. V., Hoppenreijs, E. P. A. H., Jansen, M., Kuijpers, T. W., Leavis, H., Legger, G., van Montfrans, J., Mulders-Manders, K., Potjewijd, J., Rutgers, A., Scholvinck, E. H. & van de Veerdonk, F. L. & 2 others, Vermont, C. L. & van Well, G. T. J., Aug 2024, In: Nederlands tijdschrift voor allergie, astma en klinische immunologie. 24, 3, p. 97-101

Research output: Contribution to journal › Article › Academic › peer-review

Longitudinal assessment of immunoglobulin response and disease progression in critically ill patients with community acquired pneumonia

Rademaker, E., Vernooij, L. M., van der Poll, T., Bonten, M. J. M., Leavis, H., Cremer, O. L. & Derde, L. P. G., 5 Dec 2024, In: Critical care (London, England). 28, 1, 405.

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Management of adult-onset Still's disease: evidence- and consensus-based recommendations by experts

Leavis, H. L., van Daele, P. L. A., Mulders-Manders, C., Michels, R., Rutgers, A., Legger, E., Bijl, M., Hak, E. A., Lam-Tse, W.-K., Bonte-Mineur, F., Fretter, P., Simon, A., van Paassen, P., van der Goes, M., Flendrie, M., Vercoutere, W., van Lieshout, A. W. T., Leek, A., Vastert, S. J. & Tas, S. W., 1 Jun 2024, In: Rheumatology (Oxford, England). 63, 6, p. 1656-1663 8 p.

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Neurological phenotype of adenosine deaminase 2 deficient patients: a cohort study

Verschoof, M. A., van Meenen, L. C. C., Andriessen, M. V. E., Brinkman, D. M. C., Kamphuis, S., Kuijpers, T. W., Leavis, H. L., Legger, G. E., Mulders-Manders, C. M., de Pagter, A. P. J., Rutgers, A., van Well, G. T. J., Coutinho, J. M., Hak, A. E., van Montfrans, J. M. & Klouwer, F. C. C., Jan 2024, In: European Journal of Neurology. 31, 1, p. 1-9 9 p., e16043.

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Paucity of gastrointestinal plasma cells in common variable immunodeficiency

Marsden, J. W. N., Laclé, M. M., Severs, M. & Leavis, H. L., 1 Dec 2024, In: Current opinion in allergy and clinical immunology. 24, 6, p. 464-471 8 p.

Research output: Contribution to journal › Review article › peer-review

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Pulmonary Computed Tomography Screening Frequency in Primary Antibody Deficiency

Smits, B. M., Boland, S. L., Hol, M. E., Dandis, R., Leavis, H., de Jong, P. A., Prevaes, S. M. P. J., Mohamed Hoesein, F. A. A., van Montfrans, J. M. & Ellerbroek, P. M., Apr 2024, In: Journal of Allergy and Clinical Immunology: In Practice. 12, 4, p. 1037-1048.e3

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The association of inflammatory markers with frailty and in-hospital mortality in older COVID-19 patients

Tran Van Hoi, E., Appelman, B., Mooijaart, S., Dalm, V. A. S. H., Polinder Bos, H. A., van Heemst, D., van Raaij, B. F. M., Noordam, R., Kuranova, A., Hoogerwerf, J. J., Peeters, G., Smorenberg, A., COOP Consortium, COVID-OLD study, COVID Predict Study Group & CliniCo study, 1 Oct 2024, In: Experimental Gerontology. 195, 7 p., 112534.

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The predictive value of antinuclear antibodies in patients with suspected connective tissue disease for the development of connective tissue diseases

Brunekreef, T. E., van den Heuvel, H. B., Limper, M., Leavis, H., van Laar, J. M. & Otten, H., 1 Jan 2024, In: Clinical and Experimental Rheumatology. 42, 1, p. 24-29 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

YajC, a predicted membrane protein, promotes Enterococcus faecium biofilm formation in vitro and in a rat endocarditis model

Top, J., Zhang, X., Hendrickx, A. P. A., Boeren, S., van Schaik, W., Huebner, J., Willems, R. J. L., Leavis, H. L. & Paganelli, F. L., 2024, In: FEMS Microbes. 5, xtae017.

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2023

BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

BCG-Corona Study Group, 25 Apr 2023, In: mBio. 14, 2, 16 p., e0035623.

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CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren’s Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells

Hinrichs, A. C., Kruize, A. A., Lafeber, F. P. J. G., Leavis, H. L. & van Roon, J. A. G., Aug 2023, In: International Journal of Molecular Sciences. 24, 15, 11952.

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Chronische anemie en onverklaarde ontsteking: Denk aan het VEXAS-syndroom

Translated title of the contribution: Chronic anemia and unexplained inflammation: think of VEXAS syndromevan Daele, P. L. A., van der Made, C. I., Leavis, H. L., Hak, A. E. L., Potjewijd, J. & Rutgers, A. B., 19 Apr 2023, In: Nederlands Tijdschrift voor Geneeskunde. 167, 17, 5 p., D7306.

Research output: Contribution to journal › Article › Academic › peer-review

Clinical Symptoms, Laboratory Parameters and Long-Term Follow-up in a National DADA2 Cohort

Andriessen, M. V. E., Legger, G. E., Bredius, R. G. M., van Gijn, M. E., Hak, A. E., Muller, P. C. E. H., Kamphuis, S., Klouwer, F. C. C., Kuijpers, T. W., Leavis, H. L., Nierkens, S., Rutgers, A., van der Veken, L. T., van Well, G. T. J., Mulders-Manders, C. M. & van Montfrans, J. M., Oct 2023, In: Journal of Clinical Immunology. 43, 7, p. 1581-1596 16 p.

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Clinical Validation of a Primary Antibody Deficiency Screening Algorithm for Primary Care

Messelink, M. A., Welsing, P. M. J., Devercelli, G., Marsden, J. W. N. & Leavis, H. L., Nov 2023, In: Journal of Clinical Immunology. 43, 8, p. 2022-2032 11 p.

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Continuation of therapeutic dose heparin for critically ill patients with COVID-19

on behalf of the REMAP-C. A. P. Investigators, Jul 2023, In: Intensive Care Medicine. 49, 7, p. 873-875 3 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Development of a primary care screening algorithm for the early detection of patients at risk of primary antibody deficiency

Messelink, M. A., Berbers, R. M., van Montfrans, J. M., Ellerbroek, P. M., Gladiator, A., Welsing, P. M. J. & Leavis, H., 27 May 2023, In: Allergy, asthma, and clinical immunology: official journal of the Canadian Society of Allergy and Clinical Immunology. 19, 1, 15 p., 44.

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Immune Responses 6 Months After mRNA-1273 COVID-19 Vaccination and the Effect of a Third Vaccination in Patients with Inborn Errors of Immunity

VACOPID Research Group, Aug 2023, In: Journal of Clinical Immunology. 43, 6, p. 1104-1117 14 p.

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JAK Inhibition with Baricitinib for Severe CVID-Related Enteropathy: a Case Report

Abdelmoumen, A., van Montfrans, J., van Wijk, F. & Leavis, H., Nov 2023, In: Journal of Clinical Immunology. 43, 8, p. 1766-1769 4 p.

Research output: Contribution to journal › Letter › Academic › peer-review

Leflunomide/hydroxychloroquine combination therapy targets type I IFN-associated proteins in patients with Sjögren's syndrome that show potential to predict and monitor clinical response

Hamkour, S., van der Heijden, E. H., Lopes, A. P., Blokland, S. L. M., Bekker, C. P. J., Van Helden-Meeuwsen, C. G., Versnel, M. A., Kruize, A. A., Radstake, T. R., Leavis, H. L., Hillen, M. R. & van Roon, J. A., 2 Aug 2023, In: RMD Open. 9, 3, 8 p., e002979.

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Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

REMAP-CAP Investigators, 3 Jan 2023, In: JAMA - The Journal of The American Medical Association. 329, 1, p. 39-51 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Point-of-care neutrophil CD64 as a rule in diagnostic test for bacterial infections in the emergency department

van de Ven, N. L. M., Bongers, S. H., Spijkerman, R., Koenderman, L., Leenen, L. P. H., Hietbrink, F. & COVPACH study group, 14 Mar 2023, In: BMC Emergency Medicine. 23, 1, p. 1-10 10 p., 28.

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Prolonged Disease Course of COVID-19 in a Patient with CTLA-4 Haploinsufficiency

Hoffman, T. W., Leavis, H. L., Smits, B. M., van der Veken, L. T. & van Kessel, D. A., 22 May 2023, In: Case reports in immunology. 2023, 7 p., 3977739.

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Soluble Signal Inhibitory Receptor on Leukocytes-1 Is Released from Activated Neutrophils by Proteinase 3 Cleavage

von Richthofen, H. J., Westerlaken, G. H. A., Gollnast, D., Besteman, S., Delemarre, E. M., Rodenburg, K., Moerer, P., Stapels, D. A. C., Andiappan, A. K., Rötzschke, O., Nierkens, S., Leavis, H. L., Bont, L. J., Rooijakkers, S. H. M. & Meyaard, L., 15 Feb 2023, In: Journal of immunology (Baltimore, Md. : 1950). 210, 4, p. 389-397 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

The PID Odyssey 2030: outlooks, unmet needs, hurdles, and opportunities — proceedings from the IPOPI global multi-stakeholders’ summit (June 2022)

Tadros, S., Prévot, J., Meyts, I., Sánchez-Ramón, S., Erwa, N. H., Fischer, A., Lefevre, G., Hotchko, M., Jaworski, P. M., Leavis, H., Boersma, C., Drabwell, J., van Hagen, M., Van Coillie, S., Pergent, M., Burns, S. O. & Mahlaoui, N., 2023, In: Frontiers in Immunology. 14, 1245718.

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2022

Adult-onset autoinflammation caused by somatic mutations in UBA1: A Dutch case series of patients with VEXAS

van der Made, C. I., Potjewijd, J., Hoogstins, A., Willems, H. P. J., Kwakernaak, A. J., de Sevaux, R. G. L., van Daele, P. L. A., Simons, A., Heijstek, M., Beck, D. B., Netea, M. G., van Paassen, P., Hak, A. E., van der Veken, L. T., van Gijn, M. E., Hoischen, A., van der Veerdonk, F. L., Leavis, H. L. & Rutgers, A., Jan 2022, In: The Journal of Allergy and Clinical Immunology. 149, 1, p. 432-439.e4

Research output: Contribution to journal › Article › Academic › peer-review

47 Citations (Scopus)

A guide to immunotherapy for COVID-19

van de Veerdonk, F. L., Giamarellos-Bourboulis, E., Pickkers, P., Derde, L., Leavis, H., van Crevel, R., Engel, J. J., Wiersinga, W. J., Vlaar, A. P. J., Shankar-Hari, M., van der Poll, T., Bonten, M., Angus, D. C., van der Meer, J. W. M. & Netea, M. G., Jan 2022, In: Nature Medicine. 28, 1, p. 39-50 12 p.

Research output: Contribution to journal › Review article › peer-review

109 Citations (Scopus)

Air pollution from livestock farms and the oropharyngeal microbiome of COPD patients and controls

van Kersen, W., Bossers, A., de Steenhuijsen Piters, W. A. A., de Rooij, M. M. T., Bonten, M., Fluit, A. C., Heederik, D., Paganelli, F. L., Rogers, M., Viveen, M., Bogaert, D., Leavis, H. L. & Smit, L. A. M., Nov 2022, In: Environment International. 169, p. 1-9 107497.

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Case report: Up-front allogeneic stem cell transplantation in a patient with the VEXAS syndrome

van Leeuwen-Kerkhoff, N., de Witte, M. A., Heijstek, M. W. & Leavis, H. L., Nov 2022, In: British Journal of Haematology. 199, 3, p. e12-e15

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

Hinrichs, A. C., Blokland, S. L. M., Kruize, A. A., Lafeber, F. P. J., Leavis, H. L. & van Roon, J. A. G., 1 Jun 2022, In: Frontiers in Immunology. 13, p. 1-10 887972.

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Clinical features and immune-related protein patterns of anti-MDA5 positive clinically amyopathic dermatomyositis Dutch patients

Hensgens, M. P. M., Delemarre, E. M., Drylewicz, J., Voortman, M., Krol, R. M., Dalm, V. A. S. H., Miedema, J. R., Wiertz, I., Grutters, J., Limper, M., Nierkens, S. & Leavis, H. L., 6 Oct 2022, In: Rheumatology (Oxford, England). 61, 10, p. 4087-4096 10 p.

Research output: Contribution to journal › Article › Academic › peer-review

Effect of Antiplatelet Therapy on Survival and Organ Support-Free Days in Critically Ill Patients with COVID-19: A Randomized Clinical Trial

REMAP-CAP Investigators, 5 Apr 2022, In: JAMA - The Journal of The American Medical Association. 327, 13, p. 1247-1259 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Heterozygous Variants in the DNA-binding Domain of c-Myb May Affect Normal B/T Cell Development

Smits, B. M., Hartley, T., Dünnebach, E., Bartels, M., Boycott, K. M., Kernohan, K. D., Dyment, D. A., Giltay, J. C., Haddad, E., Jarinova, O., Van Montfrans, J., Van Royen-Kerkhof, A., Van Der Veken, L. T., De Witte, M., Nierkens, S., Pham-Huy, A. & Leavis, H. L., 21 Oct 2022, In: HemaSphere. 6, 10, p. E774

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Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal a-toxin

Spaan, A. N., Neehus, A. L., Laplantine, E., Staels, F., Ogishi, M., Seeleuthner, Y., Rapaport, F., Lacey, K. A., Van Nieuwenhove, E., Chrabieh, M., Hum, D., Migaud, M., Izmiryan, A., Lorenzo, L., Kochetkov, T., Heesterbeek, D. A. C., Bardoel, B. W., DuMont, A. L., Dobbs, K. & Chardonnet, S. & 42 others, Heissel, S., Baslan, T., Zhang, P., Yang, R., Bogunovic, D., Wunderink, H. F., Haas, P. J. A., Molina, H., Van Buggenhout, G., Lyonnet, S., Notarangelo, L. D., Seppänen, M. R. J., Weil, R., Seminario, G., Gomez-Tello, H., Wouters, C., Mesdaghi, M., Shahrooei, M., Bossuyt, X., Sag, E., Topaloglu, R., Ozen, S., Leavis, H. L., van Eijk, M. M. J., Bezrodnik, L., Galicia, L. B., Hovnanian, A., Nassif, A., Bader-Meunier, B., Neven, B., Meyts, I., Schrijvers, R., Puel, A., Bustamante, J., Aksentijevich, I., Kastner, D. L., Torres, V. J., Humblet-Baron, S., Liston, A., Abel, L., Boisson, B. & Casanova, J. L., 17 Jun 2022, In: Science. 376, 6599, eabm6380.

Research output: Contribution to journal › Article › Academic › peer-review

2 Citations (Scopus)

Immune monitoring and treatment in immune-mediated inflammatory diseases

van Wijk, F., de Bruin, M., Leavis, H. & Nierkens, S., 7 Jun 2022, In: Nature Communications. 13, 1, p. 1-1 3245.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

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Immunogenicity of the mRNA-1273 COVID-19 vaccine in adult patients with inborn errors of immunity

van Leeuwen, L. P. M., GeurtsvanKessel, C. H., Ellerbroek, P. M., de Bree, G. J., Potjewijd, J., Rutgers, A., Jolink, H., van de Veerdonk, F., van Gorp, E. C. M., de Wilt, F., Bogers, S., Gommers, L., Geers, D., Bruns, A. H. W., Leavis, H. L., van Haga, J. W., Lemkes, B. A., van der Veen, A., de Kruijf-Bazen, S. F. J. & van Paassen, P. & 17 others, de Leeuw, K., van de Ven, A. A. J. M., Verbeek-Menken, P. H., van Wengen, A., Arend, S. M., Ruten-Budde, A. J., van der Ent, M. W., van Hagen, P. M., Sanders, R. W., Grobben, M., van der Straten, K., Burger, J. A., Poniman, M., Nierkens, S., van Gils, M. J., de Vries, R. D. & Dalm, V. A. S. H., Jun 2022, In: Journal of Allergy and Clinical Immunology. 149, 6, p. 1949-1957 9 p.

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In patients with primary Sjögren’s syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells

Hinrichs, A. C., Kruize, A. A., Leavis, H. L. & van Roon, J. A. G., 24 Nov 2022, In: Frontiers in Immunology. 13, 1017157.

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Stimulating severe COVID-19: the potential role of GM-CSF antagonism

Leavis, H. L., van de Veerdonk, F. L. & Murthy, S., Mar 2022, In: The Lancet Respiratory Medicine. 10, 3, p. 223-224 2 p.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

2021

Chronically Activated T-cells Retain Their Inflammatory Properties in Common Variable Immunodeficiency

Berbers, R.-M., van der Wal, M. M., van Montfrans, J. M., Ellerbroek, P. M., Dalm, V. A. S. H., van Hagen, P. M., Leavis, H. L. & van Wijk, F., Oct 2021, In: Journal of Clinical Immunology. 41, 7, p. 1621-1632 12 p.

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7 Citations (Scopus)

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Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation

Spijkerman, R., Bongers, S. H., Bindels, B. J. J., Tinnevelt, G. H., Giustarini, G., Jorritsma, N. K. N., Buitenwerf, W., van Spengler, D. E. J., Delemarre, E. M., Nierkens, S., van Goor, H. M. R., Jansen, J. J., Vrisekoop, N., Hietbrink, F., Leenen, L. P. H., Kaasjager, K. A. H., Koenderman, L. & the COVPACH study group, Jan 2021, In: Journal of Leukocyte Biology. 109, 1, p. 99-114 16 p.

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Implementation of Early Next-Generation Sequencing for Inborn Errors of Immunity: A Prospective Observational Cohort Study of Diagnostic Yield and Clinical Implications in Dutch Genome Diagnostic Centers

the Genetics First for Primary Immunodeficiency Disorders Consortium, 21 Dec 2021, In: Frontiers in Immunology. 12, 780134.

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Interleukin-6 receptor antagonists in critically ill patients with covid-19

REMAP-CAP Investigators, 22 Apr 2021, In: The New England journal of medicine. 384, 16, p. 1491-1502 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

922 Citations (Scopus)

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

REMAP-CAP Investigators, 1 Aug 2021, In: Intensive Care Medicine. 47, 8, p. 867-886 20 p.

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44 Citations (Scopus)

Repetitive Immune-Mediated Noninfectious Endocarditis Necessitating 5 Mitral Valve Replacements

Muller, S. A., Leavis, H. L., Taha, K., Koenderman, L., Chamuleau, S. A. J., Suyker, W. J. L. & Cramer, M. J., 6 Oct 2021, In: JACC Case Rep. 3, 13, p. 1483-1488 6 p.

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Severe thrombotic microangiopathy after autologous stem cell transplantation in systemic sclerosis: A case report

Sharif, M. O., Leavis, H. L., van Paassen, P., van Rhenen, A., Timmermans, S. A. M. E. G., Ton, E., Laar, J. M. V. & Spierings, J., 1 Sept 2021, In: Rheumatology (Oxford, England). 60, 9, p. E326-E328

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Targeted Proteomics Reveals Inflammatory Pathways that Classify Immune Dysregulation in Common Variable Immunodeficiency

Berbers, R.-M., Drylewicz, J., Ellerbroek, P. M., van Montfrans, J. M., Dalm, V. A. S. H., van Hagen, P. M., Keller, B., Warnatz, K., van de Ven, A., van Laar, J. M., Nierkens, S. & Leavis, H. L., Feb 2021, In: Journal of Clinical Immunology. 41, 2, p. 362-373 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

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10 Citations (Scopus)

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Helen Leavis

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