Personal profile
Biography
Dr. Gimano Amatngalim is an Assistant Professor at the Department of Cellular Disease Models and the Regenerative Medicine Center at UMC Utrecht. He received his PhD in respiratory cell biology and immunology from Leiden University Medical Center, where he studied airway epithelial host defense mechanisms in chronic obstructive pulmonary disease. He completed postdoctoral training at UMC Utrecht, where he established primary human nasal epithelial culture models as personalized disease models for monogenic airway diseases and viral infections.
His current research focuses on the development of personalized airway and lung models using epithelial stem/progenitor cells. These models are applied to study conditions such as cystic fibrosis, primary ciliary dyskinesia, bronchiectasis, and asthma. A central theme in his work is the exploration of individual-specific traits, examining how epithelial stem/progenitor cells contribute to inflammation, therapy response, and regeneration in chronic respiratory diseases.
Fellowship & awards
Longfonds (Dutch Lung Foundation) – Short-Term Research Fellowship (2015)
European Respiratory Society (ERS) – Young Scientist Sponsorship (2019)
Cystic Fibrosis Foundation (CFF) – Pilot and Feasibility Award (2023)
Longfonds (Dutch Lung Foundation) – Young Investigator Grant (2023)
European Respiratory Society (ERS) – Young Scientist Sponsorship (2024)
Research interests
- Chronic inflammatory airway diseases (e.g., cystic fibrosis, PCD, bronchiectasis, asthma)
- Airway epithelial stem/progenitor cells and personalized in vitro models
- Inflammation, regeneration, and host defense in chronic airway disease
Collaborations and top research areas from the last five years
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Functional, Cohort-Level Assessment of CFTR Modulator Responses Using Biobanked Nasal Epithelial Cells from Individuals with Cystic Fibrosis
Aalbers, B. L., Amatngalim, G. D., Aarts, E. M., Rodenburg, L. W., den Hertog-Oosterhoff, L. A., Heijerman, H. G. M. & Beekman, J. M., Jan 2026, In: Journal of Personalized Medicine. 16, 1, 51.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Dual RNA sequencing of a co-culture model of Pseudomonas aeruginosa and human 2D upper airway organoids
Pleguezuelos-Manzano, C., Beenker, W. A. G., van Son, G. J. F., Begthel, H., Amatngalim, G. D., Beekman, J. M., Clevers, H. & den Hertog, J., 17 Jan 2025, In: Scientific Reports. 15, 1, 14 p., 2222.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile5 Downloads (Pure) -
The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness
Symons, J., Chung, C., Verheijen, B. M., Shemtov, S. J., de Jong, D., Amatngalim, G., Nijhuis, M., Vermulst, M. & Gout, J.-F., 11 Jul 2025, In: Nature Communications. 16, 1, 6425.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure) -
Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders
Dreyer, H. H. M., van Tuyll van Serooskerken, E. S., Rodenburg, L. W., Bittermann, A. J. N., Arets, H. G. M., Reuling, E. M. B. P., Verweij, J. W., Haarman, E. G., van der Zee, D. C., Tytgat, S. H. A. J., van der Ent, C. K., Beekman, J. M., Amatngalim, G. D. & Lindeboom, M. Y. A., 5 Jun 2023, In: Children. 10, 6, 9 p., 1020.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile11 Downloads (Pure) -
Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations
Delpiano, L., Rodenburg, L. W., Burke, M., Nelson, G., Amatngalim, G. D., Beekman, J. M. & Gray, M. A., 15 Nov 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 47, e2307551120.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure)