Research output per year
Research output per year
prof. dr.
Research activity per year
- Young Talent Lecture and Travel Grant - Gordon research conference 2011
- Annual Top 3 publication in journal Cell reports 2013
- Best poster award International League Against Epilepsy meeting 2015
- FENS/IBRO/KAVLI network of excellence mentoring prize nomination 2016/8
- Erasmus University Fellowship (€ 200.000) 2006-2010
Calcium channelopathies and their impact on cerebellar activity
- NWO-ALW VENI (#863.08.015; € 208.000) 2008-2011
Plasticity of excitatory and inhibitory synapses in cerebellar cortex
- NWO-TOP cross discipline (#1350186; €675.000) 2010-2016
Multidisciplinary studies on Cerebellum, ataxia, epilepsy and migraine
- NWO-ALW VIDI (#016.121.346; €800.000) 2012-2017
Unravelling the cerebellar impact on thalamo-cortical networks
- Erasmus MC MRace Pilot grant (€100.000) 2015-2017
Limiting seizures and side effects of DBS in Dravet syndrome mouse model
- C.J. Vaillant fonds Seed Grant (€20.000) 2017
Contribution to silicon probe in vivo neuromonitoring system
- Coolsingel foundation (€40.000) – with pediatric neurology Erasmus MC 2015-2017
Improving treatment options for refractory epilepsy patients
- Gravitation grant NWO (€1,100,000 out of 21,900,000) – Dutch Brain Interface Initiative 2022-2031
Neuromonitoring and neurostimulation innovations
Freek obtained his doctorate degree at the Erasmus Medical Center in Rotterdam in March 2005 being supervised by Prof. Chris De Zeeuw. The title of his thesis was ‘Electrophysiological responses of floccular Purkinje cells during compensatory eye movements in mutant mice’. The subsequent post-doc appointment in the laboratories of Prof. Ype Elgersma and Prof. Chris De Zeeuw at the Erasmus Department Neuroscience from 2005 to 2008 focused on the impact of CaMKII isoforms on cerebellar plasticity and motor behavior. From 2009-2011 Freek’s research focused on the physiology and connectivity of the cerebellar nuclei in health and disease, which paved the way for starting his own research group. As an assistant and associate professor Freek focused on thalamic studies on cerebello-cerebral interactions. During this time his students came from various research disciplines (Biomedical Sciences, BioElectrical Engineering, Medicine, Nanobiology and Psychology), which provided a mixture of disciplines and expertise enabling several multidisciplinary studies. Freek’s network extends from the (bio)medical and engineering faculties of several Dutch universities to expert centers in the UK, Germany, France, Italy, Spain, Sweden, Japan and the USA.
Since January 2018 Freek has been appointed as the Chair of ‘Translation Research of Early Life Events’ at UMC Utrecht, which allows him to achieve his ambitions in connecting bench- and bed-side research. His current position is Full Professor, head of the Department for Developmental Origins of Disease in the division Woman & Child (Vrouw en Baby) at the Wilhelmina Children’s Hospital of the UMC Utrecht. The main focus of his current scientific research is how adverse early life events affect the development of the connections between cerebellum and cerebrum.
Freek has supervised >15 PhD-students, numerous postdoctoral fellows and junior PIs. He contributed >60 articles and performs peer-review for a wide range of journals (Nature Reviews Neuroscience, Nature Neuroscience, Nature Communications, Neuron, PNAS, Cell Reports, Pediatrics, Annals of Neurology, etc) and is a member of the Dutch Neurofederation, the Dutch League against epilepsy, the society of anatomists, the Dutch-Flemish brain innovations consortium, Federation of European Neuroscience Societies (FENS) and Society for Neuroscience (SFN, USA). Freek presented the work of his team and hosted sessions at various international meetings, such as Gordon Research Conference, FENS and SFN. His research has been supported by several local and national grants (VENI, VIDI, TOP, Gravitation).
Since 2017 Freek is certified for academic teaching (BKO certificate; CAT course for honors teaching) and is currently the manager education for the division Woman & Child. Since 2021 Freek has been appointed the chair of the Harmen Tiddens Society for dedicated educators in the UMC Utrecht, which focusses on building the education community.
MOST RECENT KEY PUBLICATIONS
1. Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
Ritter-Makinson, S., Clemente-Perez, A., Higashikubo, B., Cho, F. S., Holden, S. S., Bennett, E., Chkaidze, A., Eelkman Rooda, O. H. J., Cornet, M. C., Hoebeek, F. E., Yamakawa, K., Cilio, M. R., Delord, B. & Paz, J. T., 2 Jan 2019, In : Cell Reports. 26, 1, p. 54-64.
2.Differentiating Cerebellar Impact on Thalamic Nuclei
Gornati, S. V., Schäfer, C. B., Eelkman Rooda, O. H. J., Nigg, A. L., De Zeeuw, C. I. & Hoebeek, F. E., 2018, In : Cell Reports. 23, 9, p. 2690-2704.
3. Neurodevelopmental consequences of preterm isolated cerebellar hemorrhage: A systematic review
Hortensius, L. M., Dijkshoorn, A. B. C., Ecury-Goossen, G. M., Steggerda, S. J., Hoebeek, F. E., Benders, M. J. N. L. & Dudink, J., 1 Nov 2018, In : Pediatrics. 142, 5, e20180609.
4.Convergence of Primary Sensory Cortex and Cerebellar Nuclei Pathways in the Whisker System Schafer, C. B. & Hoebeek, F. E., 1 Jan 2018, In : Neuroscience. 368, p. 229-239
5.Cerebello-cerebral connectivity in the developing brain Pieterman, K., Batalle, D., Dudink, J., Tournier, J. D., Hughes, E. J., Barnett, M., Benders, M. J., Edwards, A. D., Hoebeek, F. E. & Counsell, S. J., 29 Aug 2016. In : Brain Structure and Function. p. 1-10 10 p.
6.Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice Peter, S., Ten Brinke, M. M., Stedehouder, J., Reinelt, C. M., Wu, B., Zhou, H., Zhou, K., Boele, H-J., Kushner, S. A., Lee, M. G., Schmeisser, M. J., Boeckers, T. M., Schonewille, M., Hoebeek, F. E. & De Zeeuw, C. I., 1 Sep 2016, In : Nature Communications. 7, p. 12627
National grant evaluation committee for Dutch Science Foundation (NWO', Zon-MW)
Grant reviewer for European Research Council (ERC-CoG)
Grant reviewer for French National Science Foundation (ANR)
Guest lecturer at 'Studiecentrum Rechtspraak'
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Freek Hoebeek (Chair)
Activity: Membership › Membership of committee › Academic
Freek Hoebeek (Chair)
Activity: Participating in or organising an event › Participation in workshop, seminar, course › Academic
Freek Hoebeek (Speaker)
Activity: Talk or presentation › Invited talk › Academic
LM Hortensius, Aicha B C Dijkshoorn, Ginette M Ecury-Goossen, Sylke J Steggerda, FE Hoebeek, m benders & J Dudink
20/10/18
1 Media contribution
Press/Media: Public Engagement Activities