Research output per year
Research output per year
Personal profile
Biography
Dylan de Lange started his medical education at the University of Utrecht in 1992. After graduating he started as a resident in Internal Medicine in a teaching hospital in Amersfoort but he finished his residency in the University Medical Center in Utrecht (UMC Utrecht). Afterwards he did a fellowship in Infectious Diseases and subsequently a fellowship in Intensive Care Medicine. In 2007 he joined the medical staff of the Intensive Care Unit and the Dutch Poisons Information Center (DPIC) in the University Medical Center Utrecht, where he has been working ever since.
Since 2017 he is full professor in Clinical Toxicology and the chair of the Dutch Poisons Information Center (nvic.umcutrecht.nl). As a clinical toxicologist (European Registered Toxicologist, ERT) he advises on medical treatment of intoxicated patients. The Dutch Poisons Information Center is contacted for medical advice over 240,000 times per year by other medical professionals.
He is a board member of the National Intensive Care Evaluation (NICE) Foundation, which benchmarks the all Dutch ICUs. Part of his current research is derived from this large national registry: (long term) outcome after intensive care treatment. Not only mortality is important but also the health related quality of life (HRQoL). Can we predict good/bad outcome?
His research interests obviously situate at the intersection of Clinical Toxicology and Intensive Care Medicine and focusses on "predicting outcome" in:
- critically ill intoxicated patient
- critically ill patients, especially in regard to the pharmacokinetics and toxicokinetics of antimicrobials and immunosuppressants
- critically ill patients with the use of biomarkers
In 2019 a large European research project started looking at the (long-term) outcomes of intoxicated patients on various ICUs in the World. Can we predict outcome based on variables that ate present at admission to the hospital? This INTOXICATE study is now closed and the first analyses are being published.
Side activities
Lid van de Commissie van Toezicht van de Postdoctorale Educatie Toxicologie (PET) van de Nederlandse Vereninging van Toxicologie - vanaf 2022?
Side activities
Lid van de Safety commissie van de RATE-studie - sinds 2021
Side activities
Lid van de werkgroep voor medicamenteuze behandeling van COVID-19 van de Stichting Werkgroep Antibiotica Beleid (SWAB) - sinds 2020
Side activities
Lid van het Expertiseteam Behandeling COVID-19 van de Federatie Medisch Specialisten (FMS) - sinds 2020
Side activities
Lid namens ESICM van de European Association of Hospital Pharmacists (EAHP) Special Interest Group (SIG) for the Investigation of Medication Errors in Intensive Care Units - sinds 2020
Side activities
Organisatie en docent van de de Multidisciplinaire Toxicologie cursus vanuit het Gemeensschappelijk Intoxicatie Forum (GIF) samenwerkingsverband - sinds 2019
Side activities
Congrescommissie van de Nederlandse Vereniging van Intensive Care (NVIC) - sinds 2018
Side activities
Overleg niet-geregistreerde geneesmiddelen voor antidota en calamiteitenvoorraad i.sm. RIVM/IGJ/NVIC/CBG - sinds 2017
Side activities
VIP study group van de Health Research Services and Outcome (HSRO) section van de European Society of Intensive Care Medicine (ESICM) - sinds 2015
Side activities
Vice-voorzitter van de Taskforce Infectieuze Bedreigingen van de Nederlandse Vereniging voor Intensive Care (NVIC) - sinds 2009
Side activities
Secretaris van Stichting Nederlandse Intensive Care Evaluatie (NICE) - sinds 2006
External positions
Senior editor van editorial board wetenschappelijk tijdschrift "Clinical Toxicology" - beoordelen van manuscripten voor publicatie in het tijdschrift - Taylor & Francis (editor of Clin Tox)
13 Nov 2023 → 31 Dec 3999
raad van Toezicht van de Postdoctorale Educatie in Toxicologie (PET) - Controle van de inhoud en kwaliteit van het onderwijs in toxicologie - Nederlandse Vereniging voor Toxicologie (NVT)
1 Jan 2022 → 31 Dec 3999
Lid van Special Interest Group (SIG) van de European Association of Hospital Pharmacists (EAHP) - medicatieveligheid op de ICU - European Society Intensive Care Medicine (ESICM)
4 Jan 2021 → 31 Dec 3999
Lid van het expertiseteam behandeling COVID-19 - - Federatie Medisch Specialisten (FMS)
1 Jan 2021 → 31 Dec 3999
lid van de werkgroep voor de medicamenteuze behandeling van COVID-19 - - Stichting Werkgroep Antibioticabeleid (SWAB)
1 Jul 2020 → 31 Dec 3999
Organisatie en docent van de multidisciplinaire cursus toxicoogie - docent toxicologie - Schola Medica
1 Jan 2019 → 31 Dec 3999
Congrescommissie van de NVIC - organiseren van IC congressen past bij nascholing voor collega's - Nederlandse Vereniging Intensive Care (NVIC)
1 Jan 2018 → 31 Dec 3999
Overleg niet-geregistreerde geneesmiddelen en antidota voor de calamiteitenvoorraad - Indicatiestelling en voorraad advies van antisera en antidota - RIVM
1 Jan 2017 → 31 Dec 3999
lid van de Taskforce Infectieuze Bedreigingen van de NVIC (sinds 2009) - infecties op de IC - NVIC
1 Jan 2013 → 31 Dec 3999
secretaris Stichting NICE (lid sinds 2007) - Kwaliteitsregistratie van de Nederlandse Intensive Cares - Stichting Nationale Intensive Care Evaluatie (NICE)
1 Jan 2013 → 31 Dec 3999
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Research output
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30-day mortality among very old patients admitted to European intensive care units for major trauma
Duncan, C. F., Lonsdale, D. O., Farrah, H., Farnell-Ward, S., Ryan, C., Watson, X., Cecconi, M., Fjølner, J., Szczeklik, W., Moreno, R., Artigas, A., Joannidis, M., De Lange, D. W., Guidet, B., Flaatten, H., Jung, C. & Leaver, S., Jul 2024, In: Gerontology. 70, 7, p. 715-723 9 p., 537718.Research output: Contribution to journal › Article › Academic › peer-review
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Adverse drug events caused by three high-risk drug-drug interactions in patients admitted to intensive care units: a multicentre retrospective observational study
Klopotowska, J. E., Leopold, J.-H., Bakker, T., Yasrebi-de Kom, I., Engelaer, F. M., de Jonge, E., Haspels-Hogervorst, E. K., van den Bergh, W. M., Renes, M. H., Jong, B. T., Kieft, H., Wieringa, A., Hendriks, S., Lau, C., van Bree, S. H. W., Lammers, H. J. W., Wierenga, P. C., Bosman, R. J., de Jong, V. M. & Slijkhuis, M. & 11 others, , Jan 2024, In: British Journal of Clinical Pharmacology. 90, 1, p. 164-175 12 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
Application of European Society of Cardiology guidelines for evaluating acute coronary syndrome risk in low-risk patients with cocaine-associated chest pain: Findings from the RISK study – An observational analysis
Gresnigt, F. M. J., Heikamp, L. K., van Essen, J. J. W., Walraven, L. F. J., van Ofwegen-Hanekamp, C. E. E., Mollink, S., Franssen, E. J. F., de Lange, D. W. & Riezebos, R. K., Dec 2024, In: Toxicology Reports. 13, p. 1-6 6 p., 101680.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Cardiotoxicity After Synthetic Cathinone Use: Two Cases, A Case Series and Scoping Review
Groenewegen, K. L., Gresnigt, F. M. J., Lonkhuyzen, J. J.N.-V., den Haan, C., Franssen, E. J. F., Riezebos, R. K., Ohana, D. & de Lange, D. W., Mar 2024, In: Cardiovascular Toxicology. 24, 3, p. 209-224 16 p.Research output: Contribution to journal › Review article › peer-review
Open AccessFile -
Characteristics and outcome of COVID-19 patients admitted to the ICU: a nationwide cohort study on the comparison between the consecutive stages of the COVID-19 pandemic in the Netherlands, an update
16 Jan 2024, In: Annals of Intensive Care. 14, 1, 12 p., 11.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Downloads (Pure)
Activities
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Clinical Toxicology (Journal)
Dylan de Lange (Editor)
1 Dec 2023 → …Activity: Publication peer-review and editorial work › Editorial activity › Academic
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Acute Inhalatory Toxicology
Dylan de Lange (Speaker)
7 Nov 2023Activity: Talk or presentation › Oral presentation › Professional
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Introduction Clinical Toxicology
Dylan de Lange (Speaker)
6 Nov 2023Activity: Talk or presentation › Oral presentation › Professional
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Postdoctural Education Toxicology (PET) Medical and Forensic Toxicology
Dylan de Lange (Invited speaker)
6 Nov 2023 → 14 Nov 2023Activity: Participating in or organising an event › Participation in workshop, seminar, course › Professional
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Multidisciplinaire Toxicologie Cursus
Prof.dr. D.W. (Dylan) de Lange (Invited speaker)
28 Nov 2022 → 29 Nov 2022Activity: Participating in or organising an event › Participation in workshop, seminar, course › Professional