Personal profile
Biography
Dr Dennis Beringer is an assistant professor in the Center for Translational Immunology (CTI) at the University Medical Center Utrecht, the Netherlands. He obtained his PhD at Utrecht University in the field of structural biology. After which he moved to Monash University, Australia, where he investigated the molecular details of T cell receptor (TCR) – antigen interactions in autoimmune diseases and cancer. Intrigued by TCR biology, he returned to Utrecht to join the group of Jürgen Kuball at the UMCU in 2016 to study the molecular determinants of tumor reactive γδTCRs, for which he received a Marie Curie Individual Fellowship. Currently, he and his team are focusing on the optimization of existing and the development of novel γδ-TCR based therapeutics for cancer therapy, with a special emphasis on a new class of bispecific T cell engagers called GABs.
Collaborations and top research areas from the last five years
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Cis- and trans-binding chimeric costimulatory receptors enhance T-cell fitness and tumor control
Hernández-López, P., Riillo, C., Gasull-Celades, L., Lommen, J. G. E., Heijhuurs, S., Zheng, J., van Bruggen, S., Zintchenko, M., Brandl, S. M., Minguet, S., Kuball, J. & Beringer, D. X., Jan 2026, In: Cellular and Molecular Immunology. 23, 1, p. 79-93 15 p.Research output: Contribution to journal › Article › Academic › peer-review
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Pre-existing activation states shape functional heterogeneity of human Vγ9Vδ2 T cells
Vyborova, A., Gasull-Celades, L., Brazda, P., Bedate, A. M., Karaiskaki, F., Sanders, J., Janssen, A., Straetemans, T., Beringer, D. X., Sebestyen, Z. & Kuball, J., 16 Feb 2026, In: Frontiers in Immunology. 17, p. 1696469 1696469.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
Autologous profiling reveals inter-patient heterogeneity in Vδ2 +γδTIL responses to glioblastoma driven by extracellular matrix-BTN3A axis.
Nicolasen, M. J. T., Gatti, L. C., Gasull-Celades, L., Brazda, P., Botas, M., Zawal, D., van Vliet, E. J., Cleven, A., Sebestyén, Z., Robe, P. A., Beringer, D. X. & Kuball, J., 17 Dec 2025, In: Journal for immunotherapy of cancer. 13, 12, 15 p., e013018.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Disrupting the balance between activating and inhibitory receptors of γδT cells for effective cancer immunotherapy
Beringer, D. X., Straetemans, T., Minguet, S., Riillo, C., Lynch, L., Sebestyen, Z. & Kuball, J., Aug 2025, In: Nature Reviews Cancer. 25, 8, p. 590-612 23 p.Research output: Contribution to journal › Review article › peer-review
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Dual targeting of cancer metabolome and stress antigens affects transcriptomic heterogeneity and efficacy of engineered T cells
Hernández-López, P., van Diest, E., Brazda, P., Heijhuurs, S., Meringa, A., Hoorens van Heyningen, L., Riillo, C., Schwenzel, C., Zintchenko, M., Johanna, I., Nicolasen, M. J. T., Cleven, A., Kluiver, T. A., Millen, R., Zheng, J., Karaiskaki, F., Straetemans, T., Clevers, H., de Bree, R. & Stunnenberg, H. G. & 6 others, , Jan 2024, In: Nature immunology. 25, 1, p. 88-101 14 p.Research output: Contribution to journal › Article › Academic › peer-review
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