Research output per year
Research output per year
Research activity per year
Qualifications MSc Health Sciences, MSc Clinical Epidemiology, PhD Medicine
Current Positions
Recent former Positions (a selection).
Career Summary
Carl Moons is professor of Clinical Epidemiology and former director of research at the Julius Center, UMC Utrecht (www.juliuscenter.nl). He is also figure head Artificial Intelligence for Health of the UMC Utrecht and Utrecht University, developed the AI strategy of the UMC Utrecht and established 5 dedicated AI labs (AI Living Technologies and Regenerative Medicine; AI Molecular Medicine; AI Imaging and Imaging guided interventions; AI Methods and Fundamentals; AI Healthy Living and Prevention).
He has directed and co-written the development of an international quality guideline for introduction of safe and effective AI in Healthcare (see https://guideline-ai-healthcare.com) which has been adopted in various countries. He leads two large international consortia which develop guidelines for AI in Healthcare: the TRIPOD+AI guideline for transparent and explainable reporting of AI in healthcare (see www.tripod-statement.org); and the PPROBAST+AI guideline on the assessment of quality and validity of AI algorithms in healthcare (see www.probast.org).
Carl Moons is also co-initiator and co-director of the Health Innovation Netherlands (HI-NL) infrastructure (see www.healthinnovation.nl). HINL is a unique nationwide infrastructure aiming to bring new bio-medical technologies as soon as possible to the market, to ensure for a sustainable, safe, effective, affordable and profitable MedTech and Biotech ecosystem. These biomedical innovations range from robotics, medical diagnostic and screening tests to biomarkers, decisions aids, AI algorithms and eHealth applications. HINL is established and executed by all stakeholders involved in the MedTech and Biotech field including innovators (private and public), insurers, healthcare professionals, patient and citizen organizations, competent authorities, health policy organizations and HTA specialists.
Carl Moons is former chair of the Dutch ‘Reporting and Expert center for side-effects of Implants’ (Meldpunt en Expertisecentrum Bijwerkingen Implantaten: MEBI). Furthermore, he chaired the Royal Netherlands Academy of Arts and Sciences (KNAW) committee ‘Evaluation of new technology in healthcare’. He chaired during the covid-19 pandemic the national advisory committee for the Dutch Ministry of Health on ‘Digital Solutions to Control Covid-19’.
His scientific career (>750 peer reviewed publications, books and book chapters) focuses on research on the methods for the evaluation and introduction of medical innovations, ranging from medical drugs, robotics, tests, eHealth and AI-algorithms. He is principal investigator in numerous international clinical (epidemiology) studies funded by various national and international organisations (EU, NHS, NIH). His experience covers the full range of conduct, data analysis, reporting and dissemination of such studies, varying from studies on the evaluation of medical devices and tests for diagnosis, prognosis, screening and monitoring, to etiological studies and randomised therapeutic trials, to meta-epidemiological studies, both on aggregate and individual participant data. His main focus concerns improving the methods and approaches for evaluation and implementation of medical devices, (bio)markers and prediction models. His major expertise is introducing innovations for the design, conducting, analysis and reporting of evaluations of diagnostic and prognostic tests, devices, (bio)markers and prediction models. Clinical topics include cancer, deep vein thrombosis, stroke, heart failure and peri-operative risk assessment. He teaches graduate and postgraduate students in all aspects of clinical (epidemiological) research design, conducting, analysis and reporting, throughout the world.
Indicators of Research Excellence
Over his career Professor Moons has published over 750 peer-reviewed publications (including scientific papers, books and book chapters) with >30,000 citations. He has obtained numerous (methodological and applied) research grants, including large prestigious personal grants (in summary over 20 million euro as (co-)PI). The (societal) impact of his research record has also been recognised by his memberships of, e.g., Dutch Health Council, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations and the Dutch Ministry of Health, and interviews for national and internal news magazines. He also teaches bachelor, master, post-doctoral students in clinical research across the world, including Asia and Africa.
Top 20 career publications
Awards and Grants (a brief selection)
ZonMw personal grant (VICI): A different view on diagnostic research: a framework for studying the differential diagnosis and diseases with an imperfect or missing reference test (ZonMw VICI 016.106.615).
ZonMw Personal Grant (TOP): Clinical prediction rules: towards a framework for meta-analysis, validation, and updating (ZONMW 40-00812-98-08004).
ZON-MW personal grant (VIDI): Diagnostic prediction rules: how to improve their applicability in clinical practice (ZON-MW VIDI 016.046.360).
ZonMw VISTA grant: Cost-effectiveness of tailoring anticoagulant therapy by D-Dimer testing in patients with venous thromboembolism compared to care-as-usual: VISTA study (ZONMW 80-82310-97-10062).
Current / recent grant income – As (Co-)principal investigator over the past ten years over 20 million euro.
Collaborative Track Record
Karel Moons is (co-)principal investigator in numerous international clinical (epidemiology) studies funded by various organisations (EU, NHS, NIH, Cochrane) and member of various international research consortia (including EPIC-CVD, IMI projects, FP7 and Horizons 2020 projects, TRIPOD, PROBAST, EQUATOR).
Contribution to Scientific and Community Engagement
Over his career Professor Moons has published over 600 peer-reviewed papers and book chapters, and teaches his work to bachelor, master and post-doctoral students all over the world. Besides, his (societal) impact is evident from his various memberships of Dutch Health Council committees, Chair of Committee of the Royal Netherlands Academy of Arts and Sciences, membership of numerous committees of Dutch Scientific Organisations, and interviews for national and internal news magazines.
Adjunct Professor of Clinical Epidemiology, Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, USA. (since 2005)
Adjunct Professor of Clinical Epidemiology, Center of Statistics in Medicine, Oxford University, Oxford, UK (since 2017)
Staff Cochrane Netherlands.
Member of Cochrane Collaboration; Convenor Cochrane's Prognosis Methods Group; Member of IPD Meta-analysis group and Diagnostic Test Accuracy Group.
Editor-in-chief BMC Diagnostic and Prognostic Research.
Member of the Dutch Health Council
Chair of The Netherlands Implant Side-effects Expertise Center
Initiator and ambassador of Health Innovation Initiative Holland (Hii Holland)
2003 VIDI Award The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, “Diagnostic Prediction Rules; innovative methods to improve their applicability”.
2008 TOP Grant The Netherlands Organisation for Health Research and Development, Role: Principal Investigator, "Clinical prediction rules: towards a framework for meta-analysis, validation, and updating"
2010 VICI Award The Netherlands Organisation for Health Research and Development, Role: Principal Investigator “A different view on diagnostic research: a framework for studying the Differential diagnosis and diseases with an imperfect or missing reference test"
MSc Biomedical Sciences, Radboud University Nijmegen
Award Date: 12 Dec 1996
PhD Medicine
Award Date: 30 Oct 1996
MSc Clinical Epidemiology
Award Date: 20 Jun 1994
zie attachment - Voorzitterschappen, Editor, Advisering - Cochrane, BMC, MRC, Vanderbilt, HINL
7 Aug 2024 → 31 Dec 3999
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Article › Academic › peer-review
Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review
Moons, Carl (Recipient), 2009
Prize: Prize (including medals and awards)
Moons, Carl (Recipient), 2003
Prize: Prize (including medals and awards)