Dr. Khalil performed his PhD studies in the lab of Peter Friedl at the University of Wurzburg, Germany and Radboudumc, Nijmegen, The Netherlands. Here, Antoine identified that collective invasion is a predominant mode of local spread in breast cancer patients and characterized the role of connexin channels in organizing the invading cells into leader and follower cells.

After finishing his PhD, dr. Khalil went to the lab of Johan de Rooij at the UMC Utrecht, where he pursued his investigations on cell invasion with focus on ECM mechanotransduction. Dr. Khalil investigated how cancer cells transduce biomechanical cues in the ECM and the underlying molecular mechanisms that promote invasive characteristics in particular subsets of cancer cells.

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

QL Zoology
breast cancer
collective invasion
metastasis
cell-cell junctions
cell-ECM
mechanotransduction
3D culture
organoids
leader cells

13 Article
3 Review article
2 Chapter
1 Meeting Abstract

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state
van der Net, M. C., Vliem, M. J., Kemp, L. J. S., Perez-Gonzalez, C., Haddad, T. S., Strating, E. A., Krotenberg-Garcia, A., Houtekamer, R. M., Pannekoek, W.-J., van den Anker, K. B., Zwakenberg, S., Monster, J. L., van der Horst, S. E. M., Snippert, H. J. G., Khalil, A. A., van Rheenen, J., Suijkerbuijk, S. J. E., Kranenburg, O., Simmer, F. & Nagtegaal, I. D. & 2 others, Vignjevic, D. M. & Gloerich, M., 28 Oct 2025, In: Cell Reports. 44, 10, 22 p., 116308.
Research output: Contribution to journal › Article › Academic › peer-review

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Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression
Kemp, L. J. S., Monster, J. L., Wood, C. S., Moers, M., Vliem, M. J., Khalil, A. A., Jamieson, N. B., Brosens, L. A. A., Kodach, L. L., van Dieren, J. M., Bisseling, T. M., van der Post, R. S. & Gloerich, M., 7 Jul 2025, In: Gut. 74, 8, p. 1219-1229 11 p.
Research output: Contribution to journal › Article › Academic › peer-review

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A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S. & Fortier, A.-M. & 6 others, Park, M., Fodde, R., Gloerich, M., Zwartkruis, F. J. T., Derksen, P. W. & de Rooij, J., 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.
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Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
the ISARIC Clinical Characterisation Group, 30 May 2024, In: Heliyon. 10, 10, p. 1-16 16 p., e29591.
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Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
COVID Human Genetic Effort, COVIDeF Study Group, French COVID Cohort Study Group, CoV-Contact Cohort, COVID-STORM Clinicians, COVID Clinicians, Orchestra Working Group, Amsterdam UMC COVID-19 Biobank & NIAID-USUHS COVID Study Group, 18 Jul 2024, In: Human Genetics and Genomics Advances. 5, 3, 100300.
Research output: Contribution to journal › Article › Academic › peer-review

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6 Downloads (Pure)

Antoine Khalil

Personal profile

Biography

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

Collaborations and top research areas from the last five years

Dive into details

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Antoine Khalil

Personal profile

Biography

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

Collaborations and top research areas from the last five years

Research output

Mechanosensitive calcium channels and integrins coordinate the reprogramming of colorectal cancer cells into a fetal-like state

Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection