Dr. Khalil performed his PhD studies in the lab of Peter Friedl at the University of Wurzburg, Germany and Radboudumc, Nijmegen, The Netherlands. Here, Antoine identified that collective invasion is a predominant mode of local spread in breast cancer patients and characterized the role of connexin channels in organizing the invading cells into leader and follower cells.

After finishing his PhD, dr. Khalil went to the lab of Johan de Rooij at the UMC Utrecht, where he pursued his investigations on cell invasion with focus on ECM mechanotransduction. Dr. Khalil investigated how cancer cells transduce biomechanical cues in the ECM and the underlying molecular mechanisms that promote invasive characteristics in particular subsets of cancer cells.

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

QL Zoology
breast cancer
collective invasion
metastasis
cell-cell junctions
cell-ECM
mechanotransduction
3D culture
organoids
leader cells

9 Article
3 Review article
2 Chapter
1 Meeting Abstract

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S. & Fortier, A.-M. & 6 others, Park, M., Fodde, R., Gloerich, M., Zwartkruis, F. J. T., Derksen, P. W. & de Rooij, J., 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
4 Downloads (Pure)
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms
30 May 2024, In: Heliyon. 10, 10, p. 1-16 16 p., e29591.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
4 Downloads (Pure)
Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection
18 Jul 2024, In: Human Genetics and Genomics Advances. 5, 3, 100300.
Research output: Contribution to journal › Article › Academic › peer-review

Open Access
File
2 Downloads (Pure)
The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets
Sleeboom, J. J. F., van Tienderen, G. S., Schenke-Layland, K., van der Laan, L. J. W., Khalil, A. A. & Verstegen, M. M. A., 3 Jan 2024, In: Science translational medicine. 16, 728, 3840.
Research output: Contribution to journal › Review article › peer-review
Multimodal Techniques to Study Tumor Growth, Basement Membrane Breaching, and Invasion in 3D Matrices
Smits, D. & Khalil, A. A., 2023, Cell Migration in Three Dimensions. Humana Press Inc., Vol. 2608. p. 281-303 23 p. (Methods in Molecular Biology; vol. 2608).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Open Access
File

Antoine Khalil

Personal profile

Biography

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

Collaborations and top research areas from the last five years

Dive into details

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Multimodal Techniques to Study Tumor Growth, Basement Membrane Breaching, and Invasion in 3D Matrices

Antoine Khalil

Personal profile

Biography

As of January 2022, Dr. Khalil functions as an assistant professor and is leading the group invasion of epithelial tumors at the Center for molecular medicine (CMM) in Utrecht UMC.

Keywords

Collaborations and top research areas from the last five years

Research output

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms

Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

The extracellular matrix as hallmark of cancer and metastasis: From biomechanics to therapeutic targets

Multimodal Techniques to Study Tumor Growth, Basement Membrane Breaching, and Invasion in 3D Matrices