Doctorate                        5^th of March, 2003

                                             Thesis: Optimizing conventional chemotherapy approaches.                                                                              Studies on feasibility and pharmacokinetics.

                                             Promotores: Prof. dr. E.G.E. de Vries and Prof. dr. A.G.J. van der                                                         Zee, co-promotor: Dr. P.H.B. Willemse

                                             Department Medical Oncology/Gynaecology-Oncology UMC Groningen

Current position           July 2010-now: Consultant, Fertility and Gynecology department, University Medical Center Utrecht

Prior positions              -1988-1995: Medicine Study, Rijksuniversiteit Groningen

                                             -Aug 1995-Okt 1995: Resident Internal Medicine

                                             De Weezenlanden Hospital, Zwolle

                                             -Okt 1995-May 1997: Resident Gynecology/Obstetrics

                                             De Weezenlanden Hospital, Zwolle

                                             May 1997- Febr 1998: Resident Gynecology/Obstetrics

                                             Martini Hospital, Groningen

                                             Febr 1998- July 2000: Resident and researcher Medical Oncology & Gynaecology Oncology, University Medical Center Groningen

                                             July 2000-July 2006: Traineeship  Gynecology and                                                                                   Obstetrics:  Isala Klinieken Zwolle, University Medical Center                                                                            Groningen and Medical Center Leeuwarden.

                                             2006-2010: Consultant, Fertility and Gynecology department, University Medical Center Groningen

                                             2008-July 2010: Consultant and Subspecialisation                                                                                    Fertility and Endocrinology, University Medical Center                                                                          Groningen

Past/ongoing clinical research:

A. Onco-fertility

-Principal investigator of the Personalized Cancer Care Program for breast cancer in the UMC Utrecht (2011-2015).

-BrCA-gene mutation carriers and the relation to primary ovarian insufficiency.

Studies:  BRAVA (PI) en BROCA 1 study (PhD thesis Charine van Tilborg) and BROCA-2 (PI) study (still ongoing study)

-National data of 5 years fertility preservation in the UMC Utrecht.

-Consortium Study: STIM trial: Stimulation of the ovaries in women with breast cancer undergoing fertility preservation: Alternative versus standard stimulation protocols; the study

protocol of the STIM-trial. (PI)

-Fertility preservation and childhood cancer (EXOTiC project):(Exploring the feasibility of EXcellent fertility counseling care for girls with cancer and the safety of Ovarian Tissue Cryopreservation on a national level). (PI)

B. Oocyte vitrification and oocyte donation

-National data of oocyte vitrification and oocyte banking

-Ethics of oocyte donation and oocyte banking (PhD student Emy Kool Applied Ethics, 2016-2019)

Future clinical research:

- National study fertility preservation: A retrospective data analysis of the return rate of women for the use of frozen oocytes and/or embryos after emergency IVF (MUMC)

- A national prospective follow up cohort study of women undergoing ovarian tissue cryopreservation (OTC) followed by auto-transplantation or without auto transplantation of the cryopreserved ovarian tissue. (ZorgInstituutNederland/ZonMw)

-Obstetric Medicine implementation in follow-up childhood survivors (PI together with prof. dr. M.M. Van den Heuvel-Eibrink from the Princess Máxima Center and Prof K.W.M. Bloemenkamp (PI))

-Fertility, fertility preservation and late effects in childhood cancer ((with prof. dr. M.M. Van den Heuvel-Eibrink (PI) from the Princess Máxima Center: PhD student Madeleine van der Perk)

- Fertility preservation for children with cancer: a phase III clinical trial of a novel decision aid. Dr Yasmin Jayasinghe, PhD Gynaecologist The Royal Children’s Hospital, the Royal Women’s Hospital, international collaboration.

-National oocyte vitrification studies and oocyte donation studies.

A comparative study on social egg freezing in the Netherlands and Austria to explore the value perceptions regarding egg freezing of multiple stakeholders (patients, providers, policy makers) in both countries. Collaboration with the Erasmus School of Health Policy & Management and work closely with Prof. Antoinette de Bont.

Collaboration:

Julius Centre, department of Medical Humanities

Princess Máxima Center

The Royal Children’s Hospital Australia

Dutch Network of Fertility Preservation in the SIG Reproductive Medicine/Fertility preservation.

Collaboration with the Erasmus School of Health Policy & Management

Current Professional memberships

Member of the Dutch Network Gynaecology and Obstetrics (NVOG) >2000

Member European Society Human Reproduction and Endocrinology (ESHRE) >2008

Member Dutch Working party Gynaecological Endoscopy (WGE) (>2012)

Member of the oncologic Mamma Team in the UMC Utrecht (>2011)

Member and secretary (since May 2015) of the Dutch Special Interest Group Fertility preservation (NVOG)

Member of the Special Interest Group Gamete donation (NVOG) >2016

Secretary and vice-president of the Medical Ethical Board of the Department Fertility UMC Utrecht, since April 2015

Member of the Dutch Society of Gender and Health (NVG&G) >2018 (before member of the Alliance Gender and Health)

Chair of the working group Fertility patients in children with cancer in the Prinses Maxima Center.  (>June 2018)

Guideline development committees:

- Member of the Dutch Alliance of Gender and Health care (>2012), 2014-2016 making the ‘Kennisagenda Gender and Health’ by estimating knowledge gaps and aims for future research in the field of genderspecific medicine.

-2015-2016 Member of the working group of modern families (NVOG/cie Herijking Ouderschap)

- member of Dutch guideline group: Fertility preservation for women with cancer (2015-2016),

-Initiator and member of the Dutch working group SKION agreement Fertility Preservation for girls and adolescents 0-18 yrs (2016) (gynecologist and pediatric oncologists)

-Modelreglement Embryowet (NVOG and KLEM) Advisory board August 2018

-Member of the working group for development of fertility preservation guidelines in female cancer patients (0-18 years) as part of the IGHG project/PancareLife European project (>2016-2018).

Child Health Boost grant, sept 2017. 15K euro for the start-up of the EXOTiC project (Exploring the feasibility of EXcellent fertility counseling care for girls with cancer and the safety of Ovarian Tissue Cryopreservation on a national level).

Research team: Annelies Bos, Marry van den Heuvel-Eibrink, Marc Wijnen, Birgitta Versluijs, Simone Broer en Frank Broekmans

The proposed EXOTiC project will be the start of an integral part of the joint clinical and research program on fertility preservation care for children up to 19 years of age in the Princess Máxima Center for Pediatric Oncology and the Department of Reproductive Medicine, UMC Utrecht.