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András Spaan

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András Spaan, MD PhD

dr.

 https://orcid.org/0000-0001-5981-7259
    20122026

    Research activity per year

    Personal profile

    External positions

    Visiting Fellow at the St. Giles Laboratory of Human Genetics of Infectious Diseases - Wetenschappelijk samenwerkingsverband MMB UMCU en Casanova Lab Rockefeller University NY - The Rockefeller University

    1 Jan 2021 → 31 Dec 3999

    Collaborations and top research areas from the last five years

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    • Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity

      van der Linden, T. J., Chatterjee, A., Scheepmaker, L. M., Chakraborty, D., Dutta, S., Bardoel, B. W. & Spaan, A. N., 1 Sept 2026, In: PLoS pathogens. 22, 9, e1014568.

      Research output: Contribution to journal › Article › Academic › peer-review

      Open Access
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      11 Downloads (Pure)

    • Defective RNA Polymerase III sensing of mitochondrial DNA in pulmonary epithelial cells impairs type I IFN immunity to SARS-CoV-2

      Møhlenberg, M., Jørgensen, S. E., van der Sluis, R. M., Zillinger, T., Hinke, D. M., Hollensen, A. K., Hansen, A. L., Hausfater, P., Gorochov, G., Tubach, F., Ghosn, J., Laouenan, C., Storgaard, M., Holm, C. K., Su, H., de Diego, R. P., Pujol, A., Zhang, S. Y., Zhang, Q. & Vianna, F. S. L. & 39 others, Abel, L., Cobat, A., Casanova, J. L., Mogensen, T. H., Aiuti, A., Al-Muhsen, S., Al-Mulla, F., Anderson, M. S., Andreakos, E., Arias, A. A., Arkin, L. M., Feldman, H. B., Bastard, P., Belot, A., Biggs, C. M., Bogunovic, D., Bolze, A., Bondarenko, A., Borghesi, A., Bousfiha, A. A., Brodin, P., Bryceson, Y., Spaan, A. N., Khalil, A., Buis, D. T. P., Fleuren, L., Lim, E. H. T., van Mourik, N., Reijnders, T., van der Valk, M., CoV-Contact Cohort, COVID-STORM Clinicians, Amsterdam UMC COVID-19 Biobank, NIAID-USUHS COVID Study Group, COVID Human Genetic Effort, Danish COVID-19 clinicians, COVID-19 DNABR Group, French COVID Cohort Study Group & COVIDeF Study Group, 24 Mar 2026, In: Proceedings of the National Academy of Sciences of the United States of America. 123, 12, e2522111123.

      Research output: Contribution to journal › Article › Academic › peer-review

      Open Access
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      1 Downloads (Pure)

    • Pyoderma gangrenosum caused by the molecular uncoupling of OTULIN catalytic activity and LUBAC binding

      Swaminathan, B., Gil, H. M., Bhattad, S., Janardhanan, J., Mejía Baltodano, G., Mariskanish, C., Basaria, S., Choi, J. M., Liu, Q., Scheepmaker, L. M., Mohamed, M., Boisson, B., Casanova, J.-L., Aksentijevich, I., Spaan, A. N. & Markle, J. G., Aug 2026, In: Nature immunology. 27, 8, p. 1619-1632 14 p.

      Research output: Contribution to journal › Article › Academic › peer-review

      Open Access
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    • A common form of dominant human IFNAR1 deficiency impairs IFN-α and -ω but not IFN-β-dependent immunity

      Al Qureshah, F., Le Pen, J., de Weerd, N. A., Moncada-Velez, M., Materna, M., Lin, D., Milisavljevic, B., Vianna, F., Bizien, L., Lorenzo, L., Lecuit, M., Pommier, J. D., Keles, S., Ozcelik, T., Pedraza-Sanchez, S., de Prost, N., El Zein, L., Hammoud, H., F P Ng, L. & Halwani, R. & 166 others, Sharif-Askari, N. S., Lau, Y. L., Tam, A. R., Singh, N., Bhattad, S., Berkun, Y., Chantratita, W., Aguilar-López, R., Shahrooei, M., Abel, L., Bastard, P., Jouanguy, E., Béziat, V., Zhang, P., M Rice, C., Cobat, A., Zhang, S. Y., Hertzog, P. J., Casanova, J. L., Zhang, Q., Aiuti, A., Al-Muhsen, S., Alcántara-Garduño, A. B., Andreakos, E., Arias, A. A., Feldman, H. B., Bolze, A., Borghesi, A., Bousfiha, A. A., Brodin, P., Christodoulou, J., Colobran, R., Condino-Neto, A., Duvlis, S., Duval, X., Dündar, M., Fakhreddine, S., Fellay, J., Flores, C., Franco, J. L., Gorochov, G., Gregersen, P. K., Hagin, D., Halwani, R., Herrera, M. T., Hung, I. F. N., Lau, Y. L., Leung, D., Le-Voyer, T., Mansouri, D., Mercado-García, J., Meyts, I., Mogensen, T. H., Ng, L. F. P., Novelli, A., Novelli, G., Okada, S., Ozcelik, F., de Diego, R. P., Perez-Tur, J., Pesole, G., Puel, A., Renia, L., Resnick, I., Rodríguez-Gallego, C., Sbeity, M., Sedighzadeh, S., Shahrooei, M., Soler-Palacín, P., Spaan, A. N., Tangye, S. G., Tayoun, A. A., Temel, Ş. G., Thorball, C., Torktaz, I., Trouillet-Assant, S., Turvey, S. E., Furkan Uddin, K. M., Luiz Vianna, F. S., Vinh, D. C., Zabaleta-Martínez, O., Eng, C., Bun, K., Mengheng Oum, M., Piola, P., Tarantola, A., Channa, M., Duong, V., Buchy, P., Gorman, C., Crabol, Y., Dussart, P., Bunleat, M., Panha, M., Kanarith Sim, M., Bunnakea, E., Laurent, D., Sothy, H., Santy, K., Douangnouvong, A., Chommanam, D., Phakhounthong, K., Vongsouvath, M., Seephone, M., Sibounheunang, B., Rattanavong, S., Davong, V., Vongsouvath, M., Mayxay, M., Dubot-Pérès, A., Newton, P. N., Phangmanixay, S., Phongsavath, K., Duc Anh, D., Do Quyen, M., Mai Hung, T. T., Thu Thuy, N. T., Minh Tan, M. L., Pham, A. T., Hien, N., Huong, D. T., Hai, L. T., Lam, N. V., An, P. N., Phuc, P. H., Thuy, P. B., Thu Huong, T. T., Hlaing, C. S., Min Aye, A. M., Thair, C., Linn, K., July, M., Thein, W., Kyaw, L. L., Tin, H. H., Tin, O. S., Oo, K. Y., Crabol, Y., Herrant, M., Lago, M., Seguy, M., Jouan, M., Hafner, L., Pérot, P., Eloit, M., Lecuit, M., Lortholary, O., Capelle, J., Rosset, B., Chevalier, V., Honnorat, J., Pinto, A. L., Dubot-Peres, A., de Lamballerie, X., Bleakley, K., Murgue, C. B., Ferrant, C., Devaux, C., Tissot-Dupont, H., Moatti, J. P., Mayxay, M., Bonnet, P., Fontenille, D., Delfraissy, J. F., Debré, P. & Durand, B., 3 Feb 2025, In: Journal of Experimental Medicine. 222, 2, e20241413.

      Research output: Contribution to journal › Article › Academic › peer-review

      Open Access
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    • Deleterious variants in the autophagy-related gene RB1CC1/FIP200 impair immunity to SARS-CoV-2

      Hu, L., van der Sluis, R. M., Castelino, K. B., Zhang, B. C., Ronit, A., Zillinger, T., Werner, M., Jørgensen, S. E., Hansen, A. L., Pedersen, A., Narita, R., Reinert, L. S., Bundgaard, B., Helleberg, M., Benfield, T., Storgaard, M., Hansen, K. S., Bodilsen, J., Zhang, S. Y. & Zhang, Q. & 31 others, Zatz, M., Wauters, J., von Bernuth, H., Vinh, D. C., Vianna, F. S. L., van de Beek, D., Uddin, M. J., Uddin, K. M. F., Turvey, S. E., Trouillet-Assant, S., Tiberghien, P., Thorball, C., Temel, Ş. G., Tayoun, A. A., Tangye, S. G., Tancevski, I., Su, H. C., Spaan, A. N., Soumelis, V., Soler-Palacín, P., Snow, A. L., Slaby, O., Shcherbina, A., Shahrooei, M., Seppänen, M. R. J., Sediva, A., Sancho-Shimizu, V., Rodríguez-Gallego, C., Resnick, I., Reggiori, F. & COVID Human Genetic Effort, 27 Nov 2025, In: Nature Communications. 16, 1, 10618.

      Research output: Contribution to journal › Article › Academic › peer-review

      Open Access
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      7 Downloads (Pure)
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