University Medical Center (UMC) Utrecht

2025

Absolute measurement of fast and slow neuronal signals with fluorescence lifetime photometry at high temporal resolution

Lodder, B., Kamath, T., Savenco, E., Röring, B., Siegel, M., Chouinard, J., Lee, S. J., Zagoren, C., Rosen, P., Adan, R., Tian, L. & Sabatini, B. L., 12 Jan 2025, BioRxiv, 40 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

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Accurate DNA Methylation Predictor for C9orf72 Repeat Expansion Alleles in the Pathogenic Range.

Ramesh, N., Evans, A., Wojta, K., Yang, Z., Boks, M. M., Kahn, R. S., de Boer, S. C. M., van der Lee, S. J., Pijnenburg, Y. A. L., Reus, L. M. & Ophoff, R. A., 26 Mar 2025, BioRxiv, 35 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

De novo variants in KDM2A cause a syndromic neurodevelopmental disorder.

Anderson, E. N., Drukewitz, S., Kour, S., Chimata, A. V., Rajan, D. S., Schönnagel, S., Stals, K. L., Donnelly, D., O'Sullivan, S., Mantovani, J. F., Tan, T. Y., Stark, Z., Zacher, P., Chatron, N., Monin, P., Drunat, S., Vial, Y., Latypova, X., Levy, J. & Verloes, A. & 31 others, Carter, J. N., Bonner, D. E., Shankar, S. P., Bernstein, J. A., Cohen, J. S., Comi, A., Alexis Carere, D., Dyer, L. M., Mullegama, S. V., Sanchez-Lara, P. A., Grand, K., Kim, H.-G., Ben-Mahmoud, A., Gospe, S. M., Belles, R. S., Bellus, G., Lichtenbelt, K. D., Oegema, R., Rauch, A., Ivanovski, I., Tran Mau-Them, F., Garde, A., Rabin, R., Pappas, J., Bley, A. E., Bredow, J., Wagner, T., Decker, E., Bergmann, C., Domenach, L. & Undiagnosed Diseases Network, 1 Apr 2025, medRxiv, 51 p.

Research output: Working paper › Preprint › Academic

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Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis

Park, C., Baek, K. I., Hung, R.-C., Choi, L., Jeong, K., Kim, P., Jahng, A. K., Kim, J. H., Meselhe, M., Kannan, A., Chou, C.-L., Kang, D. W., Song, E. J., Kim, Y., Bowman-Kirigin, J. A., Clark, M. D., van der Laan, S. W., Pasterkamp, G., Villa-Roel, N. & Panitch, A. & 1 others, Jo, H., 6 Mar 2025, BioRxiv, 34 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

Perry, R. N., Lenert, G., Benavente, E. D., Ma, A., Barbera, N., Mokry, M., de Kleijn, D. P. V., de Winther, M. P. J., Mayr, M., Björkegren, J. L. M., den Ruijter, H. M. & Civelek, M., 2 Apr 2025, BioRxiv, 35 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

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Genome-wide association study and multi-ancestry meta-analysis identify common variants associated with carotid artery intima-media thickness

NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, 14 Apr 2025, medRxiv.

Research output: Working paper › Preprint › Academic

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Human colon stem cells are the principal epithelial responders to bacterial antigens

de Vries, M. H., Meddens, C., Hijma, H., Berrens, A.-C., Jansen, S., Kooiman, B., Snapper, S., Clevers, H., Mokry, M., Kuijk, E. & Nieuwenhuis, E., 8 Feb 2025, BioRxiv, 29 p.

Research output: Working paper › Preprint › Academic

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Intraplaque haemorrhage quantification and molecular characterisation using attention based multiple instance learning

Cisternino, F., Song, Y., Peters, T. S., Westerman, R., de Borst, G. J., Diez Benavente, E., van den Dungen, N. A. M., van der Kraak, P. H., De Kleijn, D., Mekke, J. M., Mokry, M., Pasterkamp, G., den Ruijter, H. M., Velema, E., Miller, C. L., Glastonbury, C. A. & van der Laan, S. W., 7 Mar 2025, medRxiv, 51 p.

Research output: Working paper › Preprint › Academic

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The relationship of white matter tract orientation to vascular geometry in the human brain

Schilling, K. G., Newton, A., Tax, C. M. W., Chamberland, M., Remedios, S. W., Gao, Y., Li, M., Chang, C., Rheault, F., Sepherband, F., Anderson, A., Gore, J. C. & Landman, B., 6 Mar 2025, BioRxiv, 22 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

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2024

Adaptation of ACMG/AMP guidelines for clinical classification of BMPR2 variants in Pulmonary Arterial Hypertension resolves variants of unclear pathogenicity in ClinVar

Eichstaedt, C. A., Maldonado-Velez, G., Machado, R. D., Balachandar, S., Coulet, F., Day, K., Dooijes, D., Eyries, M., Gräf, S., Macaya, D., Shaukat, M., Southgate, L., Tenorio-Castano, J., Chung, W. K., Welch, C. L. & Aldred, M. A., 26 Nov 2024, medRxiv, 29 p.

Research output: Working paper › Preprint › Academic

A fully synthetic three-dimensional human cerebrovascular model based on histological characteristics to investigate the hemodynamic fingerprint of the layer BOLD fMRI signal formation

Báez-Yáñez, M. G., Schellekens, W., Bhogal, A. A., Roefs, E. C. A., van Osch, M. J. P., Siero, J. C. & Petridou, N., 26 May 2024, BioRxiv, p. 1-38.

Research output: Working paper › Preprint › Academic

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A unique interplay of access and selection shapes peritoneal metastasis evolution in colorectal cancer

Wassenaar, E. C., Gorelick, A. N., Hung, W.-T., Cheek, D. M., Kucukkose, E., Lee, I.-H., Blohmer, M., Degner, S., Giunta, P., Wiezer, R. M., Raicu, M. G., Ubink, I., Klaasen, S. J., Lansu, N., Watson, E. V., Corcoran, R. B., Boland, G., Getz, G., Kops, G. J. & Juric, D. & 4 others, Lennerz, J. K., Boerma, D., Kranenburg, O. & Naxerova, K., 27 Sept 2024, BioRxiv, 48 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

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Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy

Nicastro, M., Vermeer, A. M. C., Postema, P. G., Tadros, R., Bowling, F. Z., Aegisdottir, H. M., Tragante, V., Mach, L., Postma, A. V., Lodder, E. M., van Duijvenboden, K., Zwart, R., Beekman, L., Wu, L., van der Zwaag, P. A., Alders, M., Allouba, M., Aguib, Y., Santomel, J. L. & de Una, D. & 50 others, Monserrat, L., Miranda, A. M. A., Kanemaru, K., Cranley, J., van Zeggeren, I. E., Aronica, E. M. A., Ripolone, M., Zanotti, S., Sveinbjornsson, G., Ivarsdottir, E. V., Hólm, H., Guðbjartsson, D. F., Skúladóttir, Á. T., Stefánsson, K., Nadauld, L., Knowlton, K. U., Ostrowski, S. R., Sørensen, E., Vesterager Pedersen, O. B., Ghouse, J., Rand, S., Bundgaard, H., Ullum, H., Erikstrup, C., Aagaard, B., Bruun, M. T., Christiansen, M., Jensen, H. K., Carere, D. A., Cummings, C. T., Fishler, K., Tøring, P. M., Brusgaard, K., Juul, T. M., Saaby, L., Winkel, B. G., Mogensen, J., Fortunato, F., Comi, G. P., Ronchi, D., van Tintelen, J. P., Noseda, M., Airola, M. V., Christiaans, I., Wilde, A. A. M., Wilders, R., Clur, S.-A., Verkerk, A. O., Bezzina, C. R. & Lahrouchi, N., 5 Jul 2024, medRxiv, 49 p. (medRxiv).

Research output: Working paper › Preprint › Academic

Blood-based DNA methylation and exposure risk scores predict PTSD with high accuracy in military and civilian cohorts

Wani, A., Katrinli, S., Zhao, X., Daskalakis, N., Zannas, A., Aiello, A., Baker, D., Boks, M., Brick, L., Chen, C.-Y., Dalvie, S., Fortier, C., Geuze, E., Hayes, J., Kessler, R., King, A., Koen, N., Liberzon, I., Lori, A. & Luykx, J. & 22 others, Maihofer, A., Milberg, W., Miller, M., Mufford, M., Nugent, N., Rauch, S., Ressler, K., Risbrough, V., Rutten, B., Stein, D., Stein, M., Ursano, R., Verfaellie, M., Ware, E., Wildman, D., Wolf, E., Nievergelt, C., Logue, M., Smith, A., Uddin, M., Vermetten, E. & Vinkers, C., 15 Feb 2024, Research Square, 31 p.

Research output: Working paper › Preprint › Academic

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Clonally expanded IgG antibody-secreting cells preferentially target influenza nucleoprotein following homologous and heterologous infections

Kuhn, R., Panetti, C., Venerito, M., Phandee, H., Stalder, L., Shlesinger, D., D'Arcy, V. M., Hong, K. L., van Ginneken, D., Genovese, A., Joller, N., Oxenius, A., Reddy, S. T. & Yermanos, A., 11 Dec 2024, BioRxiv, 34 p.

Research output: Working paper › Preprint › Academic

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Do Not Lose Sleep Over It: Implanted Brain-computer Interface Functionality During Nighttime in Late-stage Amyotrophic Lateral Sclerosis

Leinders, S., Aarnoutse, E. J., Branco, M. P., Freudenburg, Z. V., Geukes, S. H., Schippers, A., Verberne, M. S. W., van den Boom, M., van der Vijgh, B., Crone, N. E., Denison, T., Ramsey, N. F. & Vansteensel, M. J., 15 Oct 2024, medRxiv, 26 p. (medRxiv).

Research output: Working paper › Preprint › Academic

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Don't put words in my mouth: Speech perception can generate False Positive activation of a speech BCI

Schippers, A., Vansteensel, M. J., Freudenburg, Z. V. & Ramsey, N. F., 22 Jan 2024, medRxiv, (medRxiv).

Research output: Working paper › Preprint › Academic

Open Access

Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients

Petersen, M., Coenen, M., DeCarli, C., De Luca, A., van der Lelij, E., Barkhof, F., Benke, T., Chen, C. P. L. H., Dal-Bianco, P., Dewenter, A., Duering, M., Enzinger, C., Ewers, M., Exalto, L. G., Fletcher, E. F., Franzmeier, N., Hilal, S., Hofer, E., Koek, H. L. & Maier, A. B. & 22 others, Maillard, P. M., McCreary, C. R., Papma, J. M., Pijnenburg, Y. A. L., Schmidt, R., Smith, E. E., Steketee, R. M. E., van den Berg, E., van der Flier, W. M., Venkatraghavan, V., Venketasubramanian, N., Vernooij, M. W., Wolters, F. J., Xu, X., Horn, A., Patil, K. R., Eickhoff, S. B., Thomalla, G., Biesbroek, J. M., Biessels, G. J., Cheng, B. & Alzheimer's Disease Neuroimaging Initiative, 11 Apr 2024, medRxiv, 15 p.

Research output: Working paper › Preprint › Academic

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Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: A meta-analysis of 23 military and civilian cohorts

Katrinli, S., Wani, A. H., Maihofer, A. X., Ratanatharathorn, A., Daskalakis, N. P., Montalvo-Ortiz, J., Núñez-Ríos, D. L., Zannas, A. S., Zhao, X., Aiello, A. E., Ashley-Koch, A. E., Avetyan, D., Baker, D. G., Beckham, J. C., Boks, M. P., Brick, L. A., Bromet, E., Champagne, F. A., Chen, C.-Y. & Dalvie, S. & 31 others, Dennis, M. F., Fatumo, S., Fortier, C., Galea, S., Garrett, M. E., Geuze, E., Grant, G., Michael A Hauser, Hayes, J. P., Hemmings, S. M., Huber, B. R., Jajoo, A., Jansen, S., Kessler, R. C., Kimbrel, N. A., King, A. P., Kleinman, J. E., Koen, N., Koenen, K. C., Kuan, P.-F., Liberzon, I., Linnstaedt, S. D., Lori, A., Luft, B. J., Luykx, J. J., Marx, C. E., McLean, S. A., Rutten, B. P. F., Vermetten, E., Vinkers, C. H. & PGC-PTSD Epigenetics Workgroup, PsychENCODE PTSD Brainomics Project, Traumatic Stress Brain Research Group, 15 Jul 2024, medRxiv, 46 p. (medRxiv).

Research output: Working paper › Preprint › Academic

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Fibroblasts as an in vitro model of circadian genetic and genomic studies: A temporal analysis

Francia, M., Bot, M., Boltz, T., De la Hoz, J. F., Boks, M., Kahn, R. & Ophoff, R., 5 Mar 2024, BioRxiv, 28 p.

Research output: Working paper › Preprint › Academic

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Genome-wide association study identifies 30 obsessive-compulsive disorder associated loci

23andMe Research Team, 13 Mar 2024, medRxiv, p. 1-55, 55 p.

Research output: Working paper › Preprint › Academic

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Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

García-Marín, L. M., Campos, A. I., Diaz-Torres, S., Rabinowitz, J. A., Ceja, Z., Mitchell, B. L., Grasby, K. L., Thorp, J. G., Agartz, I., Alhusaini, S., Ames, D., Amouyel, P., Andreassen, O. A., Arfanakis, K., Vasquez, A. A., Armstrong, N. J., Athanasiu, L., Bastin, M. E., Beiser, A. S. & Bennett, D. A. & 31 others, Bis, J. C., Boks, M. P., Boomsma, D. I., Brodaty, H., Brouwer, R. M., Buitelaar, J. K., Burkhardt, R., Cahn, W., Calhoun, V. D., Carmichael, O. T., Chakravarty, M., Chen, Q., Ching, C. R. K., Cichon, S., Crespo-Facorro, B., Crivello, F., Dale, A. M., Smith, G. D., de Geus, E. J., De Jager, P. L., de Zubicaray, G. I., Debette, S., DeCarli, C., Depondt, C., Desrivières, S., Ikram, M. K., Kahn, R. S., Klein, M., Shen, L., Weinberger, D. R. & Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER), 15 Aug 2024, medRxiv, (medRxiv).

Research output: Working paper › Preprint › Academic

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GestaltMatcher Database - A global reference for facial phenotypic variability in rare human diseases

Lesmann, H., Hustinx, A., Moosa, S., Klinkhammer, H., Marchi, E., Caro, P., Abdelrazek, I. M., Pantel, J. T., Hagen, M. T., Thong, M.-K., Binti Mazlan, R. A., Tae, S. K., Kamphans, T., Meiswinkel, W., Li, J.-M., Javanmardi, B., Knaus, A., Uwineza, A., Knopp, C. & Tkemaladze, T. & 31 others, Elbracht, M., Mattern, L., Jamra, R. A., Velmans, C., Strehlow, V., Jacob, M., Peron, A., Dias, C., Nunes, B. C., Vilella, T., Pinheiro, I. F., Kim, C. A., Melaragno, M. I., Weiland, H., Kaptain, S., Chwiałkowska, K., Kwasniewski, M., Saad, R., Wiethoff, S., Goel, H., Tang, C., Hau, A., Barakat, T. S., Panek, P., Nabil, A., Suh, J., Braun, F., Gomy, I., Averdunk, L., Oegema, R. & Hellen Lesmann, 10 Jun 2024, Research Square, 51 p. (Research square).

Research output: Working paper › Preprint › Academic

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Identifying genetic differences between bipolar disorder and major depression through multiple GWAS

Bipolar Disorder Working Group of the Psychiatric Genetics Consortium, 30 Jan 2024, medRxiv, 46 p.

Research output: Working paper › Preprint › Academic

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IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

Cutilli, A., Jansen, S. A., Paolucci, F., Mokry, M., Mocholi, E., Lindemans, C. A. & Coffer, P. J., 7 Feb 2024, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Independent and joint effects of genomic and exposomic loads for schizophrenia on distressing and persisting psychotic experiences in adolescence

Vincenzo, M. D., Prachason, T., Sampogna, G., Arias-Magnasco, A., Danae Lin, B., Pries, L.-K., van Os, J., Rutten, B. P. F., Barzilay, R., Fiorillo, A. & Guloksuz, S., 11 Nov 2024, medRxiv, 23 p.

Research output: Working paper › Preprint › Academic

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Learning immune receptor representations with protein language models

Dounas, A., Cotet, T. S. & Yermanos, A., 6 Feb 2024, 24 p.

Research output: Working paper › Preprint › Academic

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Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functions

Ardisasmita, I., Joore, I., Levy, N., Myszczyszyn, A., Marsee, A., Sinnige, T., Ruiter, J., Ferdinandusse, S., Dudaryeva, O., Gruber, E., Daive, V., Levato, R., Spee, B., Verstegen, M. M., van der Laan, L. J. W., Nieuwenhuis , E. E. S., Schene, I. & Fuchs, S., 29 Oct 2024, BioRxiv, 28 p.

Research output: Working paper › Preprint › Academic

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On the influence of the vascular architecture on Gradient Echo and Spin Echo BOLD fMRI signals across cortical depth: a simulation approach based on realistic 3D vascular networks

Báez-Yáñez, M. G., Siero, J. C. W., Curcic, V., van Osch, M. J. P. & Petridou, N., 30 May 2024, BioRxiv, 33 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

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Protein language model pseudolikelihoods capture features of in vivo B cell selection and evolution

van Ginneken, D., Samant, A., Daga-Krumins, K., Agrafiotis, A., Kladis, E., Reddy, S. T. & Yermanos, A., 11 Dec 2024, BioRxiv, 27 p.

Research output: Working paper › Preprint › Academic

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Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

Lei, C. L., Clark, A. P., Clerx, M., Wei, S., Bloothooft, M., de Boer, T. P., Christini, D. J., Krogh-Madsen, T. & Mirams, G. R., 24 Jul 2024, BioRxiv, 19 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

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Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial Hypertension

Gomez-Arroyo, J., Houweling, A. C., Bogaard, H. J., Aman, J., Kitzmiller, J. A., Porollo, A., Dooijes, D., Meijboom, L. J., Hale, P., Pauciulo, M. W., Hong, J., Zhu, N., Welch, C., Shen, Y., Zacharias, W. J., McCormack, F. X., Aldred, M. A., Weirauch, M. T., Graf, S. & Rhodes, C. & 5 others, Chung, W. K., Whitsett, J. A., Martin, L. J., Kalinichenko, V. V. & Nichols, W. C., 22 Sept 2024, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

Structural brain abnormalities and aggressive behaviour in schizophrenia: Mega-analysis of data from 2095 patients and 2861 healthy controls via the ENIGMA consortium

Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER), 5 Feb 2024, medRxiv, 20 p.

Research output: Working paper › Preprint › Academic

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Unveiling the crucial neuronal role of the proteasomal ATPase subunit gene PSMC5 in neurodevelopmental proteasomopathies.

Küry, S., Stanton, J. E., van Woerden, G., Hsieh, T.-C., Rosenfelt, C., Scott-Boyer, M. P., Most, V., Wang, T., Papendorf, J. J., de Konink, C., Deb, W., Vignard, V., Studencka-Turski, M., Besnard, T., Hajdukowicz, A. M., Thiel, F., Möller, S., Florenceau, L., Cuinat, S. & Marsac, S. & 111 others, Wentzensen, I., Tuttle, A., Forster, C., Striesow, J., Golnik, R., Ortiz, D., Jenkins, L., Rosenfeld, J. A., Ziegler, A., Houdayer, C., Bonneau, D., Torti, E., Begtrup, A., Monaghan, K. G., Mullegama, S. V., Volker-Touw, C. M. L. N., van Gassen, K. L. I., Oegema, R., de Pagter, M., Steindl, K., Rauch, A., Ivanovski, I., McDonald, K., Boothe, E., Dauber, A., Baker, J., Fabie, N. A. V., Bernier, R. A., Turner, T. N., Srivastava, S., Dies, K. A., Swanson, L., Costin, C., Jobling, R. K., Pappas, J., Rabin, R., Niyazov, D., Tsai, A.C.-H., Kovak, K., Beck, D. B., Malicdan, M., Adams, D. R., Wolfe, L., Ganetzky, R. D., Muraresku, C., Babikyan, D., Sedláček, Z., Hančárová, M., Timberlake, A. T., Al Saif, H., Nestler, B., King, K., Hajianpour, M. J., Costain, G., Prendergast, D., Li, C., Geneviève, D., Vitobello, A., Sorlin, A., Philippe, C., Harel, T., Toker, O., Sabir, A., Lim, D., Hamilton, M., Bryson, L., Cleary, E., Weber, S., Hoffman, T. L., Cueto-González, A. M., Tizzano, E. F., Gómez-Andrés, D., Codina-Solà, M., Ververi, A., Pavlidou, E., Lambropoulos, A., Garganis, K., Rio, M., Levy, J., Jurgensmeyer, S., McRae, A. M., Lessard, M. K., D'Agostino, M. D., De Bie, I., Wegler, M., Jamra, R. A., Kamphausen, S. B., Bothe, V., Busch, L. M., Völker, U., Hammer, E., Wende, K., Cogné, B., Isidor, B., Meiler, J., Bosc-Rosati, A., Marcoux, J., Bousquet, M.-P., Poschmann, J., Laumonnier, F., Hildebrand, P. W., Eichler, E. E., McWalter, K., Krawitz, P. M., Droit, A., Elgersma, Y., Grabrucker, A. M., Bolduc, F. V., Bézieau, S., Ebstein, F. & Krüger, E., 26 Jan 2024, medRxiv.

Research output: Working paper › Preprint › Academic

2023

A click-based electrocorticographic brain-computer interface enables long-term high-performance switch-scan spelling

Crone, N., Candrea, D., Shah, S., Luo, S., Angrick, M., Rabbani, Q., Coogan, C., Milsap, G., Nathan, K., Wester, B., Anderson, W., Rosenblatt, K., Clawson, L., Maragakis, N., Vansteensel, M., Tenore, F., Ramsey, N., Fifer, M. & Uchil, A., 25 Sept 2023, Research Square, p. 1-26, 26 p.

Research output: Working paper › Preprint › Academic

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A multidimensional analysis reveals distinct immune phenotypes and tertiary lymphoid structure-like aggregates in the bone marrow of pediatric acute myeloid leukemia

Koedijk, J. B., van der Werf, I., Penter, L., Vermeulen, M. A., Barneh, F., Perzolli, A., Meesters-Ensing, J. I., Fiocco, M., de Groot-Kruseman, H. A., Moeniralam, R., Christensen, K. B., Porter, B., Pfaff, K., Garcia, J. S., Rodig, S. J., Wu, C. J., Hasle, H., Nierkens, S., Belderbos, M. E. & Zwaan, C. M. & 1 others, Heidenreich, O., 30 Oct 2023, medRxiv.

Research output: Working paper › Preprint › Academic

Open Access

Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection

Loehr, A. R., Timmerman, D. M., Liu, M., Gillis, A. J. M., Matthews, M., Bloom, J. C., Nicholls, P. K., Page, D. C., Miller, A. D., Looijenga, L. H. J. & Weiss, R. S., 12 Sept 2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

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Beyond gene-disease validity: capturing structured data on inheritance, allelic-requirement, disease-relevant variant classes, and disease mechanism for inherited cardiac conditions

Josephs, K. S., Roberts, A. M., Theotokis, P., Walsh, R., Ostrowski, P. J., Edwards, M., Fleming, A., Thaxton, C., Roberts, J. D., Care, M., Zareba, W., Adler, A., Sturm, A. C., Tadros, R., Novelli, V., Owens, E., Bronicki, L., Jarinova, O., Callewaert, B. & Peters, S. & 15 others, Lumbers, T., Jordan, E., Asatryan, B., Krishnan, N., Hershberger, R. E., Chahal, C. A. A., Landstrom, A. P., James, C., McNally, E. M., Judge, D. P., van Tintelen, P., Wilde, A., Gollob, M., Ingles, J. & Ware, J. S., 3 Apr 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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Cell type deconvolution of bulk blood RNA-Seq to reveal biological insights of neuropsychiatric disorders

Boltz, T., Schwarz, T., Bot, M., Hou, K., Caggiano, C., Lapinska, S., Duan, C., Boks, M. P., Kahn, R. S., Zaitlen, N., Pasaniuc, B. & Ophoff, R., 25 May 2023, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

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41 Downloads (Pure)

Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

Jansen, S. A., Cutilli, A., de Koning, C., van Hoesel, M., Sierra, L. S., Nierkens, S., Mokry, M., Nieuwenhuis, E. E. S., Hanash, A. M., Mocholi, E., Coffer, P. J. & Lindemans, C. A., 30 Apr 2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Colchicine promotes atherosclerotic plaque stability independently of inflammation

Li, W., Lin, A., Hutton, M., Dhaliwal, H., Nadel, J., Rodor, J., Tumanov, S., Örd, T., Hadden, M., Mokry, M., Mol, B. M., Pasterkamp, G., Padula, M. P., Geczy, C. L., Ramaswamy, Y., Sluimer, J. C., Kaikkonen, M. U., Stocker, R., Baker, A. H. & Fisher, E. A. & 2 others, Patel, S. & Misra, A., 3 Oct 2023, BioRxiv, 22 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

Discovery of 95 PTSD loci provides insight into genetic architecture and neurobiology of trauma and stress-related disorders

Nievergelt, C. M., Maihofer, A. X., Atkinson, E. G., Chen, C.-Y., Choi, K. W., Coleman, J. R., Daskalakis, N. P., Duncan, L. E., Polimanti, R., Aaronson, C., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegoviç, E., Babic, D., Bacanu, S.-A. & Baker, D. G. & 215 others, Batzler, A., Beckham, J. C., Belangero, S., Benjet, C., Bergner, C., Bierer, L. M., Biernacka, J. M., Bierut, L. J., Bisson, J. I., Boks, M. P., Bolger, E. A., Brandolino, A., Breen, G., Bressan, R. A., Bryant, R. A., Bustamante, A. C., Bybjerg-Grauholm, J., Bækvad-Hansen, M., Børglum, A. D., Børte, S., Cahn, L., Calabrese, J. R., Caldas-de-Almeida, J. M., Chatzinakos, C., Cheema, S., Clouston, S. A. P., Colodro-Conde, L., Coombes, B. J., Cruz-Fuentes, C. S., Dale, A. M., Dalvie, S., Davis, L. K., Deckert, J., Delahanty, D. L., Dennis, M. F., deRoon-Cassini, T., Desarnaud, F., DiPietro, C. P., Disner, S. G., Docherty, A. R., Domschke, K., Dyb, G., Kulenovic, A. D., Edenberg, H. J., Evans, A., Fabbri, C., Fani, N., Farrer, L. A., Feder, A., Feeny, N. C., Flory, J. D., Forbes, D., Franz, C. E., Galea, S., Garrett, M. E., Gelaye, B., Gelernter, J., Geuze, E., Gillespie, C. F., Goci, A., Goleva, S. B., Gordon, S. D., Grasser, L. R., Guindalini, C., Haas, M., Hagenaars, S., Hauser, M. A., Heath, A. C., Hemmings, S. M., Hesselbrock, V., Hickie, I. B., Hogan, K., Hougaard, D. M., Huang, H., Huckins, L. M., Hveem, K., Jakovljevic, M., Javanbakht, A., Jenkins, G. D., Johnson, J., Jones, I., Jovanovic, T., Karstoft, K.-I., Kaufman, M. L., Kennedy, J. L., Kessler, R. C., Khan, A., Kimbrel, N. A., King, A. P., Koen, N., Kotov, R., Kranzler, H. R., Krebs, K., Kremen, W. S., Kuan, P.-F., Lawford, B. R., Lebois, L. A. M., Lehto, K., Levey, D. F., Lewis, C., Liberzon, I., Linnstaedt, S. D., Logue, M. W., Lori, A., Lu, Y., Luft, B. J., Lupton, M. K., Luykx, J. J., Makotkine, I., Maples-Keller, J. L., Marchese, S., Marmar, C., Martin, N. G., MartÍnez-Levy, G. A., McAloney, K., McFarlane, A., McLaughlin, K. A., McLean, S. A., Medland, S. E., Mehta, D., Meyers, J., Michopoulos, V., Mikita, E. A., Milani, L., Milberg, W., Miller, M. W., Morey, R. A., Morris, C. P., Mors, O., Mortensen, P. B., Mufford, M. S., Nelson, E. C., Nordentoft, M., Norman, S. B., Nugent, N. R., O'Donnell, M., Orcutt, H. K., Pan, P. M., Panizzon, M. S., Pathak, G. A., Peters, E. S., Peterson, A. L., Peverill, M., Pietrzak, R. H., Polusny, M. A., Porjesz, B., Powers, A., Qin, X.-J., Ratanatharathorn, A., Risbrough, V. B., Roberts, A. L., Rothbaum, B. O., Rothbaum, A. O., Roy-Byrne, P., Ruggiero, K. J., Rung, A., Runz, H., Rutten, B. P. F., de Viteri, S. S., Salum, G. A., Sampson, L., Sanchez, S. E., Santoro, M., Seah, C., Seedat, S., Seng, J. S., Shabalin, A., Sheerin, C. M., Silove, D., Smith, A. K., Smoller, J. W., Sponheim, S. R., Stein, D. J., Stensland, S., Stevens, J. S., Sumner, J. A., Teicher, M. H., Thompson, W. K., Tiwari, A. K., Trapido, E., Uddin, M., Ursano, R. J., Valdimarsdóttir, U., van den Heuvel, L. L., Van Hooff, M., van Rooij, S. J., Vermetten, E., Vinkers, C. H., Voisey, J., Wang, Z., Wang, Y., Waszczuk, M., Weber, H., Wendt, F. R., Werge, T., Williams, M. A., Williamson, D. E., Winsvold, B. S., Winternitz, S., Wolf, E. J., Wolf, C., Xia, Y., Xiong, Y., Yehuda, R., Young, R. M., Young, K. A., Zai, C. C., Zai, G. C., Zervas, M., Zhao, H., Zoellner, L. A., Zwart, J.-A., Stein, M. B., Ressler, K. J. & Koenen, K. C., 2 Sept 2023, medRxiv.

Research output: Working paper › Preprint › Academic

Estimation of introduction and transmission rates of SARS-CoV-2 in a prospective household study

van Boven, M., van Dorp, C. H., Westerhof, I., Jaddoe, V., Heuvelman, V., Duijts, L., Fourie, E., Sluiter-Post, J., van Houten, M. A., Badoux, P., Euser, S., Herpers, B., Eggink, D., de Hoog, M., Boom, T., Wildenbeest, J., Bont, L., Rozhnova, G., Bonten, M. J. & Kretzschmar, M. E. & 1 others, Bruijning-Verhagen, P., 5 Jun 2023, medRxiv, 21 p. (medRxiv).

Research output: Working paper › Preprint › Academic

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8 Downloads (Pure)

EV-Elute: a universal platform for enrichment of functional surface marker-defined extracellular vesicle subpopulations

de Voogt, W., Frunt, R., Leandro, R., Triesscheijn, C., Monica, B., Paspali, I., Tielemans, M., Gitz-Francois, J. J. J. M., Seinen, C., de Jong, O. & Kooijmans, S., 29 Oct 2023, BioRxiv, 28 p.

Research output: Working paper › Preprint › Academic

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4 Downloads (Pure)

Evidence of survival bias in the association between APOE-ϵ4 and age of ischemic stroke onset.

SiGN, FinnGen, Women’s Health Initiative, 1 Dec 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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1 Downloads (Pure)

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

van de Kooij, B., Schreuder, A., Pavani, R. S., Garzero, V., Van Hoeck, A., San Martin Alonso, M., Koerse, D., Wendel, T. J., Callen, E., Boom, J., Mei, H., Cuppen, E., Nussenzweig, A., van Attikum, H. & Noordermeer, S. M., 24 Feb 2023, BioRxiv, p. 1-37, 37 p.

Research output: Working paper › Preprint › Academic

Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

Benavente, E. D., Karnewar, S., Buono, M., Mili, E., Hartman, R. J. G., Kapteijn, D., Slenders, L., Daniels, M., Aherrahrou, R., Reinberger, T., Mol, B. M., de Borst, G. J., de Kleijn, D. P. V., Prange, K. H. M., Depuydt, M. A. C., de Winther, M. P. J., Kuiper, J., Bj Rkegren, J. L. M., Erdmann, J. & Civelek, M. & 4 others, Mokry, M., Owens, G. K., Pasterkamp, G. & den Ruijter, H. M., 9 Feb 2023, BioRxiv.

Research output: Working paper › Preprint › Academic

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20 Downloads (Pure)

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

Karnewar, S., Karnewar, V., Deaton, R., Shankman, L. S., Benavente, E. D., Williams, C. M., Bradley, X., Alencar, G. F., Bulut, G. B., Kirmani, S., Baylis, R. A., Zunder, E. R., den Ruijter, H. M., Pasterkamp, G. & Owens, G. K., 14 Oct 2023, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., Lopez, N. G., Mosquera, J. V., Auguste, G., Farber, E., Ma, W. F., Wong, D., Onengut-Gumuscu, S., Kavousi, M., Peyser, P. A., van der Laan, S. W., Leeper, N. J., Kovacic, J. C., Björkegren, J. L. M. & Miller, C. L., 14 Feb 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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7 Downloads (Pure)

Lack of association between HLA and asymptomatic SARS-CoV-2 infection

COVID Human Genetic Effort, 8 Dec 2023, BMJ, (medRxiv).

Research output: Working paper › Preprint › Academic

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4 Downloads (Pure)

University Medical Center (UMC) Utrecht

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