Pulmonology patient care

Research output

Research output per year 1990 2015 2016 2017 2019 2020 2021 2022 2023 2024 2024

• 219 Article
• 15 Meeting Abstract
• 12 Comment/Letter to the editor
• 12 Doctoral thesis 1 (Research UU / Graduation UU)
• 22 More
  • 9 Review article
  • 6 Letter
  • 3 Chapter
  • 2 Editorial
  • 2 Doctoral thesis 2 (Research NOT UU / Graduation UU)

Research output per year

Research output per year

Search results

• 2024

  A dyadic perspective on parent-child dyadic coping in children with a chronic condition

  van der Wal, R. C., Nijhof, S. L., Leisten, L. M., van de Putte, E. M., van der Ent, C. K., Hindriks-Keegstra, A. W., Bodenmann, G., Finkenauer, C. & Nap-van der Vlist, M. M., Jun 2024, In: Journal of Psychosomatic Research. 181, 111668.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • chronic condition 100%
  • coping 61%
  • Child 34%
  • Parents 32%
  • Communication 32%
  1 Downloads (Pure)

• BMI increase during early childhood in boys with cystic fibrosis and early adrenarche

  Tamer, G., Arets, H. G. M., van der Ent, C. K., van Santen, H. M. & van der Kamp, H. J., Apr 2024, In: Pediatric Pulmonology. 59, 4, p. 991-996 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Adrenarche 100%
  • Cystic Fibrosis 60%
  • Dehydroepiandrosterone Sulfate 52%
  • Body Mass Index 44%
  • Bone and Bones 8%

• Centralized intestinal organoid generation is a feasible and safe approach for personalized medicine as demonstrated in the HIT-CF Europe Organoid Study

  Jul 2024, In: Journal of Cystic Fibrosis. 23, 4, p. 703-706 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Precision Medicine 82%
  • Biopsy 46%
  • Suction 31%
  • Surgical Instruments 26%

• Cerebrospinal fluid inflammatory markers to differentiate between neonatal bacterial meningitis and sepsis: A prospective study of diagnostic accuracy

  Groeneveld, N. S., Olie, S. E., Visser, D. H., Snoek, L., van de Beek, D., Brouwer, M. C. & Bijlsma, M. W., May 2024, In: International Journal of Infectious Diseases. 142, 106970.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Bacterial Meningitides 100%
  • Meningitis 81%
  • Cerebrospinal Fluid 70%
  • Sepsis 65%
  • Area Under Curve 57%

• Enhanced aortic stiffness in adolescents with chronic disease is associated with decreased left ventricular global longitudinal strain

  Verpalen, V. A., Ververs, F. A., Slieker, M., Nuboer, R., Swart, J. F., van der Ent, C. K., Fejzic, Z., Westenberg, J. J. M., Leiner, T., Grotenhuis, H. B. & Schipper, H. S., 1 Jun 2024, In: IJC Heart and Vasculature. 52, 101385.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Vascular Stiffness 100%
  • Pulse Wave Analysis 68%
  • Chronic Disease 63%
  • Left Ventricular Function 41%
  • Coenzyme A 35%
  1 Downloads (Pure)

• Optimization of performance of Dutch newborn screening for cystic fibrosis

  Bouva, M. J., Dankert-Roelse, J. E., van der Ploeg, C., Verschoof-Puite, R. K., Zomer-van Ommen, D. D., Gille, J., Jakobs, B. S., Heijnen, M. & de Winter-de Groot, K. M., Jan 2024, In: Journal of Cystic Fibrosis. 23, 1, p. 120-125 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neonatal Screening 100%
  • Pancreatitis-Associated Proteins 84%
  • Cystic Fibrosis 83%
  • Trypsinogen 71%
  • Costs and Cost Analysis 30%

• OrgaSegment: deep-learning based organoid segmentation to quantify CFTR dependent fluid secretion

  Lefferts, J. W., Kroes, S., Smith, M. B., Niemöller, P. J., Nieuwenhuijze, N. D. A., Sonneveld van Kooten, H. N., van der Ent, C. K., Beekman, J. M. & van Beuningen, S. F. B., 13 Mar 2024, In: Communications biology. 7, 1, 9 p., 319.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Deep Learning 100%
  • Fluids and Secretions 98%
  • Organoids 95%
  • Conductance 69%
  • cystic fibrosis 66%
  3 Downloads (Pure)

• Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis

  Eijkemans, M., Mommers, M., Harskamp-van Ginkel, M. W., Vrijkotte, T. G. M., Ludvigsson, J., Faresjö, Å., Bergström, A., Ekström, S., Grote, V., Koletzko, B., Bønnelykke, K., Eliasen, A. U., Bager, P., Melbye, M., Annesi-Maesano, I., Baïz, N., Barros, H., Santos, A. C., Duijts, L., Mensink-Bout, S. M., & 31 othersFlexeder, C., Koletzko, S., Schikowski, T., Eggesbø, M. Å., Lenters, V., Fernández-Tardón, G., Subiza-Perez, M., Garcia-Aymerich, J., López-Vicente, M., Sunyer, J., Torrent, M., Ballester, F., Kelleher, C., Mehegan, J., Berg, A. V., Herberth, G., Standl, M., Kuehni, C. E., Pedersen, E. S. L., Jansen, M., Gehring, U., Boer, J. M. A., Devereux, G., Turner, S., Peltola, V., Lagström, H., Inskip, H. M., Pike, K. C., Dalmeijer, G. W., Ent, C. K. V. D. & Thijs, C., 15 Aug 2024, In: BMJ open respiratory research. 11, 1, e001630.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Pulmonary Computed Tomography Screening Frequency in Primary Antibody Deficiency

  Smits, B. M., Boland, S. L., Hol, M. E., Dandis, R., Leavis, H., de Jong, P. A., Prevaes, S. M. P. J., Mohamed Hoesein, F. A. A., van Montfrans, J. M. & Ellerbroek, P. M., Apr 2024, In: Journal of Allergy and Clinical Immunology: In Practice. 12, 4, p. 1037-1048.e3

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Primary Immunodeficiency Diseases 100%
  • Tomography 49%
  • Interstitial Lung Diseases 40%
  • Lung 39%
  • Disease Progression 23%
  2 Downloads (Pure)

• Repeatability and reproducibility of the Forskolin-induced swelling (FIS) assay on intestinal organoids from people with Cystic Fibrosis

  Bierlaagh, M. C., Ramalho, A. S., Silva, I. A. L., Vonk, A. M., van den Bor, R. M., van Mourik, P., Pott, J., Suen, S. W. F., Boj, S. F., Vries, R. G. J., Lammertyn, E., Vermeulen, F., Amaral, M. D., de Boeck, K., van der Ent, C. K. & Beekman, J. M., Jul 2024, In: Journal of Cystic Fibrosis. 23, 4, p. 693-702 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Colforsin 83%
  • Cystic Fibrosis 74%
  • Theranostic Nanomedicine 16%
  • Precision Medicine 13%

• Reply to Sujoy Khan

  van der Rijst, L. P., de Winter-de Groot, K. M., de Bruin-Weller, M. S. & de Graaf, M., Aug 2024, In: Pediatric Allergy and Immunology. 35, 8, e14222.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
• 2023

  16S rRNA-Based Microbiota Profiling Assists Conventional Culture Analysis of Airway Samples from Pediatric Cystic Fibrosis Patients

  Kristensen, M., de Koff, E. M., Chu, M. L., Groendijk, S., Tramper-Stranders, G. A., de Winter-de Groot, K. M., Janssens, H. M., Tiddens, H. A., van Westreenen, M., Sanders, E. A. M., Arets, B. H. G. M., van der Ent, C. K., Prevaes, S. M. P. J. & Bogaert, D., Jun 2023, In: Microbiology spectrum. 11, 3, p. 1-8 e0405722.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • cystic fibrosis 100%
  • pediatrics 92%
  • 16S Ribosomal RNA 75%
  • Microbiota 72%
  • Cystic Fibrosis 71%

• A cross-sectional study on gaming intensity and social vulnerability in adolescents that have a chronic condition

  Alexandridis, D., Nijhof, S. L., van der Rijst, V. G., van der Neut, D. Y., Spijkerman, R., Stevens, G. W. J. M., Bakkes, S. C. J., Lesscher, H. M. B., van den Eijnden, R. J. J. M., van der Ent, C. K., van den Berg, G. & Peeters, M., 17 Apr 2023, In: Frontiers in Public Health. 11, 10 p., 1128156.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • chronic condition 100%
  • cross-sectional study 79%
  • vulnerability 64%
  • Cross-Sectional Studies 52%
  • adolescent 46%

• Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders

  Dreyer, H. H. M., van Tuyll van Serooskerken, E. S., Rodenburg, L. W., Bittermann, A. J. N., Arets, H. G. M., Reuling, E. M. B. P., Verweij, J. W., Haarman, E. G., van der Zee, D. C., Tytgat, S. H. A. J., van der Ent, C. K., Beekman, J. M., Amatngalim, G. D. & Lindeboom, M. Y. A., 5 Jun 2023, In: Children (Basel, Switzerland). 10, 6, p. 1-9 9 p., 1020.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Esophageal Atresia 100%
  • Respiratory System 68%
  • Cilia 42%
  • Nasal Lavage Fluid 37%
  • Organoids 31%
  6 Downloads (Pure)

• Bacterial Colonization of the Lower Airways in Children With Esophageal Atresia

  van Tuyll van Serooskerken, E. S., Duhoky, R., Verweij, J. W., Bont, L., Arets, H. G. M., Bittermann, A. J. N., van der Zee, D. C., Tytgat, S. H. A. J. & Lindeboom, M. Y. A., 1 Aug 2023, In: The Pediatric infectious disease journal. 42, 8, p. 644-647 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Esophageal Atresia 100%
  • Bronchoalveolar Lavage 56%
  • Child 31%
  • Respiratory Tract Infections 19%
  • Tracheomalacia 15%

• CFTR Function Restoration upon Elexacaftor/Tezacaftor/Ivacaftor Treatment in Patient-Derived Intestinal Organoids with Rare CFTR Genotypes.

  Lefferts, J. W., Bierlaagh, M. C., Kroes, S., Nieuwenhuijze, N. D. A., Sonneveld van Kooten, H. N., Niemöller, P. J., Verburg, T. F., Janssens, H. M., Muilwijk, D., van Beuningen, S. F. B., van der Ent, C. K. & Beekman, J. M., Oct 2023, In: International Journal of Molecular Sciences. 24, 19, 14 p., 14539.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • tezacaftor; ivacaftor 100%
  • Ivacaftor 99%
  • cystic fibrosis 84%
  • Organoids 62%
  • regulators 60%
  9 Downloads (Pure)

• Childhood infection burden, recent antibiotic exposure and vascular phenotypes in preschool children

  Yu, A., Jansen, M. A. C., Dalmeijer, G. W., Bruijning-Verhagen, P., van der Ent, C. K., Grobbee, D. E., Burgner, D. P. & Uiterwaal, C. S. P. M., Sept 2023, In: PLoS ONE. 18, 9, e0290633.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Preschool Children 100%
  • Anti-Bacterial Agents 59%
  • Phenotype 54%
  • Blood Vessels 53%
  • Infections 43%
  10 Downloads (Pure)

• Cystic Fibrosis Cases Missed by Newborn Bloodspot Screening-Towards a Consistent Definition and Data Acquisition

  21 Nov 2023, In: International Journal of Neonatal Screening. 9, 4, 5 p., 65.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neonatal Screening 100%
  • Cystic Fibrosis 83%
  • Occupational Groups 12%
  5 Downloads (Pure)

• Daily intranasal palivizumab to prevent respiratory syncytial virus infection in healthy preterm infants: a phase 1/2b randomized placebo-controlled trial

  Dec 2023, In: EClinicalMedicine. 66, 102324.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Palivizumab 100%
  • Respiratory Syncytial Virus Infections 82%
  • Premature Infants 61%
  • Placebos 44%
  • Randomized Controlled Trials 43%
  14 Downloads (Pure)

• Development and outcomes of a patient driven cystic fibrosis quality of care improvement project

  Noordhoek, J. J., Jeyaratnam, J., Zomer, D., Gulmans, V. A. M., van der Ent, C. K. & Heijerman, H. G. M., Jan 2023, In: Journal of Cystic Fibrosis. 22, 1, p. 172-178 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Quality Improvement 100%
  • Cystic Fibrosis 99%
  • Quality of Health Care 88%
  • Netherlands 24%
  • Organizations 21%

• Development and validation of a novel personalized electronic patient-reported outcome measure to assess quality of life (Q-LIFE): a prospective observational study in people with Cystic Fibrosis

  Muilwijk, D., van Paridon, T. J., van der Heijden, D. C., Faber-Bisschop, B. M., Zomer-van Ommen, D. D., Heijerman, H. G. M. & van der Ent, C. K., Aug 2023, In: EClinicalMedicine. 62, 102116.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Patient Reported Outcome Measures 100%
  • Cystic Fibrosis 88%
  • Observational Studies 70%
  • Quality of Life 58%
  • Prospective Studies 57%
  7 Downloads (Pure)

• Environmental and parental risk factors for congenital solitary functioning kidney — a case–control study

  Aug 2023, In: Pediatric Nephrology. 38, 8, p. 2631-2641 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Solitary Kidney 100%
  • Confidence Intervals 45%
  • Odds Ratio 12%
  • Mothers 12%
  • Gene-Environment Interaction 11%
  11 Downloads (Pure)

• Epidemiology and management of nontuberculous mycobacterial disease in people with cystic fibrosis, the Netherlands

  Mar 2023, In: Journal of Cystic Fibrosis. 22, 2, p. 327-333 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nontuberculous Mycobacteria 100%
  • Cystic Fibrosis 75%
  • Netherlands 74%
  • Epidemiology 60%
  • Child 13%
  7 Downloads (Pure)

• European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance

  Munck, A., Berger, D. O., Southern, K. W., Carducci, C., de Winter-de Groot, K. M., Gartner, S., Kashirskaya, N., Linnane, B., Proesmans, M., Sands, D., Sommerburg, O., Castellani, C. & Barben, J., May 2023, In: Journal of Cystic Fibrosis. 22, 3, p. 484-495 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neonatal Screening 100%
  • DOP protocol 51%
  • DNA 35%
  • Datasets 16%
  • Costs and Cost Analysis 13%

• Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis

  Rodenburg, L. W., Metzemaekers, M., van der Windt, I. S., Smits, S. M. A., den Hertog-Oosterhoff, L. A., Kruisselbrink, E., Brunsveld, J. E., Michel, S., de Winter-de Groot, K. M., van der Ent, C. K., Stadhouders, R., Beekman, J. M. & Amatngalim, G. D., 30 Oct 2023, In: Scientific Reports. 13, 1, 18573.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nasal Mucosa 100%
  • Cystic Fibrosis 83%
  • Nose 69%
  • Epithelium 65%
  • Epithelial Cells 51%

• FDA-approved drug screening in patient-derived organoids demonstrates potential of drug repurposing for rare cystic fibrosis genotypes

  de Poel, E., Spelier, S., Hagemeijer, M. C., van Mourik, P., Suen, S. W. F., Vonk, A. M., Brunsveld, J. E., Ithakisiou, G. N., Kruisselbrink, E., Oppelaar, H., Berkers, G., de Winter de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., Bakker, M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J. M., & 5 othersKoppelman, G. H., Blaazer, A. R., Muijlwijk-Koezen, J. E., van der Ent, C. K. & Beekman, J. M., May 2023, In: Journal of Cystic Fibrosis. 22, 3, p. 548-559 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Drug Repositioning 100%
  • Organoids 95%
  • Preclinical Drug Evaluations 86%
  • Phosphodiesterase 4 Inhibitors 83%
  • Cystic Fibrosis 71%

• Graft dilatation and Barrett's esophagus in adults after gastric pull-up and jejunal interposition for long-gap esophageal atresia

  van Tuyll van Serooskerken, E. S., Gallo, G., Weusten, B. L., Westerhof, J., Brosens, L. A., Zwaveling, S., Ruiterkamp, J., Hulscher, J. B., Arets, H. G., Bittermann, A. J., van der Zee, D. C., Tytgat, S. H. & Lindeboom, M. Y., 16 Sept 2023, In: World Journal of Gastrointestinal Endoscopy. 15, 9, p. 553-563 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Esophageal Atresia 100%
  • Barrett Esophagus 88%
  • Dilatation 60%
  • Stomach 52%
  • Transplants 45%
  16 Downloads (Pure)

• High-throughput functional assay in cystic fibrosis patient-derived organoids allows drug repurposing

  Spelier, S., de Poel, E., Ithakisiou, G. N., Suen, S. W. F., Hagemeijer, M. C., Muilwijk, D., Vonk, A. M., Brunsveld, J. E., Kruisselbrink, E., van der Ent, C. K. & Beekman, J. M., Jan 2023, In: ERJ Open Research. 9, 1, 00495-2022.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Drug Repositioning 100%
  • Organoids 95%
  • Cystic Fibrosis Transmembrane Conductance Regulator 91%
  • Cystic Fibrosis 71%
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 21%
  4 Citations (Scopus)

  7 Downloads (Pure)

• Impaired SARS-CoV-2 specific T-cell response in patients with severe COVID-19

  Rümke, L. W., Smit, W. L., Bossink, A., Limonard, G. J. M., Muilwijk, D., Haas, L. E. M., Reusken, C., van der Wal, S., Thio, B. J., van Os, Y. M. G., Gremmels, H., Beekman, J. M., Nijhuis, M., Wensing, A. M. J., Heron, M. & Thijsen, S. F. T., Apr 2023, In: Frontiers in Immunology. 14, 9 p., 1046639.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • SARS Virus 100%
  • T-Lymphocytes 41%
  • Viruses 22%
  • Nucleocapsid 22%
  • Immunosorbents 21%

• Is Measuring Physical Literacy in School-Aged Children With Cystic Fibrosis or Congenital Heart Disease Needed?

  Noordstar, J. J., Sprong, M. C. A., Slieker, M. G., Takken, T., van Brussel, M., van der Ent, C. K. & Hulzebos, E. H. J., 1 Jan 2023, In: Pediatric Physical Therapy. 35, 1, p. 43-47 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cardiorespiratory Fitness 100%
  • Literacy 91%
  • Cystic Fibrosis 75%
  • Heart Diseases 62%
  • Motivation 46%

• Lung function decline preceding chronic respiratory failure in spinal muscular atrophy: a national prospective cohort study

  Veldhoen, E. S., Wijngaarde, C. A., van Eijk, R. P. A., Asselman, F-L., Seddiqi, N., Otto, L. A. M., Stam, M., Cuppen, I., Wadman, R. I., van Asperen, R. M. W., Hulzebos, E. H. J., van den Oudenrijn, L. P. V., Bartels, B., Boezer, J., Gaytant, M., van der Ent, C. K. & van der Pol, W. L., 23 Feb 2023, In: Orphanet Journal of Rare Diseases. 18, 1, 10 p., 40.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Spinal Muscular Atrophy 100%
  • Artificial Respiration 73%
  • Respiratory Insufficiency 72%
  • Cohort Studies 52%
  • Prospective Studies 49%
  12 Downloads (Pure)

• Organized Sports Activities Are Safe for Children With Sickle Cell Disease: A Pilot Intervention Study

  Noordstar, J. J., Hulzebos, E. H. J., van der Ent, C. K., Suijker, M. H. & Bartels, M., 1 Aug 2023, In: Journal of Pediatric Hematology/oncology. 45, 6, p. e710-e715

  Research output: Contribution to journal › Article › Academic › peer-review

  • Sickle Cell Anemia 100%
  • Sports 80%
  • Child 39%
  • Youth Sports 19%
  • Soccer 15%

• Paediatric short fatigue questionnaire, a 4-item fatigue questionnaire for children

  Nap-van der Vlist, M. M., Vroegindeweij, A., Hoefnagels, J. W., van der Ent, C. K., Swart, J. F., van de Putte, E. M. & Nijhof, S. L., Feb 2023, In: Journal of Psychosomatic Research. 165, 111130.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • fatigue 100%
  • Fatigue 76%
  • Pediatrics 58%
  • questionnaire 46%
  • Child 39%
  19 Downloads (Pure)

• Radiological and long-term clinical response to elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis with advanced lung disease

  Aalbers, B. L., Mohamed Hoesein, F. A. A., Hofland, R. W., Bronsveld, I., Kruijswijk, M. A., Schotman, S., Slingerland, C. W., Panhuis, H., van der Ent, C. K. & Heijerman, H. G. M., Aug 2023, In: Pediatric Pulmonology. 58, 8, p. 2317-2322 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • tezacaftor; ivacaftor 100%
  • Compassionate Use Trials 72%
  • Cystic Fibrosis 46%
  • Lung Diseases 42%
  • Sweat 28%
  25 Downloads (Pure)

• Self-reported quantity and quality of sleep in children and adolescents with a chronic condition compared to healthy controls

  Biemans, C. F. M., Nijhof, S. L., Gorter, J. W., Stevens, G. J. W. M., van de Putte, E., Hoefnagels, J. W., van den Berg, A., van der Ent, C. K., Dudink, J. & Verschuren, O. W., Jul 2023, In: European Journal of Pediatrics. 182, 7, p. 3139-3146 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Sleep 100%
  • Medically Unexplained Symptoms 60%
  • Child 55%
  • Sex Ratio 8%
  • Propensity Score 7%
  19 Downloads (Pure)

• Targeted locus amplification reveals heterogeneity between and within CFTR genotypes and association with CFTR function in patient-derived intestinal organoids

  Lefferts, J. W., Boersma, V., Nieuwenhuijze, N. D. A., Suen, S. W. F., Hajo, K., Collantes, N. S., Vermeulen, C., Groeneweg, T., Hagemeijer, M. C., de Jonge, H. R., van der Ent, C. K., Splinter, E. & Beekman, J. M., May 2023, In: Journal of Cystic Fibrosis. 22, 3, p. 538-547 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Organoids 100%
  • Cystic Fibrosis Transmembrane Conductance Regulator 95%
  • Genotype 54%
  • Cystic Fibrosis 22%
  • Alleles 11%

• The RISE study protocol: resilience impacted by positive stressful events for people with cystic fibrosis

  van der Heijden, E., van den Bor, R. M., van der Ent, C. K., Nijhof, S. L. & van der Laan, S. E. I., 1 May 2023, In: ERJ Open Research. 9, 3, 11 p., 00535-2022.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • tezacaftor; ivacaftor 100%
  • Cystic Fibrosis 46%
  • Biological Factors 7%
  • Research Ethics Committees 7%
  • Drug Combinations 7%

• Traits, trends and hits of orphan drug designations in cystic fibrosis

  Costa, E., Girotti, S., van den Ham, H. A., Cipolli, M., van der Ent, C. K., Taylor-Cousar, J. L. & Leufkens, H. G. M., Sept 2023, In: Journal of Cystic Fibrosis. 22, 5, p. 949-957 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Orphan Drug Production 100%
  • Cystic Fibrosis 64%
  • Drug Development 39%
  • Marketing 26%
  • United States Food and Drug Administration 24%
  15 Downloads (Pure)

• Uncovering risk factors for kidney injury in children with a solitary functioning kidney

  Jan 2023, In: Kidney International. 103, 1, p. 156-165 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Solitary Kidney 100%
  • Kidney 40%
  • Wounds and Injuries 37%
  • Child 33%
  • Glomerular Filtration Rate 16%
  7 Downloads (Pure)

• VOCAL: An observational study of ivacaftor for people with cystic fibrosis and selected non–G551D-CFTR gating mutations

  Simmonds, N. J., van der Ent, C. K., Colombo, C., Kinnman, N., DeSouza, C., Thorat, T., Chew, M. L., Chandarana, K. & Castellani, C., Jan 2023, In: Journal of Cystic Fibrosis. 22, 1, p. 124-131 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • ivacaftor 100%
  • Cystic Fibrosis 57%
  • Observational Studies 46%
  • Mutation 33%
  • Forced Expiratory Volume 11%
  1 Downloads (Pure)
• 2022

  Analysing the protection from respiratory tract infections and allergic diseases early in life by human milk components: the PRIMA birth cohort

  14 Feb 2022, In: BMC Infectious Diseases. 22, 1, 152.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Human Milk 100%
  • Respiratory Tract Infections 84%
  • Parturition 62%
  • Hypersensitivity 16%
  • Birthing Centers 15%
  17 Downloads (Pure)

• Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

  Rodenburg, L. W., Delpiano, L., Railean, V., Centeio, R., Pinto, M. C., Smits, S. M. A., van der Windt, I. S., van Hugten, C. F. J., van Beuningen, S. F. B., Rodenburg, R. N. P., van der Ent, C. K., Amaral, M. D., Kunzelmann, K., Gray, M. A., Beekman, J. M. & Amatngalim, G. D., 21 Oct 2022, In: International Journal of Molecular Sciences. 23, 20, 12657.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • cystic fibrosis 100%
  • secretions 77%
  • Drug Repositioning 77%
  • Fluids and Secretions 75%
  • Nasal 74%
  4 Downloads (Pure)

• Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children

  1 Oct 2022, In: European Respiratory Journal. 60, 4, p. 1-13 13 p., 2102395.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Respiratory Tract Infections 100%
  • Asthma 83%
  • Meta-Analysis 80%
  • Lung 57%
  • Vital Capacity 52%
  14 Citations (Scopus)

  7 Downloads (Pure)

• Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study

  Jul 2022, In: Journal of Cystic Fibrosis. 21, 4, p. e221-e231

  Research output: Contribution to journal › Article › Academic › peer-review

  • SARS Virus 100%
  • Cystic Fibrosis 66%
  • Observational Studies 52%
  • Oxygen 36%
  • Infections 24%

• Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression

  Muilwijk, D., de Poel, E., van Mourik, P., Suen, S. W. F., Vonk, A. M., Brunsveld, J. E., Kruisselbrink, E., Oppelaar, H., Hagemeijer, M. C., Berkers, G., de Winter-de Groot, K. M., Heida-Michel, S., Jans, S. R., van Panhuis, H., van der Eerden, M. M., van der Meer, R., Roukema, J., Dompeling, E., Weersink, E. J. M., Koppelman, G. H., & 5 othersVries, R., Zomer-van Ommen, D. D., Eijkemans, M. J. C., van der Ent, C. K. & Beekman, J. M., 1 Aug 2022, In: The European respiratory journal. 60, 2, p. 1-11 2100508.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Colforsin 83%
  • Cystic Fibrosis 74%
  • Disease Progression 60%
  • Cystic Fibrosis Transmembrane Conductance Regulator 35%
  20 Downloads (Pure)

• Forskolin induced swelling (FIS) assay in intestinal organoids to guide eligibility for compassionate use treatment in a CF patient with a rare genotype

  Aalbers, B. L., Brunsveld, J. E., van der Ent, C. K., van den Eijnden, J. C., Beekman, J. M. & Heijerman, H. G. M., Mar 2022, In: Journal of Cystic Fibrosis. 21, 2, p. 254-257 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Compassionate Use Trials 100%
  • Organoids 86%
  • Colforsin 71%
  • Genotype 47%
  • Mutation 36%
  8 Downloads (Pure)

• Functional Restoration of CFTR Nonsense Mutations in Intestinal Organoids

  de Poel, E., Spelier, S., Suen, S. W. F., Kruisselbrink, E., Graeber, S. Y., Mall, M. A., Weersink, E. J. M., van der Eerden, M. M., Koppelman, G. H., van der Ent, C. K. & Beekman, J. M., Mar 2022, In: Journal of Cystic Fibrosis. 21, 2, p. 246-253 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Cystic Fibrosis Transmembrane Conductance Regulator 95%
  • Nonsense Codon 87%
  • ivacaftor 55%
  • Nonsense Mediated mRNA Decay 49%
  1 Citation (Scopus)

  16 Downloads (Pure)

• Long-term effectiveness of dual CFTR modulator treatment of cystic fibrosis

  Muilwijk, D., Ommen, D. D. Z. V., Gulmans, V. A. M., Eijkemans, M. J. C. & van der Ent, C. K., 1 Oct 2022, In: ERJ Open Research. 8, 4, p. 1-10 00204-2022.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • prednylidene 100%
  • Cystic Fibrosis Transmembrane Conductance Regulator 85%
  • Cystic Fibrosis 66%
  • Body Mass Index 34%
  • Duration of Therapy 27%
  3 Citations (Scopus)

  17 Downloads (Pure)

• Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

  Amatngalim, G. D., Rodenburg, L. W., Aalbers, B. L., Raeven, H. H., Aarts, E. M., Sarhane, D., Spelier, S., Lefferts, J. W., Silva, I. A., Nijenhuis, W., Vrendenbarg, S., Kruisselbrink, E., Brunsveld, J. E., van Drunen, C. M., Michel, S., de Winter-de Groot, K. M., Heijerman, H. G., Kapitein, L. C., Amaral, M. D., van der Ent, C. K., & 1 othersBeekman, J. M., Dec 2022, In: Life Science Alliance. 5, 12, p. 1-14 e202101320.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Nasal Mucosa 88%
  • Cystic Fibrosis 74%
  • Pharmaceutical Preparations 31%
  • Nose 30%
  4 Downloads (Pure)

• Natural history of respiratory muscle strength in spinal muscular atrophy: a prospective national cohort study

  Veldhoen, E. S., Wijngaarde, C. A., Hulzebos, E. H. J., Wösten-van Asperen, R. M., Wadman, R. I., van Eijk, R. P. A., Asselman, F. L., Stam, M., Otto, L. A. M., Cuppen, I., Scheijmans, F. E. V., den Oudenrijn, L. P. V. V., Bartels, B., Gaytant, M. A., van der Ent, C. K. & van der Pol, W. L., 21 Feb 2022, In: Orphanet Journal of Rare Diseases. 17, 1, p. 1-11 70.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Spinal Muscular Atrophy 100%
  • Respiratory Muscles 93%
  • Muscle Strength 78%
  • Natural History 77%
  • Cohort Studies 52%
  6 Downloads (Pure)