Neurology & Neurosurgery

Research output

Research output per year 1996 2016 2017 2018 2019 2020 2021 2022 2024

• 213 Article
• 20 Comment/Letter to the editor
• 10 Review article
• 9 Doctoral thesis 1 (Research UU / Graduation UU)
• 22 More
  • 7 Meeting Abstract
  • 7 Letter
  • 4 Editorial
  • 1 Chapter
  • 1 Abstract
  • 1 Short survey
  • 1 Working paper

Research output per year

Research output per year

Search results

• 2024

  ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons

  Zelina, P., de Ruiter, A. A., Kolsteeg, C., van Ginneken, I., Vos, H. R., Supiot, L. F., Burgering, B. M. T., Meye, F. J., Veldink, J. H., van den Berg, L. H. & Pasterkamp, R. J., 4 Sept 2024, In: Acta neuropathologica communications. 12, 1, 144.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Assessment of risk of ALS conferred by the GGGGCC hexanucleotide repeat expansion in C9orf72 among first-degree relatives of patients with ALS carrying the repeat expansion

  Van Wijk, I. F., Van Eijk, R. P. A., Van Boxmeer, L., Westeneng, H. J., Van Es, M. A., Van Rheenen, W., Van Den Berg, L. H., Eijkemans, M. J. C. & Veldink, J. H., Feb 2024, In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 25, 1-2, p. 188-196 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• ATAXIN-2 intermediate-length polyglutamine expansions elicit ALS-associated metabolic and immune phenotypes

  Vieira de Sá, R., Sudria-Lopez, E., Cañizares Luna, M., Harschnitz, O., van den Heuvel, D. M. A., Kling, S., Vonk, D., Westeneng, H-J., Karst, H., Bloemenkamp, L., Varderidou-Minasian, S., Schlegel, D. K., Mars, M., Broekhoven, M. H., van Kronenburg, N. C. H., Adolfs, Y., Vangoor, V. R., de Jongh, R., Ljubikj, T., Peeters, L., & 16 othersSeeler, S., Mocholi, E., Basak, O., Gordon, D., Giuliani, F., Verhoeff, T., Korsten, G., Calafat Pla, T., Venø, M. T., Kjems, J., Talbot, K., van Es, M. A., Veldink, J. H., van den Berg, L. H., Zelina, P. & Pasterkamp, R. J., 29 Aug 2024, In: Nature Communications. 15, 1, 7484.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Computing linkage disequilibrium aware genome embeddings using autoencoders

  Taş, G., Westerdijk, T., Postma, E., Veldink, J. H., Schonhuth, A. & Balvert, M., 1 Jun 2024, In: Bioinformatics. 40, 6, 10 p., btae326.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Drug classes affecting intracranial aneurysm risk: Genetic correlation and Mendelian randomization

  Ruigrok, Y. M., Veldink, J. H. & Bakker, M. K., Sept 2024, In: European Stroke Journal. 9, 3, p. 687-695 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intracranial Aneurysm 100%
  • Random Allocation 90%
  • Subarachnoid Hemorrhage 48%
  • Pharmaceutical Preparations 38%
  • Antidepressive Agents 33%

• Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS

  Marriott, H., Spargo, T. P., Al Khleifat, A., Andersen, P. M., Başak, N. A., Cooper-Knock, J., Corcia, P., Couratier, P., de Carvalho, M., Drory, V., Gotkine, M., Landers, J. E., McLaughlin, R., Pardina, J. S. M., Morrison, K. E., Pinto, S., Shaw, C. E., Shaw, P. J., Silani, V., Ticozzi, N., & 9 othersvan Damme, P., van den Berg, L. H., Vourc'h, P., Weber, M., Veldink, J. H., Dobson, R. J., Schwab, P., Al-Chalabi, A. & Iacoangeli, A., Jul 2024, In: Annals of Clinical and Translational Neurology. 11, 7, p. 1775-1786 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Phenotype prediction using biologically interpretable neural networks on multi-cohort multi-omics data

  2 Aug 2024, In: npj Systems Biology and Applications. 10, 1, p. 1-10 10 p., 81.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Potential causal association between gut microbiome and posttraumatic stress disorder

  He, Q., Wang, W., Xu, D., Xiong, Y., Tao, C., You, C., Ma, L., Ma, J., Nievergelt, C. M., Maihofer, A. X., Klengel, T., Atkinson, E. G., Chen, C. Y., Choi, K. W., Coleman, J. R. I., Dalvie, S., Duncan, L. E., Logue, M. W., Provost, A. C., Ratanatharathorn, A., & 165 othersStein, M. B., Torres, K., Aiello, A. E., Almli, L. M., Amstadter, A. B., Andersen, S. B., Andreassen, O. A., Arbisi, P. A., Ashley-Koch, A. E., Austin, S. B., Avdibegovic, E., Babić, D., Bækvad-Hansen, M., Baker, D. G., Beckham, J. C., Bierut, L. J., Bisson, J. I., Boks, M. P., Bolger, E. A., Børglum, A. D., Bradley, B., Brashear, M., Breen, G., Bryant, R. A., Bustamante, A. C., Bybjerg-Grauholm, J., Calabrese, J. R., Caldas-de-Almeida, J. M., Dale, A. M., Daly, M. J., Daskalakis, N. P., Deckert, J., Delahanty, D. L., Dennis, M. F., Disner, S. G., Domschke, K., Dzubur-Kulenovic, A., Erbes, C. R., Evans, A., Farrer, L. A., Feeny, N. C., Flory, J. D., Forbes, D., Franz, C. E., Galea, S., Garrett, M. E., Gelaye, B., Gelernter, J., Geuze, E., Gillespie, C., Uka, A. G., Gordon, S. D., Guffanti, G., Hammamieh, R., Harnal, S., Hauser, M. A., Heath, A. C., Hemmings, S. M. J., Hougaard, D. M., Jakovljevic, M., Jett, M., Johnson, E. O., Jones, I., Jovanovic, T., Qin, X. J., Junglen, A. G., Karstoft, K. I., Kaufman, M. L., Kessler, R. C., Khan, A., Kimbrel, N. A., King, A. P., Koen, N., Kranzler, H. R., Kremen, W. S., Lawford, B. R., Lebois, L. A. M., Lewis, C. E., Linnstaedt, S. D., Lori, A., Lugonja, B., Luykx, J. J., Lyons, M. J., Maples-Keller, J., Marmar, C., Martin, A. R., Martin, N. G., Maurer, D., Mavissakalian, M. R., McFarlane, A., McGlinchey, R. E., McLaughlin, K. A., McLean, S. A., McLeay, S., Mehta, D., Milberg, W. P., Miller, M. W., Morey, R. A., Morris, C. P., Mors, O., Mortensen, P. B., Neale, B. M., Nelson, E. C., Nordentoft, M., Norman, S. B., O’Donnell, M., Orcutt, H. K., Panizzon, M. S., Peters, E. S., Peterson, A. L., Peverill, M., Pietrzak, R. H., Polusny, M. A., Rice, J. P., Ripke, S., Risbrough, V. B., Roberts, A. L., Rothbaum, A. O., Rothbaum, B. O., Roy-Byrne, P., Ruggiero, K., Rung, A., Rutten, B. P. F., Saccone, N. L., Sanchez, S. E., Schijven, D., Seedat, S., Seligowski, A. V., Seng, J. S., Sheerin, C. M., Silove, D., Smith, A. K., Smoller, J. W., Solovieff, N., Sponheim, S. R., Stein, D. J., Sumner, J. A., Teicher, M. H., Thompson, W. K., Trapido, E., Uddin, M., Ursano, R. J., van den Heuvel, L. L., van Hooff, M., Vermetten, E., Vinkers, C. H., Voisey, J., Wang, Y., Wang, Z., Werge, T., Williams, M. A., Williamson, D. E., Winternitz, S., Wolf, C., Wolf, E. J., Wolff, J. D., Yehuda, R., Young, K. A., Young, R. M. D., Zhao, H., Zoellner, L. A., Liberzon, I., Ressler, K. J., Haas, M. & Koenen, K. C., 31 Jan 2024, In: Translational Psychiatry. 14, 1, 67.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Gastrointestinal Microbiome 100%
  • Post-Traumatic Stress Disorders 99%
  • Datasets 40%
  • Random Allocation 37%
  • Genomics 25%
  9 Downloads (Pure)

• Prognostic value of histopathologic traits independent of stromal tumor-infiltrating lymphocyte levels in chemotherapy-naïve patients with triple-negative breast cancer

  de Boo, L. W., Jóźwiak, K., Ter Hoeve, N. D., van Diest, P. J., Opdam, M., Wang, Y., Schmidt, M. K., de Jong, V., Kleiterp, S., Cornelissen, S., Baars, D., Koornstra, R. H. T., Kerver, E. D., van Dalen, T., Bins, A. D., Beeker, A., van den Heiligenberg, S. M., de Jong, P. C., Bakker, S. D., Rietbroek, R. C., & 30 othersKonings, I. R., Blankenburgh, R., Bijlsma, R. M., Imholz, A. L. T., Stathonikos, N., Vreuls, W., Sanders, J., Rosenberg, E. H., Koop, E. A., Varga, Z., van Deurzen, C. H. M., Mooyaart, A. L., Córdoba, A., Groen, E., Bart, J., Willems, S. M., Zolota, V., Wesseling, J., Sapino, A., Chmielik, E., Ryska, A., Broeks, A., Voogd, A. C., van der Wall, E., Siesling, S., Salgado, R., Dackus, G. M. H. E., Hauptmann, M., Kok, M. & Linn, S. C., Mar 2024, In: ESMO open. 9, 3, 102923.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Tumor-Infiltrating Lymphocytes 100%
  • Triple Negative Breast Neoplasms 95%
  • Confidence Intervals 47%
  • Drug Therapy 46%
  • Adjuvant Chemotherapy 26%

• Rare and common genetic determinants of mitochondrial function determine severity but not risk of amyotrophic lateral sclerosis

  Harvey, C., Weinreich, M., Lee, J. A. K., Shaw, A. C., Ferraiuolo, L., Mortiboys, H., Zhang, S., Hop, P. J., Zwamborn, R. A. J., van Eijk, K., Julian, T. H., Moll, T., Iacoangeli, A., Al Khleifat, A., Quinn, J. P., Pfaff, A. L., Kõks, S., Poulton, J., Battle, S. L., Arking, D. E., & 5 othersSnyder, M. P., Veldink, J. H., Kenna, K. P., Shaw, P. J. & Cooper-Knock, J., 15 Feb 2024, In: Heliyon. 10, 3, e24975.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
• 2023

  Age- and sex-specific associations between risk scores for schizophrenia and self-reported health in the general population

  Paquin, V., Pries, L-K., Ten Have, M., Bak, M., Gunther, N., de Graaf, R., van Dorsselaer, S., Lin, B. D., van Eijk, K. R., Kenis, G., Richards, A., O'Donovan, M. C., Luykx, J. J., Rutten, B. P. F., van Os, J., Shah, J. L. & Guloksuz, S., Jan 2023, In: Social Psychiatry and Psychiatric Epidemiology. 58, 1, p. 43-52 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • schizophrenia 100%
  • Schizophrenia 74%
  • Health 44%
  • health 41%
  • Population 36%
  17 Downloads (Pure)

• A Genome-Wide Association Study of Outcome After Aneurysmal Subarachnoid Haemorrhage: Discovery Analysis

  Gaastra, B., Alexander, S., Bakker, M. K., Bhagat, H., Bijlenga, P., Blackburn, S. L., Collins, M. K., Doré, S., Griessenauer, C. J., Hendrix, P., Hong, E. P., Hostettler, I. C., Houlden, H., IIhara, K., Jeon, J. P., Kim, B. J., Li, J., Morel, S., Nyquist, P., Ren, D., & 5 othersRuigrok, Y. M., Werring, D., Tapper, W., Galea, I. & Bulters, D., Oct 2023, In: Translational Stroke Research. 14, 5, p. 681-687 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Subarachnoid Hemorrhage 100%
  • Genome-Wide Association Study 99%
  • Genome 25%
  • sphingosine 1-phosphate 24%
  • Meta-Analysis 14%
  17 Downloads (Pure)

• Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study

  Bakker, M. K., Van Straten, T., Chong, M., Paré, G., Gill, D. & Ruigrok, Y. M., 1 Jan 2023, In: Stroke. 54, 1, p. 208-216 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intracranial Aneurysm 100%
  • Random Allocation 90%
  • Pharmaceutical Preparations 38%
  • Epilepsy 14%
  • Odds Ratio 10%
  6 Downloads (Pure)

• Association of Risk Variants in the CFH Gene With Elevated Levels of Coagulation and Complement Factors in Idiopathic Multifocal Choroiditis

  de Groot, E. L., Ossewaarde-van Norel, J., de Boer, J. H., Hiddingh, S., Bakker, B., van Huet, R. A. C., Ten Dam-van Loon, N. H., Thiadens, A. A. H. J., Meester-Smoor, M. A., de Jong-Hesse, Y., Los, L. I., den Hollander, A. I., Boon, C. J. F., Kiemeney, L. A., van Eijk, K. R., Bakker, M. K., Hoyng, C. B. & Kuiper, J. J. W., 17 Aug 2023, In: JAMA ophthalmology. 141, 8, p. 737-745 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Multifocal Choroiditis 100%
  • Blood Coagulation Factors 66%
  • Genes 23%
  • Alleles 14%
  • factor H-related protein 2 10%
  5 Downloads (Pure)

• Associations between genetic liabilities to smoking behavior and schizophrenia symptoms in patients with a psychotic disorder, their siblings and healthy controls

  May 2023, In: Psychiatry Research. 323, p. 1-8 115143.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Psychotic Disorders 100%
  • Siblings 97%
  • Schizophrenia 87%
  • Smoking 77%
  • Phenotype 18%
  15 Downloads (Pure)

• Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia

  Lin, B. D., Pinzón-Espinosa, J., Blouzard, E., Van Der Horst, M. Z., Okhuijsen-Pfeifer, C., Van Eijk, K. R., Guloksuz, S., Peyrot, W. J. & Luykx, J. J., 1 Feb 2023, In: JAMA Psychiatry. 80, 2, p. 181-185 5 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Clozapine 100%
  • Psychotic Disorders 79%
  • Schizophrenia 69%
  • Antipsychotic Agents 51%
  • Odds Ratio 41%

• Context v. algorithm: Evidence that a transdiagnostic framework of contextual clinical characterization is of more clinical value than categorical diagnosis

  Van Os, J., Pries, L. K., Ten Have, M., De Graaf, R., Van Dorsselaer, S., Bak, M., Kenis, G., Lin, B. D., Gunther, N., Luykx, J. J., Rutten, B. P. F. & Guloksuz, S., 25 Apr 2023, In: Psychological medicine. 53, 5, p. 1825-1833 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • staging 100%
  • need for care 58%
  • sociodemographic factors 52%
  • evidence 51%
  • Psychological Extraversion 51%
  14 Downloads (Pure)

• Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

  1 Mar 2023, In: Stroke. 54, 3, p. 810-818 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intracranial Aneurysm 100%
  • Subarachnoid Hemorrhage 96%
  • Incidence 9%
  • Odds Ratio 8%
  • Internal Carotid Artery 7%
  1 Citation (Scopus)

  5 Downloads (Pure)

• Genetic variability in sporadic amyotrophic lateral sclerosis

  Van Daele, S. H., Moisse, M., van Vugt, J. J. F. A., Zwamborn, R. A. J., van der Spek, R., van Rheenen, W., Van Eijk, K., Kenna, K., Corcia, P., Vourc'h, P., Couratier, P., Hardiman, O., McLaughin, R., Gotkine, M., Drory, V., Ticozzi, N., Silani, V., Ratti, A., de Carvalho, M., Mora Pardina, J. S., & 14 othersPovedano, M., Andersen, P. M., Weber, M., Başak, N. A., Shaw, C., Shaw, P. J., Morrison, K. E., Landers, J. E., Glass, J. D., van Es, M., van den Berg, L. H., Al-Chalabi, A., Veldink, J. & Van Damme, P., 1 Sept 2023, In: Brain : a journal of neurology. 146, 9, p. 3760-3769 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Amyotrophic lateral sclerosis 1 100%
  • Amyotrophic Lateral Sclerosis 73%
  • Genes 30%
  • Genetic Variation 19%
  • Medical Genetics 18%
  13 Downloads (Pure)

• Genetic variation in NFE2L2 is associated with outcome following aneurysmal subarachnoid haemorrhage

  Gaastra, B., Duncan, P., Bakker, M. K., Hostettler, I. C., Alg, V. S., Houlden, H., Ruigrok, Y. M., Galea, I., Tapper, W., Werring, D. & Bulters, D., Jan 2023, In: European Journal of Neurology. 30, 1, p. 116-124 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Subarachnoid Hemorrhage 100%
  • Genetic Variation 92%
  • Single Nucleotide Polymorphism 40%
  • Computer Simulation 29%
  • Alleles 23%
  1 Citation (Scopus)

  25 Downloads (Pure)

• Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

  Jun 2023, In: Nature Genetics. 55, 6, p. 964-972 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Spontaneous Coronary Artery Dissection 100%
  • Genome-Wide Association Study 65%
  • Meta-Analysis 47%
  • Arteries 46%
  • Genes 25%
  3 Downloads (Pure)

• Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: Testing gene × environment moderation and mediation

  Elkrief, L., Lin, B., Marchi, M., Afzali, M. H., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Desrivières, S., Flor, H., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Martinot, J. L., Martinot, M. L. P., Nees, F., Orfanos, D. P., Paus, T., Poustka, L., Hohmann, S., & 8 othersFröhner, J. H., Smolka, M. N., Walter, H., Whelan, R., Schumann, G., Luykx, J., Boks, M. P. & Conrod, P. J., 23 Apr 2023, In: Psychological medicine. 53, 5, p. 1759-1769 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • schizophrenia 100%
  • Cannabis 97%
  • adulthood 78%
  • mediation 76%
  • Schizophrenia 74%
  8 Downloads (Pure)

• Integrative genetic analysis illuminates ALS heritability and identifies risk genes

  Megat, S., Mora, N., Sanogo, J., Roman, O., Catanese, A., Alami, N. O., Freischmidt, A., Mingaj, X., De Calbiac, H., Muratet, F., Dirrig-Grosch, S., Dieterle, S., Van Bakel, N., Müller, K., Sieverding, K., Weishaupt, J., Andersen, P. M., Weber, M., Neuwirth, C., Margelisch, M., & 18 othersSommacal, A., Van Eijk, K. R., Veldink, J. H., Lautrette, G., Couratier, P., Camuzat, A., Le Ber, I., Grassano, M., Chio, A., Boeckers, T., Ludolph, A. C., Roselli, F., Yilmazer-Hanke, D., Millecamps, S., Kabashi, E., Storkebaum, E., Sellier, C. & Dupuis, L., Dec 2023, In: Nature Communications. 14, 1, 342.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Large-scale analysis of structural brain asymmetries in schizophrenia via the ENIGMA consortium

  4 Apr 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2213880120.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Schizophrenia 100%
  • Datasets 72%
  • Brain 60%
  • Globus Pallidus 35%
  • Gyrus Cinguli 31%
  3 Downloads (Pure)

• Longitudinal associations between alcohol use, smoking, genetic risk scoring and symptoms of depression in the general population: A prospective 6-year cohort study

  De Boer, N., Vermeulen, J., Lin, B., Van Os, J., Ten Have, M., De Graaf, R., Van Dorsselaer, S., Bak, M., Rutten, B., Batalla, A., Guloksuz, S. & Luykx, J. J., 11 Mar 2023, In: Psychological medicine. 53, 4, p. 1409-1417 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • smoking 100%
  • alcohol 81%
  • Alcohols 79%
  • Smoking 77%
  • Cohort Studies 72%
  10 Downloads (Pure)

• Polygenic risk, familial liability and stress reactivity in psychosis: an experience sampling study

  Schick, A., van Winkel, R., Lin, B. D., Luykx, J. J., de Zwarte, S. M. C., van Eijk, K. R., Reininghaus, U., Myin-Germeys, I. & Reininghaus, U., 7 May 2023, In: Psychological medicine. 53, 7, p. 2798-2807 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Ecological Momentary Assessment 100%
  • Sampling Studies 91%
  • psychosis 82%
  • Psychotic Disorders 67%
  • liability 64%
  14 Downloads (Pure)

• The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study

  15 Feb 2023, In: Biological Psychiatry. 93, 4, p. 362-369 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Attention Deficit Disorder with Hyperactivity 100%
  • Post-Traumatic Stress Disorders 96%
  • Random Allocation 96%
  • Population 38%
  • Siblings 30%

• Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis

  Tazelaar, G. H. P., Hop, P. J., Seelen, M., van Vugt, J. J. F. A., van Rheenen, W., Kool, L., van Eijk, K. R., Gijzen, M., Dooijes, D., Moisse, M., Calvo, A., Moglia, C., Brunetti, M., Canosa, A., Nordin, A., Pardina, J. S. M., Ravits, J., Al-Chalabi, A., Chio, A., McLaughlin, R. L., & 9 othersHardiman, O., Van Damme, P., de Carvalho, M., Neuwirth, C., Weber, M., Andersen, P. M., van den Berg, L. H., Veldink, J. H. & van Es, M. A., Feb 2023, In: Neurobiology of Aging. 122, p. 76-87 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Monozygotic Twins 100%
  • Whole Genome Sequencing 96%
  • Amyotrophic Lateral Sclerosis 89%
  • Mutation 46%
  • Motor Neurons 40%
  7 Downloads (Pure)
• 2022

  A polygenic-informed approach to a predictive EEG signature empowers antidepressant treatment prediction: A proof-of-concept study

  Meijs, H., Prentice, A., Lin, B. D., De Wilde, B., Van Hecke, J., Niemegeers, P., van Eijk, K., Luykx, J. J. & Arns, M., Sept 2022, In: European Neuropsychopharmacology. 62, p. 49-60 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Proof of Concept Study 100%
  • Antidepressive Agents 72%
  • Transcranial Magnetic Stimulation 71%
  • Electroencephalography 67%
  • Psychotherapy 46%
  20 Downloads (Pure)

• Childhood maltreatment mediates the effect of the genetic background on psychosis risk in young adults

  Marchi, M., Elkrief, L., Alkema, A., van Gastel, W., Schubart, C. D., van Eijk, K. R., Luykx, J. J., Branje, S., Mastrotheodoros, S., Galeazzi, G. M., van Os, J., Cecil, C. A., Conrod, P. J. & Boks, M. P., Dec 2022, In: Translational Psychiatry. 12, 1, p. 1-10 219.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Genetic Background 100%
  • Psychotic Disorders 87%
  • Young Adult 75%
  • Schizophrenia 43%
  • Marijuana Smoking 10%
  3 Downloads (Pure)

• Comprehensive analyses of RNA-seq and genome-wide data point to enrichment of neuronal cell type subsets in neuropsychiatric disorders

  Olislagers, M., Rademaker, K., Adan, R. A. H., Lin, B. D. & Luykx, J. J., Feb 2022, In: Molecular Psychiatry. 27, 2, p. 947-955 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • RNA-Seq 100%
  • Genome 58%
  • Datasets 20%
  • Pyramidal Cells 18%
  • Genome-Wide Association Study 17%
  6 Downloads (Pure)

• Enhancing Discovery of Genetic Variants for Posttraumatic Stress Disorder Through Integration of Quantitative Phenotypes and Trauma Exposure Information

  1 Apr 2022, In: Biological Psychiatry. 91, 7, p. 626-636 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Post-Traumatic Stress Disorders 100%
  • Phenotype 61%
  • Genome-Wide Association Study 49%
  • Wounds and Injuries 49%
  • Veterans 14%
  4 Downloads (Pure)

• Event-related potentials and use of psychotropic medication in major psychiatric disorders

  Kool, L., Oranje, B., Meijs, H., De Wilde, B., Van Hecke, J., Niemegeers, P. & Luykx, J. J., Aug 2022, In: Psychiatry Research. 314, p. 1-10 114637.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Evoked Potentials 100%
  • Mental Disorders 83%
  • Psychotic Disorders 79%
  • Substance-Related Disorders 75%
  • Mood Disorders 66%
  6 Downloads (Pure)

• Genetic variants associated with longitudinal changes in brain structure across the lifespan

  Apr 2022, In: Nature Neuroscience. 25, 4, p. 421-432 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Longevity 100%
  • Brain 54%
  • Sleep Initiation and Maintenance Disorders 13%
  • Genome-Wide Association Study 12%
  • Growth 12%

• Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

  7 Apr 2022, In: Translational Psychiatry. 12, 1, 145.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Clozapine 100%
  • Genome-Wide Association Study 89%
  • Schizophrenia 69%
  • Cytochrome P-450 CYP2C19 64%
  • Genotype 43%
  12 Downloads (Pure)

• Genome-Wide Association Study of Clinical Outcome After Aneurysmal Subarachnoid Haemorrhage: Protocol

  Gaastra, B., Alexander, S., Bakker, M. K., Bhagat, H., Bijlenga, P., Blackburn, S., Collins, M. K., Doré, S., Griessenauer, C., Hendrix, P., Hong, E. P., Hostettler, I. C., Houlden, H., IIhara, K., Jeon, J. P., Kim, B. J., Kumar, M., Morel, S., Nyquist, P., Ren, D., & 5 othersRuigrok, Y. M., Werring, D., Galea, I., Bulters, D. & Tapper, W., Aug 2022, In: Translational Stroke Research. 13, 4, p. 565-576 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Subarachnoid Hemorrhage 100%
  • Genome-Wide Association Study 99%
  • Glasgow Outcome Scale 31%
  • Congresses 23%
  • Genetic Variation 23%
  8 Downloads (Pure)

• Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis

  Zhang, S., Cooper-Knock, J., Weimer, A. K., Shi, M., Moll, T., Marshall, J. N. G., Harvey, C., Nezhad, H. G., Franklin, J., Souza, C. D. S., Ning, K., Wang, C., Li, J., Dilliott, A. A., Farhan, S., Elhaik, E., Pasniceanu, I., Livesey, M. R., Eitan, C., Hornstein, E., & 5 othersKenna, K. P., Veldink, J. H., Ferraiuolo, L., Shaw, P. J. & Snyder, M. P., 16 Mar 2022, In: Neuron. 110, 6, p. 992-1008.e11

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Amyotrophic Lateral Sclerosis 100%
  • Genome 63%
  • Genome-Wide Association Study 48%
  • Motor Neurons 45%
  • Motor Neuron Disease 29%
  1 Downloads (Pure)

• Genome-wide linkage analysis combined with genome sequencing in large families with intracranial aneurysms

  Bakker, M. K., Cobyte, S., Hennekam, F. A. M., Rinkel, G. J. E., Veldink, J. H. & Ruigrok, Y. M., Jul 2022, In: European Journal of Human Genetics. 30, 7, p. 833-840 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intracranial Aneurysm 100%
  • Genome 62%
  • Rupture 15%
  • Cerebral Arteries 11%
  • Population Control 10%
  5 Downloads (Pure)

• Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

  23 Feb 2022, In: Science translational medicine. 14, 633, p. 1-15 eabj0264.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Amyotrophic Lateral Sclerosis 100%
  • Metabolic Networks and Pathways 93%
  • DNA Methylation 91%
  • Cholesterol 68%
  • Genome 63%

• Intracranial Aneurysm Classifier Using Phenotypic Factors: An International Pooled Analysis

  Sept 2022, In: Journal of Personalized Medicine. 12, 9, p. 1-14 1410.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Intracranial Aneurysm 100%
  • Rupture 21%
  • Ruptured Aneurysm 18%
  • Subarachnoid Hemorrhage 5%
  • Smokers 4%
  18 Downloads (Pure)

• Psychological trauma and the genetic overlap between posttraumatic stress disorder and major depressive disorder

  4 Dec 2022, In: Psychological medicine. 52, 16, p. 3975-3984 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Psychological Trauma 100%
  • posttraumatic stress disorder 80%
  • Major Depressive Disorder 72%
  • Post-Traumatic Stress Disorders 68%
  • trauma 60%
  3 Citations (Scopus)

• Rare copy number variation in posttraumatic stress disorder

  Dec 2022, In: Molecular Psychiatry. 27, 12, p. 5062-5069 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Post-Traumatic Stress Disorders 100%
  • Mental Disorders 27%
  • Overlapping Genes 24%
  • Genetic Crossing Over 24%
  • Genome 23%
  21 Downloads (Pure)

• Selective outcome reporting across psychopharmacotherapy randomized controlled trials

  Lancee, M., Schuring, M., Tijdink, J. K., Chan, A. W., Vinkers, C. H. & Luykx, J. J., Mar 2022, In: International Journal of Methods in Psychiatric Research. 31, 1, p. 1-4 e1900.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Randomized Controlled Trials 100%
  • Odds Ratio 95%
  • Mental Disorders 60%
  • Major Depressive Disorder 38%
  • Depressive Disorder 38%
  19 Downloads (Pure)

• Sex Hormones and Risk of Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study

  Molenberg, R., Thio, C. H. L., Aalbers, M. W., Uyttenboogaart, M., Larsson, S. C., Bakker, M. K., Ruigrok, Y. M., Snieder, H. & Van Dijk, J. M. C., 1 Sept 2022, In: Stroke. 53, 9, p. 2870-2875 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Sex Hormone-Binding Globulin 100%
  • Gonadal Steroid Hormones 86%
  • Subarachnoid Hemorrhage 83%
  • Random Allocation 77%
  • Testosterone 62%
  6 Downloads (Pure)

• Stroke genetics informs drug discovery and risk prediction across ancestries

  3 Nov 2022, In: Nature. 611, 7934, p. 115-123 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Drug Discovery 100%
  • Stroke 66%
  • Genome-Wide Association Study 40%
  • Meta-Analysis 14%
  • Pharmaceutical Preparations 12%
  8 Downloads (Pure)

• Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

  Al Khleifat, A., Iacoangeli, A., van Vugt, J. J. F. A., Bowles, H., Moisse, M., Zwamborn, R. A. J., van der Spek, R. A. A., Shatunov, A., Cooper-Knock, J., Topp, S., Byrne, R., Gellera, C., López, V., Jones, A. R., Opie-Martin, S., Vural, A., Campos, Y., van Rheenen, W., Kenna, B., Van Eijk, K. R., & 27 othersKenna, K., Weber, M., Smith, B., Fogh, I., Silani, V., Morrison, K. E., Dobson, R., van Es, M. A., McLaughlin, R. L., Vourc'h, P., Chio, A., Corcia, P., de Carvalho, M., Gotkine, M., Panades, M. P., Mora, J. S., Shaw, P. J., Landers, J. E., Glass, J. D., Shaw, C. E., Basak, N., Hardiman, O., Robberecht, W., Van Damme, P., van den Berg, L. H., Veldink, J. H. & Al-Chalabi, A., 28 Jan 2022, In: npj Genomic Medicine. 7, 1, p. 1-8 8.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Amyotrophic Lateral Sclerosis 100%
  • Genome 63%
  • Genomic Structural Variation 19%
  • Genes 14%
  • Insertional Mutagenesis 13%
  6 Downloads (Pure)

• Telomere length analysis in amyotrophic lateral sclerosis using large-scale whole genome sequence data

  15 Dec 2022, In: Frontiers in Cellular Neuroscience. 16, p. 1050596 1050596.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  • Telomere 100%
  • Amyotrophic Lateral Sclerosis 97%
  • Genome 61%
  • Amyotrophic lateral sclerosis 1 34%
  • Genetic Variation 12%

• Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma

  van Kessel, E., Berendsen, S., Baumfalk, A. E., Venugopal, H., Krijnen, E. A., Spliet, W. G. M., Van Hecke, W., Giuliani, F., Seute, T., Van Zandvoort, M. J. E., Snijders, T. J. & Robe, P. A., 1 Oct 2022, In: Neuro-Oncology. 24, 10, p. 1660-1670 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Glioma 100%
  • Neoplasms 34%
  • Tumor Burden 34%
  • Cognitive Dysfunction 29%
  • Semaphorin-3A 27%
  13 Downloads (Pure)

• Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS

  Apr 2022, In: Nature Neuroscience. 25, 4, p. 433-445 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Interleukin-18 Receptor beta Subunit 100%
  • Whole Genome Sequencing 52%
  • Amyotrophic Lateral Sclerosis 48%
  • 3' Untranslated Regions 46%
  • Genome 30%
• 2021

  Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells

  Zhang, C., van Leeuwen, W., Blotenburg, M., Aguilera-Gomez, A., Brussee, S., Grond, R., Kampinga, H. H. & Rabouille, C., 1 Sept 2021, In: Journal of cell science. 134, 17, jcs258685.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Drosophila 100%
  • Salts 94%
  • Phosphotransferases 83%
  • Amino Acids 75%
  • Salt Stress 58%
  1 Citation (Scopus)

  19 Downloads (Pure)