Group Snippert, section Molecular Cancer Research

2024

DNA damage induces p53-independent apoptosis through ribosome stalling

Boon, N. J., Oliveira, R. A., Körner, P-R., Kochavi, A., Mertens, S., Malka, Y., Voogd, R., van der Horst, S. E. M., Huismans, M. A., Smabers, L. P., Draper, J. M., Wessels, L. F. A., Haahr, P., Roodhart, J. M. L., Schumacher, T. N. M., Snippert, H. J., Agami, R. & Brummelkamp, T. R., 17 May 2024, In: Science. 384, 6697, p. 785-792 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

EXO1 protects BRCA1-deficient cells against toxic DNA lesions

van de Kooij, B., Schreuder, A., Pavani, R., Garzero, V., Uruci, S., Wendel, T. J., van Hoeck, A., San Martin Alonso, M., Everts, M., Koerse, D., Callen, E., Boom, J., Mei, H., Cuppen, E., Luijsterburg, M. S., van Vugt, M. A. T. M., Nussenzweig, A., van Attikum, H. & Noordermeer, S. M., 15 Feb 2024, In: Molecular Cell. 84, 4, p. 659-674.e7

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Homopolymer switches mediate adaptive mutability in mismatch repair-deficient colorectal cancer

Kayhanian, H., Cross, W., van der Horst, S. E. M., Barmpoutis, P., Lakatos, E., Caravagna, G., Zapata, L., Van Hoeck, A., Middelkamp, S., Litchfield, K., Steele, C., Waddingham, W., Patel, D., Milite, S., Jin, C., Baker, A-M., Alexander, D. C., Khan, K., Hochhauser, D., Novelli, M., & 17 othersWerner, B., van Boxtel, R., Hageman, J. H., Buissant des Amorie, J. R., Linares, J., Ligtenberg, M. J. L., Nagtegaal, I. D., Laclé, M. M., Moons, L. M. G., Brosens, L. A. A., Pillay, N., Sottoriva, A., Graham, T. A., Rodriguez-Justo, M., Shiu, K-K., Snippert, H. J. G. & Jansen, M., Aug 2024, In: Nature Genetics. 56, 7, p. 1420-1433 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Smabers, L. P., Wensink, E., Verissimo, C. S., Koedoot, E., Pitsa, K-C., Huismans, M. A., Higuera Barón, C., Doorn, M., Valkenburg-van Iersel, L. B., Cirkel, G. A., Brousali, A., Overmeer, R., Koopman, M., Braat, M. N., Penning de Vries, B., Elias, S. G., Vries, R. G., Kranenburg, O., Boj, S. F. & Roodhart, J. M., 27 Feb 2024, In: Journal of experimental & clinical cancer research. 43, 1, p. 1-16 16 p., 61.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

2023

Co-cultures of colon cancer cells and cancer-associated fibroblasts recapitulate the aggressive features of mesenchymal-like colon cancer

Strating, E., Verhagen, M. P., Wensink, E., Dünnebach, E., Wijler, L., Aranguren, I., De la Cruz, A. S., Peters, N. A., Hageman, J. H., van der Net, M. M. C., van Schelven, S., Laoukili, J., Fodde, R., Roodhart, J., Nierkens, S., Snippert, H., Gloerich, M., Rinkes, I. B., Elias, S. G. & Kranenburg, O., 2023, In: Frontiers in Immunology. 14, 1053920.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

11 Downloads (Pure)

Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox

Middelkamp, S., Manders, F., Peci, F., van Roosmalen, M. J., González, D. M., Bertrums, E. J. M., van der Werf, I., Derks, L. L. M., Groenen, N. M., Verheul, M., Trabut, L., Pleguezuelos-Manzano, C., Brandsma, A. M., Antoniou, E., Reinhardt, D., Bierings, M., Belderbos, M. E. & van Boxtel, R., 13 Sept 2023, In: Cell genomics. 3, 9, 23 p., 100389.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

21 Downloads (Pure)

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Mertens, S., Huismans, M. A., Verissimo, C. S., Ponsioen, B., Overmeer, R., Proost, N., van Tellingen, O., van de Ven, M., Begthel, H., Boj, S. F., Clevers, H., Roodhart, J. M. L., Bos, J. L. & Snippert, H. J. G., 25 Apr 2023, In: Cell Reports. 42, 4, 112324.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

25 Downloads (Pure)

EXO1-mediated DNA repair by single-strand annealing is essential for BRCA1-deficient cells

van de Kooij, B., Schreuder, A., Pavani, R. S., Garzero, V., Van Hoeck, A., San Martin Alonso, M., Koerse, D., Wendel, T. J., Callen, E., Boom, J., Mei, H., Cuppen, E., Nussenzweig, A., van Attikum, H. & Noordermeer, S. M., 24 Feb 2023, BioRxiv, p. 1-37, 37 p.

Research output: Working paper › Preprint › Academic

Pan-cancer whole-genome comparison of primary and metastatic solid tumours

Martínez-Jiménez, F., Movasati, A., Brunner, S. R., Nguyen, L., Priestley, P., Cuppen, E. & Van Hoeck, A., 8 Jun 2023, In: Nature. 618, 7964, p. 333-341 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

28 Downloads (Pure)

The genome-wide mutational consequences of DNA hypomethylation

Besselink, N., Keijer, J., Vermeulen, C., Boymans, S., de Ridder, J., van Hoeck, A., Cuppen, E. & Kuijk, E., 27 Apr 2023, In: Scientific Reports. 13, 1, 6874.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

1 Downloads (Pure)

2022

Cellular Heterogeneity during Metastatic Colonization of Colorectal Cancer: Investigating phenotypic, transcriptomic, and chromatin changes over time

Puschhof, M., 14 Nov 2022, Utrecht University. 295 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

File

48 Downloads (Pure)

Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage

Bollen, Y., Hageman, J. H., van Leenen, P., Derks, L. L. M., Ponsioen, B., Buissant des Amorie, J. R., Verlaan-Klink, I., van den Bos, M., Terstappen, L. W. M. M., van Boxtel, R. & Snippert, H. J. G., 28 Jan 2022, In: PLoS Biology. 20, 1, p. 1-16 e3001527.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

26 Downloads (Pure)

Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Heinz, M. C., Peters, N. A., Oost, K. C., Lindeboom, R. G. H., van Voorthuijsen, L., Fumagalli, A., van der Net, M. C., de Medeiros, G., Hageman, J. H., Verlaan-Klink, I., Borel Rinkes, I. H. M., Liberali, P., Gloerich, M., van Rheenen, J., Vermeulen, M., Kranenburg, O. & Snippert, H. J. G., 15 May 2022, In: Cancer Research. 82, 10, p. 1953-1968 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

2 Downloads (Pure)

Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines

Glykofridis, I. E., Henneman, A. A., Balk, J. A., Haas, R. G. D., Westland, D., Piersma, S. R., Knol, J. C., Pham, T. V., Boekhout, M., Zwartkruis, F. J. T., Wolthuis, R. M. F. & Jimenez, C. R., Sept 2022, In: Molecular and Cellular Proteomics. 21, 9, 100263.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

8 Downloads (Pure)

Retrograde movements determine effective stem cell numbers in the intestine

Azkanaz, M., Corominas-Murtra, B., Ellenbroek, S. I. J., Bruens, L., Webb, A. T., Laskaris, D., Oost, K. C., Lafirenze, S. J. A., Annusver, K., Messal, H. A., Iqbal, S., Flanagan, D. J., Huels, D. J., Rojas-Rodríguez, F., Vizoso, M., Kasper, M., Sansom, O. J., Snippert, H. J., Liberali, P., Simons, B. D., & 3 othersKatajisto, P., Hannezo, E. & van Rheenen, J., 21 Jul 2022, In: Nature. 607, 7919, p. 548-554 7 p.

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Scopus)

2021

A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium

van der Linden, F. H., Mahlandt, E. K., Arts, J. J. G., Beumer, J., Puschhof, J., de Man, S. M. A., Chertkova, A. O., Ponsioen, B., Clevers, H., van Buul, J. D., Postma, M., Gadella, T. W. J. & Goedhart, J., Dec 2021, In: Nature Communications. 12, 1, p. 1-13 7159.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Chromosomal copy number heterogeneity predicts survival rates across cancers

van Dijk, E., van den Bosch, T., Lenos, K. J., El Makrini, K., Nijman, L. E., van Essen, H. F. B., Lansu, N., Boekhout, M., Hageman, J. H., Fitzgerald, R. C., Punt, C. J. A., Tuynman, J. B., Snippert, H. J. G., Kops, G. J. P. L., Medema, J. P., Ylstra, B., Vermeulen, L. & Miedema, D. M., Dec 2021, In: Nature Communications. 12, 1, p. 1-12 3188.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

5 Downloads (Pure)

Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells

Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S. & den Hertog, J., 15 Apr 2021, In: Oncogene. 40, 15, p. 2741-2755 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

1 Citation (Scopus)

6 Downloads (Pure)

Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Ponsioen, B., Post, J. B., Buissant des Amorie, J. R., Laskaris, D., van Ineveld, R. L., Kersten, S., Bertotti, A., Sassi, F., Sipieter, F., Cappe, B., Mertens, S., Verlaan-Klink, I., Boj, S. F., Vries, R. G. J., Rehmann, H., Vandenabeele, P., Riquet, F. B., Trusolino, L., Bos, J. L. & Snippert, H. J. G., Apr 2021, In: Nature Cell Biology. 23, 4, p. 377-390 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Bollen, Y., Stelloo, E., van Leenen, P., van den Bos, M., Ponsioen, B., Lu, B., van Roosmalen, M. J., Bolhaqueiro, A. C. F., Kimberley, C., Mossner, M., Cross, W. C. H., Besselink, N. J. M., van der Roest, B., Boymans, S., Oost, K. C., de Vries, S. G., Rehmann, H., Cuppen, E., Lens, S. M. A., Kops, G. J. P. L., & 6 othersKloosterman, W. P., Terstappen, L. W. M. M., Barnes, C. P., Sottoriva, A., Graham, T. A. & Snippert, H. J. G., Aug 2021, In: Nature Genetics. 53, 8, p. 1187-1195 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

14 Downloads (Pure)

2020

A Biosensor for the Mitotic Kinase MPS1 Reveals Spatiotemporal Activity Dynamics and Regulation

Kuijt, T. E. F., Lambers, M. L. A., Weterings, S., Ponsioen, B., Bolhaqueiro, A. C. F., Staijen, D. H. M. & Kops, G. J. P. L., 5 Oct 2020, In: Current Biology. 30, 19, p. 3862-3870.e6

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

10 Downloads (Pure)

Calorie Restriction Increases the Number of Competing Stem Cells and Decreases Mutation Retention in the Intestine

Bruens, L., Ellenbroek, S. I. J., Suijkerbuijk, S. J. E., Azkanaz, M., Hale, A. J., Toonen, P., Flanagan, D. J., Sansom, O. J., Snippert, H. J. & van Rheenen, J., 21 Jul 2020, In: Cell Reports. 32, 3, p. 1-10 107937.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

7 Downloads (Pure)

Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants

Post, J. B., Roodhart, J. M. L. & Snippert, H. J. G., Feb 2020, In: Trends in Cancer. 6, 2, p. 111-129 19 p.

Research output: Contribution to journal › Review article › peer-review

High-Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells

Beumer, J., Puschhof, J., Bauzá-Martinez, J., Martínez-Silgado, A., Elmentaite, R., James, K. R., Ross, A., Hendriks, D., Artegiani, B., Busslinger, G. A., Ponsioen, B., Andersson-Rolf, A., Saftien, A., Boot, C., Kretzschmar, K., Geurts, M. H., Bar-Ephraim, Y. E., Pleguezuelos-Manzano, C., Post, Y., Begthel, H., & 12 othersvan der Linden, F., Lopez-Iglesias, C., van de Wetering, W. J., van der Linden, R., Peters, P. J., Heck, A. J. R., Goedhart, J., Snippert, H., Zilbauer, M., Teichmann, S. A., Wu, W. & Clevers, H., 11 Jun 2020, In: Cell. 181, 6, p. 1291-1306.e19

Research output: Contribution to journal › Article › Academic › peer-review

Intestinal Regeneration: Regulation by the Microenvironment

Hageman, J. H., Heinz, M. C., Kretzschmar, K., van der Vaart, J., Clevers, H. & Snippert, H. J. G., 24 Aug 2020, In: Developmental Cell. 54, 4, p. 435-446 12 p.

Research output: Contribution to journal › Review article › peer-review

In vivo visualization of intestinal stem cell and crypt dynamics

Bruens, L., 19 Nov 2020, Utrecht University. 164 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

File

4 Downloads (Pure)

Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

de Witte, C. J., Espejo Valle-Inclan, J., Hami, N., Lõhmussaar, K., Kopper, O., Vreuls, C. P. H., Jonges, G. N., van Diest, P., Nguyen, L., Clevers, H., Kloosterman, W. P., Cuppen, E., Snippert, H. J. G., Zweemer, R. P., Witteveen, P. O. & Stelloo, E., 16 Jun 2020, In: Cell Reports. 31, 11, 8 p., 107762.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

10 Downloads (Pure)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli, A., Oost, K. C., Kester, L., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., Heinz, M. C., Postrach, D., Seinstra, D., Sieuwerts, A. M., Martens, J. W. M., van der Elst, S., van Baalen, M., Bhowmick, D., Vrisekoop, N., Ellenbroek, S. I. J., & 3 othersSuijkerbuijk, S. J. E., Snippert, H. J. & van Rheenen, J., 2 Apr 2020, In: Cell stem cell. 26, 4, p. 569-578.e7

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

5 Citations (Scopus)

9 Downloads (Pure)

Snake Venom Gland Organoids

Post, Y., Puschhof, J., Beumer, J., Kerkkamp, H. M., de Bakker, M. A. G., Slagboom, J., de Barbanson, B., Wevers, N. R., Spijkers, X. M., Olivier, T., Kazandjian, T. D., Ainsworth, S., Iglesias, C. L., van de Wetering, W. J., Heinz, M. C., van Ineveld, R. L., van Kleef, R. G. D. M., Begthel, H., Korving, J., Bar-Ephraim, Y. E., & 11 othersGetreuer, W., Rios, A. C., Westerink, R. H. S., Snippert, H. J. G., van Oudenaarden, A., Peters, P. J., Vonk, F. J., Kool, J., Richardson, M. K., Casewell, N. R. & Clevers, H., 23 Jan 2020, In: Cell. 180, 2, p. 233-247.e21

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

2019

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., van Wijk, L. M., Revilla, S. A., Theeuwsen, R., van de Ven, M., van Roosmalen, M. J., Ponsioen, B., Ho, V. W. H., Neel, B. G., Bosse, T., Gaarenstroom, K. N., & 11 othersVrieling, H., Vreeswijk, M. P. G., van Diest, P. J., Witteveen, P. O., Jonges, T., Bos, J. L., van Oudenaarden, A., Zweemer, R. P., Snippert, H. J. G., Kloosterman, W. P. & Clevers, H., May 2019, In: Nature Medicine. 25, 5, p. 838-849 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cell fate dynamics in intestinal homeostasis and cancer

Oost, K. C., 4 Jun 2019, [Utrecht]: Utrecht University. 204 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

File

High-resolution 3D imaging of fixed and cleared organoids

Dekkers, J. F., Alieva, M., Wellens, L. M., Ariese, H. C. R., Jamieson, P. R., Vonk, A. M., Amatngalim, G. D., Hu, H., Oost, K. C., Snippert, H. J. G., Beekman, J. M., Wehrens, E. J., Visvader, J. E., Clevers, H. & Rios, A. C., 1 Jun 2019, In: Nature Protocols. 14, 6, p. 1756-1771 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Kucukkose, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., Sasaki, N., Dutta, D., Boj, S. F., Vries, R. G. J., Lansdorp, P. M., van de Wetering, M., van Oudenaarden, A., Clevers, H., Kranenburg, O., Foijer, F., & 2 othersSnippert, H. J. G. & Kops, G. J. P. L., May 2019, In: Nature Genetics. 51, 5, p. 824-834 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

PLK1 plays dual roles in centralspindlin regulation during cytokinesis

Adriaans, I. E., Basant, A., Ponsioen, B., Glotzer, M. & Lens, S. M. A., 1 Apr 2019, In: Journal of Cell Biology. 218, 4, p. 1250-1264 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

7 Downloads (Pure)

Similar but different: Oncogenic MAPK pathway mutations in colorectal cancer

Post, J. B., 3 Dec 2019, [Utrecht]: Utrecht University. 209 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

File

2018

A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression

Fumagalli, A., Suijkerbuijk, S. J. E., Begthel, H., Beerling, E., Oost, K. C., Snippert, H. J., Van Rheenen, J. & Drost, J., 1 Feb 2018, In: Nature Protocols. 13, 2, p. 235-247 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

Live imaging of cell division in 3D stem-cell organoid cultures

Bolhaqueiro, A. C. F., van Jaarsveld, R. H., Ponsioen, B., Overmeer, R. M., Snippert, H. J. & Kops, G. J. P. L., 1 Jan 2018, Methods in Cell Biology. Academic Press Inc., Vol. 145. p. 91-106 16 p. (Methods in Cell Biology; vol. 145).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene

Oost, K. C., van Voorthuijsen, L., Fumagalli, A., Lindeboom, R. G. H., Sprangers, J., Omerzu, M., Rodriguez-Colman, M. J., Heinz, M. C., Verlaan-Klink, I., Maurice, M. M., Burgering, B. M. T., van Rheenen, J., Vermeulen, M. & Snippert, H. J. G., 6 Feb 2018, In: Cell Reports [E]. 22, 6, p. 1600-1614 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells

Huels, D. J., Bruens, L., Hodder, M. C., Cammareri, P., Campbell, A. D., Ridgway, R. A., Gay, D. M., Solar-Abboud, M., Faller, W. J., Nixon, C., Zeiger, L. B., McLaughlin, M. E., Morrissey, E., Winton, D. J., Snippert, H. J., Van Rheenen, J. & Sansom, O. J., 1 Dec 2018, In: Nature Communications. 9, 1, 1132.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

1 Citation (Scopus)

2017

Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

Hindriksen, S., Bramer, A. J., Truong, M. A., Vromans, M. J. M., Post, J. B., Verlaan-Klink, I., Snippert, H. J., Lens, S. M. A. & Hadders, M. A., 2017, In: PLoS ONE [E]. 12, 6, e0179514.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells

Bruens, L. & Snippert, H. J. G., 6 Jul 2017, In: Cell Stem Cell. 21, 1, p. 3-5 3 p.

Research output: Contribution to journal › Short survey › peer-review

Interplay between metabolic identities in the intestinal crypt supports stem cell function

Rodríguez-Colman, M. J., Schewe, M., Meerlo, M., Stigter, E., Gerrits, J., Pras-Raves, M., Sacchetti, A., Hornsveld, M., Oost, K. C., Snippert, H. J., Verhoeven-Duif, N., Fodde, R. & Burgering, B. M. T., 2017, In: Nature. 543, 7645, p. 424-427 4 p.

Research output: Contribution to journal › Letter › Academic › peer-review

2016

Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Vellinga, T. T., den Uil, S., Rinkes, IHB., Marvin, D., Ponsioen, B., Alvarez-Varela, A., Fatrai, S., Scheele, C., Zwijnenburg, D. A., Snippert, H., Vermeulen, L., Medema, J. P., Stockmann, H. B., Koster, J., Fijneman, R. J. A., de Rooij, J. & Kranenburg, O., 2016, In: Oncogene. 35, 40, p. 5263-5271 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Colonic Crypts: Safe Haven from Microbial Products

Snippert, HJG., 2016, In: Cell. 165, 7, p. 1564–1566

Research output: Contribution to journal › Article › Academic › peer-review

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., van de Wetering, M., Egan, D. A., Bernards, R., Clevers, H., Bos, J. L. & Snippert, H. J., 15 Nov 2016, In: eLife. 5

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

File

2 Downloads (Pure)

2014

Stem cell dynamics in homeostasis and cancer of the intestine

Vermeulen, L. & Snippert, H. J., Jul 2014, In: Nature Reviews Cancer. 14, 7, p. 468-80 13 p.

Research output: Contribution to journal › Article › Academic › peer-review

2005

Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy

Heideman, D. A. M., Overmeer, R. M., Van Beusechem, V. W., Lamers, W. H., Hakvoort, T. B. M., Snijders, P. J. F., Craanen, M. E., Offerhaus, G. J. A., Meijer, C. J. L. M. & Gerritsen, W. R., 1 Dec 2005, In: Cancer Gene Therapy. 12, 12, p. 954-962 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

35 Citations (Scopus)

Group Snippert, section Molecular Cancer Research

Research output

Search results