Group Lens, section Molecular Cancer Research

Research output

Research output per year 1993 2000 2015 2016 2017 2020 2021 2022 2024

• 55 Article
• 7 Review article
• 5 Doctoral thesis 1 (Research UU / Graduation UU)
• 1 Comment/Letter to the editor
• 1 More
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2023

  A kinesin-based approach for inducing chromosome-specific mis-segregation in human cells

  Truong, M. A., Cané-Gasull, P., de Vries, S. G., Nijenhuis, W., Wardenaar, R., Kapitein, L. C., Foijer, F. & Lens, S. M. A., 15 May 2023, In: EMBO Journal. 42, 10, 35 p., e111559.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aneuploidy 100%
  • Chromosomes 91%
  • Force 78%
  • Chromosome Segregation 57%
  • Microtubules 45%
  2 Citations (Scopus)

  6 Downloads (Pure)

• Delineation of a KDM2B-related neurodevelopmental disorder and its associated DNA methylation signature

  van Jaarsveld, R. H., Reilly, J., Cornips, M-C., Hadders, M. A., Agolini, E., Ahimaz, P., Anyane-Yeboa, K., Bellanger, S. A., van Binsbergen, E., van den Boogaard, M-J., Brischoux-Boucher, E., Caylor, R. C., Ciolfi, A., van Essen, T. A. J., Fontana, P., Hopman, S., Iascone, M., Javier, M. M., Kamsteeg, E-J., Kerkhof, J., & 39 othersKido, J., Kim, H-G., Kleefstra, T., Lonardo, F., Lai, A., Lev, D., Levy, M. A., Lewis, M. E. S., Lichty, A., Mannens, M. M. A. M., Matsumoto, N., Maya, I., McConkey, H., Megarbane, A., Michaud, V., Miele, E., Niceta, M., Novelli, A., Onesimo, R., Pfundt, R., Popp, B., Prijoles, E., Relator, R., Redon, S., Rots, D., Rouault, K., Saida, K., Schieving, J., Tartaglia, M., Tenconi, R., Uguen, K., Verbeek, N., Walsh, C. A., Yosovich, K., Yuskaitis, C. J., Zampino, G., Sadikovic, B., Alders, M. & Oegema, R., Jan 2023, In: Genetics in medicine : official journal of the American College of Medical Genetics. 25, 1, p. 49-62 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neurodevelopmental Disorders 100%
  • DNA Methylation 84%
  • Epigenomics 74%
  • Attention Deficit Disorder with Hyperactivity 34%
  • Dual (Psychiatry) Diagnosis 24%
  9 Downloads (Pure)
• 2022

  FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

  Tavares, S., Liv, N., Pasolli, M., Opdam, M., Rätze, M. A. K., Saornil, M., Sluimer, L. M., Hengeveld, R. C. C., van Es, R., van Werkhoven, E., Vos, H., Rehmann, H., Burgering, B. M. T., Oosterkamp, H. M., Lens, S. M. A., Klumperman, J., Linn, S. C. & Derksen, P. W. B., 5 Apr 2022, In: Cell Reports. 39, 1, p. 1-24 110584.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Taxane 100%
  • taxane 90%
  • Adjuvant 86%
  • Triple Negative Breast Neoplasms 84%
  • Recycling 63%
  33 Downloads (Pure)

• Mechanistic basis for Sgo1-mediated centromere localization and function of the CPC

  Abad, M. A., Gupta, T., Hadders, M. A., Meppelink, A., Wopken, J. P., Blackburn, E., Zou, J., Gireesh, A., Buzuk, L., Kelly, D. A., McHugh, T., Rappsilber, J., Lens, S. M. A. & Jeyaprakash, A. A., 1 Aug 2022, In: The Journal of cell biology. 221, 8, p. 1-22 e202108156.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Centromere 100%
  • Survivin 98%
  • Histones 46%
  • Kinetochores 21%
  • Chromosome Segregation 20%
  14 Downloads (Pure)

• Nuclear chromosome locations dictate segregation error frequencies

  Klaasen, S. J., Truong, M. A., van Jaarsveld, R. H., Koprivec, I., Štimac, V., de Vries, S. G., Risteski, P., Kodba, S., Vukušić, K., de Luca, K. L., Marques, J. F., Gerrits, E. M., Bakker, B., Foijer, F., Kind, J., Tolić, I. M., Lens, S. M. A. & Kops, G. J. P. L., 21 Jul 2022, In: Nature. 607, 7919, p. 604–609 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Chromosomes 100%
  • Aneuploidy 85%
  • Chromothripsis 54%
  • Chromosome Segregation 39%
  • Spindle Poles 22%
• 2021

  A highly conserved pocket on PP2A-B56 is required for hSgo1 binding and cohesion protection during mitosis

  Ueki, Y., Hadders, M. A., Weisser, M. B., Nasa, I., Sotelo-Parrilla, P., Cressey, L. E., Gupta, T., Hertz, E. P. T., Kruse, T., Montoya, G., Jeyaprakash, A. A., Kettenbach, A., Lens, S. M. A. & Nilsson, J., 5 Jul 2021, In: EMBO Reports. 22, 7, p. 1-13 e52295.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cohesion 100%
  • Mitosis 80%
  • cohesins 58%
  • Meiosis 23%
  • Phosphoric Monoester Hydrolases 20%
  7 Downloads (Pure)

• Leave no sister behind

  Hadders, M. A. & Lens, S. M. A., 16 Nov 2021, In: Cell Reports. 37, 7, p. 1-2 110053.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aurora 100%
  • Developmental 76%
  • Error 47%
  • Anaphase 40%
  • Chromosome Segregation 39%
  11 Downloads (Pure)

• Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

  Bollen, Y., Stelloo, E., van Leenen, P., van den Bos, M., Ponsioen, B., Lu, B., van Roosmalen, M. J., Bolhaqueiro, A. C. F., Kimberley, C., Mossner, M., Cross, W. C. H., Besselink, N. J. M., van der Roest, B., Boymans, S., Oost, K. C., de Vries, S. G., Rehmann, H., Cuppen, E., Lens, S. M. A., Kops, G. J. P. L., & 6 othersKloosterman, W. P., Terstappen, L. W. M. M., Barnes, C. P., Sottoriva, A., Graham, T. A. & Snippert, H. J. G., Aug 2021, In: Nature Genetics. 53, 8, p. 1187-1195 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Karyotype 100%
  • Colorectal Neoplasms 77%
  • Organoids 36%
  • Neoplasms 31%
  • Cell Division 26%
  14 Downloads (Pure)
• 2020

  Human chromosome-specific aneuploidy is influenced by DNA-dependent centromeric features

  Dumont, M., Gamba, R., Gestraud, P., Klaasen, S., Worrall, J. T., De Vries, S. G., Boudreau, V., Salinas-Luypaert, C., Maddox, P. S., Lens, S. M. A., Kops, G. J. P. L., McClelland, S. E., Miga, K. H. & Fachinetti, D., 15 Jan 2020, In: EMBO Journal. 39, 2, 21 p., e102924.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Centromere 100%
  • Human Chromosomes 93%
  • Aneuploidy 88%
  • Heterogeneity 50%
  • Length 48%
  1 Citation (Scopus)

• MKLP2 Is a Motile Kinesin that Transports the Chromosomal Passenger Complex during Anaphase

  Adriaans, I. E., Hooikaas, P. J., Aher, A., Vromans, M. J. M., van Es, R. M., Grigoriev, I., Akhmanova, A. & Lens, S. M. A., 6 Jul 2020, In: Current Biology. 30, 13, p. 2628-2637.e9

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • kinesin 100%
  • Anaphase 94%
  • Kinesin 94%
  • anaphase 85%
  • cortex 67%

• Untangling the contribution of Haspin and Bub1 to Aurora B function during mitosis

  Hadders, M. A., Hindriksen, S., Truong, M. A., Mhaskar, A. N., Pepijn Wopken, J., Vromans, M. J. M. & Lens, S. M. A., 2 Mar 2020, In: Journal of Cell Biology. 219, 3, 27 p., e201907087.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Centromere 100%
  • Mitosis 81%
  • Kinetochores 80%
  • Aurora Kinase B 63%
  • Chromosome Segregation 50%
  3 Citations (Scopus)

  6 Downloads (Pure)
• 2019

  PLK1 plays dual roles in centralspindlin regulation during cytokinesis

  Adriaans, I. E., Basant, A., Ponsioen, B., Glotzer, M. & Lens, S. M. A., 1 Apr 2019, In: Journal of Cell Biology. 218, 4, p. 1250-1264 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cytokinesis 100%
  • Actomyosin 54%
  • Anaphase 53%
  • Monomeric GTP-Binding Proteins 49%
  7 Downloads (Pure)
• 2018

  Aurora A kinase phosphorylates Hec1 to regulate metaphase kinetochore-microtubule dynamics

  DeLuca, K. F., Meppelink, A., Broad, A. J., Mick, J. E., Peersen, O. B., Pektas, S., Lens, S. M. A. & DeLuca, J. G., 1 Jan 2018, In: Journal of Cell Biology. 217, 1, p. 163-177 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aurora Kinase A 100%
  • Kinetochores 88%
  • Metaphase 75%
  • Microtubules 65%
  • Centromere 41%

• Persistent repair intermediates induce senescence

  Feringa, F. M., Raaijmakers, J. A., Hadders, M. A., Vaarting, C., Macurek, L., Heitink, L., Krenning, L. & Medema, R. H., 1 Dec 2018, In: Nature Communications. 9, 1, 3923.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Double-Stranded DNA 100%
  • Cell Cycle 73%
  • deoxyribonucleic acid 67%
  • cycles 62%
  • Time 33%
• 2017

  Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

  Hindriksen, S., Bramer, A. J., Truong, M. A., Vromans, M. J. M., Post, J. B., Verlaan-Klink, I., Snippert, H. J., Lens, S. M. A. & Hadders, M. A., 2017, In: PLoS ONE [E]. 12, 6, e0179514.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Gene Editing 100%
  • Clustered Regularly Interspaced Short Palindromic Repeats 93%
  • Baculoviridae 48%
  • cohesins 29%
  • Point Mutation 19%

• Inner centromere localization of the CPC maintains centromere cohesion and allows mitotic checkpoint silencing

  Hengeveld, R. C. C., Vromans, M. J. M., Vleugel, M., Hadders, M. A. & Lens, S. M. A., 2017, In: Nature Communications [E]. 8, 15542.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • M Phase Cell Cycle Checkpoints 100%
  • passengers 95%
  • Cohesion 90%
  • chromosomes 90%
  • cohesion 89%
• 2016

  Compound heterozygous NEK1 variants in two siblings with oral-facial-digital syndrome type II (Mohr syndrome)

  Monroe, G. R., Kappen, I. F., Stokman, M. F., Terhal, P. A., van den Boogaard, M-J. H., Savelberg, S. M., van der Veken, L. T., van Es, R. J. J., Lens, S. M., Hengeveld, R. C., Creton, M. A., Janssen, N. G., Mink van der Molen, A. B., Ebbeling, M. B., Giles, R. H., Knoers, N. V. & van Haaften, G., 17 Aug 2016, In: European Journal of Human Genetics. 24, p. 1752–1760

  Research output: Contribution to journal › Article › Academic › peer-review

  • Orofaciodigital Syndromes 100%
  • Siblings 53%
  • Whole Exome Sequencing 27%
  • Cilia 27%
  • Fibroblasts 26%

• Loss of ARID1A activates ANXA1, which serves as a predictive biomarker for trastuzumab resistance

  Berns, K., Sonnenblick, A., Gennissen, A., Brohée, S., Hijmans, E. M., Evers, B., Fumagalli, D., Desmedt, C., Loibl, S., Denkert, C., Neven, P., Guo, W., Zhang, F., Knijnenburg, T. A., Bosse, T., Van Der Heijden, M. S., Hindriksen, S., Nijkamp, W., Wessels, L. F. A., Joensuu, H., & 4 othersMills, G. B., Beijersbergen, R. L., Sotiriou, C. & Bernards, R., 1 Nov 2016, In: Clinical Cancer Research. 22, 21, p. 5238-5248 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Annexin A1 100%
  • Trastuzumab 80%
  • Biomarkers 43%
  • Breast Neoplasms 43%
  • Phosphatidylinositol 3-Kinases 26%

• Tetraploid/Diploid Mosaicism in Cultured Genital Skin Fibroblasts: Is It Causally Related to Penoscrotal Hypospadias

  Giltay, J. C., Klijn, A. J., de Jong, T. P. V. M., Kats, P., van Breugel, M., Lens, S., Vromans, M., Van Der Veken, L. T. & Hochstenbach, R., 1 Jul 2016, In: Molecular Syndromology. 7, 3, p. 153-159 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Tetraploidy 100%
  • Hypospadias 94%
  • Mosaicism 91%
  • Diploidy 81%
  • Genitalia 68%
  2 Downloads (Pure)
• 2015

  Chromosome segregation regulation in human zygotes: Altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex

  Van De Werken, C., Avo Santos, M., Laven, J. S. E., Eleveld, C., Fauser, B. C. J. M., Lens, S. M. A. & Baart, E. B., 1 Oct 2015, In: Human Reproduction. 30, 10, p. 2275-2291 17 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Zygote 100%
  • Chromosome Segregation 98%
  • Histones 74%
  • Phosphorylation 55%
  • Prometaphase 48%

• Detailed imaging and genetic analysis reveal a secondary BRAF(L505H) resistance mutation and extensive intrapatient heterogeneity in metastatic BRAF mutant melanoma patients treated with vemurafenib

  Hoogstraat, M., Gadellaa-van Hooijdonk, C. G., Ubink, I., Besselink, N. J. M., Pieterse, M., Veldhuis, W., van Stralen, M., Meijer, E. F. J., Willems, S. M., Hadders, M. A., Kuilman, T., Krijgsman, O., Peeper, D. S., Koudijs, M. J., Cuppen, E., Voest, E. E. & Lolkema, M. P., May 2015, In: Pigment Cell and Melanoma Research. 28, 3, p. 318-323 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Vemurafenib 100%
  • Heterogeneity 50%
  • Mutation 46%
  • Melanoma 45%
  • Resistance 34%

• Functionality of the chromosomal passenger complex in cancer

  Hindriksen, S., Meppelink, A. & Lens, S. M. A., Feb 2015, In: Biochemical Society Transactions. 43, 1, p. 23-32 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Chromosomal Instability 100%
  • Error 60%
  • Chromosome Segregation 49%
  • Ploidies 48%
  • Cytokinesis 48%

• Increased Plasma Levels of Chemoresistance-Inducing Fatty Acid 16:4(n-3) After Consumption of Fish and Fish Oil

  Daenen, L. G. M., Cirkel, G. A., Houthuijzen, J. M., Gerrits, J., Oosterom, I., Roodhart, J. M. L., van Tinteren, H., Ishihara, K., Huitema, A. D. R., Verhoeven-Duif, N. M. & Voest, E. E., Jun 2015, In: JAMA Oncology. 1, 3, p. 350-8 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Fish Oils 100%
  • Fatty Acids 69%
  • Fishes 46%
  • Perciformes 15%
  • Healthy Volunteers 13%

• Inter-domain Cooperation in INCENP Promotes Aurora B Relocation from Centromeres to Microtubules

  van der Horst, A., Vromans, M. J. M., Bouwman, K., van der Waal, M. S., Hadders, M. A. & Lens, S. M. A., 21 Jul 2015, In: Cell Reports [E]. 12, 3, p. 380-387 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aurora 100%
  • Centromere 77%
  • Microtubules 61%
  • Anaphase 32%
  • Cytokinesis 30%

• Rif1 Is Required for Resolution of Ultrafine DNA Bridges in Anaphase to Ensure Genomic Stability

  Hengeveld, R. C. C., Schoonen, P. M., de Vries, E. G. E., Lens, S. M. A. & van Vugt, M. A. T. M., 24 Aug 2015, In: Developmental Cell. 34, 4, p. 466-474 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Bloom syndrome protein 100%
  • Catenane 97%
  • Anaphase 89%
  • Genomic Instability 76%
  • Catenated DNA 45%

• Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores

  Vleugel, M., Omerzu, M., Groenewold, V., Hadders, M. A., Lens, S. M. A. & Kops, G. J. P. L., 2015, In: Molecular Cell. 57, 5, p. 824-835 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Kinetochores 100%
  • M Phase Cell Cycle Checkpoints 25%
  • Vertebrates 17%
  • Chromosomes 15%
  • Phosphotransferases 14%

• Shugoshin-1 balances Aurora B kinase activity via PP2A to promote chromosome bi-orientation

  Meppelink, A., Kabeche, L., Vromans, M. J. M., Compton, D. A. & Lens, S. M. A., 28 Apr 2015, In: Cell Reports [E]. 11, 4, p. 508-515 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aurora 100%
  • Aurora Kinase B 97%
  • Centromere 77%
  • Kinetochores 62%
  • Chromosomes 50%
• 2011

  A positive feedback loop involving haspin and aurora B promotes CPC accumulation at centromeres in mitosis

  Wang, F., Ulyanova, N. P., Van Der Waal, M. S., Patnaik, D., Lens, S. M. A. & Higgins, J. M. G., 21 Jun 2011, In: Current Biology. 21, 12, p. 1061-1069 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Aurora 100%
  • Centromere 77%
  • centromeres 69%
  • Mitosis 62%
  • mitosis 61%
  81 Citations (Scopus)

• Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

  Huang, H-Y., Houwing, S., Kaaij, L. J. T., Meppelink, A., Redl, S., Gauci, S., Vos, H., Draper, B. W., Moens, C. B., Burgering, B. M., Ladurner, P., Krijgsveld, J., Berezikov, E. & Ketting, R. F., 8 Jul 2011, In: EMBO Journal. 30, 16, p. 3298-3308 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review
• 2004

  Apoptosis via the B cell antigen receptor requires Bax translocation and involves mitochondrial depolarization, cytochrome C release, and caspase-9 activation

  Eldering, E., Mackus, WJM., Derks, IAM., Evers, LM., Beuling, E., Teeling, P., Lens, SMA., van Oers, MHJ. & van Lier, RAW., Jul 2004, In: European Journal of Immunology. 34, 7, p. 1950-1960

  Research output: Contribution to journal › Article › Academic › peer-review

• The anti-apoptotic factor Bcl-2 can functionally substitute for the B cell survival but not for the marginal zone B cell differentiation activity of BAFF

  Tardivel, A., Tinel, A., Lens, S., Steiner, Q-G., Sauberli, E., Wilson, A., Mackay, F., Rolink, A. G., Beermann, F., Tschopp, J. & Schneider, P., Feb 2004, In: European Journal of Immunology. 34, 2, p. 509-18 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cell Differentiation 100%
  • B-Lymphocytes 94%
  • Cell Survival 93%
  • CASP8 and FADD-Like Apoptosis Regulating Protein 42%
  • Transgenic Mice 24%
• 2003

  Survivin is required for a sustained spindle checkpoint arrest in response to lack of tension

  Lens, S. M. A., Wolthuis, R. M. F., Klompmaker, R., Kauw, J., Agami, R., Brummelkamp, T., Kops, G. & Medema, R. H., 16 Jun 2003, In: EMBO Journal. 22, 12, p. 2934-2947 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Survivin 100%
  • Tension 79%
  • Kinetochores 72%
  • Mitosis 54%
  • Aurora 43%
  251 Citations (Scopus)
• 2002

  CD20-induced B cell death can bypass mitochondria and caspase activation

  van der Kolk, LE., Evers, LM., Omene, C., Lens, SMA., Lederman, S., van Lier, RAW., van Oers, MHJ. & Eldering, E., Sept 2002, In: Leukemia. 16, 9, p. 1735-1744

  Research output: Contribution to journal › Article › Academic › peer-review

• Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation

  Mackus, W. J. M., Lens, S. M. A., Medema, R. H., Kwakkenbos, M. J., Evers, L. M., Oers, M. H. J. V., Lier, R. A. W. V. & Eldering, E., Sept 2002, In: International Immunology. 14, 9, p. 973-82 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • B-Cell Antigen Receptors 100%
  • Ligation 69%
  • Cell Cycle 62%
  • Apoptosis 47%
  • Tumor Necrosis Factor-alpha 27%

• The caspase 8 inhibitor c-FLIPL modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

  Lens, SMA., Kataoka, T., Fortner, KA., Tinel, A., Ferrero, I., MacDonald, RH., Hahne, M., Beermann, F., Attinger, A., Orbea, HA., Budd, RC. & Tschopp, J., Aug 2002, In: Molecular and Cellular Biology. 22, 15, p. 5419-5433

  Research output: Contribution to journal › Article › Academic › peer-review
• 2001

  In vitro evidence for differential involvement of CTGF, TGFβ, and PDGF-BB in mesangial response to injury

  Blom, I. E., Van Dijk, A. J., Wieten, L., Duran, K., Ito, Y., Kleij, L., De Nichilo, M., Rabelink, T. J., Weening, J. J., Aten, J. & Goldschmeding, R., 1 Jan 2001, In: Nephrology Dialysis Transplantation. 16, 6, p. 1139-1148 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Connective Tissue Growth Factor 100%
  • Becaplermin 98%
  • Transforming Growth Factors 79%
  • Mesangial Cells 38%
  • Wounds and Injuries 36%
  106 Citations (Scopus)

• Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen

  Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, TG., Finke, D., Beermann, F. & Tschopp, J., 3 Dec 2001, In: Journal of Experimental Medicine. 194, 11, p. 1691-1697

  Research output: Contribution to journal › Article › Academic › peer-review

• NF-kappa B signals induce the expression of c-FLIP

  Micheau, O., Lens, S., Gaide, O., Alevizopoulos, K. & Tschopp, J., Aug 2001, In: Molecular and Cellular Biology. 21, 16, p. 5299-5305

  Research output: Contribution to journal › Article › Academic › peer-review
• 2000

  Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells

  Baars, P. A., Ribeiro Do Couto, L. M., Leusen, J. H., Hooibrink, B., Kuijpers, T. W., Lens, S. M. & van Lier, R. A., 15 Aug 2000, In: Journal of Immunology. 165, 4, p. 1910-7 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • T-Lymphocytes 100%
  • Natural Killer Cell Receptors 64%
  • C-Type Lectins 31%
  • Fas Ligand Protein 28%
  • Histocompatibility Antigens Class I 27%

• Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1 beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: A new role for Fas ligand in inflammatory responses

  Rescigno, M., Piguet, V., Valzasina, B., Lens, S., Zubler, R., French, L., Kindler, V., Tschopp, J. & Ricciardi-Castagnoli, P., 4 Dec 2000, In: Journal of Experimental Medicine. 192, 11, p. 1661-1668

  Research output: Contribution to journal › Article › Academic › peer-review

• NFkappaB decoy oligodeoxynucleotides reduce monocyte infiltration in renal allografts

  Vos, I. H., Govers, R., Gröne, H. J., Kleij, L., Schurink, M., De Weger, R. A., Goldschmeding, R. & Rabelink, T. J., Apr 2000, In: FASEB Journal. 14, 5, p. 815-22 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Oligodeoxyribonucleotides 100%
  • Allografts 72%
  • Monocytes 68%
  • Macrophages 57%
  • Kidney 44%

• TGF-beta induces the expression of the FLICE-inhibitory protein and inhibits Fas-mediated apoptosis of microglia

  Schlapbach, R., Spanaus, KS., Malipiero, U., Lens, S., Tasinato, A., Tschopp, J. & Fontana, A., Dec 2000, In: European Journal of Immunology. 30, 12, p. 3680-3688

  Research output: Contribution to journal › Article › Academic › peer-review
• 1999

  Aberrant expression and reverse signalling of CD70 on malignant B cells

  Lens, SMA., Drillenburg, P., den Drijver, BFA., van Schijndel, G., Pals, ST., van Lier, RAW. & van Oers, MHJ., Aug 1999, In: British Journal of Haematology. 106, 2, p. 491-503

  Research output: Contribution to journal › Article › Academic › peer-review
• 1998

  Dissection of pathways leading to antigen receptor-induced and Fas/CD95-induced apoptosis in human B cells

  Lens, SMA., den Drijver, BFA., Potgens, AJG., Tesselaar, K., van Oers, MHJ. & van Lier, RAW., 15 Jun 1998, In: Journal of Immunology. 160, 12, p. 6083-6092 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antigen Receptors 100%
  • Dissection 69%
  • B-Lymphocytes 61%
  • Apoptosis 49%
  • Caspase 3 35%
• 1997

  Antigen-presenting cell-derived signals determine expression levels of CD70 on primed T cells

  Lens, SMA., Baars, PA., Hooibrink, B., vanOers, MHJ. & vanLier, RAW., Jan 1997, In: Immunology. 90, 1, p. 38-45

  Research output: Contribution to journal › Article › Academic › peer-review

• Functional B cell abnormalities in HIV type 1 infection: Role of CD40L and CD70

  Wolthers, K. C., Otto, S. A., Lens, S. M. A., Van Lier, R. A. W., Miedema, F. & Meyaard, L., 10 Aug 1997, In: AIDS Research and Human Retroviruses. 13, 12, p. 1023-1029 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • CD40 Ligand 100%
  • HIV Infections 71%
  • HIV-1 70%
  • B-Lymphocytes 62%
  • T-Lymphocytes 49%
  48 Citations (Scopus)
• 1996

  A dual role for both CD40-ligand and TNF-alpha in controlling human B cell death

  Lens, SMA., Tesselaar, K., denDrijver, BFA., vanOers, MHJ. & vanLier, RAW., 15 Jan 1996, In: Journal of Immunology. 156, 2, p. 507-514 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • CD40 Ligand 100%
  • B-Lymphocytes 62%
  • Cell Death 61%
  • Tumor Necrosis Factor-alpha 57%
  • Apoptosis 24%

• Identification of a novel subpopulation of germinal center B cells characterized by expression of IgD and CD70

  Lens, SMA., Keehnen, RMJ., vanOers, MHJ., vanLier, RAW., Pals, ST. & Koopman, G., May 1996, In: European Journal of Immunology. 26, 5, p. 1007-1011

  Research output: Contribution to journal › Article › Academic › peer-review

• Increased expression of CD80, CD86 and CD70 on T cells from HIV-infected individuals upon activation in vitro: Regulation by CD4⁺ T cells

  Wolthers, K. C., Otto, S. A., Lens, S. M. A., Kolbach, D. N., Van Lier, R. A. W., Miedema, F. & Meyaard, L., 1 Jan 1996, In: European Journal of Immunology. 26, 8, p. 1700-1706 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • HIV 100%
  • T-Lymphocytes 89%
  • In Vitro Techniques 63%
  • Ligands 36%
  • Antigen-Presenting Cells 17%
  66 Citations (Scopus)
• 1995

  Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation

  Hintzen, R. Q., Lens, S. M., Lammers, K., Kuiper, H., Beckmann, M. P. & van Lier, R. A., 15 Mar 1995, In: Journal of Immunology. 154, 6, p. 2612-23 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Ligands 100%
  • T-Lymphocytes 87%
  • CD27 Ligand 33%
  • Interleukin-2 31%
  • B7-1 Antigen 28%