Group Klumperman, section Cell Biology

Research output

Research output per year 1993 2015 2017 2018 2019 2020 2021 2022 2024

• 93 Article
• 6 Review article
• 5 Doctoral thesis 1 (Research UU / Graduation UU)
• 4 Chapter
• 9 More
  • 4 Comment/Letter to the editor
  • 3 Doctoral thesis 2 (Research NOT UU / Graduation UU)
  • 1 Meeting Abstract
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  Apolipoprotein L1 (APOL1) renal risk variant-mediated podocyte cytotoxicity depends on African haplotype and surface expression

  Gupta, N., Waas, B., Austin, D., De Mazière, A. M., Kujala, P., Stockwell, A. D., Li, T., Yaspan, B. L., Klumperman, J. & Scales, S. J., 14 Feb 2024, In: Scientific Reports. 14, 1, p. 1-16 16 p., 3765.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Apolipoprotein L1 100%
  • Podocytes 70%
  • Haplotypes 53%
  • Kidney 30%
  • HEK293 Cells 26%
  2 Downloads (Pure)

• Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis

  Carvalheiro, T., Marut, W., Pascoal Ramos, M. I., García, S., Fleury, D., Affandi, A. J., Meijers, A. S., Giovannone, B., Tieland, R. G., Elshof, E., Ottria, A., Cossu, M., Meizlish, M. L., Veenendaal, T., Ramanujam, M., Moreno-García, M. E., Klumperman, J., Liv, N., Radstake, T. R. D. J. & Meyaard, L., Jun 2024, In: Journal of Autoimmunity. 146, 103219.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Systemic Scleroderma 100%
  • Collagen 66%
  • Fibrosis 65%
  • Collagen Receptors 21%
  • indium-bleomycin 19%
  2 Downloads (Pure)

• Loss of the HOPS complex disrupts early-to-late endosome transition, impairs endosomal recycling and induces accumulation of amphisomes

  van der Beek, J., de Heus, C., Sanza, P., Liv, N. & Klumperman, J., 1 Mar 2024, In: Molecular Biology of the Cell. 35, 3, ar40.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endosomes 100%
  • IGF Type 2 Receptor 63%
  • Endocytosis 45%
  • Cations 44%
  • Cathepsins 29%
  1 Downloads (Pure)

• Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

  Butkovič, R., Walker, A. P., Healy, M. D., McNally, K. E., Liu, M., Veenendaal, T., Kato, K., Liv, N., Klumperman, J., Collins, B. M. & Cullen, P. J., 21 Aug 2024, In: Nature Communications. 15, 1, 15 p., 7180.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
• 2023

  A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

  van der Krift, F., Zijlmans, D. W., Shukla, R., Javed, A., Koukos, P. I., Schwarz, L. L. E., Timmermans-Sprang, E. P. M., Maas, P. E. M., Gahtory, D., van den Nieuwboer, M., Mol, J. A., Strous, G. J., Bonvin, A. M. J. J., van der Stelt, M., Veldhuizen, E. J. A., Weingarth, M., Vermeulen, M., Klumperman, J. & Maurice, M. M., Nov 2023, In: Life Science Alliance. 6, 11, p. 1-19 19 p., e202302058.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • folylpolyglutamate synthetase 100%
  • Antifolate 83%
  • Folic Acid Antagonists 79%
  • methotrexate 74%
  • Methotrexate 71%

• Correlative Live-cell-volume Electron Microscopy: Bridging Cellular Dynamics to 3D-Ultrastructure

  de Heus, C., Fermie, J., Loginov, S., Gerritsen, H. C., Klumperman, J. & Liv, N., 22 Jul 2023, In: Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada. 29, 1, p. 1188 1 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Nicotinic acetylcholine receptor signaling maintains epithelial barrier integrity

  Katheder, N. S., Browder, K. C., Chang, D., De Maziere, A., Kujala, P., van Dijk, S., Klumperman, J., Lu, T-C., Li, H., Lai, Z., Sangaraju, D. & Jasper, H., 8 Dec 2023, In: eLife. 12, 27 p., e86381.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nicotinic Receptors 100%
  • Acetylcholine 96%
  • Diptera 42%
  • Genes 36%
  • Chronic Obstructive Pulmonary Disease 34%
  6 Downloads (Pure)

• RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

  Rawat, S., Chatterjee, D., Marwaha, R., Charak, G., Kumar, G., Shaw, S., Khatter, D., Sharma, S., de Heus, C., Liv, N., Klumperman, J., Tuli, A. & Sharma, M., 2 Jan 2023, In: The Journal of cell biology. 222, 1, e202108001.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Dyneins 100%
  • Endosomes 85%
  • Lysosomes 77%
  • Dynactin Complex 29%
  • Hydrolases 22%
  7 Downloads (Pure)

• Ultrastructural Localization of Endogenous LC3 by On-Section Correlative Light-Electron Microscopy

  van der Beek, J., Veenendaal, T., de Heus, C., van Dijk, S., Ten Brink, C., Liv, N. & Klumperman, J., 31 Mar 2023, In: Journal of visualized experiments : JoVE. 193, 193, 17 p., e65067.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Electron microscopy 100%
  • Optical microscopy 84%
  • Electron Microscopy 67%
  • Microscopy 64%
  • Fluorescence microscopy 25%
• 2022

  An optimized protocol for immuno-electron microscopy of endogenous LC3

  De Mazière, A., van der Beek, J., van Dijk, S., de Heus, C., Reggiori, F., Koike, M. & Klumperman, J., Dec 2022, In: Autophagy. 18, 12, p. 3004-3022 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Immunoelectron Microscopy 100%
  • bafilomycin A 75%
  • Electron Microscopy 70%
  • Gold 55%
  • Staphylococcal Protein A 47%
  6 Downloads (Pure)

• Bimodal endocytic probe for three-dimensional correlative light and electron microscopy

  Fermie, J., de Jager, L., Foster, H. E., Veenendaal, T., de Heus, C., van Dijk, S., Ten Brink, C., Oorschot, V., Yang, L., Li, W., Müller, W. H., Howes, S., Carter, A. P., Förster, F., Posthuma, G., Gerritsen, H. C., Klumperman, J. & Liv, N., 23 May 2022, In: Cell reports methods. 2, 5, p. 1-22 100220.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Electron microscopy 100%
  • Optical microscopy 84%
  • Optical Microscopy 68%
  • Electron Microscopy 67%
  • Microscopy 64%
  13 Downloads (Pure)

• Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models

  Dejanovic, B., Wu, T., Tsai, M-C., Graykowski, D., Gandham, V. D., Rose, C. M., Bakalarski, C. E., Ngu, H., Wang, Y., Pandey, S., Rezzonico, M. G., Friedman, B. A., Edmonds, R., De Mazière, A., Rakosi-Schmidt, R., Singh, T., Klumperman, J., Foreman, O., Chang, M. C., Xie, L., & 2 othersSheng, M. & Hanson, J. E., Sept 2022, In: Nature Aging. 2, 9, p. 837-850 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Complement C1q 100%
  • Microglia 67%
  • Astrocytes 60%
  • Synapses 60%
  • Alzheimer Disease 51%

• Correlative Organelle Microscopy: Fluorescence Guided Volume Electron Microscopy of Intracellular Processes

  Loginov, S. V., Fermie, J., Fokkema, J., Agronskaia, A. V., De Heus, C., Blab, G. A., Klumperman, J., Gerritsen, H. C. & Liv, N., 11 Apr 2022, In: Frontiers in Cell and Developmental Biology. 10, 829545.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lysosomes 100%
  • Fluorescence Microscopy 97%
  • Organelles 94%
  • Electron Microscopy 84%
  • Endoplasmic Reticulum 46%
  13 Downloads (Pure)

• Epigenetic modulation of neuroblastoma enhances T cell and NK cell immunogenicity by inducing a tumor-cell lineage switch

  Cornel, A. M., Dunnebach, E., Hofman, D. A., Das, S., Sengupta, S., Van Den Ham, F., Wienke, J., Strijker, J. G. M., Van Den Beemt, D. A. M. H., Essing, A. H. W., Koopmans, B., Engels, S. A. G., Lo Presti, V., Szanto, C. S., George, R. E., Molenaar, J. J., Van Heesch, S., Dierselhuis, M. P. & Nierkens, S., 15 Dec 2022, In: Journal for ImmunoTherapy of Cancer. 10, 12, e005002.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cell Lineage 100%
  • Neuroblastoma 95%
  • Natural Killer Cells 88%
  • Epigenomics 83%
  • T-Lymphocytes 58%

• High Resolution Proteomic Analysis of Subcellular Fractionated Boar Spermatozoa Provides Comprehensive Insights Into Perinuclear Theca-Residing Proteins

  Zhang, M., Chiozzi, R. Z., Skerrett-Byrne, D. A., Veenendaal, T., Klumperman, J., Heck, A. J. R., Nixon, B., Helms, J. B., Gadella, B. M. & Bromfield, E. G., 18 Feb 2022, In: Frontiers in Cell and Developmental Biology. 10, p. 1-18 836208.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Spermatozoa 100%
  • Proteomics 99%
  • Proteins 39%
  • Fertilization 24%
  • Proteasome Endopeptidase Complex 16%
  7 Downloads (Pure)

• Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo

  van Leeuwen, W., VanInsberghe, M., Battich, N., Salmén, F., van Oudenaarden, A. & Rabouille, C., 20 Jun 2022, In: Cell reports methods. 2, 6, 100235.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • RNA Editing 100%
  • RNA 86%
  • Transcriptome 66%
  • Mammalian Cell 37%
  • Oxidative Stress 35%
  13 Downloads (Pure)

• Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

  Meister, M. T., Groot Koerkamp, M. J. A., de Souza, T., Breunis, W. B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H. H. D., Janse, A., Dolman, M. E. M., Eising, S., Langenberg, K. P. S., van Tuil, M., Knops, R. R. G., van Scheltinga, S. T., Hiemcke-Jiwa, L. S., Flucke, U., Merks, J. H. M., & 9 othersvan Noesel, M. M., Tops, B. B. J., Hehir-Kwa, J. Y., Kemmeren, P., Molenaar, J. J., van de Wetering, M., van Boxtel, R., Drost, J. & Holstege, F. C. P., 10 Oct 2022, In: Embo Molecular Medicine. 14, 10, e16001.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Rhabdomyosarcoma 90%
  • Preclinical Drug Evaluations 30%
  • Neoplasms 24%
  • Embryonal Rhabdomyosarcoma 18%
  7 Downloads (Pure)

• Quantitative correlative microscopy reveals the ultrastructural distribution of endogenous endosomal proteins

  van der Beek, J., de Heus, C., Liv, N. & Klumperman, J., 3 Jan 2022, In: The Journal of cell biology. 221, 1, e202106044.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endosomes 100%
  • Microscopy 74%
  • Proteins 32%
  • Lysosomes 30%
  • Fluorescence Microscopy 29%
  6 Downloads (Pure)

• Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis

  van der Velden, L. M., Maas, P., van Amersfoort, M., Timmermans-Sprang, E. P. M., Mensinga, A., van der Vaart, E., Malergue, F., Viëtor, H., Derksen, P. W. B., Klumperman, J., van Agthoven, A., Egan, D. A., Mol, J. A. & Strous, G. J., 28 Jul 2022, In: Frontiers in Endocrinology. 13, 926210.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Somatotropin Receptors 100%
  • Somatomedins 76%
  • Growth Hormone 68%
  • Cell Proliferation 23%
  • Breast Neoplasms 22%
  6 Downloads (Pure)

• Specific Silencing of Microglial Gene Expression in the Rat Brain by Nanoparticle-Based Small Interfering RNA Delivery

  Guo, S., Cázarez-Márquez, F., Jiao, H., Foppen, E., Korpel, N. L., Grootemaat, A. E., Liv, N., Gao, Y., Van Der Wel, N., Zhou, B., Nie, G. & Yi, C. X., 2 Feb 2022, In: ACS Applied Materials and Interfaces. 14, 4, p. 5066-5079 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Small Interfering RNA 100%
  • Lipids 96%
  • RNA 86%
  • Rats 85%
  • Gene expression 78%

• Stress-induced phase separation of ERES components into Sec bodies precedes ER exit inhibition in mammalian cells

  van Leeuwen, W., Nguyen, D. T. M., Grond, R., Veenendaal, T., Rabouille, C. & Farías, G. G., 1 Dec 2022, In: Journal of cell science. 135, 23, jcs260294.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Salt Stress 100%
  • Secretory Pathway 71%
  • Starvation 66%
  • Drosophila 57%
  • Protein Isoforms 49%
  20 Downloads (Pure)

• The potential and limitations of intrahepatic cholangiocyte organoids to study inborn errors of metabolism

  Lehmann, V., Schene, I. F., Ardisasmita, A. I., Liv, N., Veenendaal, T., Klumperman, J., van der Doef, H. P. J., Verkade, H. J., Verstegen, M. M. A., van der Laan, L. J. W., Jans, J. J. M., Verhoeven-Duif, N. M., van Hasselt, P. M., Nieuwenhuis, E. E. S., Spee, B. & Fuchs, S. A., Mar 2022, In: Journal of Inherited Metabolic Disease. 45, 2, p. 353-365 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Inborn Errors Metabolism 98%
  • Metabolic Networks and Pathways 21%
  • Methylmalonic acidemia 16%
  • Branched Chain Amino Acids 14%
  4 Downloads (Pure)

• Ultrastructural Characteristics of Myocardial Reperfusion Injury and Effect of Selective Intracoronary Hypothermia: An Observational Study in Isolated Beating Porcine Hearts

  El Farissi, M., Buscone, S., Bax, N. A. M., van Rijswijk, J. W., Veenendaal, T., Keulards, D. C. J., Zelis, J. M., van Tuijl, S., Eerdekens, R., Demandt, J., Vervaat, F., Zimmermann, F. M., Bouwmeester, S., Rave, Y., Zhu, K. S., Conrad, C., van 't Veer, M., Pijls, N. H. J., Klumperman, J., Bouten, C. V. C., & 1 othersOtterspoor, L. C., 1 Jun 2022, In: Therapeutic hypothermia and temperature management. 12, 2, p. 129-137 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Myocardial Reperfusion Injury 100%
  • Hypothermia 81%
  • Swine 61%
  • Observational Studies 60%
  • Heart 50%
• 2021

  Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells

  Zhang, C., van Leeuwen, W., Blotenburg, M., Aguilera-Gomez, A., Brussee, S., Grond, R., Kampinga, H. H. & Rabouille, C., 1 Sept 2021, In: Journal of cell science. 134, 17, jcs258685.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Drosophila 100%
  • Salts 94%
  • Phosphotransferases 83%
  • Amino Acids 75%
  • Salt Stress 58%
  1 Citation (Scopus)

  19 Downloads (Pure)

• A polygenic resilience score moderates the genetic risk for schizophrenia

  Mar 2021, In: Molecular Psychiatry. 26, 3, p. 800-815 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Schizophrenia 100%
  • Disease Resistance 32%
  • Penetrance 28%
  • Genomics 24%
  • Psychiatry 18%
  12 Downloads (Pure)

• Cysteamine-bicalutamide combination therapy corrects proximal tubule phenotype in cystinosis

  Jamalpoor, A., van Gelder, C. A., Yousef Yengej, F. A., Zaal, E. A., Berlingerio, S. P., Veys, K. R., Pou Casellas, C., Voskuil, K., Essa, K., Ammerlaan, C. M., Rega, L. R., van der Welle, R. E., Lilien, M. R., Rookmaaker, M. B., Clevers, H., Klumperman, J., Levtchenko, E., Berkers, C. R., Verhaar, M. C., Altelaar, M., & 2 othersMasereeuw, R. & Janssen, M. J., 7 Jul 2021, In: Embo Molecular Medicine. 13, 7, p. 1-20 e13067.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cystinosis 100%
  • bicalutamide 96%
  • Cysteamine 93%
  • Proximal Kidney Tubule 54%
  • Phenotype 38%
  2 Downloads (Pure)

• Fatty acylation enhances the cellular internalization and cytosolic distribution of a cystine-knot peptide

  Gao, X., Mazière, A. D., Beard, R., Klumperman, J. & Hannoush, R. N., 19 Nov 2021, In: iScience. 24, 11, p. 1-17 103220.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Acylation 100%
  • Cystine 94%
  • Peptides 46%
  • Fatty Acids 17%
  • Myristic Acid 14%
  5 Downloads (Pure)

• Hherisomes, Hedgehog specialized recycling endosomes, are required for high level Hedgehog signaling and tissue growth

  Pizette, S., Matusek, T., Herpers, B., Thérond, P. P. & Rabouille, C., 15 May 2021, In: Journal of cell science. 134, 10, p. 1-16 jcs258603.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hedgehogs 100%
  • Endosomes 85%
  • Growth 38%
  • Imaginal Discs 10%
  • Immunoelectron Microscopy 8%

• Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation

  van der Welle, R. E. N., Jobling, R., Burns, C., Sanza, P., van der Beek, J. A., Fasano, A., Chen, L., Zwartkruis, F. J., Zwakenberg, S., Griffin, E. F., Ten Brink, C., Veenendaal, T., Liv, N., van Ravenswaaij-Arts, C. M. A., Lemmink, H. H., Pfundt, R., Blaser, S., Sepulveda, C., Lozano, A. M., Yoon, G., & 6 othersSantiago-Sim, T., Asensio, C. S., Caldwell, G. A., Caldwell, K. A., Chitayat, D. & Klumperman, J., 7 May 2021, In: Embo Molecular Medicine. 13, 5, p. 1-24 24 p., e13258.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Mechanistic Target of Rapamycin Complex 1 100%
  • Protein Transport 88%
  • Transcription Factors 59%
  • Synucleins 12%
  • Dystonia 9%
  4 Downloads (Pure)

• Optimization of negative stage bias potential for faster imaging in large-scale electron microscopy

  Lane, R., Vos, Y., Wolters, A. H. G., Kessel, L. V., Chen, S. E., Liv, N., Klumperman, J., Giepmans, B. N. G. & Hoogenboom, J. P., Jan 2021, In: Journal of structural biology: X. 5, 11 p., 100046.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Electron Microscopy 100%
  • Signal-To-Noise Ratio 66%
  • Microscopy 48%
  • Magnetic Fields 33%
  • Immersion 31%
  9 Downloads (Pure)

• Organoid-based drug screening reveals neddylation as therapeutic target for malignant rhabdoid tumors

  Calandrini, C., van Hooff, S. R., Paassen, I., Ayyildiz, D., Derakhshan, S., Dolman, M. E. M., Langenberg, K. P. S., van de Ven, M., de Heus, C., Liv, N., Kool, M., de Krijger, R. R., Tytgat, G. A. M., van den Heuvel-Eibrink, M. M., Molenaar, J. J. & Drost, J., 24 Aug 2021, In: Cell Reports. 36, 8, p. 1-1 109568.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Rhabdoid Tumor 100%
  • Organoids 87%
  • Preclinical Drug Evaluations 79%
  • pevonedistat 58%
  • Drug 35%
  15 Downloads (Pure)

• Pancreatic beta-Cell-Specific Deletion of VPS41 Causes Diabetes Due to Defects in Insulin Secretion

  Burns, C. H., Yau, B., Rodriguez, A., Triplett, J., Maslar, D., An, Y. S., van der Welle, R. E. N., Kossina, R. G., Fisher, M. R., Strout, G. W., Bayguinov, P. O., Veenendaal, T., Chitayat, D., Fitzpatrick, J. A. J., Klumperman, J., Kebede, M. A. & Asensio, C. S., 1 Feb 2021, In: Diabetes. 70, 2, p. 436-448 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Secretory Vesicles 100%
  • Insulin-Secreting Cells 93%
  • Insulin Secretion 86%
  • Insulin 52%
  • Exocytosis 24%

• The stress-sensing domain of activated IRE1 alpha forms helical filaments in narrow ER membrane tubes

  Tran, N-H., Carter, S. D., De Mazière, A., Ashkenazi, A., Klumperman, J., Walter, P. & Jensen, G. J., 1 Oct 2021, In: Science. 374, 6563, p. 52-57 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Endoplasmic Reticulum 100%
  • Unfolded Protein Response 65%
  • Membranes 62%
  • Electron Microscope Tomography 38%
  • Immunoelectron Microscopy 31%
• 2020

  An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity

  Calandrini, C., Schutgens, F., Oka, R., Margaritis, T., Candelli, T., Mathijsen, L., Ammerlaan, C., van Ineveld, R. L., Derakhshan, S., de Haan, S., Dolman, E., Lijnzaad, P., Custers, L., Begthel, H., Kerstens, H. H. D., Visser, L. L., Rookmaaker, M., Verhaar, M., Tytgat, G. A. M., Kemmeren, P., & 11 othersde Krijger, R. R., Al-Saadi, R., Pritchard-Jones, K., Kool, M., Rios, A. C., van den Heuvel-Eibrink, M. M., Molenaar, J. J., van Boxtel, R., Holstege, F. C. P., Clevers, H. & Drost, J., 11 Mar 2020, In: Nature Communications. 11, 1, 14 p., 1310.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • kidneys 94%
  • Kidney Neoplasms 85%
  • tumors 72%
  • cancer 71%
  8 Downloads (Pure)

• A paralog-specific role of COPI vesicles in the neuronal differentiation of mouse pluripotent cells

  Jain Goyal, M., Zhao, X., Bozhinova, M., Andrade-López, K., de Heus, C., Schulze-Dramac, S., Müller-McNicoll, M., Klumperman, J. & Béthune, J., Sept 2020, In: Life Science Alliance. 3, 9, 15 p., e202000714.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • vesicle 100%
  • COP-Coated Vesicles 88%
  • Coatomer Protein 82%
  • Coat Protein Complex I 80%
  • protein 70%
  8 Downloads (Pure)

• Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation

  Nalle, S. C., Barreira da Silva, R., Zhang, H., Decker, M., Chalouni, C., Xu, M., Posthuma, G., de Mazière, A., Klumperman, J., Baz Morelli, A., Fleire, S. J., Verkman, A. S., Trombetta, E. S., Albert, M. L. & Mellman, I., 24 Nov 2020, In: PLoS ONE. 15, 11, p. 1-19 e0238484.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Aquaporin 3 100%
  • Cross-Priming 86%
  • endosomes 75%
  • aquaporins 73%
  • Endosomes 68%
  6 Downloads (Pure)

• Integrated super resolution fluorescence microscopy and transmission electron microscopy

  Mohammadian, S., Agronskaia, A. V., Blab, G. A., van Donselaar, E. G., de Heus, C., Liv, N., Klumperman, J. & Gerritsen, H. C., Aug 2020, In: Ultramicroscopy. 215, 11 p., 113007.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Fluorescence microscopy 100%
  • Electron microscopy 88%
  • Transmission electron microscopy 69%
  • Fluorescence Microscopy 68%
  • Electron Microscopy 59%
  18 Downloads (Pure)

• Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

  Ludikhuize, M. C., Meerlo, M., Gallego, M. P., Xanthakis, D., Burgaya Julià, M., Nguyen, N. T. B., Brombacher, E. C., Liv, N., Maurice, M. M., Paik, J. H., Burgering, B. M. T. & Rodriguez Colman, M. J., 3 Nov 2020, In: Cell Metabolism. 32, 5, p. 889-900.e7

  Research output: Contribution to journal › Article › Academic › peer-review

  • Paneth Cells 100%
  • Mitochondria 94%
  • Cell Differentiation 92%
  • Stem Cells 84%
  • Small Cytoplasmic RNA 40%

• Quantifying lymphocyte vacuolization serves as a measure of CLN3 disease severity

  Kuper, W. F. E., Oostendorp, M., van den Broek, B. T. A., van Veghel, K., Nonkes, L. J. P., Nieuwenhuis, E. E. S., Fuchs, S. A., Veenendaal, T., Klumperman, J., Huisman, A., Nierkens, S. & van Hasselt, P. M., Jul 2020, In: JIMD Reports. 54, 1, p. 87-97 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lysosomal-Associated Membrane Protein 1 100%
  • Lymphocytes 79%
  • Cytometry 48%
  • Protein 47%
  • Flow 29%
  1 Citation (Scopus)

• SKIP-HOPS recruits TBC1D15 for a Rab7-to-Arl8b identity switch to control late endosome transport

  Jongsma, M. L., Bakker, J., Cabukusta, B., Liv, N., van Elsland, D., Fermie, J., Akkermans, J. L., Kuijl, C., van der Zanden, S. Y., Janssen, L., Hoogzaad, D., van der Kant, R., Wijdeven, R. H., Klumperman, J., Berlin, I. & Neefjes, J., 16 Mar 2020, In: EMBO Journal. 39, 6, p. 1-25 e102301.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endosomes 100%
  • Effector 97%
  • Membranes 53%
  • GTP Phosphohydrolases 34%
  • Organelles 28%
  8 Downloads (Pure)

• The function of GORASPs in Golgi apparatus organization in vivo

  Grond, R., Veenendaal, T., Duran, J. M., Raote, I., van Es, J. H., Corstjens, S., Delfgou, L., El Haddouti, B., Malhotra, V. & Rabouille, C., 7 Sept 2020, In: The Journal of cell biology. 219, 9, 11 p., e202004191.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Coat Protein Complex I 100%
  • Golgi Apparatus 69%
  • In Vitro Techniques 26%
  • Proteins 22%
  5 Downloads (Pure)

• Wiskott-Aldrich syndrome protein restricts cGAS-STING activation by dsDNA immune complexes

  Piperno, G. M., Naseem, A., Silvestrelli, G., Amadio, R., Caronni, N., Cervantes Luevano, K. E., Liv, N., Klumperman, J., Colliva, A., Ali, H., Graziano, F., Benaroch, P., Haecker, H., Hanna, R. N. & Benvenuti, F., 3 Sept 2020, In: JCI Insight. 5, 17, e132857.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Wiskott-Aldrich Syndrome Protein 100%
  • Antigen-Antibody Complex 66%
  • DNA 35%
  • Nucleic Acids 31%
  • Actins 27%
  5 Downloads (Pure)
• 2019

  A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five

  Khundadze, M., Ribaudo, F., Hussain, A., Rosentreter, J., Nietzsche, S., Thelen, M., Winter, D., Hoffmann, B., Afzal, M. A., Hermann, T., de Heus, C., Piskor, E-M., Kosan, C., Franzka, P., von Kleist, L., Stauber, T., Klumperman, J., Damme, M., Proikas-Cezanne, T. & Hübner, C. A., Jul 2019, In: Neurobiology of Disease. 127, p. 419-431 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Axons 100%
  • Adaptor Protein Complex Subunits 71%
  • Hereditary Spastic Paraplegia 56%
  • Neurologic Gait Disorders 56%
  • Autophagosomes 46%

• DGAT2 partially compensates for lipid-induced ER stress in human DGAT1-deficient intestinal stem cells[S]

  van Rijn, J. M., van Hoesel, M., de Heus, C., van Vugt, A. H. M., Klumperman, J., Nieuwenhuis, E., Houwen, R. H. J. & Middendorp, S., Oct 2019, In: Journal of Lipid Research. 60, 10, p. 1787-1800 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lipid Droplets 100%
  • Organoids 66%
  • Stem Cells 62%
  • Lipid 58%
  • Lipids 55%

• High accuracy, fiducial marker-based image registration of correlative microscopy images

  Mohammadian, S., Fokkema, J., Agronskaia, A. V., Liv, N., de Heus, C., van Donselaar, E., Blab, G. A., Klumperman, J. & Gerritsen, H. C., 1 Mar 2019, In: Scientific Reports. 9, 1, 3211.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Fiducial Markers 100%
  • Electron Microscopy 59%
  • Microscopy 57%
  • Fluorescence Microscopy 48%
  • Materials Science 10%

• Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart

  Honkoop, H., de Bakker, D. E., Aharonov, A., Kruse, F., Shakked, A., Nguyen, P. D., de Heus, C., Garric, L., Muraro, M. J., Shoffner, A., Tessadori, F., Peterson, J. C., Noort, W., Bertozzi, A., Weidinger, G., Posthuma, G., Grun, D., van der Laarse, W. J., Klumperman, J., Jaspers, R. T., & 4 othersPoss, K. D., van Oudenaarden, A., Tzahor, E. & Bakkers, J., 23 Dec 2019, In: eLife. 8, e50163.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Single-Cell Analysis 100%
  • Cardiac Myocytes 69%
  • RNA Sequencing 61%
  • Metabolic 60%
  • Heart 48%
  12 Downloads (Pure)

• The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance

  Wijers, M., Zanoni, P., Liv, N., Vos, D. Y., Jäckstein, M. Y., Smit, M., Wilbrink, S., Wolters, J. C., van der Veen, Y. T., Huijkman, N., Dekker, D., Kloosterhuis, N., van Dijk, T. H., Billadeau, D. D., Kuipers, F., Klumperman, J., von Eckardstein, A., Kuivenhoven, J. A. & van de Sluis, B., 6 Jun 2019, In: JCI Insight. 4, 11, e126462.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Wiskott-Aldrich Syndrome Protein 100%
  • LDL Cholesterol 58%
  • HDL Cholesterol 57%
  • LDL Receptors 53%
  • Liver 33%

• The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage

  Koerver, L., Papadopoulos, C., Liu, B., Kravic, B., Rota, G., Brecht, L., Veenendaal, T., Polajnar, M., Bluemke, A., Ehrmann, M., Klumperman, J., Jäättelä, M., Behrends, C. & Meyer, H., 4 Oct 2019, In: EMBO Reports. 20, 10, e48014.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • P62 100%
  • Ubiquitin-Conjugating Enzymes 87%
  • Macroautophagy 83%
  • Silencing RNA 77%
  • Effector 65%

• Transcriptional and epigenetic profiling of nutrient-deprived cells to identify novel regulators of autophagy

  Peeters, J. G. C., Picavet, L. W., Coenen, S. G. J. M., Mauthe, M., Vervoort, S. J., Mocholi, E., de Heus, C., Klumperman, J., Vastert, S. J., Reggiori, F., Coffer, P. J., Mokry, M. & van Loosdregt, J., 2 Jan 2019, In: Autophagy. 15, 1, p. 98-112 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Autophagy 100%
  • Epigenomics 90%
  • Nutrients 88%
  • histone H3 trimethyl Lys4 14%
  • Macroautophagy 14%
  5 Citations (Scopus)

• Visualizing the cellular route of entry of a cystine-knot peptide with Xfect transfection reagent by electron microscopy

  Gao, X., De Mazière, A., Iaea, D. B., Arthur, C. P., Klumperman, J., Ciferri, C. & Hannoush, R. N., 6 May 2019, In: Scientific Reports. 9, 1, 6907.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cystine 100%
  • Electron Microscopy 66%
  • Transfection 66%
  • Peptides 49%
  • Cell-Penetrating Peptides 35%
  1 Downloads (Pure)