Research output per year
Research output per year
Research output
- 25 results
Search results
-
2024
A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion
Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S., Fortier, A-M., & 6 others, 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Direct Infusion Mass Spectrometry to Rapidly Map Metabolic Flux of Substrates Labeled with Stable Isotopes
Meijer, N. W. F., Zwakenberg, S., Gerrits, J., Westland, D., Ardisasmita, A. I., Fuchs, S. A., Verhoeven-Duif, N. M., Jans, J. J. M. & Zwartkruis, F. J. T., 25 Apr 2024, In: Metabolites. 14, 5, 13 p., 246.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Nuclear receptor Nur77 and Yin-Yang 1 synergistically increase mitochondrial abundance and activity in macrophages
Koenis, D. S., Evers-van Gogh, I. J. A., van Loenen, P. B., Zwart, W., Kalkhoven, E. & de Vries, C. J. M., Jul 2024, In: FEBS letters. 598, 14, p. 1715-1729 15 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2023
Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex
Clemente-Olivo, M. P., Hernández-Quiles, M., Sparrius, R., van der Stoel, M. M., Janssen, V., Habibe, J. J., van den Burg, J., Jongejan, A., Alcaraz-Sobrevals, P., van Es, R., Vos, H., Kalkhoven, E. & de Vries, C. J. M., Apr 2023, In: Cellular signalling. 104, 110587.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
The malate-aspartate shuttle is important for de novo serine biosynthesis
Broeks, M. H., Meijer, N. W. F., Westland, D., Bosma, M., Gerrits, J., German, H. M., Ciapaite, J., van Karnebeek, C. D. M., Wanders, R. J. A., Zwartkruis, F. J. T., Verhoeven-Duif, N. M. & Jans, J. J. M., 26 Sept 2023, In: Cell Reports. 42, 9, p. 1-18 113043.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile34 Downloads (Pure) -
The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo
Hernández-Quiles, M., Martinez Campesino, L., Morris, I., Ilyas, Z., Reynolds, S., Soon Tan, N., Sobrevals Alcaraz, P., Stigter, E. C. A., Varga, Á., Varga, J., van Es, R., Vos, H., Wilson, H. L., Kiss-Toth, E. & Kalkhoven, E., Dec 2023, In: Molecular Metabolism. 78, 101829.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2022
Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB Phosphoserines
Glykofridis, I. E., Henneman, A. A., Balk, J. A., Haas, R. G. D., Westland, D., Piersma, S. R., Knol, J. C., Pham, T. V., Boekhout, M., Zwartkruis, F. J. T., Wolthuis, R. M. F. & Jimenez, C. R., Sept 2022, In: Molecular and Cellular Proteomics. 21, 9, 100263.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
Madsen, M. S., Broekema, M. F., Madsen, M. R., Koppen, A., Borgman, A., Gräwe, C., Thomsen, E. G. K., Westland, D., Kranendonk, M. E. G., Koerkamp, M. G., Hamers, N., Bonvin, A. M. J. J., Pittol, J. M. R., Natarajan, K. N., Kersten, S., Holstege, F. C. P., Monajemi, H., van Mil, S. W. C., Vermeulen, M., Kragelund, B. B., & 3 others, Dec 2022, In: Nature Communications. 13, 1, 7090.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Recurrent exon-deleting activating mutations in AHR act as drivers of urinary tract cancer
Vlaar, J. M., Borgman, A., Kalkhoven, E., Westland, D., Besselink, N., Shale, C., Faltas, B. M., Priestley, P., Kuijk, E. & Cuppen, E., 16 Jun 2022, In: Scientific Reports. 12, 1, p. 1-12 10081.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
TRIB3 Modulates PPARγ-Mediated Growth Inhibition by Interfering with the MLL Complex in Breast Cancer Cells
Hernández-Quiles, M., Baak, R., Orea-Soufi, A., Borgman, A., den Haan, S., Sobrevals Alcaraz, P., Jongejan, A., van Es, R., Velasco, G., Vos, H. & Kalkhoven, E., 11 Sept 2022, In: International Journal of Molecular Sciences. 23, 18, 10535.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2021
Comprehensive profiling of mammalian tribbles interactomes implicates TRIB3 in gene repression
1 Dec 2021, In: Cancers. 13, 24, 6318.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
Splice variants of metabolic nuclear receptors: Relevance for metabolic disease and therapeutic targeting
Mukha, A., Kalkhoven, E. & van Mil, S. W. C., 1 Oct 2021, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1867, 10, p. 1-13 13 p., 166183.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile8 Downloads (Pure) -
2020
Cytokine Output of Adipocyte-iNKT Cell Interplay Is Skewed by a Lipid-Rich Microenvironment
van Eijkeren, R. J., Morris, I., Borgman, A., Markovska, A. & Kalkhoven, E., 31 Jul 2020, In: Frontiers in Endocrinology. 11, p. 1-10 479.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile6 Downloads (Pure) -
FXR Isoforms Control Different Metabolic Functions in Liver Cells via Binding to Specific DNA Motifs
Ramos Pittol, J. M., Milona, A., Morris, I., Willemsen, E. C. L., van der Veen, S. W., Kalkhoven, E. & van Mil, S. W. C., Nov 2020, In: Gastroenterology. 159, 5, p. 1853-1865.e10Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2019
Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation
Rakhshandehroo, M., van Eijkeren, R. J., Gabriel, T. L., de Haar, C., Gijzel, S. M. W., Hamers, N., Ferraz, M. J., Aerts, J. M. F. G., Schipper, H. S., van Eijk, M., Boes, M. & Kalkhoven, E., 1 Aug 2019, In: Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids. 1864, 8, p. 1157-1167 11 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile2 Downloads (Pure) -
Anaesthetic depth and complications after major surgery: an international, randomised controlled trial
23 Nov 2019, In: The Lancet. 394, 10212, p. 1907-1914 8 p.Research output: Contribution to journal › Article › Academic › peer-review
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Natural helix 9 mutants of PPARγ differently affect its transcriptional activity
Broekema, M. F., Massink, M. P. G., Donato, C., de Ligt, J., Schaarschmidt, J., Borgman, A., Schooneman, M. G., Melchers, D., Gerding, M. N., Houtman, R., Bonvin, A. M. J. J., Majithia, A. R., Monajemi, H., van Haaften, G. W., Soeters, M. R. & Kalkhoven, E., 1 Feb 2019, In: Molecular Metabolism. 20, p. 115-127 13 p.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile1 Citation (Scopus) -
2018
Profiling of 3696 nuclear receptor-coregulator interactions: A resource for biological and clinical discovery
Broekema, M. F., Hollman, D. A. A., Koppen, A., Van Den Ham, H. J., Melchers, D., Pijnenburg, D., Ruijtenbeek, R., Van Mil, S. W. C., Houtman, R. & Kalkhoven, E., 1 Jun 2018, In: Endocrinology. 159, 6, p. 2397-2406 10 p.Research output: Contribution to journal › Article › Academic › peer-review
6 Citations (Scopus) -
2017
Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults
Keustermans, G. C., Kofink, D., Eikendal, A., De Jager, W., Meerding, J., Nuboer, R., Waltenberger, J., Kraaijeveld, A. O., Jukema, J. W., Sels, J. W., Garssen, J., Prakken, B. J., Asselbergs, F. W., Kalkhoven, E., Hoefer, I. E., Pasterkamp, G. & Schipper, H. S., 1 Dec 2017, In: Scientific Reports. 7, 1, p. 1-8 16826.Research output: Contribution to journal › Article › Academic › peer-review
Open AccessFile -
2015
Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation
Tessadori, F., Noël, E. S., Rens, E. G., Magliozzi, R., Evers-van Gogh, I., Guardavaccaro, D., Merks, R. M. H. & Bakkers, J., 9 Mar 2015, In: Developmental Cell. 32, 5, p. 631-639 9 p.Research output: Contribution to journal › Article › Academic › peer-review
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2002
Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes
Martens, J. H. A., Verlaan, M., Kalkhoven, E., Dorsman, J. C. & Zantema, A., 10 Apr 2002, In: Molecular and Cellular Biology. 22, 8, p. 2598-2606 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access80 Citations (Scopus) -
The PHD type zinc finger is an integral part of the CBP acetyltransferase domain
Kalkhoven, E., Teunissen, H., Houweling, A., Verrijzer, C. P. & Zantema, A., 25 Mar 2002, In: Molecular and Cellular Biology. 22, 7, p. 1961-1970 10 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access78 Citations (Scopus) -
2001
A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300
Vries, R. G. J., Prudenziati, M., Zwartjes, C., Verlaan, M., Kalkhoven, E. & Zantema, A., 1 Nov 2001, In: EMBO Journal. 20, 21, p. 6095-6103 9 p.Research output: Contribution to journal › Article › Academic › peer-review
Open Access69 Citations (Scopus) -
2000
Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression
Valentine, J. E., Kalkhoven, E., White, R., Hoare, S. & Parker, M. G., 18 Aug 2000, In: Journal of Biological Chemistry. 275, 33, p. 25322-25329 8 p.Research output: Contribution to journal › Article › Academic › peer-review
72 Citations (Scopus) -
1998
Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor
Kalkhoven, E., Valentine, J. E., Heery, D. M. & Parker, M. G., 2 Jan 1998, In: EMBO Journal. 17, 1, p. 232-243 12 p.Research output: Contribution to journal › Article › Academic › peer-review
266 Citations (Scopus)