Group Burgering, section Molecular Cancer Research

Research output

Research output per year 1993 2020 2021 2022 2023 2024 2024

• 115 Article
• 19 Doctoral thesis 2 (Research NOT UU / Graduation UU)
• 8 Doctoral thesis 1 (Research UU / Graduation UU)
• 6 Review article
• 12 More
  • 4 Meeting Abstract
  • 4 Comment/Letter to the editor
  • 3 Letter
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

  Venema, W. J., Hiddingh, S., van Loosdregt, J., Bowes, J., Balliu, B., de Boer, J. H., Ossewaarde-van Norel, J., Thompson, S. D., Langefeld, C. D., de Ligt, A., van der Veken, L. T., Krijger, P. H. L., de Laat, W. & Kuiper, J. J. W., 10 Jan 2024, In: Cell genomics. 4, 1, 100460.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Lethal 100%
  • Enhancer 99%
  • Autoimmune Diseases 72%
  • Single Nucleotide Polymorphism 70%
  • Genes 33%
  21 Downloads (Pure)

• A farnesyl-dependent structural role for CENP-E in expansion of the fibrous corona

  Wu, J., Raas, M. W. D., Alcaraz, P. S., Vos, H. R., Tromer, E. C., Snel, B. & Kops, G. J. P. L., 1 Jan 2024, In: Journal of Cell Biology. 223, 1, p. 1-21 21 p., e202303007.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Kinetochores 100%
  • Kinesin 65%
  • Microtubules 49%
  • Prometaphase 38%
  • Prenylation 35%

• ALS-associated C21ORF2 variant disrupts DNA damage repair, mitochondrial metabolism, neuronal excitability and NEK1 levels in human motor neurons

  Zelina, P., de Ruiter, A. A., Kolsteeg, C., van Ginneken, I., Vos, H. R., Supiot, L. F., Burgering, B. M. T., Meye, F. J., Veldink, J. H., van den Berg, L. H. & Pasterkamp, R. J., 4 Sept 2024, In: Acta neuropathologica communications. 12, 1, 144.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Combine and conquer as a strategy to treat RAS-driven cancers

  Jansen, R. A., 23 Apr 2024, Utrecht University. 143 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Neoplasms 100%
  • Pharmaceutical Preparations 44%
  • Imatinib Mesylate 40%
  • Mutation 40%
  • Cell Division 22%
  3 Downloads (Pure)

• Complexity in Simplicity: Unraveling the Heterogeneous Nature of Malignant Rhabdoid Tumors

  Paassen, I. E. K., 20 Sept 2024, Utrecht University. 215 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

• Connecting the dots: Developing multimodal sequencing technologies to study gene regulation in single cells

  Lochs, S., 27 Jun 2024, Utrecht University. 241 p.

  Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

  Open Access

  File

  • Technology 100%
  • Genes 61%
  • Chromatin 45%
  • Epigenomics 33%
  • Genome 25%

• Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics

  Stelloo, S., Alejo-Vinogradova, M. T., van Gelder, C. A. G. H., Zijlmans, D. W., van Oostrom, M. J., Valverde, J. M., Lamers, L. A., Rus, T., Sobrevals Alcaraz, P., Schäfers, T., Furlan, C., Jansen, P. W. T. C., Baltissen, M. P. A., Sonnen, K. F., Burgering, B., Altelaar, M. A. F. M., Vos, H. R. & Vermeulen, M., 5 Jul 2024, In: Cell stem cell. 31, 7, p. 1072-1090.e8

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Germ Layers 100%
  • Embryonic Development 72%
  • Proteomics 72%
  • Synthetic Biology 36%
  • Developmental Biology 34%

• Dietary cystine restriction increases the proliferative capacity of the small intestine of mice

  de Jong, J. C. W., van Rooijen, K. S., Stigter, E. C. A., Gülersönmez, M. C., de Zoete, M. R., Top, J., Baars, M. J. D., Vercoulen, Y., Kuipers, F., Van Mil, S. W. C. & Ijssennagger, N., Jan 2024, In: PLoS ONE. 19, 1 January, e0290493.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cystine 100%
  • Small Intestine 70%
  • Cysteine 29%
  • Vegan Diet 25%
  • Vegetarian Diet 21%
  10 Downloads (Pure)

• Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA

  1 Jun 2024, In: Hepatology (Baltimore, Md.). 79, 6, p. 1279-1292 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Feasibility of an MR-based digital specimen for tongue cancer resection specimens: a novel approach for margin evaluation

  de Koning, K. J., Dankbaar, J. W., de Keizer, B., Willemsen, K., van der Toorn, A., Breimer, G. E., van Es, R. J. J., de Bree, R., Noorlag, R. & Philippens, M. E. P., 28 Mar 2024, In: Frontiers in oncology. 14, 11 p., 1342857.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Tongue Neoplasms 100%
  • Magnetic Resonance Spectroscopy 62%
  • Sensitivity and Specificity 34%
  • Hematoxylin 27%
  • Eosine Yellowish-(YS) 27%

• Finding the hidden patterns: single-cell omics to reduce late effects

  de Kanter, J. K., 9 Apr 2024, Utrecht: Utrecht University. 242 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Second Primary Neoplasms 100%
  • Platinum Compounds 64%
  • Pharmaceutical Preparations 49%
  • Ganciclovir 40%
  • DNA Damage 38%
  39 Downloads (Pure)

• Genetic dissection of the 11q13 amplicon in squamous cell carcinoma

  Mahieu, C. I., 25 Apr 2024, Utrecht University. 188 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Keratinocytes 100%
  • Dissection 88%
  • Squamous Cell Carcinoma 86%
  • Squamous Cell Carcinoma of Head and Neck 46%
  • Clustered Regularly Interspaced Short Palindromic Repeats 35%
  2 Downloads (Pure)

• Human fetal brain self-organizes into long-term expanding organoids

  Hendriks, D., Pagliaro, A., Andreatta, F., Ma, Z., van Giessen, J., Massalini, S., López-Iglesias, C., van Son, G. J. F., DeMartino, J., Damen, J. M. A., Zoutendijk, I., Staliarova, N., Bredenoord, A. L., Holstege, F. C. P., Peters, P. J., Margaritis, T., Chuva de Sousa Lopes, S., Wu, W., Clevers, H. & Artegiani, B., 1 Feb 2024, In: Cell. 187, 3, p. 712-732.e38

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Heterogeneity 70%
  • Probe 46%
  • Brain 37%
  • Central Nervous System 28%

• Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA.

  van Soest, D. M. K., Polderman, P. E., den Toom, W. T. F., Keijer, J. P., van Roosmalen, M. J., Leyten, T. M. F., Lehmann, J., Zwakenberg, S., De Henau, S., van Boxtel, R., Burgering, B. M. T. & Dansen, T. B., 28 Mar 2024, In: Nature Communications. 15, 1, p. 1-16 16 p., 2725.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • mitochondria 100%
  • Reactive Oxygen Metabolite 91%
  • Oncogenic Transformation 89%
  • deoxyribonucleic acid 88%
  • Mutation 82%

• Space odyssey: characterizing transcriptional regulation at a distance

  Huang, Y., 11 Jan 2024, Utrecht: Utrecht University. 177 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  • cohesins 100%
  • Gene Expression 83%
  • DNA 39%
  • Genome 23%
  • Genes 14%

• Structural variation in pediatric cancer: characterizing tumor genomes to improve patient care

  van Belzen, I. A. E. M., 17 Oct 2024, Utrecht University. 268 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)
• 2023

  All roads lead to SHP2

  Mulero-Sanchéz, A., 19 Oct 2023, Utrecht: Utrecht University. 198 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Neoplasms 100%
  • Receptor Protein-Tyrosine Kinases 60%
  • Phosphoric Monoester Hydrolases 57%
  • Phosphatidylinositol 3-Kinases 55%
  • (5-(2,4-bis((3S)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol 52%
  6 Downloads (Pure)

• CAF-1 deposits newly synthesized histones during DNA replication using distinct mechanisms on the leading and lagging strands

  Rouillon, C., Eckhardt, B. V., Kollenstart, L., Gruss, F., Verkennis, A. E. E., Rondeel, I., Krijger, P. H. L., Ricci, G., Biran, A., van Laar, T., Delvaux de Fenffe, C. M., Luppens, G., Albanese, P., Sato, K., Scheltema, R. A., de Laat, W., Knipscheer, P., Dekker, N. H., Groth, A. & Mattiroli, F., 8 May 2023, In: Nucleic acids research. 51, 8, p. 3770-3792 23 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Chromatin Assembly Factor-1 100%
  • DNA Replication 54%
  • Histones 51%
  • Proliferating Cell Nuclear Antigen 14%
  • Chromatin 12%
  13 Downloads (Pure)

• Comprehensive benchmark and architectural analysis of deep learning models for nanopore sequencing basecalling

  Pagès-Gallego, M. & de Ridder, J., 11 Apr 2023, In: Genome Biology. 24, 1, p. 1-18 18 p., 71.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nanopore Sequencing 100%
  • nanopores 89%
  • Deep Learning 81%
  • Benchmarking 63%
  • benchmarking 55%

• Early adipogenesis is repressed through the newly identified FHL2-NFAT5 signaling complex

  Clemente-Olivo, M. P., Hernández-Quiles, M., Sparrius, R., van der Stoel, M. M., Janssen, V., Habibe, J. J., van den Burg, J., Jongejan, A., Alcaraz-Sobrevals, P., van Es, R., Vos, H., Kalkhoven, E. & de Vries, C. J. M., Apr 2023, In: Cellular signalling. 104, 110587.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • NFATC Transcription Factors 100%
  • Adipogenesis 89%
  • Adipocytes 71%
  • Signal Transduction 58%
  • 3T3-L1 Cells 24%

• Elevated enhancer-oncogene contacts and higher oncogene expression levels by recurrent CTCF inactivating mutations in acute T cell leukemia

  Smits, W. K., Vermeulen, C., Hagelaar, R., Kimura, S., Vroegindeweij, E. M., Buijs-Gladdines, J. G. C. A. M., van de Geer, E., Verstegen, M. J. A. M., Splinter, E., van Reijmersdal, S. V., Buijs, A., Galjart, N., van Eyndhoven, W., van Min, M., Kuiper, R., Kemmeren, P., Mullighan, C. G., de Laat, W. & Meijerink, J. P. P., 25 Apr 2023, In: Cell Reports. 42, 4, 25 p., 112373.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Enhancer 100%
  • Oncogenes 80%
  • Mutation 71%
  • Leukemia 69%
  • CCCTC-Binding Factor 67%

• Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

  Hendriks, D., Brouwers, J. F., Hamer, K., Geurts, M. H., Luciana, L., Massalini, S., López-Iglesias, C., Peters, P. J., Rodríguez-Colman, M. J., Chuva de Sousa Lopes, S., Artegiani, B. & Clevers, H., Nov 2023, In: Nature Biotechnology. 41, 11, p. 1567-1581 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hepatocytes 100%
  • Lipogenesis 88%
  • Organoids 78%
  • Fatty acids 73%
  • Liver 71%
  15 Downloads (Pure)

• En route to better treatment of rhabdomyosarcoma: signaling pathways, tumor organoid models and single-cell RNA-sequencing

  Meister, M. T., 7 Jun 2023, Utrecht: Utrecht University. 279 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Organoids 100%
  • Rhabdomyosarcoma 90%
  • RNA Sequence Analysis 85%
  • Neoplasms 24%
  • Therapeutics 12%
  2 Downloads (Pure)

• Formalin-Fixed, Paraffin-Embedded-Targeted Locus Capture: A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors

  Stelloo, E., Meijers, R. W. J., Swennenhuis, J. F., Allahyar, A., Hajo, K., Cangiano, M., de Leng, W. W. J., van Helvert, S., Van der Meulen, J., Creytens, D., van Kempen, L. C., Cleton-Jansen, A-M., Bovee, J. V. M. G., de Laat, W., Splinter, E. & Feitsma, H., Oct 2023, In: Journal of Molecular Diagnostics. 25, 10, p. 758-770 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Gene Fusion 100%
  • High-Throughput Nucleotide Sequencing 84%
  • Formaldehyde 82%
  • Paraffin 82%
  • Technology 57%
  9 Downloads (Pure)

• Human IAPP is a contributor to painful diabetic peripheral neuropathy

  Albariqi, M. M., Versteeg, S., Brakkee, E. M., Coert, J. H., Elenbaas, B. O., Prado, J., Hack, C. E., Höppener, J. W. & Eijkelkamp, N., 17 Apr 2023, In: Journal of Clinical Investigation. 133, 8, e156993.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Islet Amyloid Polypeptide 100%
  • Diabetic Neuropathies 89%
  • Peripheral Nervous System Diseases 81%
  • Type 2 Diabetes Mellitus 24%
  • Nerve Fibers 16%
  3 Downloads (Pure)

• Integration of Philosophy of Science in Biomedical Data Science Education to Foster Better Scientific Practice

  Pieterman-Bos, A. & van Mil, M., Dec 2023, In: Science & Education. 32, 6, p. 1709-1738 30 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • philosophy of science 100%
  • education 24%
  • learning 23%
  • research implementation 17%
  • statistical method 14%
  8 Downloads (Pure)

• Lipoproteins act as vehicles for lipid antigen delivery and activation of invariant natural killer T-cells

  Engelen, S. E., Ververs, F. A., Markovska, A., Lagerholm, B. C., Kraaijenhof, J. M., Yousif, L. I., Zurke, Y-X., Gulersonmez, C. M., Kooijman, S., Goddard, M., van Eijkeren, R. J., Jervis, P. J., Besra, G. S., Haitjema, S., Asselbergs, F. W., Kalkhoven, E., Ploegh, H. L., Boes, M., Cerundolo, V., Hovingh, G. K., & 5 othersSalio, M., Stigter, E. C., Rensen, P. C., Monaco, C. & Schipper, H. S., 8 May 2023, In: JCI Insight. 8, 9, e158089.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Natural Killer T-Cells 100%
  • Lipoproteins 79%
  • Antigen-Presenting Cells 54%
  • Lipids 54%
  • Antigens 53%
  10 Downloads (Pure)

• Metabolic rewiring in keratinocytes by miR-31-5p identifies therapeutic intervention for psoriasis

  Wang, M-J., Huang, H-J., Xu, Y-Y., Vos, H., Gulersonmez, C., Stigter, E., Gerritsen, J., Gallego, M. P., van Es, R., Li, L., Deng, H., Han, L., Huang, R-Y., Lu, C-J. & Burgering, B. M., 11 Apr 2023, In: Embo Molecular Medicine. 15, 4, e15674.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Psoriasis 100%
  • Keratinocytes 98%
  • MicroRNAs 85%
  • Glucose 31%
  • Th17 Cells 30%

• Moral imagination as an instrument for ethics education for biomedical researchers

  Gerrits, E. M., Assen, L. S., Noordegraaf-Eelens, L., Bredenoord, A. L. & van Mil, M. H. W., Dec 2023, In: International Journal of Ethics Education. 8, p. 275-289 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Moral Imagination 100%
  • Moral Reasoning 47%
  • Teaching Strategies 40%
  • Competency 38%
  • Education 34%
  25 Downloads (Pure)

• Multi-country metabolic signature discovery for chicken health classification

  Wolthuis, J. C., Magnúsdóttir, S., Stigter, E., Tang, Y. F., Jans, J., Gilbert, M., van der Hee, B., Langhout, P., Gerrits, W., Kies, A., de Ridder, J. & van Mil, S., 2 Feb 2023, In: Metabolomics. 19, 2, 9.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Branched-Chain Amino Acid 100%
  • Polyamine 74%
  • Chickens 67%
  • Metabolic 56%
  • Pharmacological Metabolism 53%
  2 Downloads (Pure)

• Oxygen-consumption based quantification of chemogenetic H₂O₂ production in live human cells

  den Toom, W. T. F., van Soest, D. M. K., Polderman, P. E., van Triest, M. H., Bruurs, L. J. M., De Henau, S., Burgering, B. M. T. & Dansen, T. B., Sept 2023, In: Free Radical Biology and Medicine. 206, p. 134-142 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • D-Amino-Acid Oxidase 100%
  • Oxygen Consumption 59%
  • Acid 20%
  • Respiration 18%
  • Culture Media 14%
  2 Downloads (Pure)

• Patterns of somatic mutations in normal cells

  Manders, F., 21 Feb 2023, Utrecht University. 220 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Mutation 100%
  • Mutation Accumulation 82%
  • Down Syndrome 61%
  • DNA Repair 55%
  • Blood Cells 48%
  38 Downloads (Pure)

• Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation

  Mocholi, E., Russo, L., Gopal, K., Ramstead, A. G., Hochrein, S. M., Vos, H. R., Geeven, G., Adegoke, A. O., Hoekstra, A., van Es, R. M., Pittol, J. R., Vastert, S., Rutter, J., Radstake, T., van Loosdregt, J., Berkers, C., Mokry, M., Anderson, C. C., O'Connell, R. M., Vaeth, M., & 3 othersUssher, J., Burgering, B. M. T. & Coffer, P. J., 27 Jun 2023, In: Cell Reports. 42, 6, p. 1-24 112583.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Chromatin Assembly and Disassembly 100%
  • Pyruvic Acid 91%
  • Pyruvate 88%
  • Histone 68%
  • Pharmacological Metabolism 65%
  11 Downloads (Pure)

• Rifaximin stimulates nitrogen detoxification by PXR-independent mechanisms in human small intestinal organoids

  de Wit, K., Beuers, U., Mukha, A., Stigter, E., Gulersonmez, M. C., Ramos Pittol, J. M., Middendorp, S., Takkenberg, R. B. & van Mil, S. W. C., Mar 2023, In: Liver International. 43, 3, p. 649-659 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Rifaximin 100%
  • Pregnane X Receptor 94%
  • Organoids 86%
  • Nitrogen 64%
  • Hepatic Encephalopathy 14%
  15 Downloads (Pure)

• Senescence as a steppingstone for cancer treatment: If you stop, you might fall

  Jochems, F., 26 Oct 2023, Utrecht: Utrecht University. 248 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Oncology 100%
  • Cells 72%
  • Cell death 42%
  • Tumors 11%
  • Genes 10%
  29 Downloads (Pure)

• SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells

  Sluimer, L. M., Bullock, E., Rätze, M. A. K., Enserink, L., Overbeeke, C., Hornsveld, M., Brunton, V. G., Derksen, P. W. B. & Tavares, S., Feb 2023, In: Journal of cell science. 136, 3, jcs260243.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Phosphotransferases 100%
  • Breast Neoplasms 82%
  • Psychological Inhibition 79%
  • proto-oncogene protein c-fes-fps 67%
  • Growth 65%

• The pseudokinase TRIB3 controls adipocyte lipid homeostasis and proliferation in vitro and in vivo

  Hernández-Quiles, M., Martinez Campesino, L., Morris, I., Ilyas, Z., Reynolds, S., Soon Tan, N., Sobrevals Alcaraz, P., Stigter, E. C. A., Varga, Á., Varga, J., van Es, R., Vos, H., Wilson, H. L., Kiss-Toth, E. & Kalkhoven, E., Dec 2023, In: Molecular Metabolism. 78, 101829.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Adipocytes 100%
  • Homeostasis 77%
  • Lipidomics 71%
  • Lipids 68%
  • Knockout Mice 48%

• The structure-function paradigm reshaped by intrinsically disordered regions

  Gui, T., 30 Oct 2023, Utrecht University. 170 p.

  Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

  Open Access

  File

  • Catenins 100%
  • Proteins 48%
  • Peptides 33%
  • Drug Discovery 27%
  • Biological Phenomena 25%
  9 Downloads (Pure)

• Ultra-fast deep-learned CNS tumour classification during surgery

  Vermeulen, C., Pagès-Gallego, M., Kester, L., Kranendonk, M. E. G., Wesseling, P., Verburg, N., de Witt Hamer, P., Kooi, E. J., Dankmeijer, L., van der Lugt, J., van Baarsen, K., Hoving, E. W., Tops, B. B. J. & de Ridder, J., 26 Oct 2023, In: Nature. 622, p. 842-849 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Central Nervous System Neoplasms 100%
  • Nanopore Sequencing 68%
  • Neoplasms 52%
  • Patient Transfer 47%
  • Methylation 36%
• 2022

  Building regulatory landscapes reveals that an enhancer can recruit cohesin to create contact domains, engage CTCF sites and activate distant genes

  Rinzema, N. J., Sofiadis, K., Tjalsma, S. J. D., Verstegen, M. J. A. M., Oz, Y., Valdes-Quezada, C., Felder, A. K., Filipovska, T., van der Elst, S., de Andrade dos Ramos, Z., Han, R., Krijger, P. H. L. & de Laat, W., Jun 2022, In: Nature Structural and Molecular Biology. 29, 6, p. 563-574 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • cohesins 100%
  • Chromatin 37%
  • Genes 28%
  • Developmental Genes 19%
  • Genetic Enhancer Elements 17%
  6 Citations (Scopus)

  21 Downloads (Pure)

• Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis

  te Boekhorst, V., Jiang, L., Mählen, M., Meerlo, M., Dunkel, G., Durst, F. C., Yang, Y., Levine, H., Burgering, B. M. T. & Friedl, P., 24 Jan 2022, In: Current Biology. 32, 2, p. 412-427.e8

  Research output: Contribution to journal › Article › Academic › peer-review

  • calpain 100%
  • metastasis 98%
  • Calpain 95%
  • Plastic Property 89%
  • cell movement 83%
  1 Citation (Scopus)

• Current challenges in understanding the role of enhancers in disease

  Zaugg, J. B., Sahlén, P., Andersson, R., Alberich-Jorda, M., de Laat, W., Deplancke, B., Ferrer, J., Mandrup, S., Natoli, G., Plewczynski, D., Rada-Iglesias, A. & Spicuglia, S., Dec 2022, In: Nature Structural and Molecular Biology. 29, 12, p. 1148-1158 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Population Biological Variation 100%
  • Gene Expression 97%
  • Epigenomics 71%
  • Direction compound 58%
  • Neoplasms 26%

• Dynamics and Heterogeneity of mRNA Translation and RNA Virus Infections

  Boersma, S., 18 May 2022, Utrecht University. 263 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • RNA Virus Infections 100%
  • Protein Biosynthesis 65%
  • Single Molecule Imaging 41%
  • Messenger RNA 24%
  • RNA Viruses 20%
  19 Downloads (Pure)

• Educating for Responsible Research Practice in Biomedical Sciences: Towards Learning Goals

  Gerrits, E. M., Bredenoord, A. L. & van Mil, M. H. W., Aug 2022, In: Science and Education. 31, 4, p. 977-996 20 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • research practice 100%
  • conduct of research 46%
  • biomedicine 42%
  • learning 36%
  • reflexivity 33%

• FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

  Tavares, S., Liv, N., Pasolli, M., Opdam, M., Rätze, M. A. K., Saornil, M., Sluimer, L. M., Hengeveld, R. C. C., van Es, R., van Werkhoven, E., Vos, H., Rehmann, H., Burgering, B. M. T., Oosterkamp, H. M., Lens, S. M. A., Klumperman, J., Linn, S. C. & Derksen, P. W. B., 5 Apr 2022, In: Cell Reports. 39, 1, p. 1-24 110584.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Taxane 100%
  • taxane 90%
  • Adjuvant 86%
  • Triple Negative Breast Neoplasms 84%
  • Recycling 63%
  33 Downloads (Pure)

• How enhancers shape and activate the genome

  Rinzema, N. J., 14 Jul 2022, Utrecht University. 118 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • cohesins 100%
  • Genome 47%
  • Gene Expression 29%
  • DNA 22%
  • Synthetic Genes 14%
  3 Downloads (Pure)

• How to fulfill the expert role in public dialogue: The Dutch dialogue on human germline genetic modification as a case

  Reincke, C. M., Bredenoord, A. L., van Baalen, S. & van Mil, M. H. W., 22 Nov 2022, In: Frontiers in Communication. 7, 985759.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • genetic modification 100%
  • communication sciences 64%
  • dialogue 47%
  • expert 42%
  • responsibility 36%
  8 Downloads (Pure)

• Impaired activity of the fusogenic micropeptide Myomixer causes myopathy resembling Carey-Fineman-Ziter syndrome

  Ramirez-Martinez, A., Zhang, Y., van den Boogaard, M-J., McAnally, J. R., Rodriguez-Caycedo, C., Chai, A. C., Chemello, F., Massink, M. P., Cuppen, I., Elferink, M. G., van Es, R. J., Janssen, N. G., Walraven-van Oijen, L. P., Liu, N., Bassel-Duby, R., van Jaarsveld, R. H. & Olson, E. N., 1 Jun 2022, In: Journal of Clinical Investigation. 132, 11, p. 1-11 e159002.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Myopathy, congenital nonprogressive with Moebius and Robin sequences 100%
  • Muscular Diseases 48%
  • Myoblasts 30%
  • Neuromuscular Diseases 11%
  • Muscles 10%
  3 Citations (Scopus)

  3 Downloads (Pure)

• Mapping mutations in human cells: How extrinsic agents and aging alter the genetic code

  Rosendahl Huber, A., 10 Feb 2022, Utrecht University. 204 p.

  Research output: Thesis › Doctoral thesis 2 (Research NOT UU / Graduation UU)

  Open Access

  File

  • Genetic Code 100%
  • Mutation 39%
  • colibactin 26%
  • Bacteria 19%
  • Drug Therapy 16%
  1 Downloads (Pure)

• Mesenchymal tumor organoid models recapitulate rhabdomyosarcoma subtypes

  Meister, M. T., Groot Koerkamp, M. J. A., de Souza, T., Breunis, W. B., Frazer-Mendelewska, E., Brok, M., DeMartino, J., Manders, F., Calandrini, C., Kerstens, H. H. D., Janse, A., Dolman, M. E. M., Eising, S., Langenberg, K. P. S., van Tuil, M., Knops, R. R. G., van Scheltinga, S. T., Hiemcke-Jiwa, L. S., Flucke, U., Merks, J. H. M., & 9 othersvan Noesel, M. M., Tops, B. B. J., Hehir-Kwa, J. Y., Kemmeren, P., Molenaar, J. J., van de Wetering, M., van Boxtel, R., Drost, J. & Holstege, F. C. P., 10 Oct 2022, In: Embo Molecular Medicine. 14, 10, e16001.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Organoids 100%
  • Rhabdomyosarcoma 90%
  • Preclinical Drug Evaluations 30%
  • Neoplasms 24%
  • Embryonal Rhabdomyosarcoma 18%
  7 Downloads (Pure)