Group Bos, section Molecular Cancer Research

2024

A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S., Fortier, A-M., & 6 othersPark, M., Fodde, R., Gloerich, M., Zwartkruis, F. J. T., Derksen, P. W. & de Rooij, J., 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.

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Organoids as a biomarker for personalized treatment in metastatic colorectal cancer: drug screen optimization and correlation with patient response

Smabers, L. P., Wensink, E., Verissimo, C. S., Koedoot, E., Pitsa, K-C., Huismans, M. A., Higuera Barón, C., Doorn, M., Valkenburg-van Iersel, L. B., Cirkel, G. A., Brousali, A., Overmeer, R., Koopman, M., Braat, M. N., Penning de Vries, B., Elias, S. G., Vries, R. G., Kranenburg, O., Boj, S. F. & Roodhart, J. M., 27 Feb 2024, In: Journal of experimental & clinical cancer research. 43, 1, p. 1-16 16 p., 61.

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2023

A second case of glutaminase hyperactivity: Expanding the phenotype with epilepsy

Rumping, L., Pouwels, P. J. W., Wolf, N. I., Rehmann, H., Wamelink, M. M. C., Waisfisz, Q., Jans, J. J. M., Prinsen, H. C. M. T., van de Kamp, J. M. & van Hasselt, P. M., May 2023, In: JIMD Reports. 64, 3, p. 217-222 6 p.

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Bi-allelic variants in NAE1 cause intellectual disability, ischiopubic hypoplasia, stress-mediated lymphopenia and neurodegeneration

Muffels, I. J. J., Schene, I. F., Rehmann, H., Massink, M. P. G., van der Wal, M. M., Bauder, C., Labeur, M., Armando, N. G., Lequin, M. H., Houben, M. L., Giltay, J. C., Haitjema, S., Huisman, A., Vansenne, F., Bluvstein, J., Pappas, J., Shailee, L. V., Zarate, Y. A., Mokry, M., van Haaften, G. W., & 5 othersNieuwenhuis, E. E. S., Refojo, D., van Wijk, F., Fuchs, S. A. & van Hasselt, P. M., 5 Jan 2023, In: American Journal of Human Genetics. 110, 1, p. 146-160 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

Mertens, S., Huismans, M. A., Verissimo, C. S., Ponsioen, B., Overmeer, R., Proost, N., van Tellingen, O., van de Ven, M., Begthel, H., Boj, S. F., Clevers, H., Roodhart, J. M. L., Bos, J. L. & Snippert, H. J. G., 25 Apr 2023, In: Cell Reports. 42, 4, 112324.

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Functional determination of emicizumab in presence of factor VIII activity

Hamedani, N. S., Donners, A. A. M. T., van Luin, M., Gasper, S., Rühl, H., Klein, C., Albert, T., EL Amrani, M., Pötzsch, B., Oldenburg, J. & Müller, J., Dec 2023, In: Journal of Thrombosis and Haemostasis. 21, 12, p. 3490-3500 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Oxygen-consumption based quantification of chemogenetic H₂O₂ production in live human cells

den Toom, W. T. F., van Soest, D. M. K., Polderman, P. E., van Triest, M. H., Bruurs, L. J. M., De Henau, S., Burgering, B. M. T. & Dansen, T. B., Sept 2023, In: Free Radical Biology and Medicine. 206, p. 134-142 9 p.

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2022

Calpain-2 regulates hypoxia/HIF-induced plasticity toward amoeboid cancer cell migration and metastasis

te Boekhorst, V., Jiang, L., Mählen, M., Meerlo, M., Dunkel, G., Durst, F. C., Yang, Y., Levine, H., Burgering, B. M. T. & Friedl, P., 24 Jan 2022, In: Current Biology. 32, 2, p. 412-427.e8

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer

Tavares, S., Liv, N., Pasolli, M., Opdam, M., Rätze, M. A. K., Saornil, M., Sluimer, L. M., Hengeveld, R. C. C., van Es, R., van Werkhoven, E., Vos, H., Rehmann, H., Burgering, B. M. T., Oosterkamp, H. M., Lens, S. M. A., Klumperman, J., Linn, S. C. & Derksen, P. W. B., 5 Apr 2022, In: Cell Reports. 39, 1, p. 1-24 110584.

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Liver Colonization by Colorectal Cancer Metastases Requires YAP-Controlled Plasticity at the Micrometastatic Stage

Heinz, M. C., Peters, N. A., Oost, K. C., Lindeboom, R. G. H., van Voorthuijsen, L., Fumagalli, A., van der Net, M. C., de Medeiros, G., Hageman, J. H., Verlaan-Klink, I., Borel Rinkes, I. H. M., Liberali, P., Gloerich, M., van Rheenen, J., Vermeulen, M., Kranenburg, O. & Snippert, H. J. G., 15 May 2022, In: Cancer Research. 82, 10, p. 1953-1968 16 p.

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2021

Development of a plain-language guide for discussing breast cancer genetic counseling and testing with patients with limited health literacy

van der Giessen, J. A. M., Ausems, M. G. E. M., van Riel, E., de Jong, A., Fransen, M. P. & van Dulmen, S., Jun 2021, In: Supportive Care in Cancer. 29, 6, p. 2895-2905 11 p.

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Medium-throughput drug-and radiotherapy screening assay using patient-derived organoids

Putker, M., Millen, R., Overmeer, R., Driehuis, E., Zandvliet, M. M. J. M., Clevers, H., Boj, S. F. & Li, Q. X., 30 Apr 2021, In: Journal of Visualized Experiments. 2021, 170, e62495.

Research output: Contribution to journal › Article › Academic › peer-review

mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy

Schlingmann, K. P., Jouret, F., Shen, K., Nigam, A., Arjona, F. J., Dafinger, C., Houillier, P., Jones, D. P., Kleinerüschkamp, F., Oh, J., Godefroid, N., Eltan, M., Güran, T., Burtey, S., Parotte, M-C., König, J., Braun, A., Bos, C., Ibars Serra, M., Rehmann, H., & 16 othersZwartkruis, F. J. T., Renkema, K. Y., Klingel, K., Schulze-Bahr, E., Schermer, B., Bergmann, C., Altmüller, J., Thiele, H., Beck, B. B., Dahan, K., Sabatini, D., Liebau, M. C., Vargas-Poussou, R., Knoers, N. V. A. M., Konrad, M. & de Baaij, J. H. F., Nov 2021, In: Journal of the American Society of Nephrology. 32, 11, p. 2885-2899 15 p.

Research output: Contribution to journal › Article › Academic › peer-review

NAA80 bi-allelic missense variants result in high-frequency hearing loss, muscle weakness and developmental delay

Muffels, I. J. J., Wiame, E., Fuchs, S. A., Massink, M. P. G., Rehmann, H., Musch, J. L. I., Van Haaften, G., Vertommen, D., van Schaftingen, E. & van Hasselt, P. M., 2021, In: Brain communications. 3, 4, p. 1-14 fcab256.

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2 Citations (Scopus)

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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

Ponsioen, B., Post, J. B., Buissant des Amorie, J. R., Laskaris, D., van Ineveld, R. L., Kersten, S., Bertotti, A., Sassi, F., Sipieter, F., Cappe, B., Mertens, S., Verlaan-Klink, I., Boj, S. F., Vries, R. G. J., Rehmann, H., Vandenabeele, P., Riquet, F. B., Trusolino, L., Bos, J. L. & Snippert, H. J. G., Apr 2021, In: Nature Cell Biology. 23, 4, p. 377-390 14 p.

Research output: Contribution to journal › Article › Academic › peer-review

Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Bollen, Y., Stelloo, E., van Leenen, P., van den Bos, M., Ponsioen, B., Lu, B., van Roosmalen, M. J., Bolhaqueiro, A. C. F., Kimberley, C., Mossner, M., Cross, W. C. H., Besselink, N. J. M., van der Roest, B., Boymans, S., Oost, K. C., de Vries, S. G., Rehmann, H., Cuppen, E., Lens, S. M. A., Kops, G. J. P. L., & 6 othersKloosterman, W. P., Terstappen, L. W. M. M., Barnes, C. P., Sottoriva, A., Graham, T. A. & Snippert, H. J. G., Aug 2021, In: Nature Genetics. 53, 8, p. 1187-1195 9 p.

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Treatment of ARS deficiencies with specific amino acids

Kok, G., Tseng, L., Schene, I. F., Dijsselhof, M. E., Salomons, G., Mendes, M. I., Smith, D. E. C., Wiedemann, A., Canton, M., Feillet, F., de Koning, T. J., Boothe, M., Dean, J., Kassel, R., Ferreira, E. A., van den Born, M., Nieuwenhuis, E. E. S., Rehmann, H., Terheggen-Lagro, S. W. J., van Karnebeek, C. D. M., & 1 othersFuchs, S. A., Nov 2021, In: Genetics in Medicine. 23, 11, p. 2202-2207 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

2020

Colorectal Cancer Modeling with Organoids: Discriminating between Oncogenic RAS and BRAF Variants

Post, J. B., Roodhart, J. M. L. & Snippert, H. J. G., Feb 2020, In: Trends in Cancer. 6, 2, p. 111-129 19 p.

Research output: Contribution to journal › Review article › peer-review

Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids

Dekkers, J. F., Whittle, J. R., Vaillant, F., Chen, H. R., Dawson, C., Liu, K., Geurts, M. H., Herold, M. J., Clevers, H., Lindeman, G. J. & Visvader, J. E., 1 May 2020, In: Journal of the National Cancer Institute. 112, 5, p. 540-544 5 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

Fumagalli, A., Oost, K. C., Kester, L., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., Heinz, M. C., Postrach, D., Seinstra, D., Sieuwerts, A. M., Martens, J. W. M., van der Elst, S., van Baalen, M., Bhowmick, D., Vrisekoop, N., Ellenbroek, S. I. J., & 3 othersSuijkerbuijk, S. J. E., Snippert, H. J. & van Rheenen, J., 2 Apr 2020, In: Cell stem cell. 26, 4, p. 569-578.e7

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5 Citations (Scopus)

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2019

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity

Kopper, O., de Witte, C. J., Lõhmussaar, K., Valle-Inclan, J. E., Hami, N., Kester, L., Balgobind, A. V., Korving, J., Proost, N., Begthel, H., van Wijk, L. M., Revilla, S. A., Theeuwsen, R., van de Ven, M., van Roosmalen, M. J., Ponsioen, B., Ho, V. W. H., Neel, B. G., Bosse, T., Gaarenstroom, K. N., & 11 othersVrieling, H., Vreeswijk, M. P. G., van Diest, P. J., Witteveen, P. O., Jonges, T., Bos, J. L., van Oudenaarden, A., Zweemer, R. P., Snippert, H. J. G., Kloosterman, W. P. & Clevers, H., May 2019, In: Nature Medicine. 25, 5, p. 838-849 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Cadherin mechanotransduction in leader-follower cell specification during collective migration

Khalil, A. A. & de Rooij, J., 1 Mar 2019, In: Experimental Cell Research. 376, 1, p. 86-91 6 p.

Research output: Contribution to journal › Review article › peer-review

De Novo Heterozygous POLR2A Variants Cause a Neurodevelopmental Syndrome with Profound Infantile-Onset Hypotonia

Haijes, H. A., Koster, M. J. E., Rehmann, H., Li, D., Hakonarson, H., Cappuccio, G., Hancarova, M., Lehalle, D., Reardon, W., Schaefer, G. B., Lehman, A., van de Laar, I. M. B. H., Tesselaar, C. D., Turner, C., Goldenberg, A., Patrier, S., Thevenon, J., Pinelli, M., Brunetti-Pierri, N., Prchalová, D., & 24 othersHavlovicová, M., Vlckova, M., Sedláček, Z., Lopez, E., Ragoussis, V., Pagnamenta, A. T., Kini, U., Vos, H. R., van Es, R. M., van Schaik, R. F. M. A., van Essen, T. A. J., Kibaek, M., Taylor, J. C., Sullivan, J., Shashi, V., Petrovski, S., Fagerberg, C., Martin, D. M., van Gassen, K. L. I., Pfundt, R., Falk, M. J., McCormick, E. M., Timmers, H. T. M. & van Hasselt, P. M., 1 Aug 2019, In: American Journal of Human Genetics. 105, 2, p. 283-301 19 p.

Research output: Contribution to journal › Article › Academic › peer-review

Discovery of pyridoxal reductase activity as part of human vitamin B6 metabolism

Ramos, R. J., Albersen, M., Vringer, E., Bosma, M., Zwakenberg, S., Zwartkruis, F., Jans, J. J. M. & Verhoeven-Duif, N. M., Jun 2019, In: Biochimica et biophysica acta-General subjects. 1863, 6, p. 1088-1097 10 p.

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GLS hyperactivity causes glutamate excess, infantile cataract and profound developmental delay

Rumping, L., Tessadori, F., Pouwels, P. J. W., Vringer, E., Wijnen, J. P., Bhogal, A. A., Savelberg, S. M. C., Duran, K. J., Bakkers, M. J. G., Ramos, R. J. J., Schellekens, P. A. W., Kroes, H. Y., Klomp, D. W. J., Black, G. C. M., Taylor, R. L., Bakkers, J. P. W., Prinsen, H. C. M. T., van der Knaap, M. S., Dansen, T. B., Rehmann, H., & 6 othersZwartkruis, F. J. T., Houwen, R. H. J., van Haaften, G., Verhoeven-Duif, N. M., Jans, J. J. M. & van Hasselt, P. M., 1 Jan 2019, In: Human Molecular Genetics. 28, 1, p. 96-104 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

12 Citations (Scopus)

High-resolution 3D imaging of fixed and cleared organoids

Dekkers, J. F., Alieva, M., Wellens, L. M., Ariese, H. C. R., Jamieson, P. R., Vonk, A. M., Amatngalim, G. D., Hu, H., Oost, K. C., Snippert, H. J. G., Beekman, J. M., Wehrens, E. J., Visvader, J. E., Clevers, H. & Rios, A. C., 1 Jun 2019, In: Nature Protocols. 14, 6, p. 1756-1771 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Identification of a Loss-of-Function Mutation in the Context of Glutaminase Deficiency and Neonatal Epileptic Encephalopathy

Rumping, L., Büttner, B., Maier, O., Rehmann, H., Lequin, M., Schlump, J. U., Schmitt, B., Schiebergen-Bronkhorst, B., Prinsen, H. C. M. T., Losa, M., Fingerhut, R., Lemke, J. R., Zwartkruis, F. J. T., Houwen, R. H. J., Jans, J. J. M., Verhoeven-Duif, N. M., Van Hasselt, P. M. & Jamra, R., 1 Mar 2019, In: JAMA Neurology. 76, 3, p. 342-350 9 p.

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3 Citations (Scopus)

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Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase

Małecki, J. D. M., Willemen, H. L. D. M., Pinto, R., Ho, A. Y. Y., Moen, A., Kjønstad, I. F., Burgering, B. M. T., Zwartkruis, F., Eijkelkamp, N. & Falnes, P., 25 Jan 2019, In: Journal of Biological Chemistry. 294, 4, p. 1128-1141 14 p.

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3 Citations (Scopus)

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MDH1 deficiency is a metabolic disorder of the malate–aspartate shuttle associated with early onset severe encephalopathy

Broeks, M. H., Shamseldin, H. E., Alhashem, A., Hashem, M., Abdulwahab, F., Alshedi, T., Alobaid, I., Zwartkruis, F., Westland, D., Fuchs, S., Verhoeven-Duif, N. M., Jans, J. J. M. & Alkuraya, F. S., Dec 2019, In: Human Genetics. 138, 11-12, p. 1247-1257 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids

Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Kucukkose, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., Sasaki, N., Dutta, D., Boj, S. F., Vries, R. G. J., Lansdorp, P. M., van de Wetering, M., van Oudenaarden, A., Clevers, H., Kranenburg, O., Foijer, F., & 2 othersSnippert, H. J. G. & Kops, G. J. P. L., May 2019, In: Nature Genetics. 51, 5, p. 824-834 11 p.

Research output: Contribution to journal › Article › Academic › peer-review

2018

Shared Decision Making in Prostate Cancer Care—Encouraging Every Patient to be Actively Involved in Decision Making or Ensuring the Patient Preferred Level of Involvement?

van Stam, M. A., Pieterse, A. H., van der Poel, H. G., Bosch, J. L. H. R., Tillier, C., Horenblas, S. & Aaronson, N. K., 1 Sept 2018, In: Journal of Urology. 200, 3, p. 582-589 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Scopus)

Validation of ergonomic instructions in robot-assisted surgery simulator training

van’t Hullenaar, C. D. P., Mertens, A. C., Ruurda, J. P. & Broeders, I. A. M. J., May 2018, In: Surgical Endoscopy. 32, 5, p. 2533-2540 8 p.

Research output: Contribution to journal › Article › Academic › peer-review

2017

A two-tiered mechanism enables localized Cdc42 signaling during enterocyte polarization

Bruurs, L. J. M., Zwakenberg, S., van der Net, M. C., Zwartkruis, F. J. & Bos, J. L., Apr 2017, In: Molecular and Cellular Biology. 37, 7, e00547-16.

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Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells

Hindriksen, S., Bramer, A. J., Truong, M. A., Vromans, M. J. M., Post, J. B., Verlaan-Klink, I., Snippert, H. J., Lens, S. M. A. & Hadders, M. A., 2017, In: PLoS ONE [E]. 12, 6, e0179514.

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Genome-wide CRISPR screens reveal a Wnt-FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

Steinhart, Z., Pavlovic, Z., Chandrashekhar, M., Hart, T., Wang, X., Zhang, X., Robitaille, M., Brown, K. R., Jaksani, S., Overmeer, R., Boj, S. F., Adams, J., Pan, J., Clevers, H., Sidhu, S., Moffat, J. & Angers, S., 1 Jan 2017, In: Nature Medicine. 23, 1, p. 60-68 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Interaction of Epac with Non-canonical Cyclic Nucleotides

Rehmann, H., 2017, Non-canonical Cyclic Nucleotides. Seifert, R. (ed.). Springer International Publishing, p. 135-147 13 p. (Handbook of Experimental Pharmacology; vol. 238).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

Resolving the cadherin-F-actin connection

Han, M. K. L. & de Rooij, J., Jan 2017, In: Nature Cell Biology. 19, 1, p. 14-16 3 p.

Research output: Contribution to journal › Article › Academic › peer-review

Symmetry breaking signaling mechanisms during cell polarization

Bruurs, LJM., 14 Feb 2017, Utrecht University. 140 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

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The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension

Haarhuis, J. H. I., van der Weide, R. H., Blomen, V. A., Yáñez-Cuna, J. O., Amendola, M., van Ruiten, M. S., Krijger, P. H. L., Teunissen, H., Medema, R. H., van Steensel, B., Brummelkamp, T. R., de Wit, E. & Rowland, B. D., 4 May 2017, In: Cell. 169, 4, p. 693-707.e14

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3 Citations (Scopus)

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Zygotic vinculin is not essential for embryonic development in zebrafish

Han, M. K. L., Van Der Krogt, G. N. M. & De Rooij, J., 1 Aug 2017, In: PLoS ONE. 12, 8, e0182278.

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1 Citation (Scopus)

2016

Cadherin mechanotransduction in morphogenesis: the importance of α-catenin and vinculin

Han, MKL., 9 Jun 2016, 183 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

Open Access

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Collagen-rich stroma in aggressive colon tumors induces mesenchymal gene expression and tumor cell invasion

Vellinga, T. T., den Uil, S., Rinkes, IHB., Marvin, D., Ponsioen, B., Alvarez-Varela, A., Fatrai, S., Scheele, C., Zwijnenburg, D. A., Snippert, H., Vermeulen, L., Medema, J. P., Stockmann, H. B., Koster, J., Fijneman, R. J. A., de Rooij, J. & Kranenburg, O., 2016, In: Oncogene. 35, 40, p. 5263-5271 9 p.

Research output: Contribution to journal › Article › Academic › peer-review

Converging and Unique Mechanisms of Mechanotransduction at Adhesion Sites

Han, M. K. L. & de Rooij, J., Aug 2016, In: Trends in Cell Biology. 26, 8, p. 612-23 12 p.

Research output: Contribution to journal › Article › Academic › peer-review

Molecular Mechanistic Reasoning: Toward Bridging the Gap Between the Molecular and Cellular Levels in Life Science Education

van Mil, M. H. W., Postma, P. A., Boerwinkel, D. J., Klaassen, K. & Waarlo, A. J., 1 May 2016, In: Science Education. 100, 3, p. 517-585 69 p.

Research output: Contribution to journal › Article › Academic › peer-review

42 Citations (Scopus)

Ras Association-Domain Dimers Bring Proteins Together

Rehmann, H. & Bos, J. L., 6 Dec 2016, In: Structure. 24, 12, p. 2039-2040 2 p.

Research output: Contribution to journal › Article › Academic › peer-review

Sequential intravital imaging reveals in vivo dynamics of pancreatic tissue transplanted under the kidney capsule in mice

van Gurp, L., Loomans, C. J. M., van Krieken, P. P., Dharmadhikari, G., Jansen, E., Ringnalda, F. C. A. S., Beerling, E., van Rheenen, J. & de Koning, E. J. P., 1 Nov 2016, In: Diabetologia. 59, 11, p. 2387-2392 6 p.

Research output: Contribution to journal › Article › Academic › peer-review

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Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening

Verissimo, C. S., Overmeer, R. M., Ponsioen, B., Drost, J., Mertens, S., Verlaan-Klink, I., Gerwen, B. V., van der Ven, M., van de Wetering, M., Egan, D. A., Bernards, R., Clevers, H., Bos, J. L. & Snippert, H. J., 15 Nov 2016, In: eLife. 5

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TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype

Fessler, E., Drost, J., van Hooff, S. R., Linnekamp, J. F., Wang, X., Jansen, M., De Sousa E Melo, F., Prasetyanti, P. R., Ijspeert, J. E. G., Franitza, M., Nürnberg, P., van Noesel, C. J. M., Dekker, E., Vermeulen, L., Clevers, H. & Medema, J. P., 1 Jul 2016, In: Embo Molecular Medicine. 8, 7, p. 745-760 16 p.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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6 Citations (Scopus)

The exertion of cell-cell adhesions

le Duc, Q., 21 Jan 2016, Utrecht University. 129 p.

Research output: Thesis › Doctoral thesis 1 (Research UU / Graduation UU)

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Dorland, Y. L., Malinova, T. S., van Stalborch, A-M. D., Grieve, A. G., van Geemen, D., Jansen, N. S., de Kreuk, B-J., Nawaz, K., Kole, J., Geerts, D., Musters, R. J. P., de Rooij, J., Hordijk, P. L. & Huveneers, S., 15 Jul 2016, In: Nature Communications [E]. 7, 12210.

Research output: Contribution to journal › Article › Academic › peer-review

Open Access

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Group Bos, section Molecular Cancer Research

Research output

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