Gastroenterology & Hepatology

Research output

Research output per year 1987 1998 2003 2004 2010 2011 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2025

• 370 Article
• 42 Meeting Abstract
• 22 Doctoral thesis 1 (Research UU / Graduation UU)
• 20 Chapter
• 73 More
  • 18 Comment/Letter to the editor
  • 16 Abstract
  • 16 Poster
  • 11 Review article
  • 4 Editorial
  • 3 Web publication/site
  • 1 Book editing
  • 1 Conference contribution
  • 1 Paper
  • 1 Doctoral thesis 3 (Research UU / Graduation NOT UU)
  • 1 Preprint

Research output per year

Research output per year

Search results

• 2022

  Genetic landscape of paediatric acute liver failure

  Lenz, D., Schlieben, L. D., Shimura, M., Bianzano, A., Garbade, S., Smirnov, D., Kopajtich, R., Adam, R., Aldrian, D., Barić, I., Baumann, U., Bozbulut, N. E., Bufler, P., Burnyte, B., Calvo, P. L., Crushell, E., Dalgic, B., Das, A., Dezsofi, A. & Dick, A. & 1 others, Houwen, R., Jun 2022, In: Journal of Pediatric Gastroenterology and Nutrition. 74, S2, p. 676-677 2 p.

  Research output: Contribution to journal › Meeting Abstract › Academic

  • Genetics 100%

• Genomic instability in early embryonic development

  Kuijk, E. W., Apr 2022, In: European Journal of Human Genetics. 30, SUPPL 1, p. 22-22

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2021

  Oral Abstracts

  Gonzales, E., Thompson, R. J., Kamath, B. M., Lacaille, F., Lainka, E., Shteyer, E., D'Antiga, L., Houwen, R., Verkade, H. J., Durmaz, Ö., Grammatikopoulos, T., Loomes, K. M., Karpen, S. J., Mack, C. L., Ni, Q., Kjems, L. & Horn, P., Oct 2021, In: Hepatology. 74, S1, p. 30A-31A 2 p.

  Research output: Contribution to journal › Meeting Abstract › Academic

  • Pruritus 100%
  • Bile Acid 100%
  • Autotaxin 100%
  • Progressive Familial Intrahepatic Cholestasis 50%
  • Liver Disease 10%

• Substantial clinical benefits with odevixibat treatment across progressive familial intrahepatic cholestasis genetic deficiencies: subgroup analysis of serum bile acids, pruritus, and safety using pooled data from the PEDFIC 1 and 2 studies

  Thompson, R., Horn, P., Houwen, R. H. J., Lacaille, F., Ni, Q., Stein, P., Tessier, M. E., Thompson, C., Vittorio, J. & Kjems, L., Jul 2021, In: Journal of Hepatology. 75, Supplement 2, p. S684-S685

  Research output: Contribution to journal › Meeting Abstract › Academic

  • Progressive Familial Intrahepatic Cholestasis 100%
  • Subgroup Analysis 100%
  • Pruritus 100%
  • Bile Acid 100%
  • Bile Salt Export Pump 100%
• 2020

  Human Regulatory T Cells at the Maternal-Fetal Interface Show Functional Site-Specific Adaptation with Tumor-Infiltrating-Like Features.

  Wienke, J., Brouwers, L., Mokry, M., van Wijk, F. & Van Rijn, B. B., Mar 2020, In: Reproductive Sciences. 27, SUPPL 1, p. 116A-116A

  Research output: Contribution to journal › Meeting Abstract › Academic

• Proteolytic Immuno-SRM Analysis of ATP7B in dried blood spots (DBS) for screening and diagnosis of Wilson Disease (WD)

  Collins, C., Dayuha, R., Duong, P., Horslen, S. P., Camarata, M., Coskun, A. K., Houwen, R., Pop, T., Zoller, H., Weiss, K. H., Schilsky, M. L., Ferenci, P. & Hahn, S., Nov 2020, In: Hepatology. 72, S1, p. 869A-870A 1447.

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2019

  Human Placental Bed Endothelial Cell Transcriptomics and Systemic Biomarker Profiling Reveals Inflammatory Endothelial Activation in Early Onset Preeclampsia.

  Brouwers, L., Wienke, J., Mokry, M., Nikkels, P. G. J., Vogelvang, T. E., Franx, A., van Wijk, F. & van Rijn, B. B., Mar 2019, In: Reproductive Sciences. 26, p. 77A-78A

  Research output: Contribution to journal › Meeting Abstract › Academic

• Integrated analysis of transcriptional regulation in PLN R14del cardiomyopathy

  Pei, J., Harakalova, M., Nagyova, E., Gho, J. M. I. H., Sepehrkhouy, S., van Dinter, J., van Mil, A., Buijsrogge, M. P., de Jonge, N., Huibers, M. M., Nieuwenhuis, E. E. S., den Ruijter, H. M., Pasterkamp, G., Doevendans, P. A., Hajjar, R., Mercola, M., Sluijter, J. P. G., de Weger, R. A., Cheng, C. & Vink, A. & 2 others, Mokry, M. & Asselbergs, F. W., Jul 2019, In: European Journal of Human Genetics. 27, p. 790-791

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2016

  Intestinal Organoid Swelling And Relation With Disease Severity And Response To Therapy

  Berkers, G., de Winter-de Groot, K. M., Dekkers, J. F., Vonk, A. M., Kruisselbrink, E., Hagemeijer, M. C., Heida-Michel, S., Geerdink, M., Arets, H. G., van der Wilt, R. E., Houwen, R. H., van de Graaf, E., Majoor, C. J., Koppelman, G. H., Roukema, J., Heijerman, H., van der Meer, R., Vries, R., Clevers, H. C. & de Jonge, H. & 5 others, Escher, J. C., Tiddens, H., Janssens, H., Beekman, J. & van der Ent, C. K., Oct 2016, In: Pediatric Pulmonology. 51, Suppl. S45, p. 159-160 S12.3.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Stratifying Young Children With Cf For Disease Severity Using Intestinal Organoid Swelling, Intestinal Current Measurement Or Sweat Chloride Concentration As Cftr-Dependent Biomarker

  de Winter-de Groot, K. M., Janssens, H., van Uum, R., Dekkers, F., Berkers, G., Vonk, A. M., Kruisselbrink, E., Vries, R., Clevers, H. C., Houwen, R. H., Escher, J., van der Ent, C. K., Tiddens, H. & Beekman, J., Oct 2016, In: Pediatric Pulmonology. 51, Suppl. S45, p. 290-290 259.

  Research output: Contribution to journal › Meeting Abstract › Other research output

  Open Access

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  9 Downloads (Pure)
• 2015

  Novel treatment options to improve aberrant pre-messenger RNA splicing and protein folding in ATP8B1 deficiency

  van der Woerd, W., Mulder, J., Pagani, F., Beuers, U., Houwen, R. & van de Graaf, S. F. J., 2015, In: Journal of Hepatology. p. S232 1 p., O084.

  Research output: Contribution to journal › Meeting Abstract › Academic

  Open Access

  File
  31 Downloads (Pure)

• Pediatric Achalasia: Diagnosis, Management and Follow-Up in the Netherlands

  Smits, M., van Lennep, M., Benninga, M. A., Houwen, R., Kokke, F., van der Zee, D., Bodewes, F. A. J. A., Van den Neucker, A. M., de Meij, T., Schweizer, J. J., Escher, J. C., Damen, G. M. & van Wijk, M., 26 Apr 2015, In: Gastroenterology. 148, 4, 1 p., Su2063.

  Research output: Contribution to journal › Meeting Abstract › Academic

  Open Access

  File

  • Pediatrics 100%
  • Achalasia 100%
  6 Downloads (Pure)
• 2014

  Elevated faecal calprotectin does not differentiate between IBD and a juvenile polyp

  Wolters, V. M., Pluimakers, V. G., Kokke, F. T. M., Nikkels, P. G. J., Houben, M. L. & Houwen, R. H. J., Sept 2014, In: Journal of Crohn's & Colitis. 8, p. S407-S407 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• International prospective study of distal intestinal obstruction syndrome

  Munck, A., Alberti, C., Boizeau, P., Colombo, C., Kashirskaya, N., Ellemunter, H., Fotoulaki, M., Houwen, R., Robberecht, E. & Wilschanski, M., 4 Sept 2014, In: Pediatric Pulmonology. p. 411 1 p., 532.

  Research output: Contribution to journal › Meeting Abstract › Academic

• International Prospective Study of Distal Intestinal Obstruction Syndrome (DIOS)

  Wilschanski, M., Colombo, C., Kashirskaya, N., Ellemunter, H., Fotoulaki, M., Houwen, R., Robberecht, E. & Munck, A., May 2014, In: Gastroenterology. p. S-806 - S-807 2 p., Tu 1299.

  Research output: Contribution to journal › Meeting Abstract › Academic

  Open Access

  File
  1 Downloads (Pure)
• 2008

  Isolation, culture, and characterization of porcine germ cells

  Kuijk, E., Colenbrander, B. & Roelen, B., 2008, In: Biology of Reproduction. p. 229-229

  Research output: Contribution to journal › Meeting Abstract › Academic
• 2005

  Liver disease in children with cystic fibrosis: prevalence and clinical characteristics

  Translated title of the contribution: Liver disease in children with cystic fibrosis: prevalence and clinical characteristicsSlieker, M. G., van der Doef, H. P. J., van der Ent, C. K. & Houwen, R. H. J., 2005, In: Journal of Cystic Fibrosis. 4, S1, p. S76 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2004

  A functional genetics approach to unravel molecular pathways in celiac disease

  Translated title of the contribution: A functional genetics approach to unravel molecular pathways in celiac diseaseWijmenga, C., Diosdado, B., Franke, L. H., Monsuur, A. J., van Oort, E., Wapenaar, M. C., Zhernakova, A. P., Houwen, R. H. J. & Mulder, C. J. J., 2004, In: Clinical Chemistry and Laboratory Medicine. 42, 8, p. A31 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2003

  A major non-HLA locus in celiac disease maps to chromosome 19

  Translated title of the contribution: A major non-HLA locus in celiac disease maps to chromosome 19van Belzen, M. J., Meijer, J. W., Sandkuijl, L. A., Bardoel, A. F. J., Mulder, C. J., Pearson, P. L., Wijmenga, C. & Houwen, R. H. J., 2003, In: Gastroenterology. 124, p. W1365 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A major non-HLA locus in celiac disease maps to chromosome 19

  Translated title of the contribution: A major non-HLA locus in celiac disease maps to chromosome 19van Belzen, M. J., Meijer, J., Sandkuijl, L. A., Bardoel, A. F. J., Mulder, M. F., Pearson, P. L., Wymenga, C. & Houwen, R. H. J., 2003, In: Journal of Pediatric Gastroenterology and Nutrition. 36, p. 521 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A major non-HLA locus in celiac disease maps to chromosome 19

  Translated title of the contribution: A major non-HLA locus in celiac disease maps to chromosome 19van Belzen, M. J., Meijer, J. W. R., Sandkuijl, L. A., Bardoel, A. F. J., Mulder, C. J. J., Pearson, P. L., Wijmenga, C. & Houwen, R. H. J., 2003, In: Gastroenterology. 124, 4, Suppl S, p. A656 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A major non-HLA locus in coeliac disease maps to chromosome 19

  Translated title of the contribution: A major non-HLA locus in coeliac disease maps to chromosome 19van Belzen, M. J., Meijer, J. W. R., Sandkuijl, L. A., Bardoel, A. F. J., Mulder, C. J. J., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2003, In: European Journal of Human Genetics. 11, S1, p. 55 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Glutenintolerantie en toch geen coeliakie

  Translated title of the contribution: Glutenintolerantie en toch geen coeliakieSchie, D. L., Nikkels, P. G. J., Meijer, Y., Rijkers, G. T. & Houwen, R. H. J., 2003, In: Nederlands Tijdschrift voor Geneeskunde. S1, p. 5 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Identification of a celiac disease gene on chromosome 19

  Translated title of the contribution: Identification of a celiac disease gene on chromosome 19van Belzen, M. J., Zhernakova, A. P., Bardoel, A. F. J., Houwen, R. H. J., Mulder, C. J. J. & Wijmenga, C., 2003, In: American Journal of Human Genetics. 73, 5 (S), p. 520 1 p., 2056, p. 520.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Immunohistochemically recognized bile salt export protein in unremarkably expressed at the canaliculus in persons with ATP8B1 disease

  Translated title of the contribution: Immunohistochemically recognized bile salt export protein in unremarkably expressed at the canaliculus in persons with ATP8B1 diseaseKnisely, A. S., Meier, Y., Stieger, B., Portmann, B. C., Rayner, A. C., Strautnieks, S. S., Thompson, R. J., Houwen, R. H. J., Klomp, L. W. J. & Bull, L. N., 2003, In: Hepatology. p. 390A

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Mapping of a coeliac disease locus in a four-generation Dutch family to chromosome 9

  Translated title of the contribution: Mapping of a coeliac disease locus in a four-generation Dutch family to chromosome 9Vrolijk, M. M., van Belzen, M. J., Meijer, J. W. R., Pearson, P. L., Sandkuijl, L. A., Houwen, R. H. J. & Wijmenga, C., 2003, In: European Journal of Human Genetics. 11, S1, p. 258 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Optimale eiwitbelasting bij kinderen met Cystic Fibrose.

  Translated title of the contribution: Optimale eiwitbelasting bij kinderen met Cystic Fibrose.Geukers, V. G. M., Oudshoorn, J. H., Taminiau, J. A. J. M., van der Ent, C. K., Schilte, P. P. M., Ruiter, A. F. C., Ackermans, M. T., Endert, E., Jonkers-Schuitema, C. F., Heymans, H. S. A. & Sauerwein, H. P., 2003, In: Nederlands Tijdschrift voor Geneeskunde. S1, p. 7 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Risicofactoren voor cystic fibrosis-gerelateerde leverziekten

  Translated title of the contribution: Risicofactoren voor cystic fibrosis-gerelateerde leverziektenSlieker, M. G., Deckers-Kocken, J. M., Uiterwaal, C. S. P. M., van der Ent, C. K. & Houwen, R. H. J., 2003, In: Tijdschrift voor Kindergeneeskunde. S1, p. 7-8 2 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• The H1069Q mutation in Wilson disease is correlated with a late and neurological presentation

  Translated title of the contribution: The H1069Q mutation in Wilson disease is correlated with a late and neurological presentationStapelbroek, J. M., Ploos van Amstel, J. K., van Hattum, J., van den Berg, L. H. & Houwen, R. H. J., 2003, In: Journal of Pediatric Gastroenterology and Nutrition. 36, p. 529 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2002

  A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19

  Translated title of the contribution: A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19van Belzen, M. J., Bardoel, A. F. J., van der Hoeven, W., Mulder, C. J. J., Meijer, J., Sandkuijl, L. A., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2002, In: American Journal of Human Genetics. 71, Suppl. 4, p. 498 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19

  Translated title of the contribution: A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19van Belzen, M. J., Bardoel, A. F. J., van der Hoeven, W., Mulder, C. J. J., Meijer, J. W. R., Sandkuijl, L. A., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2002, In: NVGE Najaarsvergadering abstractboek. p. 88 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19

  Translated title of the contribution: A genome-wide search for celiac disease loci in Dutch affected siblings shows significant linkage to chromosome 19van Belzen, M. J., Bardoel, A. F. J., van der Hoeven, W., Sandkuijl, L. A., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2002, In: European Journal of Gastroenterology and Hepatology. 14, 12, p. A80-A81 2 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2001

  Een ELISA methode gebaseerd op recombinant humaan tTG (Celikey) is betrouwbaarder bij het identificeren van patienten met coeliakie dan antigliadine antilichamen, antiendomysium antilichamen of een tTG ELISA gebaseerd op cavia tTG

  Translated title of the contribution: Een ELISA methode gebaseerd op recombinant humaan tTG (Celikey) is betrouwbaarder bij het identificeren van patienten met coeliakie dan antigliadine antilichamen, antiendomysium antilichamen of een tTG ELISA gebaseerd op cavia tTGWolters, V. M., Moulaert, A. F. S. R., Daalder, R., Burger, H., Brooimans, R. A., de Schryver, J. E. A. R., Rijkers, G. T. & Houwen, R. H. J., 2001, In: Tijdschrift voor Kindergeneeskunde. 69, S10, p. S10 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Humane tTG ELISA (Celikey) is ook bruikbaar bij de follow-up van coeliakie

  Translated title of the contribution: Humane tTG ELISA (Celikey) is ook bruikbaar bij de follow-up van coeliakieDaalder, R., Wolters, V. M., Brooimans, R. A., de Schryver, J. E. A. R., Rijkers, G. T. & Houwen, R. H. J., 2001, In: Tijdschrift voor Kindergeneeskunde. 69, S15, p. S15 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Human tTG ELISA outperforms guinea pig based tTG and EMA when screening for celiac disease in patients with GI complaints

  Translated title of the contribution: Human tTG ELISA outperforms guinea pig based tTG and EMA when screening for celiac disease in patients with GI complaintsWolters, V. M., Moulaert, A. F. S. R., Brooimans, R. A., de Schryver, J. E. A. R., Rijkers, G. T. & Houwen, R. H. J., 2001, In: Journal of Pediatric Gastroenterology and Nutrition. 32, S1, p. 379 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Linkage and association analysis of the tissue transglutaminase gene: the tTG gene is not involved in celiac disease

  Translated title of the contribution: Linkage and association analysis of the tissue transglutaminase gene: the tTG gene is not involved in celiac diseasevan Belzen, M. J., Mulder, C. J., Oren, A., Strengman, E., Pearson, P. L., Sandkuijl, L. A., Houwen, R. H. J. & Wijmenga, C., 2001, In: Gastroenterology. 120, S1, p. 699 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Mechanisms of hepatobiliary copper transport

  Translated title of the contribution: Mechanisms of hepatobiliary copper transportKlomp, L. W. J., Klomp, A. E. M., Houwen, R. H. J., Berger, R. & Gitlin, J. D., 2001, In: Gut. 49, S2269, 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• Towards understanding the pathogenesis of coeliac disease: a genetic approach to identify susceptibility genes

  Translated title of the contribution: Towards understanding the pathogenesis of coeliac disease: a genetic approach to identify susceptibility genesvan Belzen, M. J., Mulder, G. J., Sandkuijl, L. A., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2001, In: Gut. 49, S1303

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 2000

  Prenatal diagnosis in 3-phosphoglycerate dehydrogenase deficiency.

  Translated title of the contribution: Prenatal diagnosis in 3-phosphoglycerate dehydrogenase deficiency.de Koning, T. J., Klomp, L. W. J., Beemer, F. A., van Oppen, C., Duran, M., Poll-The, B. T., van den Berg, I. E. T., Ploos van Amstel, J. K. & Berger, R., 2000, In: Journal of Inherited Metabolic Disease. 23, p. 73 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output

• The CTLA-4 gene is not associated with celiac disease in the Dutch population

  Translated title of the contribution: The CTLA-4 gene is not associated with celiac disease in the Dutch populationvan Belzen, M. J., Oren, A., Strengman, E., Mulder, C. J., Sandkuijl, L. A., Pearson, P. L., Houwen, R. H. J. & Wijmenga, C., 2000, In: European Journal of Human Genetics. 8 supp 1, p. 134 521 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 1998

  Phosphomannose isomerase deficiency with cyclic vomiting and congenital hepatic fibrosis

  Translated title of the contribution: Phosphomannose isomerase deficiency with cyclic vomiting and congenital hepatic fibrosisde Koning, T. J., Dorland, L., Nikkels, P. G. J., van Diggelen, O. P., Boonman, A. M. C., de Jong, G. J., van Noort, W. L., Schryver, J. E. A. R., Duran, M., van den Berg, I. E. T., Gerwig, G. J., Berger, R. & Poll-The, B. T., 1998, In: Journal of Inherited Metabolic Disease. 21, Suppl. 2, p. 96-96 1 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output
• 1996

  Therapie trouw en kwaliteit van leven bij adolescenten met coeliakie

  Translated title of the contribution: Therapie trouw en kwaliteit van leven bij adolescenten met coeliakieSchepers, V. P. M., Visser, A. C. E., Houwen, R. H. J. & Sinnema, G., 1996, In: Tijdschrift voor Kindergeneeskunde. 64, 1, p. 78-79 2 p.

  Research output: Contribution to journal › Meeting Abstract › Other research output