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  • 2024

    Fibroblasts as an in vitro model of circadian genetic and genomic studies

    Francia, M., Bot, M., Boltz, T., De la Hoz, J. F., Boks, M., Kahn, R. S. & Ophoff, R. A., Sept 2024, In: Mammalian Genome. 35, 3, p. 432-444 13 p.

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  • Genetic variants for head size share genes and pathways with cancer

    21 May 2024, In: Cell Reports Medicine. 5, 5, 101529.

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  • Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk

    Ori, A. P. S., Olde Loohuis, L. M., Guintivano, J., Hannon, E., Dempster, E., St. Clair, D., Bass, N. J., McQuillin, A., Mill, J., Sullivan, P. F., Kahn, R. S., Horvath, S. & Ophoff, R. A., 8 Apr 2024, In: Clinical Epigenetics. 16, 1, p. 1-14 14 p., 53.

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  • 2023

    Polygenic risk score-based phenome-wide association study identifies novel associations for Tourette syndrome

    23 Feb 2023, In: Translational Psychiatry. 13, 1, 69.

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  • Schizophrenia-associated somatic copy-number variants from 12,834 cases reveal recurrent NRXN1 and ABCB11 disruptions

    9 Aug 2023, In: Cell genomics. 3, 8, 100356.

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  • Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

    19 May 2023, In: iScience. 26, 5, 106701.

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  • 2022

    Common Genetic Variation and Age of Onset of Anorexia Nervosa

    Oct 2022, In: Biological psychiatry global open science. 2, 4, p. 368-378 11 p.

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    3 Citations (Scopus)
  • 2021

    1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

    22 Mar 2021, In: Translational Psychiatry. 11, 1, p. 1-16 16 p., 182.

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  • Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

    Apr 2021, In: Molecular Psychiatry. 26, 4, p. 1286-1298 13 p.

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  • Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Dec 2021, In: Nature Genetics. 53, 12, p. 1636-1648 13 p.

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  • Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group

    Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M. E., Carrillo-Roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz Santiañez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas Gutiérrez, D., & 62 othersVan't Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R., Büchel, C., Burke Quinlan, E., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., McRae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J., Walter, H., Wardlaw, J. M., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D. I., Calhoun, V., Crespo-Facorro, B., Deary, I. J., Hulshoff Pol, H., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., Aug 2021, In: Molecular Psychiatry. 26, 8, p. 3884-3895 12 p.

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  • Genome-wide association study identifies 48 common genetic variants associated with handedness

    Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., de Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M., & 30 othersDuffy, D. L., Eriksson, J. G., Esko, T., Feenstra, B., Geller, F., Gieger, C., Giegling, I., Gordon, S. D., Han, J., Hansen, T. F., Hartmann, A. M., Hayward, C., Heikkilä, K., Hicks, A. A., Hirschhorn, J. N., Hottenga, J. J., Huffman, J. E., Hwang, L. D., Ikram, M. A., Kaprio, J., Kemp, J. P., Khaw, K. T., Klopp, N., Konte, B., Kutalik, Z., Lahti, J., Li, X., Loos, R. J. F., Luciano, M. & Ophoff, R. A., Jan 2021, In: NATURE HUMAN BEHAVIOUR. 5, 1, p. 59-70 12 p.

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  • Investigating rare pathogenic/likely pathogenic exonic variation in bipolar disorder

    Sept 2021, In: Molecular Psychiatry. 26, 9, p. 5239-5250 12 p.

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  • 2020

    Complement genes contribute sex-biased vulnerability in diverse disorders

    25 Jun 2020, In: Nature. 582, 7813, p. 577-581 5 p.

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    6 Citations (Scopus)

  • Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

    1 Mar 2020, In: Molecular Psychiatry. 25, 3, p. 584-602 19 p.

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  • Exploring the clinical utility of two staging models for bipolar disorder

    van der Markt, A., Klumpers, U. M. H., Dols, A., Draisma, S., Boks, M. P., van Bergen, A., Ophoff, R. A., Beekman, A. T. F. & Kupka, R. W., Feb 2020, In: Bipolar Disorders. 22, 1, p. 38-45 8 p.

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  • Extensions of Multiple-Group Item Response Theory Alignment: Application to Psychiatric Phenotypes in an International Genomics Consortium

    Mansolf, M., Vreeker, A., Reise, S. P., Freimer, N. B., Glahn, D. C., Gur, R. E., Moore, T. M., Pato, C. N., Pato, M. T., Palotie, A., Holm, M., Suvisaari, J., Partonen, T., Kieseppä, T., Paunio, T., Boks, M., Kahn, R., Ophoff, R. A., Bearden, C. E., Loohuis, L. O., & 3 othersTeshiba, T., deGeorge, D. & Bilder, R. M., Oct 2020, In: Educational and Psychological Measurement. 80, 5, p. 870-909 40 p.

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  • Lithium Use during Pregnancy and the Risk of Miscarriage

    Poels, E. M. P., Kamperman, A. M., Vreeker, A., Gilden, J., Boks, M. P., Kahn, R. S., Ophoff, R. A. & Bergink, V., 11 Jun 2020, In: Journal of Clinical medicine. 9, 6, p. 1-5 5 p., 1819.

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  • No association between anti-thyroidperoxidase antibodies and bipolar disorder: A study in the Dutch Bipolar Cohort and a meta-analysis

    Snijders, G. J. L. J., de Witte, L. D., van den Berk, D., van der Laan, C., Regeer, E., Begemann, M. J. H., Berdenis van Berlekom, A., Litjens, M., Boks, M. P., Ophoff, R. A., Kahn, R. S. & Hillegers, M. H. J., Feb 2020, In: Psychoneuroendocrinology. 112, p. 1-8 104518.

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  • The genetic architecture of the human cerebral cortex

    20 Mar 2020, In: Science. 367, 6484, aay6690.

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  • The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls

    15 Jul 2020, In: Biological Psychiatry. 88, 2, p. 169-184 16 p.

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  • The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia

    Mar 2020, In: Schizophrenia Bulletin. 46, 2, p. 336-344 9 p.

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  • Whole blood transcriptome analysis in bipolar disorder reveals strong lithium effect

    Krebs, C. E., Ori, A. P. S., Vreeker, A., Wu, T., Cantor, R. M., Boks, M. P. M., Kahn, R. S., Olde Loohuis, L. M. & Ophoff, R. A., Nov 2020, In: Psychological Medicine. 50, 15, p. 2575-2586 12 p.

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  • 2019

    Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population

    1 May 2019, In: JAMA Psychiatry. 76, 5, p. 516-525 10 p.

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  • Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches

    15 Oct 2019, In: Biological Psychiatry. 86, 8, p. 577-586 10 p.

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  • Exploration of Shared Genetic Architecture Between Subcortical Brain Volumes and Anorexia Nervosa

    1 Jul 2019, In: Molecular Neurobiology. 56, 7, p. 5146-5156 11 p.

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  • Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

    Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Hoffman, G., Wang, W., Pardinas, A. F., Rajagopal, V. M., Als, T. D., Nguyen, H. T., Girdhar, K., Boocock, J., Roussos, P., Fromer, M., Kramer, R., Domenici, E., Gamazon, E. R., Purcell, S., Demontis, D., Borglum, A. D., Walters, J. T. R., & 30 othersO'Donovan, M. C., Sullivan, P., Owen, M. J., Devlin, B., Sieberts, S. K., Cox, N. J., Im, H. K., Sklar, P., Stahl, E. A., Johnson, J. S., Shah, H. R., Klein, L. L., Dang, K. K., Logsdon, B. A., Mahajan, M. C., Mangravite, L. M., Toyoshiba, H., Gur, R. E., Hahn, C-G., Schadt, E., Lewis, D. A., Haroutunian, V., Peters, M. A., Lipska, B. K., Buxbaum, J. D., Hirai, K., Cahn, W., Kahn, R. S., Van Os, J. & Ophoff, R. A., Apr 2019, In: Nature Genetics. 51, 4, p. 659-674 16 p.

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  • Genetic architecture of subcortical brain structures in 38,851 individuals

    1 Nov 2019, In: Nature Genetics. 51, 11, p. 1624-1636 13 p.

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  • Genome-wide association study identifies 30 loci associated with bipolar disorder

    1 May 2019, In: Nature Genetics. 51, 5, p. 793-803 11 p.

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    14 Citations (Scopus)

  • Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Medland, S. E., Ripke, S., Yao, S., Giusti-Rodríguez, P., Hanscombe, K. B., Purves, K. L., Adan, R. A. H., Alfredsson, L., Ando, T., Andreassen, O. A., & 31 othersBaker, J. H., Berrettini, W. H., Boehm, I., Boni, C., Perica, V. B., Buehren, K., Burghardt, R., Cassina, M., Cichon, S., Clementi, M., Cone, R. D., Courtet, P., Crow, S., Crowley, J. J., Danner, U. N., Davis, O. S. P., de Zwaan, M., Dedoussis, G., Degortes, D., DeSocio, J. E., Dick, D. M., Dikeos, D., Dina, C., Dmitrzak-Weglarz, M., Docampo, E., Duncan, L. E., Egberts, K., Kas, M. J. H., Lin, B. D., Ophoff, R. A. & Luykx, J., Aug 2019, In: Nature Genetics. 51, 8, p. 1207-1214 8 p.

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  • Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

    12 Dec 2019, In: Cell. 179, 7, p. 1469-1482.e11

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  • GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores

    Cahn, W., 1 Aug 2019, In: American Journal of Psychiatry. 176, 8, p. 651-660 10 p.

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  • The association between antibodies to neurotropic pathogens and bipolar disorder: A study in the Dutch Bipolar (DB) Cohort and meta-analysis

    Snijders, G. J. L. J., van Mierlo, H. C., Boks, M. P., Begemann, M. J. H., Sutterland, A. L., Litjens, M., Ophoff, R. A., Kahn, R. S. & de Witte, L. D., 20 Nov 2019, In: Translational Psychiatry. 9, 1, 13 p., 311.

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  • 2018

    Age at first birth in women is genetically associated with increased risk of schizophrenia

    Ni, G., Gratten, J., Wray, N. R., Lee, S. H., Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., & 281 othersBacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Haan, L. D., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Juliá, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'callaghan, E., O'dushlaine, C., O'neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Os, J. V., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., Clair, D. S., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'donovan, M. C., 1 Dec 2018, In: Scientific Reports. 8, 1, 10168.

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  • Double hits in schizophrenia

    1 Aug 2018, In: Human Molecular Genetics. 27, 15, p. 2755-2761 7 p.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Functionally distinct ERAP1 and ERAP2 are a hallmark of HLA-A29-(Birdshot) Uveitis

    Kuiper, J. J. W., Setten, J. V., Devall, M., Cretu-Stancu, M., Hiddingh, S., Ophoff, R. A., Missotten, T. O. A. R., Velthoven, M. V., Den Hollander, A. I., Hoyng, C. B., James, E., Reeves, E., Cordero-Coma, M., Fonollosa, A., Adán, A., Martín, J., Koeleman, B. P. C., Boer, J. H. D., Pulit, S. L., Márquez, A., & 1 othersRadstake, T. R. D. J., 15 Dec 2018, In: Human Molecular Genetics. 27, 24, p. 4333-4343 11 p.

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    2 Citations (Scopus)

  • Improving genetic prediction by leveraging genetic correlations among human diseases and traits

    Maier, R. M., Zhu, Z., Lee, S. H., Trzaskowski, M., Ruderfer, D. M., Stahl, E. A., Ripke, S., Wray, N. R., Yang, J., Visscher, P. M., Robinson, M. R., Forstner, A. J., Mcquillin, A., Trubetskoy, V., Wang, W., Wang, Y., Coleman, J. R. I., Gaspar, H. A., De Leeuw, C. A., Whitehead Pavlides, J. M., & 221 othersOlde Loohuis, L. M., Pers, T. H., Lee, P. H., Charney, A. W., Dobbyn, A. L., Huckins, L., Boocock, J., Giambartolomei, C., Roussos, P., Mullins, N., Awasthi, S., Agerbo, E., Als, T. D., Pedersen, C. B., Grove, J., Kupka, R., Regeer, E. J., Anjorin, A., Casas, M., Mahon, P. B., Allardyce, J., Escott-Price, V., Forty, L., Fraser, C., Kogevinas, M., Frank, J., Streit, F., Strohmaier, J., Treutlein, J., Witt, S. H., Kennedy, J. L., Strauss, J. S., Garnham, J., O'donovan, C., Slaney, C., Steinberg, S., Thorgeirsson, T. E., Hautzinger, M., Steffens, M., Perlis, R. H., Sánchez-Mora, C., Hipolito, M., Lawson, W. B., Nwulia, E. A., Levy, S. E., Foroud, T. M., Jamain, S., Young, A. H., Mckay, J. D., Albani, D., Zandi, P., Potash, J. B., Zhang, P., Raymond Depaulo, J., Bergen, S. E., Juréus, A., Karlsson, R., Kandaswamy, R., Mcguffin, P., Rivera, M., Lissowska, J., Cruceanu, C., Lucae, S., Cervantes, P., Budde, M., Gade, K., Heilbronner, U., Pedersen, M. G., Morris, D. W., Weickert, C. S., Weickert, T. W., Macintyre, D. J., Lawrence, J., Elvsåshagen, T., Smeland, O. B., Djurovic, S., Xi, S., Green, E. K., Czerski, P. M., Hauser, J., Xu, W., Vedder, H., Oruc, L., Spijker, A. T., Gordon, S. D., Medland, S. E., Curtis, D., Mühleisen, T. W., Badner, J., Scheftner, W. A., Sigurdsson, E., Schork, N. J., Schatzberg, A. F., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hansen, C. S., Knowles, J. A., Szelinger, S., Montgomery, G. W., Boks, M., Adolfsson, A. N., Hoffmann, P., Bauer, M., Pfennig, A., Leber, M., Kittel-Schneider, S., Reif, A., Del-Favero, J., Fischer, S. B., Herms, S., Reinbold, C. S., Degenhardt, F., Koller, A. C., Maaser, A., Ori, A., Dale, A. M., Fan, C. C., Greenwood, T. A., Nievergelt, C. M., Shehktman, T., Shilling, P. D., Byerley, W., Bunney, W., Alliey-Rodriguez, N., Clarke, T. K., Liu, C., Coryell, W., Akil, H., Burmeister, M., Flickinger, M., Li, J. Z., Mcinnis, M. G., Meng, F., Thompson, R. C., Watson, S. J., Zollner, S., Guan, W., Green, M. J., Craig, D., Sobell, J. L., Milani, L., Gordon-Smith, K., Knott, S. V., Perry, A., Parra, J. G., Mayoral, F., Rivas, F., Rice, J. P., Barchas, J. D., Børglum, A. D., Mortensen, P. B., Mors, O., Grigoroiu-Serbanescu, M., Bellivier, F., Etain, B., Leboyer, M., Ramos-Quiroga, J. A., Agartz, I., Amin, F., Azevedo, M. H., Bass, N., Black, D. W., Blackwood, D. H. R., Bruggeman, R., Buccola, N. G., Choudhury, K., Cloninger, C. R., Corvin, A., Craddock, N., Daly, M. J., Datta, S., Donohoe, G. J., Duan, J., Dudbridge, F., Fanous, A., Freedman, R., Freimer, N. B., Friedl, M., Gill, M., Gurling, H., De Haan, L., Hamshere, M. L., Hartmann, A. M., Holmans, P. A., Kahn, R. S., Keller, M. C., Kenny, E., Kirov, G. K., Krabbendam, L., Krasucki, R., Lencz, T., Levinson, D. F., Lieberman, J. A., Lin, D. Y., Linszen, D. H., Magnusson, P. K. E., Maier, W., Malhotra, A. K., Mattheisen, M., Mattingsdal, M., Mccarroll, S. A., Medeiros, H., Melle, I., Milanova, V., Myin-Germeys, I., Neale, B. M., Ophoff, R. A., Owen, M. J., Pimm, J., Purcell, S. M., Puri, V., Quested, D. J., Rossin, L., Sanders, A. R., Shi, J., Sklar, P., St Clair, D., Stroup, T. S., Van Os, J., Wiersma, D. & Zammit, S., 1 Dec 2018, In: Nature Communications. 9, 1, 989.

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    5 Citations (Scopus)

  • The Alkaline Phosphatase (ALPL) Locus Is Associated with B6 Vitamer Levels in CSF and Plasma

    Loohuis, L. M., Albersen, M., de Jong, S., Wu, T., Luykx, J. J., Jans, J. J. M., Verhoeven-Duif, N. M. & Ophoff, R. A., 22 Dec 2018, In: Genes. 10, 1, 8.

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  • 2016

    Subcortical brain volume abnormalities in 2028 individuals with schizophrenia and 2540 healthy controls via the ENIGMA consortium

    van Erp, T. G. M., Hibar, D. P., Rasmussen, J. M., Glahn, D. C., Pearlson, G. D., Andreassen, O. A., Agartz, I., Westlye, L. T., Haukvik, U. K., Dale, A. M., Melle, I., Hartberg, C. B., Gruber, O., Kraemer, B., Zilles, D., Donohoe, G., Kelly, S., McDonald, C., Morris, D. W., Cannon, D. M., & 38 othersCorvin, A., Machielsen, M. W. J., Koenders, L., de Haan, L., Veltman, D. J., Satterthwaite, T. D., Wolf, D. H., Gur, R. C., Gur, R. E., Potkin, S. G., Mathalon, D. H., Mueller, B. A., Preda, A., Macciardi, F., Ehrlich, S., Walton, E., Hass, J., Calhoun, V. D., Bockholt, H. J., Sponheim, S. R., Shoemaker, J. M., van Haren, N. E. M., Pol, H. E. H., Ophoff, R. A., Kahn, R. S., Roiz-Santiañez, R., Crespo-Facorro, B., Wang, L., Alpert, K. I., Jönsson, E. G., Dimitrova, R., Bois, C., Whalley, H. C., McIntosh, A. M., Lawrie, S. M., Hashimoto, R., Thompson, P. M. & Turner, J. A., Apr 2016, In: Molecular Psychiatry. 21, 4, p. 547–553

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  • 2015

    A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

    Bossini-Castillo, L., de Kovel, C., Kallberg, H., van 't Slot, R., Italiaander, A., Coenen, M., Tak, P. P., Posthumus, M. D., Wijmenga, C., Huizinga, T., van der Helm-van Mil, A. H. M., Stoeken-Rijsbergen, G., Rodriguez-Rodriguez, L., Balsa, A., Gonzalez-Alvaro, I., Angel Gonzalez-Gay, M., Gomez-Vaquero, C., Franke, B., Vermeulen, S., van der Horst-Bruinsma, I. E., & 16 othersDijkmans, B. A. C., Wolbink, G. J., Ophoff, R. A., Maehlen, M. T., van Riel, P., Merriman, M., Klareskog, L., Lie, B. A., Merriman, T., Crusius, J. B. A., Brouwer, E., Martin, J., de Vries, N., Toes, R., Padyukov, L. & Koeleman, B. P. C., Mar 2015, In: Annals of the Rheumatic Diseases. 74, 3, 10 p., 15.

    Research output: Contribution to journal › Article › Academic › peer-review

  • Common genetic variants influence human subcortical brain structures

    Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Mallar Chakravarty, M., Chen, Q., Ching, C. R. K., & 30 othersCuellar-Partida, G., Den Braber, A., Giddaluru, S., Goldman, A. L., Grimm, O., Guadalupe, T., Hass, J., Woldehawariat, G., Holmes, A. J., Hoogman, M., Janowitz, D., Jia, T., Kim, S., Klein, M., Kraemer, B., Lee, P. H., Olde Loohuis, L. M., Luciano, M., MacAre, C., Mather, K. A., Mattheisen, M., Van Eijk, K. R., Cahn, W., Kahn, R. S., Van Haren, N. E. M., Brouwer, R. M., Hulshoff Pol, H. E., Ophoff, R. A., Schmidt, R. & Ikram, M. A., 9 Apr 2015, In: Nature. 520, 7546, p. 224-229 6 p.

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    326 Citations (Scopus)

  • Genome-wide association study of NMDA receptor coagonists in human cerebrospinal fluid and plasma

    Luykx, J. J., Bakker, S. C., Visser, W. F., Verhoeven-Duif, N., Buizer-Voskamp, J. E., den Heijer, J. M., Boks, M. P. M., Sul, J. H., Eskin, E., Ori, A. P., Cantor, R. M., Vorstman, J., Strengman, E., DeYoung, J., Kappen, T. H., Pariama, E., van Dongen, E. P. A., Borgdorff, P., Bruins, P., de Koning, T. J., & 2 othersKahn, R. S. & Ophoff, R. A., Dec 2015, In: Molecular Psychiatry. 20, 12, p. 1557-1564 8 p.

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  • Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder

    Maier, R., Moser, G., Chen, G. B., Ripke, S., Coryell, W., Potash, J. B., Scheftner, W. A., Shi, J., Weissman, M. M., Hultman, C. M., Landén, M., Levinson, D. F., Kendler, K. S., Smoller, J. W., Wray, N. R., Lee, S. H., Absher, D., Agartz, I., Akil, H., Amin, F., & 30 othersAndreassen, O. A., Anjorin, A., Anney, R., Arking, D. E., Asherson, P., Azevedo, M. H., Backlund, L., Badner, J. A., Bailey, A. J., Banaschewski, T., Barchas, J. D., Barnes, M. R., Barrett, T. B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S. E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Binder, E. B., Black, D. W., Blackwood, D. H. R., Cahn, W., Kahn, R. S., Ophoff, R. A. & Van Os, J., 5 Feb 2015, In: American Journal of Human Genetics. 96, 2, p. 283-294 12 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    79 Citations (Scopus)

  • LD score regression distinguishes confounding from polygenicity in genome-wide association studies

    Bulik-Sullivan, B., Loh, P. R., Finucane, H. K., Ripke, S., Yang, J., Patterson, N., Daly, M. J., Price, A. L., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., & 30 othersAlexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Cairns, M. J., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Kahn, R. S., Murphy, K. C., Van Os, J. & Ophoff, R. A., 25 Feb 2015, In: Nature Genetics. 47, 3, p. 291-295 5 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    414 Citations (Scopus)

  • Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

    Vilhjálmsson, B. J., Yang, J., Finucane, H. K., Gusev, A., Lindström, S., Ripke, S., Genovese, G., Loh, P. R., Bhatia, G., Do, R., Hayeck, T., Won, H. H., Neale, B., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., & 30 othersHuang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Cahn, W., Cheng, W., Cheng, W., Kahn, R. S., Kahn, R. S., Myin-Germeys, I., Van Os, J., Van Os, J., Sanders, A. R., Strengman, E., Ophoff, R. A., Schmutzler, R. K., Schmutzler, R. K. & Van Der Luijt, R. B., 1 Jan 2015, In: American Journal of Human Genetics. 97, 4, p. 576-592 17 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    107 Citations (Scopus)

  • Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

    O’dushlaine, C., Rossin, L., Lee, P. H., Duncan, L., Parikshak, N. N., Newhouse, S., Ripke, S., Neale, B. M., Purcell, S. M., Posthuma, D., Nurnberger, J. I., Lee, S. H., Faraone, S. V., Perlis, R. H., Mowry, B. J., Thapar, A., Goddard, M. E., Witte, J. S., Absher, D., Agartz, I., & 30 othersAkil, H., Amin, F., Andreassen, O. A., Anjorin, A., Anney, R., Anttila, V., Arking, D. E., Asherson, P., Azevedo, M. H., Backlund, L., Badner, J. A., Bailey, A. J., Banaschewski, T., Barchas, J. D., Barnes, M. R., Barrett, T. B., Bass, N., Battaglia, A., Bauer, M., Bayés, M., Bellivier, F., Bergen, S. E., Berrettini, W., Betancur, C., Bettecken, T., Biederman, J., Cahn, W., Kahn, R. S., Ophoff, R. A. & Van Os, J., 17 Feb 2015, In: Nature Neuroscience. 18, 2, p. 199-209 11 p.

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    271 Citations (Scopus)
  • 2014

    A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

    1 Mar 2014, In: Biological Psychiatry. 75, 5, p. 386-397 12 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    26 Citations (Scopus)

  • Biological insights from 108 schizophrenia-associated genetic loci

    Ripke, S., Neale, B. M., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Bulik-Sullivan, B., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., & 280 othersBergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Bruggeman, R., Buccola, N. G., Buckner, R. L., Byerley, W., Cahn, W., Cai, G., Campion, D., Cantor, R. M., Carr, V. J., Carrera, N., Catts, S. V., Chambert, K. D., Chan, R. C. K., Chen, R. Y. L., Chen, E. Y. H., Cheng, W., Cheung, E. F. C., Chong, S. A., Cloninger, C. R., Cohen, D., Cohen, N., Cormican, P., Craddock, N., Crowley, J. J., Curtis, D., Davidson, M., Davis, K. L., Degenhardt, F., Del Favero, J., Demontis, D., Dikeos, D., Dinan, T., Djurovic, S., Donohoe, G., Drapeau, E., Duan, J., Dudbridge, F., Durmishi, N., Eichhammer, P., Eriksson, J., Escott-Price, V., Essioux, L., Fanous, A. H., Farrell, M. S., Frank, J., Franke, L., Freedman, R., Freimer, N. B., Friedl, M., Friedman, J. I., Fromer, M., Genovese, G., Georgieva, L., Giegling, I., Giusti-Rodríguez, P., Godard, S., Goldstein, J. I., Golimbet, V., Gopal, S., Gratten, J., De Haan, L., Hammer, C., Hamshere, M. L., Hansen, M., Hansen, T., Haroutunian, V., Hartmann, A. M., Henskens, F. A., Herms, S., Hirschhorn, J. N., Hoffmann, P., Hofman, A., Hollegaard, M. V., Hougaard, D. M., Ikeda, M., Joa, I., Julià, A., Kahn, R. S., Kalaydjieva, L., Karachanak-Yankova, S., Karjalainen, J., Kavanagh, D., Keller, M. C., Kennedy, J. L., Khrunin, A., Kim, Y., Klovins, J., Knowles, J. A., Konte, B., Kucinskas, V., Kucinskiene, Z. A., Kuzelova-Ptackova, H., Kähler, A. K., Laurent, C., Keong, J. L. C., Lee, S. H., Legge, S. E., Lerer, B., Li, M., Li, T., Liang, K. Y., Lieberman, J., Limborska, S., Loughland, C. M., Lubinski, J., Lönnqvist, J., Macek, M., Magnusson, P. K. E., Maher, B. S., Maier, W., Mallet, J., Marsal, S., Mattheisen, M., Mattingsdal, M., McCarley, R. W., McDonald, C., McIntosh, A. M., Meier, S., Meijer, C. J., Melegh, B., Melle, I., Mesholam-Gately, R. I., Metspalu, A., Michie, P. T., Milani, L., Milanova, V., Mokrab, Y., Morris, D. W., Mors, O., Murphy, K. C., Murray, R. M., Myin-Germeys, I., Müller-Myhsok, B., Nelis, M., Nenadic, I., Nertney, D. A., Nestadt, G., Nicodemus, K. K., Nikitina-Zake, L., Nisenbaum, L., Nordin, A., O'Callaghan, E., O'Dushlaine, C., O'Neill, F. A., Oh, S. Y., Olincy, A., Olsen, L., Van Os, J., Pantelis, C., Papadimitriou, G. N., Papiol, S., Parkhomenko, E., Pato, M. T., Paunio, T., Pejovic-Milovancevic, M., Perkins, D. O., Pietiläinen, O., Pimm, J., Pocklington, A. J., Powell, J., Price, A., Pulver, A. E., Purcell, S. M., Quested, D., Rasmussen, H. B., Reichenberg, A., Reimers, M. A., Richards, A. L., Roffman, J. L., Roussos, P., Ruderfer, D. M., Salomaa, V., Sanders, A. R., Schall, U., Schubert, C. R., Schulze, T. G., Schwab, S. G., Scolnick, E. M., Scott, R. J., Seidman, L. J., Shi, J., Sigurdsson, E., Silagadze, T., Silverman, J. M., Sim, K., Slominsky, P., Smoller, J. W., So, H. C., Spencer, C. C. A., Stahl, E. A., Stefansson, H., Steinberg, S., Stogmann, E., Straub, R. E., Strengman, E., Strohmaier, J., Stroup, T. S., Subramaniam, M., Suvisaari, J., Svrakic, D. M., Szatkiewicz, J. P., Söderman, E., Thirumalai, S., Toncheva, D., Tosato, S., Veijola, J., Waddington, J., Walsh, D., Wang, D., Wang, Q., Webb, B. T., Weiser, M., Wildenauer, D. B., Williams, N. M., Williams, S., Witt, S. H., Wolen, A. R., Wong, E. H. M., Wormley, B. K., Xi, H. S., Zai, C. C., Zheng, X., Zimprich, F., Wray, N. R., Stefansson, K., Visscher, P. M., Adolfsson, R., Andreassen, O. A., Blackwood, D. H. R., Bramon, E., Buxbaum, J. D., Børglum, A. D., Cichon, S., Darvasi, A., Domenici, E., Ehrenreich, H., Esko, T., Gejman, P. V., Gill, M., Gurling, H., Hultman, C. M., Iwata, N., Jablensky, A. V., Jönsson, E. G., Kendler, K. S., Kirov, G., Knight, J., Lencz, T., Levinson, D. F., Li, Q. S., Liu, J., Malhotra, A. K., McCarroll, S. A., McQuillin, A., Moran, J. L., Mortensen, P. B., Mowry, B. J., Nöthen, M. M., Ophoff, R. A., Owen, M. J., Palotie, A., Pato, C. N., Petryshen, T. L., Posthuma, D., Rietschel, M., Riley, B. P., Rujescu, D., Sham, P. C., Sklar, P., St Clair, D., Weinberger, D. R., Wendland, J. R., Werge, T., Daly, M. J., Sullivan, P. F. & O'Donovan, M. C., 1 Jan 2014, In: Nature. 511, 7510, p. 421-427 7 p.

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    2210 Citations (Scopus)

  • Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

    Gusev, A., Lee, S. H., Trynka, G., Finucane, H., Vilhjálmsson, B. J., Xu, H., Zang, C., Ripke, S., Bulik-Sullivan, B., Stahl, E. A., Kähler, A. K., Hultman, C. M., Purcell, S. M., McCarroll, S. A., Daly, M. J., Pasaniuc, B., Sullivan, P. F., Neale, B. M., Wray, N. R., Raychaudhuri, S., & 30 othersPrice, A. L., Corvin, A., Walters, J. T. R., Farh, K. H., Holmans, P. A., Lee, P., Collier, D. A., Huang, H., Pers, T. H., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, S. A., Begemann, M., Belliveau, R. A., Bene, J., Bergen, S. E., Bevilacqua, E., Bigdeli, T. B., Black, D. W., Børglum, A. D., Bruggeman, R., Cahn, W., Chen, E. Y. H., Kahn, R. S., Murphy, K. C., Van Os, J. & Ophoff, R. A., 1 Jan 2014, In: American Journal of Human Genetics. 95, 5, p. 535-552 18 p.

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    192 Citations (Scopus)

  • Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway

    Nicodemus, K. K., Hargreaves, A., Morris, D., Anney, R., Gill, M., Corvin, A., Donohoe, G., Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D. Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., St Clair, D., & 224 othersGurling, H., Werge, T., Rujescu, D., Blackwood, D. H., Pato, C. N., Malhotra, A. K., Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Byerley, W. F., Cahn, W., Cantor, R. M., Carr, V. J., Catts, S. V., Choudhury, K., Cloninger, C., Cormican, P., Craddock, N., Danoy, P. A., Datta, S., de Haan, L., Demontis, D., Dikeos, D., Djurovic, S., Donnelly, P., Duong, L., Dwyer, S., Fink-Jensen, A., Freedman, R., Freimer, N. B., Friedl, M., Georgieva, L., Giegling, I., Glenthøj, B., Godard, S., Hamshere, M., Hansen, M., Hansen, T., Hartmann, A. M., Henskens, F. A., Hougaard, D. M., Hultman, C. M., Ingason, A., Jablensky, A. V., Jakobsen, K. D., Jay, M., Jürgens, G., Kahn, R. S., Keller, M. C., Kenis, G., Kenny, E., Kim, Y., Kirov, G. K., Konnerth, H., Konte, B., Krabbendam, L., Krasucki, R., Lasseter, V. K., Laurent, C., Lawrence, J., Lencz, T., Lerer, F., Liang, K. Y., Lichtenstein, P., Lieberman, J. A., Linszen, D. H., Lönnqvist, J., Loughland, C. M., Maclean, A. W., Maher, B. S., Maier, W., Mallet, J., Malloy, P., Mattheisen, M., Mattingsdal, M., McGhee, K. A., McGrath, J. J., McIntosh, A., McLean, D. E., McQuillin, A., Melle, I., Michie, P. T., Milanova, V., Mors, O., Mortensen, P. B., Moskvina, V., Muglia, P., Myin-Germeys, I., Nertney, D. A., Nestadt, G., Nielsen, J., Nikolov, I., Nordentoft, M., Norton, N., Nöthen, M. M., O'Dushlaine, C. T., Olincy, A., Olsen, L., O'Neill, F., Ørntoft, T. F., Owen, M. J., Pantelis, C., Papadimitriou, G., Pato, M. T., Peltonen, L., Petursson, H., Pickard, B., Pimm, J., Pulver, A. E., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Réthelyi, J. M., Ribble, R., Rietschel, M., Riley, B. P., Ruggeri, M., Schall, U., Schulze, T. G., Schwab, S. G., Scott, R. J., Shi, J., Sigurdsson, E., Silverman, J. M., Spencer, C. C., Stefansson, K., Strange, A., Strengman, E., Stroup, T., Suvisaari, J., Terenius, L., Thirumalai, S., Thygesen, J. H., Timm, S., Toncheva, D., van den Oord, E., van Os, J., van Winkel, R., Veldink, J., Walsh, D., Wang, A. G., Wiersma, D., Wildenauer, D. B., Williams, H. J., Williams, N. M., Wormley, B., Zammit, S., Sullivan, P. F., O'Donovan, M. C., Daly, M. J., Gejman, P., Barroso, I., Blackwell, J. M., Bramon, E., Casas, J. P., Deloukas, P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Waller, M., Weston, P., Widaa, S. & Whittaker, P., 1 Jul 2014, In: JAMA Psychiatry. 71, 7, p. 778-785 8 p.

    Research output: Contribution to journal › Article › Academic › peer-review

    16 Citations (Scopus)