Department of Experimental Pulmonary Diseases

Research output

Research output per year 1985 1993 2017 2018 2019 2020 2021 2024

• 189 Article
• 21 Review article
• 13 Doctoral thesis 1 (Research UU / Graduation UU)
• 8 Comment/Letter to the editor
• 8 More
  • 3 Letter
  • 2 Meeting Abstract
  • 2 Editorial
  • 1 Doctoral thesis 2 (Research NOT UU / Graduation UU)

Research output per year

Research output per year

Search results

• 2024

  Automated, Point-of-Care mobile flow cytometry: Bringing the laboratory to the sample

  Jukema, B. N., Pelgrim, T. C., Spoelder, M., Bongers, C. C. W. G., Hopman, M. T. E., Smit, K., Rijk, M. H., Venekamp, R. P., Vrisekoop, N. & Koenderman, L., 30 Apr 2024, In: Heliyon. 10, 8, p. 1-13 13 p., e28883.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Flow Cytometry 67%
  • Hospital Laboratories 37%
  • Eosinophils 28%
  • Monocytes 24%

• Point-of-care neutrophil and monocyte surface markers differentiate bacterial from viral infections at the emergency department within 30 min

  Jukema, B. N., de Hond, T. A. P., Kroon, M., Maranus, A. E., Koenderman, L. & Kaasjager, K. A. H., Apr 2024, In: Journal of Leukocyte Biology. 115, 4, p. 714-722 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Bacterial Infections 82%
  • Monocytes 73%
  • Hospital Emergency Service 71%
  • Neutrophils 69%
  4 Downloads (Pure)

• Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors

  Pettinella, F., Mariotti, B., Lattanzi, C., Bruderek, K., Donini, M., Costa, S., Marini, O., Iannoto, G., Gasperini, S., Caveggion, E., Castellucci, M., Calzetti, F., Bianchetto-Aguilera, F., Gardiman, E., Giani, M., Dusi, S., Cantini, M., Vassanelli, A., Pavone, D., Milella, M., & 15 othersPilotto, S., Biondani, P., Höing, B., Schleupner, M. C., Hussain, T., Hadaschik, B., Kaspar, C., Visco, C., Tecchio, C., Koenderman, L., Bazzoni, F., Tamassia, N., Brandau, S., Cassatella, M. A. & Scapini, P., 20 Feb 2024, In: Cell Reports Medicine. 5, 2, 101380.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Receptors, Prostaglandin E, EP2 Subtype 100%
  • RNA Sequencing 95%
  • Prostaglandin E 90%
  • Myeloid-Derived Suppressor Cells 77%
  • Granulocyte Colony-Stimulating Factor 61%
• 2023

  Comprehensive multivariate evaluation of the effects on cell phenotypes in multicolor flow cytometry data using ANOVA simultaneous component analysis

  Bertinetto, C. G., Spijkerman, R., Hesselink, L., Tinnevelt, G. H., Bongers, C. C. W. G., Postma, G. J., Hopman, M. T. E., Koenderman, L. & Jansen, J. J., Jul 2023, In: Journal of Chemometrics. 37, 7, 17 p., e3402.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Flow Cytometry 100%
  • Flow cytometry 93%
  • Phenotype 75%
  • Cytometry 65%
  • Analysis of variance (ANOVA) 64%
  7 Downloads (Pure)

• Eosinophils—from cradle to grave

  Jesenak, M., Diamant, Z., Simon, D., Tufvesson, E., Seys, S. F., Mukherjee, M., Lacy, P., Vijverberg, S., Slisz, T., Sediva, A., Simon, H. U., Striz, I., Plevkova, J., Schwarze, J., Kosturiak, R., Alexis, N. E., Untersmayr, E., Vasakova, M. K., Knol, E. & Koenderman, L., Dec 2023, In: Allergy: European Journal of Allergy and Clinical Immunology. 78, 12, p. 3077-3102 26 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Eosinophils 100%
  • Homeostasis 16%
  • Adjustment Disorders 15%
  • Biological Products 11%
  • Antiviral Agents 9%

• Identification of neutrophil phenotype categories in geriatric hip fracture patients aids in personalized medicine

  Nijdam, T. M. P., Jukema, B. N., de Fraiture, E. J., Spijkerman, R., Schuijt, H. J., Spoelder, M., Bongers, C. C. W. G., Hopman, M. T. E., Koenderman, L., Hietbrink, F. & van der Velde, D., Dec 2023, In: OTA international : the open access journal of orthopaedic trauma. 6, 5, e291.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Precision Medicine 100%
  • Hip Fractures 99%
  • Geriatrics 88%
  • Neutrophils 72%
  • Phenotype 55%
  4 Downloads (Pure)

• N⁶-Methyladenosine Directly Regulates CD40L Expression in CD4⁺ T Lymphocytes

  van Vroonhoven, E. C. N., Picavet, L. W., Scholman, R. C., van den Dungen, N. A. M., Mokry, M., Evers, A., Lebbink, R. J., Calis, J. J. A., Vastert, S. J. & van Loosdregt, J., Jul 2023, In: Biology. 12, 7, 11 p., 1004.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • N(6)-methyladenosine 100%
  • CD40 Ligand 78%
  • T-lymphocytes 57%
  • ligands 57%
  • T-Lymphocytes 39%
  5 Downloads (Pure)

• Nuclear segmentation facilitates neutrophil migration

  Shen, C., Mulder, E., Buitenwerf, W., Postat, J., Jansen, A., Kox, M., Mandl, J. N. & Vrisekoop, N., 1 Jun 2023, In: Journal of cell science. 136, 11, 7 p., jcs260768.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Confined Spaces 25%
  • Emergency Responders 22%
  • Lab-On-A-Chip Devices 21%
  • Neutrophil Infiltration 18%
  7 Downloads (Pure)

• Point-of-care neutrophil CD64 as a rule in diagnostic test for bacterial infections in the emergency department

  van de Ven, N. L. M., Bongers, S. H., Spijkerman, R., Koenderman, L., Leenen, L. P. H. & Hietbrink, F., 14 Mar 2023, In: BMC Emergency Medicine. 23, 1, p. 1-10 10 p., 28.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Routine Diagnostic Tests 83%
  • Bacterial Infections 82%
  • Hospital Emergency Service 71%
  • Neutrophils 69%
  14 Downloads (Pure)

• Quality over quantity; eosinophil activation status will deepen the insight into eosinophilic diseases

  Hilvering, B. & Koenderman, L., Feb 2023, In: Respiratory Medicine. 207, 107094.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Eosinophils 100%
  • Asthma 20%
  • Parasitic Diseases 9%
  • Acute Disease 9%
  • Therapeutics 7%
  19 Downloads (Pure)

• Visualization of the inflammatory response to injury by neutrophil phenotype categories: Neutrophil phenotypes after trauma

  de Fraiture, E. J., Bongers, S. H., Jukema, B. N., Koenderman, L., Vrisekoop, N., van Wessem, K. J. P., Leenen, L. P. H. & Hietbrink, F., Apr 2023, In: European Journal of Trauma and Emergency Surgery. 49, 2, p. 1023-1034 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Phenotype 76%
  • Wounds and Injuries 61%
  • Point-of-Care Systems 47%
  • Injury Severity Score 16%
  1 Downloads (Pure)
• 2022

  Dragon 1 Protocol Manuscript: Training, Accreditation, Implementation and Safety Evaluation of Portal and Hepatic Vein Embolization (PVE/HVE) to Accelerate Future Liver Remnant (FLR) Hypertrophy

  Korenblik, R., Olij, B., Aldrighetti, L. A., Hilal, M. A., Ahle, M., Arslan, B., van Baardewijk, L. J., Baclija, I., Bent, C., Bertrand, C. L., Björnsson, B., de Boer, M. T., de Boer, S. W., Bokkers, R. P. H., Rinkes, I. H. M. B., Breitenstein, S., Bruijnen, R. C. G., Bruners, P., Büchler, M. W., Camacho, J. C., & 101 othersCappelli, A., Carling, U., Chan, B. K. Y., Chang, D. H., Choi, J., Font, J. C., Crawford, M., Croagh, D., Cugat, E., Davis, R., De Boo, D. W., De Cobelli, F., De Wispelaere, J. F., van Delden, O. M., Delle, M., Detry, O., Díaz-Nieto, R., Dili, A., Erdmann, J. I., Fisher, O., Fondevila, C., Fretland, Å., Borobia, F. G., Gelabert, A., Gérard, L., Giuliante, F., Gobardhan, P. D., Gómez, F., Grünberger, T., Grünhagen, D. J., Guitart, J., Hagendoorn, J., Heil, J., Heise, D., Herrero, E., Hess, G. F., Hoffmann, M. H., Iezzi, R., Imani, F., Nguyen, J., Jovine, E., Kalff, J. C., Kazemier, G., Kingham, T. P., Kleeff, J., Kollmar, O., Leclercq, W. K. G., Ben, S. L., Lucidi, V., MacDonald, A., Madoff, D. C., Manekeller, S., Martel, G., Mehrabi, A., Mehrzad, H., Meijerink, M. R., Menon, K., Metrakos, P., Meyer, C., Moelker, A., Modi, S., Montanari, N., Navines, J., Neumann, U. P., Peddu, P., Primrose, J. N., Qu, X., Raptis, D., Ratti, F., Ridouani, F., Rogan, C., Ronellenfitsch, U., Ryan, S., Sallemi, C., Moragues, J. S., Sandström, P., Sarriá, L., Schnitzbauer, A., Serenari, M., Serrablo, A., Smits, M. L. J., Sparrelid, E., Spüntrup, E., Stavrou, G. A., Sutcliffe, R. P., Tancredi, I., Tasse, J. C., Udupa, V., Valenti, D., Fundora, Y., Vogl, T. J., Wang, X., White, S. A., Wohlgemuth, W. A., Yu, D., Zijlstra, I. A. J., Binkert, C. A., Bemelmans, M. H. A., van der Leij, C., Schadde, E. & van Dam, R. M., Sept 2022, In: Cardiovascular and Interventional Radiology. 45, 9, p. 1391-1398 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Hepatic Veins 100%
  • Accreditation 97%
  • Manuscripts 96%
  • Portal Vein 84%
  • Hypertrophy 75%
  6 Downloads (Pure)

• Neutrophil and Eosinophil Responses Remain Abnormal for Several Months in Primary Care Patients With COVID-19 Disease

  Jukema, B. N., Smit, K., Hopman, M. T. E., Bongers, C. C. W. G., Pelgrim, T. C., Rijk, M. H., Platteel, T. N., Venekamp, R. P., Zwart, D. L. M., Rutten, F. H. & Koenderman, L., 2022, In: Frontiers in allergy. 3, 942699.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Eosinophils 100%
  • Primary Health Care 81%
  • Neutrophils 80%
  • Neutrophil Activation 19%
  • Flow Cytometry 12%
  11 Downloads (Pure)

• Neutrophils Promote Glioblastoma Tumor Cell Migration after Biopsy

  Chen, N., Alieva, M., van der Most, T., Klazen, J. A. Z., Vollmann-Zwerenz, A., Hau, P. & Vrisekoop, N., 14 Jul 2022, In: Cells. 11, 14, p. 1-11 2196.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Glioblastoma 100%
  • Cell Movement 82%
  • Neutrophils 79%
  • Biopsy 61%
  • Environment 57%
  6 Downloads (Pure)

• Shift of Neutrophils From Blood to Bone Marrow Upon Extensive Experimental Trauma Surgery

  Teuben, M. P. J., Heeres, M., Blokhuis, T., Spijkerman, R., Knot, E., Vrisekoop, N., Pfeifer, R., Pape, H. C., Koenderman, L. & Leenen, L. P. H., 17 May 2022, In: Frontiers in Immunology. 13, p. 1-13 883863.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Bone Marrow 93%
  • Wounds and Injuries 61%
  • Cell Surface Receptors 10%
  • Neutropenia 9%
  6 Downloads (Pure)

• Standardized porcine unilateral femoral nailing is associated with changes in PMN activation status, rather than aberrant systemic PMN prevalence

  Jun 2022, In: European Journal of Trauma and Emergency Surgery. 48, 3, p. 1601-1611 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Granulocytes 100%
  • Thigh 81%
  • Swine 79%
  • Intramedullary Fracture Fixation 76%
  • Femur 38%
  4 Downloads (Pure)

• The journey of neutropoiesis: how complex landscapes in bone marrow guide continuous neutrophil lineage determination

  Overbeeke, C., Tak, T. & Koenderman, L., 14 Apr 2022, In: Blood. 139, 15, p. 2285-2293 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Apoptotic 100%
  • Clearance 94%
  • White 73%
  • Neutrophils 68%
  • Bone Marrow 63%
  1 Downloads (Pure)

• Transformation of multicolour flow cytometry data with OTflow prevents misleading multivariate analysis results and incorrect immunological conclusions

  Folcarelli, R., van Staveren, S., Tinnevelt, G., Cadot, E., Vrisekoop, N., Buydens, L., Koenderman, L., Jansen, J. & van den Brink, O. F., Jan 2022, In: Cytometry Part A. 101, 1, p. 72-85 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Flow Cytometry 100%
  • Multivariate Analysis 93%
  • Artifacts 42%
  • Datasets 17%
  • Population 17%
  2 Downloads (Pure)
• 2021

  Analysis of human neutrophil phenotypes as biomarker to monitor exercise-induced immune changes

  Spijkerman, R., Hesselink, L., Bertinetto, C., Bongers, C. C. W. G., Hietbrink, F., Vrisekoop, N., Leenen, L. P. H., Hopman, M. T. E., Jansen, J. J. & Koenderman, L., Apr 2021, In: Journal of Leukocyte Biology. 109, 4, p. 833-842 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Biomarkers 83%
  • Phenotype 76%
  • Immune System 57%
  • Innate Immunity 50%
  10 Downloads (Pure)

• An increase in CD62Ldim neutrophils precedes the development of pulmonary embolisms in COVID-19 patients

  Spijkerman, R., Jorritsma, N. K., Bongers, S. H., Bindels, B. J., Jukema, B. N., Hesselink, L., Hietbrink, F., Leenen, L. P., van Goor, H. M., Vrisekoop, N., Kaasjager, K. A. & Koenderman, L., Jun 2021, In: Scandinavian Journal of Immunology. 93, 6, 8 p., e13023.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Pulmonary Embolism 100%
  • Neutrophils 79%
  • Virus Diseases 74%
  • Neutrophil Activation 15%
  • Phenotype 15%
  6 Downloads (Pure)

• CD5 levels define functionally heterogeneous populations of naïve human CD4+ T cells

  Sood, A., Lebel, M-È., Dong, M., Fournier, M., Vobecky, S. J., Haddad, É., Delisle, J-S., Mandl, J. N., Vrisekoop, N. & Melichar, H. J., Jun 2021, In: European Journal of Immunology. 51, 6, p. 1365-1376 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • T-Lymphocytes 100%
  • Population 63%
  • Peptides 34%
  • Cell- and Tissue-Based Therapy 17%
  • Memory 13%

• Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways

  Prado, J., Westerink, R. H. S., Popov-Celeketic, J., Steen-Louws, C., Pandit, A., Versteeg, S., van de Worp, W., Kanters, D. H. A. J., Reedquist, K. A., Koenderman, L., Hack, C. E. & Eijkelkamp, N., 16 Mar 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 11, e2009647118.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cytokine Receptors 100%
  • Sensory Receptor Cells 88%
  • Interleukin-4 76%
  • Cluster Analysis 74%
  • Cytokines 51%
  12 Citations (Scopus)

  3 Downloads (Pure)

• Differential effects of short- and long-term treatment with mepolizumab on eosinophil kinetics in blood and sputum in eosinophilic asthma

  Hassani, M., Tak, T., van Aalst, C., van Nederveen, S., Tesselaar, K., Vrisekoop, N. & Koenderman, L., 20 Aug 2021, In: iScience. 24, 8, 19 p., 102913.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • mepolizumab 100%
  • Sputum 59%
  • Eosinophils 57%
  • Interleukin-5 47%
  • Asthma 46%
  8 Downloads (Pure)

• Flow cytometric evaluation of the neutrophil compartment in COVID-19 at hospital presentation: A normal response to an abnormal situation

  Spijkerman, R., Bongers, S. H., Bindels, B. J. J., Tinnevelt, G. H., Giustarini, G., Jorritsma, N. K. N., Buitenwerf, W., van Spengler, D. E. J., Delemarre, E. M., Nierkens, S., van Goor, H. M. R., Jansen, J. J., Vrisekoop, N., Hietbrink, F., Leenen, L. P. H., Kaasjager, K. A. H. & Koenderman, L., Jan 2021, In: Journal of Leukocyte Biology. 109, 1, p. 99-114 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Coronavirus 100%
  • Neutrophils 62%
  • Severe Acute Respiratory Syndrome 8%
  • Neutrophil Activation 8%
  • Point-of-Care Systems 7%
  3 Citations (Scopus)

  5 Downloads (Pure)

• Instant intra-operative neutropenia despite the emergence of banded (CD16dim/CD62Lbright) neutrophils in peripheral blood - An observational study during extensive trauma-surgery in pigs

  Teuben, M., Heeres, M., Blokhuis, T., Hollman, A., Vrisekoop, N., Tan, E., Pfeifer, R., Pape, H-C., Koenderman, L. & Leenen, L. P. H., Mar 2021, In: Injury. 52, 3, p. 426-433 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neutropenia 100%
  • Swine 78%
  • Neutrophils 78%
  • Observational Studies 77%
  • Wounds and Injuries 48%

• Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation

  Bongers, S. H., Chen, N., van Grinsven, E., van Staveren, S., Hassani, M., Spijkerman, R., Hesselink, L., Lo Tam Loi, A. T., van Aalst, C., Leijte, G. P., Kox, M., Pickkers, P., Hietbrink, F., Leenen, L. P. H., Koenderman, L. & Vrisekoop, N., 24 Jun 2021, In: Frontiers in Immunology. 12, p. 1-12 674079.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neutrophils 100%
  • Kinetics 92%
  • Inflammation 75%
  • Endotoxemia 34%
  • Bone Marrow 31%
  2 Citations (Scopus)

  5 Downloads (Pure)

• Monitoring eosinophils to guide therapy with Biologics in Asthma: does the compartment matter?

  Koenderman, L., Hassani, M., Mukherjee, M. & Nair, P., Apr 2021, In: Allergy. 76, 4, p. 1294-1297 4 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Biological Therapy 100%
  • Eosinophils 81%
  • Asthma 65%
  • Endothelium 32%
  • eosinophilopoietin 27%
  7 Downloads (Pure)

• Preoperative Cerebrospinal Fluid Cortisol and the Risk of Postoperative Delirium: A Prospective Study of Older Hip Fracture Patients

  Witlox, J., Adamis, DI., Koenderman, L., Kalisvaart, K., De Jonghe, J. F. M., Houdijk, A. P. J., MacLullich, A. M. J., Eikelenboom, P. & Van Gool, W. A., Apr 2021, In: Dementia and Geriatric Cognitive Disorders. 49, 6, p. 604-610 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Delirium 100%
  • Hip Fractures 94%
  • Hydrocortisone 77%
  • Cerebrospinal Fluid 75%
  • Prospective Studies 55%

• Refractory neutrophils and monocytes in patients with inflammatory bowel disease after repeated bouts of prolonged exercise

  Spijkerman, R., Hesselink, L., Bertinetto, C., Bongers, C. C. W. G., Hietbrink, F., Vrisekoop, N., Leenen, L. P. H., Hopman, M. T. E., Jansen, J. J. & Koenderman, L., Nov 2021, In: Cytometry. Part B, Clinical Cytometry.. 100, 6, p. 676-682 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Inflammatory Bowel Diseases 100%
  • Monocytes 87%
  • Neutrophils 82%
  • Walkers 76%
  • Exercise 68%
  9 Downloads (Pure)

• Repetitive Immune-Mediated Noninfectious Endocarditis Necessitating 5 Mitral Valve Replacements

  Muller, S. A., Leavis, H. L., Taha, K., Koenderman, L., Chamuleau, S. A. J., Suyker, W. J. L. & Cramer, M. J., 6 Oct 2021, In: JACC Case Rep. 3, 13, p. 1483-1488 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endocarditis 100%
  • Mitral Valve 96%
  • Interleukin 1 Receptor Antagonist Protein 43%
  • Prednisone 32%
  • Anti-Inflammatory Agents 23%
  8 Downloads (Pure)

• Serum Biomarker Profile Including CCL1, CXCL10, VEGF, and Adenosine Deaminase Activity Distinguishes Active From Remotely Acquired Latent Tuberculosis

  Delemarre, E. M., van Hoorn, L., Bossink, A. W. J., Drylewicz, J., Joosten, S. A., Ottenhoff, T. H. M., Akkerman, O. W., Goletti, D., Petruccioli, E., Navarra, A., van den Broek, B. T. A., Paardekooper, S. P. A., van Haeften, I., Koenderman, L., Lammers, J-W. J., Thijsen, S. F. T., Hofland, R. W. & Nierkens, S., 7 Oct 2021, In: Frontiers in Immunology. 12, p. 1-12 725447.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • C Chemokines 100%
  • Chemokine CXCL10 90%
  • Latent Tuberculosis 83%
  • Adenosine Deaminase 81%
  • Vascular Endothelial Growth Factor A 55%
  1 Downloads (Pure)

• The Systemic Immune Response in COVID-19 Is Associated with a Shift to Formyl-Peptide Unresponsive Eosinophils

  Koenderman, L., Siemers, M. J., van Aalst, C., Bongers, S. H., Spijkerman, R., Bindels, B. J. J., Giustarini, G., van Goor, H. M. R., Kaasjager, K. A. H. & Vrisekoop, N., 5 May 2021, In: Cells. 10, 5, 12 p., 1109.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cytometry 100%
  • Refractory 99%
  • Eosinophils 92%
  • Flow 61%
  • Peptides 61%

• Thrombotic Events in COVID-19 Are Associated With a Lower Use of Prophylactic Anticoagulation Before Hospitalization and Followed by Decreases in Platelet Reactivity

  22 Apr 2021, In: Frontiers in medicine. 8, p. 1-11 650129.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Coronavirus 100%
  • Blood Platelets 61%
  • Hospitalization 58%
  • thrombin receptor peptide (42-47) 29%
  • Odds Ratio 17%
  2 Citations (Scopus)

  15 Downloads (Pure)
• 2020

  Differentiation and activation of eosinophils in the human bone marrow during experimental human endotoxemia

  Hassani, M., Leijte, G., Bruse, N., Kox, M., Pickkers, P., Vrisekoop, N. & Koenderman, L., Nov 2020, In: Journal of Leukocyte Biology. 108, 5, p. 1665-1671 7 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endotoxemia 100%
  • Eosinophils 79%
  • Bone Marrow 60%
  • Granulocyte Precursor Cells 29%
  • Endotoxins 14%
  6 Downloads (Pure)

• Fragile neutrophils in surgical patients: A phenomenon associated with critical illness

  Hesselink, L., Spijkerman, R., Hellebrekers, P., van Bourgondiën, R. J., Blasse, E., Haitjema, S., Huisman, A., van Solinge, W. W., Van Wessem, K. J. P., Koenderman, L., Leenen, L. P. H. & Hietbrink, F., 4 Aug 2020, In: PLoS ONE. 15, 8, 19 p., e0236596.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Critical Illness 100%
  • Neutrophils 84%
  • Leukocytes 76%
  • Propidium 61%
  • Hematology 34%

• Multi-set Pre-processing of Multicolor Flow Cytometry Data

  Folcarelli, R., Tinnevelt, G. H., Hilvering, B., Wouters, K., van Staveren, S., Postma, G. J., Vrisekoop, N., Buydens, L. M. C., Koenderman, L. & Jansen, J. J., 2020, In: Scientific Reports. 10, 1, 12 p., 9716.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Flow Cytometry 100%
  • Cell Count 49%
  • Data Analysis 24%
  • Technology 21%
  5 Downloads (Pure)

• New automated analysis to monitor neutrophil function point-of-care in the intensive care unit after trauma

  Hesselink, L., Spijkerman, R., de Fraiture, E., Bongers, S., Van Wessem, K. J. P., Vrisekoop, N., Koenderman, L., Leenen, L. P. H. & Hietbrink, F., 14 Mar 2020, In: Intensive Care Medicine Experimental. 8, 1, p. 1-12 12.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Intensive Care Units 73%
  • Neutrophils 69%
  • Wounds and Injuries 43%
  • Infections 18%

• Persistent inflammation, immunosuppression and catabolism syndrome (PICS) after polytrauma: A rare syndrome with major consequences

  Hesselink, L., Hoepelman, R. J., Spijkerman, R., de Groot, M. C. H., van Wessem, K. J. P., Koenderman, L., Leenen, L. P. H. & Hietbrink, F., 10 Jan 2020, In: Journal of Clinical medicine. 9, 1, p. 1-13 13 p., 191.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Multiple Trauma 100%
  • Immunosuppression 78%
  • Inflammation 51%
  • Critical Illness 29%
  • Chronic Disease 23%
  8 Citations (Scopus)

• Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

  Fumagalli, A., Oost, K. C., Kester, L., Morgner, J., Bornes, L., Bruens, L., Spaargaren, L., Azkanaz, M., Schelfhorst, T., Beerling, E., Heinz, M. C., Postrach, D., Seinstra, D., Sieuwerts, A. M., Martens, J. W. M., van der Elst, S., van Baalen, M., Bhowmick, D., Vrisekoop, N., Ellenbroek, S. I. J., & 3 othersSuijkerbuijk, S. J. E., Snippert, H. J. & van Rheenen, J., 2 Apr 2020, In: Cell stem cell. 26, 4, p. 569-578.e7

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Neoplastic Stem Cells 100%
  • Colorectal Neoplasms 99%
  • Neoplasm Metastasis 77%
  • Neoplasms 40%
  • Seeds 31%
  5 Citations (Scopus)

  7 Downloads (Pure)

• Point-of-Care Analysis of Neutrophil Phenotypes: A First Step Toward Immuno-Based Precision Medicine in the Trauma ICU

  Spijkerman, R., Hesselink, L., Bongers, S., van Wessem, K. J. P., Vrisekoop, N., Hietbrink, F., Koenderman, L. & Leenen, L. P. H., 17 Jul 2020, In: Critical care explorations. 2, 7, p. 1-9 9 p., e0158.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Precision Medicine 95%
  • Neutrophils 69%
  • Phenotype 53%
  • Multiple Trauma 46%
  4 Downloads (Pure)
• 2019

  A novel data fusion method for the effective analysis of multiple panels of flow cytometry data

  Tinnevelt, G. H., van Staveren, S., Wouters, K., Wijnands, E., Verboven, K., Folcarelli, R., Koenderman, L., Buydens, L. M. C. & Jansen, J. J., 1 May 2019, In: Scientific Reports. 9, 1, 6777.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Flow Cytometry 100%
  • Discriminant Analysis 20%
  • Endotoxins 18%
  • Datasets 14%
  • Neutrophils 14%

• A Rise in Neutrophil Cell Size Precedes Organ Dysfunction After Trauma

  Hesselink, L., Heeres, M., Paraschiakos, F., Ten Berg, M., Huisman, A., Hoefer, I. E., de Groot, M. C. H., van Solinge, W. W., Dijkgraaf, M., Hellebrekers, P., Van Wessem, K. J. P., Koenderman, L., Leenen, L. P. H. & Hietbrink, F., 1 Apr 2019, In: Shock. 51, 4, p. 439-446 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cell Size 100%
  • Neutrophils 76%
  • Wounds and Injuries 47%
  • Femoral Fractures 39%
  • Multiple Trauma 12%
  16 Citations (Scopus)

• Automated flow cytometry enables high performance point-of-care analysis of leukocyte phenotypes

  Spijkerman, R., Hesselink, L., Hellebrekers, P., Vrisekoop, N., Hietbrink, F., Leenen, L. P. H. & Koenderman, L., 1 Nov 2019, In: Journal of Immunological Methods. 474, 112646.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Point-of-Care Systems 100%
  • Granulocytes 73%
  • Monocytes 73%
  • Leukocytes 70%
  • Flow Cytometry 67%
  1 Downloads (Pure)

• Eosinophils capture viruses, a capacity that is defective in asthma

  Sabogal Piñeros, Y. S., Bal, S. M., Dijkhuis, A., Majoor, C. J., Dierdorp, B. S., Dekker, T., Hoefsmit, E. P., Bonta, P. I., Picavet, D., van der Wel, N. N., Koenderman, L., Sterk, P. J., Ravanetti, L. & Lutter, R., 1 Oct 2019, In: Allergy. 74, 10, p. 1898-1909 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Eosinophils 100%
  • Asthma 80%
  • Viruses 68%
  • Antiviral Agents 24%
  • Respiratory Syncytial Viruses 22%
  1 Downloads (Pure)

• FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

  Ten Broeke, T., Honing, H., Brandsma, A. M., Jacobino, S., Bakema, J. E., Kanters, D., van der Linden, J. A. M., Bracke, M., Koenderman, L. & Leusen, J. H. W., 2019, In: Frontiers in Immunology. 9, JAN, 1 p., 3191.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Glycogen Synthase Kinase 3 100%
  • Phosphatidylinositol 3-Kinases 73%
  • Immunoglobulin A 51%
  • Cytokines 45%
  • Phosphotransferases 28%
  1 Downloads (Pure)

• Immature Neutrophils Released in Acute Inflammation Exhibit Efficient Migration despite Incomplete Segmentation of the Nucleus

  van Grinsven, E., Textor, J., Hustin, L. S. P., Wolf, K., Koenderman, L. & Vrisekoop, N., 1 Jan 2019, In: Journal of Immunology. 202, 1, p. 207-217 11 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Neutrophils 100%
  • Inflammation 75%
  • Infections 15%
  • Transendothelial and Transepithelial Migration 14%
  • Endotoxemia 12%

• In vivo characteristics of human and mouse breast tumor cell lines

  Chen, N., Ritsma, L. M. A. & Vrisekoop, N., 1 Aug 2019, In: Experimental Cell Research. 381, 1, p. 86-93 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Tumor Cell Line 100%
  • Breast Neoplasms 62%
  • Neoplasms 31%
  • Cell Polarity 24%
  • Intravital Microscopy 23%

• Submaximal heart rate seems inadequate to prescribe and monitor intensified training

  Ten Haaf, T., Foster, C., Meeusen, R., Roelands, B., Piacentini, M. F., van Staveren, S., Koenderman, L. & de Koning, J. J., Sept 2019, In: European journal of sport science. 19, 8, p. 1082-1091 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Heart Rate 100%
  • Workload 17%
  • Exercise Test 16%

• The effect of helminths on granulocyte activation: a cluster-randomized placebo-controlled trial in Indonesia

  de Ruiter, K., Tahapary, D. L., Sartono, E., Nutman, T. B., Smit, J. W. A., Koenderman, L., Supali, T. & Yazdanbakhsh, M., 16 Apr 2019, In: Journal of Infectious Diseases. 219, 9, p. 1474-1482 9 p., jiy665.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Helminths 100%
  • Indonesia 97%
  • Granulocytes 82%
  • Eosinophils 68%
  • Placebos 57%

• Trovafloxacin-induced liver injury: lack in regulation of inflammation by inhibition of nucleotide release and neutrophil movement

  Giustarini, G., Vrisekoop, N., Kruijssen, L., Wagenaar, L., van Staveren, S., van Roest, M., Bleumink, R., Bol-Schoenmakers, M., Weaver, R., Koenderman, L., Smit, J. & Pieters, R., Feb 2019, In: Toxicological sciences : an official journal of the Society of Toxicology. 167, 2, p. 385-396 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Trovafloxacin 100%
  • trovafloxacin 86%
  • Nucleotide 44%
  • Nucleotides 43%
  • Neutrophils 42%