Department of Experimental Cardiology

Research output

Research output per year 2003 2017 2018 2019 2020 2021 2022 2023 2024

• 159 Article
• 48 Review article
• 16 Doctoral thesis 1 (Research UU / Graduation UU)
• 9 Chapter
• 20 More
  • 7 Comment/Letter to the editor
  • 7 Editorial
  • 3 Meeting Abstract
  • 3 Letter

Research output per year

Research output per year

Search results

• 2024

  A Cardioprotective perfusion protocol limits myocardial functional decline during ex situ heart perfusion

  Vervoorn, M. T., Ballan, E. M., van Tuijl, S., de Jager, S. C. A., Kaffka genaamd Dengler, S. E., Sluijter, J. P. G., Doevendans, P. A. & van der Kaaij, N. P., 2024, In: JHLT Open. 3, 100042.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Perfusion 100%
  • Heart 85%
  • Cardioplegic Solutions 64%
  • Hemofiltration 60%
  • Methylprednisolone 49%

• A YAP-centered mechanotransduction loop drives collective breast cancer cell invasion

  Khalil, A. A., Smits, D., Haughton, P. D., Koorman, T., Jansen, K. A., Verhagen, M. P., van der Net, M., van Zwieten, K., Enserink, L., Jansen, L., El-Gammal, A. G., Visser, D., Pasolli, M., Tak, M., Westland, D., van Diest, P. J., Moelans, C. B., Roukens, M. G., Tavares, S., Fortier, A-M., & 6 othersPark, M., Fodde, R., Gloerich, M., Zwartkruis, F. J. T., Derksen, P. W. & de Rooij, J., 7 Jun 2024, In: Nature Communications. 15, 1, 17 p., 4866.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • breast 100%
  • Collagen 89%
  • collagens 88%
  • cancer 88%
  • keratins 71%

• Cardiac delivery of modified mRNA using lipid nanoparticles: Cellular targets and biodistribution after intramyocardial administration

  Labonia, M. C. I., Estapé Senti, M., van der Kraak, P. H., Brans, M. A. D., Dokter, I., Streef, T. J., Smits, A. M., Deshantri, A. K., de Jager, S. C. A., Schiffelers, R. M., Sluijter, J. P. G. & Vader, P., May 2024, In: Journal of controlled release : official journal of the Controlled Release Society. 369, p. 734-745 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Messenger RNA 100%
  • Nanoparticles 80%
  • Lipid 62%
  • Lipids 59%
  • Nanoparticle 45%
  1 Downloads (Pure)

• CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization

  Singh, A., Kraaijeveld, A. O., Curaj, A., Wichapong, K., Hammerich, L., de Jager, S. C. A., Bot, I., Atamas, S. P., van Berkel, T. J. C., Jukema, J. W., Comerford, I., McColl, S. R., Mees, B., Heemskerk, J. W. M., Nicolaes, G. A. F., Hackeng, T., Liehn, E. A., Tacke, F. & Biessen, E. A. L., 2024, In: Frontiers in Immunology. 15, 1327051.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • CC Chemokines 100%
  • Atherosclerosis 63%
  • Ligands 55%
  • T-Lymphocytes 48%
  • Inflammation 16%

• Cold exposure increases circulating fibroblast growth factor 21 in the eveninin males and females

  Hoekx, C. A., Martinez-Tellez, B., Straat, M. E., Verkleij, M. M. A., Kemmeren, M., Kooijman, S., Uhrbom, M., de Jager, S. C. A., Rensen, P. C. N. & Boon, M. R., Jul 2024, In: Endocrine connections. 13, 7, 10 p., e240074.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Exercise training decreases lactylation and prevents myocardial ischemia–reperfusion injury by inhibiting YTHDF2

  Xu, G. E., Yu, P., Hu, Y., Wan, W., Shen, K., Cui, X., Wang, J., Wang, T., Cui, C., Chatterjee, E., Li, G., Cretoiu, D., Sluijter, J. P. G., Xu, J., Wang, L. & Xiao, J., Aug 2024, In: Basic Research in Cardiology. 119, 4, p. 651-671 21 p.

  Research output: Contribution to journal › Article › Academic › peer-review

• Extracellular vesicle-mediated delivery of CRISPR/Cas9 ribonucleoprotein complex targeting proprotein convertase subtilisin-kexin type 9 (Pcsk9) in primary mouse hepatocytes

  Ilahibaks, N. F., Kluiver, T. A., de Jong, O. G., de Jager, S. C. A., Schiffelers, R. M., Vader, P., Peng, W. C., Lei, Z. & Sluijter, J. P. G., Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, e12389.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Proprotein Convertase 9 100%
  • Ribonucleoproteins 84%
  • Extracellular Vesicles 80%
  • Clustered Regularly Interspaced Short Palindromic Repeats 78%
  • Hepatocytes 57%
  12 Downloads (Pure)

• Extracellular vesicles as vehicles for drug delivery to the heart

  Ilahibaks, N. F., Lei, Z. & Sluijter, J. P. G., 9 Jul 2024, In: European heart journal. 45, 26, p. 2273-2275 3 p.

  Research output: Contribution to journal › Article › Academic

• Generation of human induced pluripotent stem cell (hiPSC) lines derived from three patients carrying the pathogenic CRYAB (A527G) mutation and one non-carrier family member

  Kelters, I. R., Verbueken, D., Beekink, T., Van Laake, L. W., Sluijter, J. P. G., Maas, R. G. C. & Buikema, J. W., Oct 2024, In: Stem Cell Research. 80, 4 p., 103497.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Growth differentiation factor 15 is not modified after weight loss induced by liraglutide in South Asians and Europids with type 2 diabetes mellitus

  Hoekx, C. A., Straat, M. E., Bizino, M. B., van Eyk, H. J., Lamb, H. J., Smit, J. W. A., Jazet, I. M., de Jager, S. C. A., Boon, M. R. & Martinez-Tellez, B., 1 Aug 2024, In: Experimental physiology. 109, 8, p. 1292-1304 13 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

• Hemofiltration Improves Blood Perfusate Conditions Leading to Improved Ex Situ Heart Perfusion

  Kaffka Genaamd Dengler, S. E., Mishra, M., Vervoorn, M. T., Kernkamp, J., van Tuijl, S., de Jager, S. C. A., Sluijter, J. P. G., Doevendans, P. A. & van der Kaaij, N. P., 1 Jan 2024, In: ASAIO journal. 70, 1, p. 38-43 6 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hemofiltration 100%
  • Blood 66%
  • Dobutamine 63%
  • Perfusion 54%
  • Heart 47%

• Hypothermic and cryogenic preservation of cardiac tissue-engineered constructs

  Janssen, J., Chirico, N., Ainsworth, M. J., Cedillo-Servin, G., Viola, M., Dokter, I., Vermonden, T., Doevendans, P. A., Serra, M., Voets, I. K., Malda, J., Castilho, M., van Laake, L. W., Sluijter, J. P. G., Sampaio-Pinto, V. & van Mil, A., 23 Jul 2024, In: Biomaterials science. 12, 15, p. 3866-3881 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Tissue Preservation 100%
  • Tissue Engineering 69%
  • Cardiac Myocytes 66%
  • hypothermosol 59%
  • Rewarming 56%

• Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches

  Welsh, J. A., Goberdhan, D. C. I., O’Driscoll, L., Buzas, E. I., Blenkiron, C., Bussolati, B., Cai, H., Di Vizio, D., Driedonks, T. A. P., Erdbrügger, U., Falcon-Perez, J. M., Fu, Q. L., Hill, A. F., Lenassi, M., Lim, S. K., M˜y, G. M., Mohanty, S., Möller, A., Nieuwland, R., Ochiya, T., & 20 othersSahoo, S., Torrecilhas, A. C., Zheng, L., Zijlstra, A., Abuelreich, S., Bagabas, R., Bergese, P., Bridges, E. M., Brucale, M., Burger, D., Carney, R. P., Cocucci, E., Crescitelli, R., Hanser, E., Harris, A. L., Haughey, N. J., Hendrix, A., Ivanov, A. R., Jovanovic-Talisman, T. & Kruh-Garcia, N. A., 7 Feb 2024, In: Journal of Extracellular Vesicles. 13, 2, 84 p., e12404.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Research Personnel 8%
  • Body Fluids 6%
  • Advisory Committees 6%
  • Terminology 6%

• Size matters: Functional differences of small extracellular vesicle subpopulations in cardiac repair responses

  van de Wakker, S., Bauzá-Martinez, J., Rios Arceo, C., Manjikian, H., Snijders Blok, C. J. B., Roefs, M., Maas, R. G., Willms, E., Pronker, M. F., de Jong, O., Wu, W., Görgens, A., Andaloussi, S. E. L., Sluijter, J. & Vader, P., 13 Jan 2024, In: Journal of Extracellular Vesicles. 13, 1, 21 p., 12396.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Stem Cells 62%
  • Proteasome Endopeptidase Complex 44%
  • Gel Chromatography 42%
  • Proteins 15%
  1 Downloads (Pure)

• Statins affect human iPSC-derived cardiomyocytes by interfering with mitochondrial function and intracellular acidification.

  Somers, T., Siddiqi, S., Maas, R. G., Sluijter, J., Buikema, J. W., H. H. van den Broek, P., J Meuwissen, T., J. Morshuis, W., G. M. Russel, F. & J. J. Schirris, T., Apr 2024, In: Basic Research in Cardiology. 119, 2, p. 309-327 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors 100%
  • Atorvastatin 99%
  • Cardiac Myocytes 95%
  • Lactones 79%
  • simvastatin acid 73%

• Validation of the slaughterhouse porcine heart model for ex-situ heart perfusion studies

  Kaffka genaamd Dengler, S., Mishra, M., van Tuijl, S., de Jager, S., Sluijter, J. P. G., Doevendans, PA. & van der Kaaij, NP., Apr 2024, In: Perfusion. 39, 3, p. 555-563 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Abattoirs 100%
  • Swine 58%
  • Perfusion 55%
  • Heart 47%
  • animal 19%
  9 Downloads (Pure)

• Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species

  Fang, J., Yang, Q., Maas, R. G. C., Buono, M., Meijlink, B., Lotgerink Bruinenberg, D., Benavente, E. D., Mokry, M., van Mil, A., Qian, L., Goumans, M-J., Schiffelers, R., Lei, Z. & Sluijter, J. P. G., 17 Jan 2024, In: Stem Cell Research & Therapy [E]. 15, 1, p. 19 19.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Vitamin C 100%
  • Ascorbic Acid 82%
  • Reactive Oxygen Metabolite 78%
  • Reactive Oxygen Species 66%
  • Fibroblasts 49%
• 2023

  3D Human iPSC Blood Vessel Organoids as a Source of Flow-Adaptive Vascular Cells for Creating a Human-Relevant 3D-Scaffold Based Macrovessel Model

  Meijer, E. M., Koch, S. E., van Dijk, C. G. M., Maas, R. G. C., Chrifi, I., Szymczyk, W., Besseling, P. J., Pomp, L., Koomen, V. J. C. H., Buikema, J. W., Bouten, C. V. C., Verhaar, M. C., Smits, A. I. P. M. & Cheng, C., Jan 2023, In: Advanced Biology. 7, 1, 2200137.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Endothelial cells 100%
  • Organoids 88%
  • Shear Stress 80%
  • Scaffolds 79%
  • Blood vessels 79%
  7 Downloads (Pure)

• Automatic measurement of short-term variability of repolarization to indicate ventricular arrhythmias in a porcine model of cardiac ischaemia

  Loen, V., Smoczynska, A., Hernandez, A. A., Scheerder, C. O. S., van der Linde, B. H. R., Beekman, H. D. M., Cervera-Barea, A., Boink, G. J. J., Sluijter, J. P. G., van der Heyden, M. A. G., Meine, M. & Vos, M. A., 1 Nov 2023, In: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 25, 11, euad341.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Cardiac Arrhythmias 100%
  • Swine 93%
  • Ischemia 89%
  • Myocardial Infarction 49%
  • Cardiac Electrophysiologic Techniques 23%
  5 Downloads (Pure)

• Cardiac progenitor cell-derived extracellular vesicles promote angiogenesis through both associated- and co-isolated proteins

  Roefs, M. T., Bauzá-Martinez, J., van de Wakker, S. I., Qin, J., Olijve, W. T., Tuinte, R., Rozeboom, M., Snijders Blok, C., Mol, E. A., Wu, W., Vader, P. & Sluijter, J. P. G., 1 Aug 2023, In: Communications biology. 6, 1, 800.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • angiogenesis 100%
  • Extracellular Vesicles 96%
  • stem cells 81%
  • Iodixanol 73%
  • Stem Cells 59%
  23 Downloads (Pure)

• Cellular polyploidy in organ homeostasis and regeneration

  Fang, J., de Bruin, A., Villunger, A., Schiffelers, R., Lei, Z. & Sluijter, J. P. G., 1 Aug 2023, In: Protein & cell. 14, 8, p. 560-578 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Polyploidy 100%
  • Apoptotic 91%
  • Regeneration 66%
  • Homeostasis 58%
  • Diploidy 21%
  25 Downloads (Pure)

• Characteristics of peripheral blood cells are independently related to major adverse cardiovascular events after carotid endarterectomy

  Overmars, L. M., Mekke, J. M., van Solinge, W. W., De Jager, S. C. A., Hulsbergen-Veelken, C. A. R., Hoefer, I. E., de Kleijn, D. P. V., de Borst, G. J., van der Laan, S. W. & Haitjema, S., Jun 2023, In: Atherosclerosis Plus. 52, p. 32-40 9 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Carotid Endarterectomy 100%
  • Erythrocyte Indices 77%
  • Blood Cells 69%
  • Neutrophils 33%
  • Hemorrhage 27%
  6 Downloads (Pure)

• Cold Oxygenated Machine Perfusion Improves Functional Survival of Slaughterhouse Porcine Hearts

  Kaffka Genaamd Dengler, S. E., Mishra, M., van Tuijl, S., de Jager, S. C. A., Sluijter, J. P. G., Doevendans, P. A. & van der Kaaij, N. P., 1 Aug 2023, In: ASAIO journal. 69, 8, p. 774-781 8 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Abattoirs 100%
  • Cold Temperature 65%
  • Swine 58%
  • Perfusion 55%
  • Cold storage 53%

• Convergence of melt electrowriting and extrusion-based bioprinting for vascular patterning of a myocardial construct

  Ainsworth, M. J., Chirico, N., de Ruijter, M., Hrynevich, A., Dokter, I., Sluijter, J. P. G., Malda, J., van Mil, A. & Castilho, M., 1 Jul 2023, In: Biofabrication. 15, 3, 035025.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Bioprinting 100%
  • Gelatin 66%
  • Collagen 65%
  • Extrusion 62%
  • Blood Vessels 38%
  5 Downloads (Pure)

• Cyclic strain has antifibrotic effects on the human cardiac fibroblast transcriptome in a human cardiac fibrosis-on-a-chip platform

  Bracco Gartner, T. C. L., Wang, Y., Leiteris, L., van Adrichem, I., Marsman, J., Goumans, M. J., Bouten, C. V. C., Sluijter, J. P. G., den Toonder, J. M. J., Suyker, W. J. L. & Hjortnaes, J., Aug 2023, In: Journal of the mechanical behavior of biomedical materials. 144, 13 p., 105980.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Antifibrotic 100%
  • Fibroblasts 84%
  • Strain 40%
  • Collagen 12%
  • High Throughput Screening 12%

• Elevated Plasma Immunoglobulin Levels Prior to Heart Transplantation Are Associated with Poor Post-Transplantation Survival

  van den Hoogen, P., Huibers, M. M. H., van den Dolder, F. W., de Weger, R., Siera-de Koning, E., Oerlemans, M. I. F., de Jonge, N., van Laake, L. W., Doevendans, P. A., Sluijter, J. P. G., Vink, A. & de Jager, S. C. A., Jan 2023, In: Biology. 12, 1, 61.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • heart transplant 100%
  • Plasma Level 75%
  • Heart Transplantation 64%
  • immunoglobulins 59%
  • Immunoglobulins 53%
  6 Downloads (Pure)

• Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury

  Wang, L., Feng, J., Feng, X., Meng, D., Zhao, X., Wang, J., Yu, P., Xu, G-E., Hu, M., Wang, T., Lehmann, H. I., Li, G., Sluijter, J. P. G. & Xiao, J., 19 Dec 2023, In: Cardiovascular research. 119, 16, p. 2638-2652 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Circular RNAs 100%
  • Myocardial Reperfusion Injury 93%
  • Cardiomegaly 79%
  • protein phosphatase 5 78%
  • Reperfusion Injury 70%

• Extracellular vesicle heterogeneity and its impact for regenerative medicine applications

  Van De Wakker, S. I., Meijers, F. M., Sluijter, J. P. G. & Vader, P., Sept 2023, In: Pharmacological Reviews. 75, 5, p. 1043-1061 19 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Regenerative Medicine 93%
  • Pathologic Processes 5%
  • Regeneration 4%
  • Population 4%
  8 Downloads (Pure)

• Extracellular vesicle-mediated protein delivery to the liver

  Ilahibaks, N. F., Roefs, M. T., Brans, M. A. D., Blok, C. S., de Jager, S. C. A., Schiffelers, R. M., Vader, P., Lei, Z. & Sluijter, J. P. G., Sept 2023, In: Journal of Extracellular Biology. 2, 9, 17 p., e97.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Liver 43%
  • Tacrolimus Binding Protein 1A 33%
  • Proteins 31%
  • Hepatocytes 26%

• Fusogenic Coiled-Coil Peptides Enhance Lipid Nanoparticle-Mediated mRNA Delivery upon Intramyocardial Administration

  Zeng, Y., Estapé Senti, M., Labonia, M. C. I., Papadopoulou, P., Brans, M. A. D., Dokter, I., Fens, M. H., van Mil, A., Sluijter, J. P. G., Schiffelers, R. M., Vader, P. & Kros, A., 12 Dec 2023, In: ACS Nano. 17, 23, p. 23466-23477 12 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • ribonucleic acids 100%
  • Messenger RNA 90%
  • Lipids 86%
  • Peptides 84%
  • peptides 71%
  10 Downloads (Pure)

• Generation, High-Throughput Screening, and Biobanking of Human-Induced Pluripotent Stem Cell-Derived Cardiac Spheroids

  Maas, R. G. C., Beekink, T., Chirico, N., Snijders Blok, C. J. B., Dokter, I., Sampaio-Pinto, V., van Mil, A., Doevendans, P. A., Buikema, J. W., Sluijter, J. P. G. & Stillitano, F., 10 Mar 2023, In: Journal of visualized experiments : JoVE. 193, e64365.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Stem cells 100%
  • Induced Pluripotent Stem Cells 80%
  • High Throughput Screening 75%
  • Cardiac Myocytes 65%
  • Screening 65%
  27 Downloads (Pure)

• Generation and characterization of novel human induced pluripotent stem cell (iPSC) lines originating from five asymptomatic individuals carrying the PLN-R14del pathogenic variant and a non-carrier relative

  Balducci, V., Scardigli, F., Harakalova, M., Peter. van Tintelen, J., Doevendans, P. A., Costa, K. D., Turnbull, I. C., P. G. Sluijter, J. & Stillitano, F., Oct 2023, In: Stem Cell Research. 72, 103208.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Induced Pluripotent Stem Cells 100%
  • Cardiomyopathies 86%
  • phospholamban 63%
  • Cell Line 52%
  • Dilated Cardiomyopathy 48%
  26 Downloads (Pure)

• Harnessing developmental cues for cardiomyocyte production

  Maas, R. G. C., van den Dolder, F. W., Yuan, Q., van der Velden, J., Wu, S. M., Sluijter, J. P. G. & Buikema, J. W., Aug 2023, In: Development (Cambridge). 150, 15, dev201483.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Cardiac Myocytes 100%
  • Cues 93%
  • Heart 69%
  • Fetal Heart 27%
  • Fetal Development 22%

• HIPK1 Inhibition Protects against Pathological Cardiac Hypertrophy by Inhibiting the CREB-C/EBPβ Axis

  Bei, Y., Zhu, Y., Wei, M., Yin, M., Li, L., Chen, C., Huang, Z., Liang, X., Gao, J., Yao, J., van der Kraak, P. H., Vink, A., Lei, Z., Dai, Y., Chen, H., Liang, Y., Sluijter, J. P. & Xiao, J., Jun 2023, In: Advanced Science. 10, 18, 2300585.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Carrier Proteins 100%
  • CCAAT-Enhancer-Binding Proteins 87%
  • Homeodomain Proteins 84%
  • Cyclic AMP Response Element-Binding Protein 78%
  • Cardiomegaly 67%
  1 Citation (Scopus)

  3 Downloads (Pure)

• Isoform changes of action potential regulators in the ventricles of arrhythmogenic phospholamban-R14del humanized mouse hearts

  Rogalska, M. E., Vafiadaki, E., Erpapazoglou, Z., Haghighi, K., Green, L., Mantzoros, C. S., Hajjar, R. J., Tranter, M., Karakikes, I., Kranias, E. G., Stillitano, F., Kafasla, P. & Sanoudou, D., Jan 2023, In: Metabolism: Clinical and Experimental. 138, 155344.

  Research output: Contribution to journal › Article › Academic › peer-review

• The circadian clock remains intact, but with dampened hormonal output in heart failure

  Crnko, S., Printezi, M. I., Zwetsloot, P. P. M., Leiteris, L., Lumley, A. I., Zhang, L., Ernens, I., Jansen, T. P. J., Homsma, L., Feyen, D., van Faassen, M., du Pré, B. C., Gaillard, C. A. J. M., Kemperman, H., Oerlemans, M. I. F. J., Doevendans, P. A. F. M., May, A. M., Zuithoff, N. P. A., Sluijter, J. P. G., Devaux, Y., & 1 othersvan Laake, L. W., May 2023, In: EBioMedicine. 91, 104556.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Melatonin 100%
  • Cortisol 97%
  • Circadian Clocks 94%
  • Heart Failure 55%
  • Blood Pressure 24%
  1 Downloads (Pure)

• The ESC Working Group on cardiovascular regenerative and reparative medicine

  Pompilio, G., Sanz-Ruiz, R., Sluijter, J. P. G. & Janssens, S., 14 Nov 2023, In: European heart journal. 44, 43, p. 4503-4505 3 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File
  13 Downloads (Pure)

• TOP-EVs: Technology of Protein delivery through Extracellular Vesicles is a versatile platform for intracellular protein delivery

  Ilahibaks, N. F., Ardisasmita, A. I., Xie, S., Gunnarsson, A., Brealey, J., Vader, P., de Jong, O. G., de Jager, S., Dekker, N., Peacock, B., Schiffelers, R. M., Sluijter, J. P. G. & Lei, Z., Mar 2023, In: Journal of Controlled Release. 355, p. 579-592 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Technology 55%
  • Protein 35%
  • Proteins 31%
  • Plasmids 10%
  8 Downloads (Pure)
• 2022

  ADAR2 increases in exercised heart and protects against myocardial infarction and doxorubicin-induced cardiotoxicity

  Wu, X., Wang, L., Wang, K., Li, J., Chen, R., Wu, X., Ni, G., Liu, C., Das, S., Sluijter, J. P. G., Li, X. & Xiao, J., 5 Jan 2022, In: Molecular Therapy. 30, 1, p. 400-414 15 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Cardiotoxicity 100%
  • RNA Editing 91%
  • Doxorubicin 81%
  • Myocardial Infarction 64%
  • Heart 57%
  1 Citation (Scopus)

  16 Downloads (Pure)

• Circadian Dependence of the Acute Immune Response to Myocardial Infarction

  Kilgallen, A. B., van den Akker, F., Feyen, D. A. M., Crnko, S., Snijders Blok, C. J. B., Gremmels, H., du Pré, B. C., Reijers, R., Doevendans, P. A., de Jager, S. C. A., Sluijter, J. P. G., Sampaio-Pinto, V. & van Laake, L. W., 25 May 2022, In: Frontiers in Pharmacology. 13, p. 1-13 869512.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Myocardial Infarction 100%
  • Heart 44%
  • Circadian Rhythm 36%
  • Troponin I 20%
  • Leukocyte Count 16%
  5 Downloads (Pure)

• Circadian rhythms in ischaemic heart disease: key aspects for preclinical and translational research: position paper of the ESC working group on cellular biology of the heart

  Lecour, S., Du PrCrossed D Sign©, B. C., Bøtker, H. E., Brundel, B. J. J. M., Daiber, A., Davidson, S. M., Ferdinandy, P., Girao, H., Gollmann-Tepeköylü, C., Gyöngyösi, M., Hausenloy, D. J., Madonna, R., Marber, M., Perrino, C., Pesce, M., Schulz, R., Sluijter, J. P. G., Steffens, S., Van Linthout, S., Young, M. E., & 1 othersVan Laake, L. W., 1 Aug 2022, In: Cardiovascular research. 118, 12, p. 2566-2581 16 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  • Translational Medical Research 100%
  • Circadian Rhythm 93%
  • Myocardial Ischemia 78%
  • Cell Biology 76%
  • Heart 57%
  3 Citations (Scopus)

• CXCL4 drives fibrosis by promoting several key cellular and molecular processes

  Affandi, A. J., Carvalheiro, T., Ottria, A., de Haan, J. J., Brans, M. A. D., Brandt, M. M., Tieland, R. G., Lopes, A. P., Fernández, B. M., Bekker, C. P. J., van der Linden, M., Zimmermann, M., Giovannone, B., Wichers, C. G. K., Garcia, S., de Kok, M., Stifano, G., Xu, Y. J., Kowalska, M. A., Waasdorp, M., & 6 othersCheng, C., Gibbs, S., de Jager, S. C. A., van Roon, J. A. G., Radstake, T. R. D. J. & Marut, W., 4 Jan 2022, In: Cell Reports. 38, 1, 110189.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Collagen 100%
  • Fibrosis 78%
  • Myofibroblasts 48%
  • Endothelial Cells 31%
  • Systemic Scleroderma 24%
  24 Downloads (Pure)

• Delivery of modified mRNA to damaged myocardium by systemic administration of lipid nanoparticles

  Evers, M. J. W., Du, W., Yang, Q., Kooijmans, S. A. A., Vink, A., van Steenbergen, M., Vader, P., de Jager, S. C. A., Fuchs, S. A., Mastrobattista, E., Sluijter, J. P. G., Lei, Z. & Schiffelers, R., Mar 2022, In: Journal of controlled release : official journal of the Controlled Release Society. 343, p. 207-216 10 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Nanoparticles 100%
  • Myocardium 93%
  • Lipid 77%
  • Lipids 73%
  • Nanoparticle 56%
  12 Downloads (Pure)

• Detection and localization of early- and late-stage cancers using platelet RNA

  In 't Veld, S. G. J. G., Arkani, M., Post, E., Antunes-Ferreira, M., D'Ambrosi, S., Vessies, D. C. L., Vermunt, L., Vancura, A., Muller, M., Niemeijer, A-L. N., Tannous, J., Meijer, L. L., Le Large, T. Y. S., Mantini, G., Wondergem, N. E., Heinhuis, K. M., van Wilpe, S., Smits, A. J., Drees, E. E. E., Roos, E., & 96 othersLeurs, C. E., Tjon Kon Fat, L-A., van der Lelij, E. J., Dwarshuis, G., Kamphuis, M. J., Visser, L. E., Harting, R., Gregory, A., Schweiger, M. W., Wedekind, L. E., Ramaker, J., Zwaan, K., Verschueren, H., Bahce, I., de Langen, A. J., Smit, E. F., van den Heuvel, M. M., Hartemink, K. J., Kuijpers, M. J. E., Oude Egbrink, M. G. A., Griffioen, A. W., Rossel, R., Hiltermann, T. J. N., Lee-Lewandrowski, E., Lewandrowski, K. B., De Witt Hamer, P. C., Kouwenhoven, M., Reijneveld, J. C., Leenders, W. P. J., Hoeben, A., Verdonck-de Leeuw, I. M., Leemans, C. R., Baatenburg de Jong, R. J., Terhaard, C. H. J., Takes, R. P., Langendijk, J. A., de Jager, S. C., Kraaijeveld, A. O., Pasterkamp, G., Smits, M., Schalken, J. A., Łapińska-Szumczyk, S., Łojkowska, A., Żaczek, A. J., Lokhorst, H., van de Donk, N. W. C. J., Nijhof, I., Prins, H-J., Zijlstra, J. M., Idema, S., Baayen, J. C., Teunissen, C. E., Killestein, J., Besselink, M. G., Brammen, L., Bachleitner-Hofmann, T., Mateen, F., Plukker, J. T. M., Heger, M., De Mast, Q., Lisman, T., Pegtel, D. M., Bogaard, H-J., Jassem, J., Supernat, A., Mehra, N., Gerritsen, W. R., de Kroon, C. D., Lok, C. A. R., Piek, J. M. J., Steeghs, N., van Houdt, W. J., Brakenhoff, R. H., Sonke, G. S., Verheul, H. M. W., Giovannetti, E., Kazemier, G., Sabrkhany, S., Schuuring, E., Sistermans, E. A., Wolthuis, R., Meijers-Heijboer, H., Dorsman, J., Oudejans, C., Ylstra, B., Westerman, B. A., van den Broek, D., Koppers-Lalic, D., Wesseling, P., Nilsson, R. J. A., Vandertop, W. P., Noske, D. P., Tannous, B. A., Sol, N., Best, M. G. & Wurdinger, T., 12 Sept 2022, In: Cancer Cell. 40, 9, p. 999-1009.e6

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Blood Platelets 100%
  • RNA 88%
  • Neoplasms 41%
  • Hematologic Tests 8%
  • Early Detection of Cancer 8%
  17 Citations (Scopus)

  6 Downloads (Pure)

• Elevated Serotonin and NT-proBNP Levels Predict and Detect Carcinoid Heart Disease in a Large Validation Study

  Levy, S., Kilgallen, A. B., Korse, C. M., Oerlemans, M. I. F. J., Sluijter, J. P. G., van Laake, L. W., Valk, G. D. & Tesselaar, M. E. T., 1 May 2022, In: Cancers. 14, 10, p. 1-13 2361.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

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  • Carcinoid Heart Disease 100%
  • Validation Studies 65%
  • Brain Natriuretic Peptide 65%
  • Serotonin 50%
  • activin A 16%
  3 Downloads (Pure)

• Evaluation and manipulation of tissue and cellular distribution of cardiac progenitor cell-derived extracellular vesicles

  Roefs, M. T., Heusermann, W., Brans, M. A. D., Snijders Blok, C., Lei, Z., Vader, P. & Sluijter, J. P. G., 24 Nov 2022, In: Frontiers in Pharmacology. 13, 1052091.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Extracellular Vesicles 100%
  • Tissue Distribution 92%
  • Stem Cells 62%
  • cysteinyl-arginyl-prolyl-prolyl-arginine 16%
  • Heart 13%
  9 Downloads (Pure)

• Extracellular vesicles enclosed-miR-421 suppresses air pollution (PM 2.5 )-induced cardiac dysfunction via ACE2 signalling.

  Wang, H., Wang, T., Rui, W., Xie, J., Xie, Y., Zhang, X., Guan, L., Li, G., Lei, Z., Schiffelers, R. M., Sluijter, J. P. G. & Xiao, J., May 2022, In: Journal of Extracellular Vesicles. 11, 5, p. 1-20 e12222.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • angiotensin converting enzyme 2 100%
  • Extracellular Vesicles 79%
  • Air Pollution 77%
  • Lung Injury 30%
  • GW 4869 17%
  5 Downloads (Pure)

• Follistatin-like 1 promotes proliferation of matured human hypoxic iPSC-cardiomyocytes and is secreted by cardiac fibroblasts

  Peters, M. C., Di Martino, S., Boelens, T., Qin, J., van Mil, A., Doevendans, P. A., Chamuleau, S. A. J., Sluijter, J. P. G. & Neef, K., 9 Jun 2022, In: Molecular Therapy - Methods and Clinical Development. 25, p. 3-16 14 p.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Follistatin 100%
  • Cardiac Myocytes 64%
  • Fibroblasts 51%
  • Induced Pluripotent Stem Cells 28%
  • Hypoxia 24%
  1 Citation (Scopus)

  15 Downloads (Pure)

• Functional siRNA Delivery by Extracellular Vesicle–Liposome Hybrid Nanoparticles

  Evers, M. J. W., van de Wakker, S. I., de Groot, E. M., de Jong, O. G., Gitz-François, J. J. J., Seinen, C. S., Sluijter, J. P. G., Schiffelers, R. M. & Vader, P., 2 Mar 2022, In: Advanced Healthcare Materials. 11, 5, p. 1-13 2101202.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Liposomes 100%
  • Silencing RNA 79%
  • Extracellular Vesicles 60%
  • Nanoparticles 60%
  • Small Interfering RNA 51%
  4 Downloads (Pure)

• Gut microbiome mediates the protective effects of exercise after myocardial infarction

  Zhou, Q., Deng, J., Pan, X., Meng, D., Zhu, Y., Bai, Y., Shi, C., Duan, Y., Wang, T., Li, X., Sluijter, J. P. & Xiao, J., Dec 2022, In: Microbiome. 10, 1, 82.

  Research output: Contribution to journal › Article › Academic › peer-review

  Open Access

  File

  • Gastrointestinal Microbiome 100%
  • Myocardial Infarction 73%
  • Microbiota 50%
  • 3-hydroxybenzeneacetic acid 49%
  • 4-hydroxybenzoic acid 41%
  4 Citations (Scopus)

  13 Downloads (Pure)