Circulatory Health

2025

Disturbed Flow Induces Reprogramming of Endothelial Cells to Immune-like and Foam Cells under Hypercholesterolemia during Atherogenesis

Park, C., Baek, K. I., Hung, R.-C., Choi, L., Jeong, K., Kim, P., Jahng, A. K., Kim, J. H., Meselhe, M., Kannan, A., Chou, C.-L., Kang, D. W., Song, E. J., Kim, Y., Bowman-Kirigin, J. A., Clark, M. D., van der Laan, S. W., Pasterkamp, G., Villa-Roel, N. & Panitch, A. & 1 others, Jo, H., 6 Mar 2025, BioRxiv, 34 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

Female-biased vascular smooth muscle cell gene regulatory networks predict MYH9 as a key regulator of fibrous plaque phenotype

Perry, R. N., Lenert, G., Benavente, E. D., Ma, A., Barbera, N., Mokry, M., de Kleijn, D. P. V., de Winther, M. P. J., Mayr, M., Björkegren, J. L. M., den Ruijter, H. M. & Civelek, M., 2 Apr 2025, BioRxiv, 35 p. (bioRxiv : the preprint server for biology).

Research output: Working paper › Preprint › Academic

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Human colon stem cells are the principal epithelial responders to bacterial antigens

de Vries, M. H., Meddens, C., Hijma, H., Berrens, A.-C., Jansen, S., Kooiman, B., Snapper, S., Clevers, H., Mokry, M., Kuijk, E. & Nieuwenhuis, E., 8 Feb 2025, BioRxiv, 29 p.

Research output: Working paper › Preprint › Academic

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Intraplaque haemorrhage quantification and molecular characterisation using attention based multiple instance learning

Cisternino, F., Song, Y., Peters, T. S., Westerman, R., de Borst, G. J., Diez Benavente, E., van den Dungen, N. A. M., van der Kraak, P. H., De Kleijn, D., Mekke, J. M., Mokry, M., Pasterkamp, G., den Ruijter, H. M., Velema, E., Miller, C. L., Glastonbury, C. A. & van der Laan, S. W., 7 Mar 2025, medRxiv, 51 p.

Research output: Working paper › Preprint › Academic

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2024

Adaptation of ACMG/AMP guidelines for clinical classification of BMPR2 variants in Pulmonary Arterial Hypertension resolves variants of unclear pathogenicity in ClinVar

Eichstaedt, C. A., Maldonado-Velez, G., Machado, R. D., Balachandar, S., Coulet, F., Day, K., Dooijes, D., Eyries, M., Gräf, S., Macaya, D., Shaukat, M., Southgate, L., Tenorio-Castano, J., Chung, W. K., Welch, C. L. & Aldred, M. A., 26 Nov 2024, medRxiv, 29 p.

Research output: Working paper › Preprint › Academic

A fully synthetic three-dimensional human cerebrovascular model based on histological characteristics to investigate the hemodynamic fingerprint of the layer BOLD fMRI signal formation

Báez-Yáñez, M. G., Schellekens, W., Bhogal, A. A., Roefs, E. C. A., van Osch, M. J. P., Siero, J. C. & Petridou, N., 26 May 2024, BioRxiv, p. 1-38.

Research output: Working paper › Preprint › Academic

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Biallelic variants in POPDC2 cause a novel autosomal recessive syndrome presenting with cardiac conduction defects and variable hypertrophic cardiomyopathy

Nicastro, M., Vermeer, A. M. C., Postema, P. G., Tadros, R., Bowling, F. Z., Aegisdottir, H. M., Tragante, V., Mach, L., Postma, A. V., Lodder, E. M., van Duijvenboden, K., Zwart, R., Beekman, L., Wu, L., van der Zwaag, P. A., Alders, M., Allouba, M., Aguib, Y., Santomel, J. L. & de Una, D. & 50 others, Monserrat, L., Miranda, A. M. A., Kanemaru, K., Cranley, J., van Zeggeren, I. E., Aronica, E. M. A., Ripolone, M., Zanotti, S., Sveinbjornsson, G., Ivarsdottir, E. V., Hólm, H., Guðbjartsson, D. F., Skúladóttir, Á. T., Stefánsson, K., Nadauld, L., Knowlton, K. U., Ostrowski, S. R., Sørensen, E., Vesterager Pedersen, O. B., Ghouse, J., Rand, S., Bundgaard, H., Ullum, H., Erikstrup, C., Aagaard, B., Bruun, M. T., Christiansen, M., Jensen, H. K., Carere, D. A., Cummings, C. T., Fishler, K., Tøring, P. M., Brusgaard, K., Juul, T. M., Saaby, L., Winkel, B. G., Mogensen, J., Fortunato, F., Comi, G. P., Ronchi, D., van Tintelen, J. P., Noseda, M., Airola, M. V., Christiaans, I., Wilde, A. A. M., Wilders, R., Clur, S.-A., Verkerk, A. O., Bezzina, C. R. & Lahrouchi, N., 5 Jul 2024, medRxiv, 49 p. (medRxiv).

Research output: Working paper › Preprint › Academic

Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients

Petersen, M., Coenen, M., DeCarli, C., De Luca, A., van der Lelij, E., Barkhof, F., Benke, T., Chen, C. P. L. H., Dal-Bianco, P., Dewenter, A., Duering, M., Enzinger, C., Ewers, M., Exalto, L. G., Fletcher, E. F., Franzmeier, N., Hilal, S., Hofer, E., Koek, H. L. & Maier, A. B. & 22 others, Maillard, P. M., McCreary, C. R., Papma, J. M., Pijnenburg, Y. A. L., Schmidt, R., Smith, E. E., Steketee, R. M. E., van den Berg, E., van der Flier, W. M., Venkatraghavan, V., Venketasubramanian, N., Vernooij, M. W., Wolters, F. J., Xu, X., Horn, A., Patil, K. R., Eickhoff, S. B., Thomalla, G., Biesbroek, J. M., Biessels, G. J., Cheng, B. & Alzheimer's Disease Neuroimaging Initiative, 11 Apr 2024, medRxiv, 15 p.

Research output: Working paper › Preprint › Academic

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IFNγ induces epithelial reprogramming driving CXCL11-mediated T cell migration

Cutilli, A., Jansen, S. A., Paolucci, F., Mokry, M., Mocholi, E., Lindemans, C. A. & Coffer, P. J., 7 Feb 2024, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Resolving artefacts in voltage-clamp experiments with computational modelling: an application to fast sodium current recordings

Lei, C. L., Clark, A. P., Clerx, M., Wei, S., Bloothooft, M., de Boer, T. P., Christini, D. J., Krogh-Madsen, T. & Mirams, G. R., 24 Jul 2024, BioRxiv, 19 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

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Role of Forkhead box F1 in the Pathobiology of Pulmonary Arterial Hypertension

Gomez-Arroyo, J., Houweling, A. C., Bogaard, H. J., Aman, J., Kitzmiller, J. A., Porollo, A., Dooijes, D., Meijboom, L. J., Hale, P., Pauciulo, M. W., Hong, J., Zhu, N., Welch, C., Shen, Y., Zacharias, W. J., McCormack, F. X., Aldred, M. A., Weirauch, M. T., Graf, S. & Rhodes, C. & 5 others, Chung, W. K., Whitsett, J. A., Martin, L. J., Kalinichenko, V. V. & Nichols, W. C., 22 Sept 2024, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

2023

Beyond gene-disease validity: capturing structured data on inheritance, allelic-requirement, disease-relevant variant classes, and disease mechanism for inherited cardiac conditions

Josephs, K. S., Roberts, A. M., Theotokis, P., Walsh, R., Ostrowski, P. J., Edwards, M., Fleming, A., Thaxton, C., Roberts, J. D., Care, M., Zareba, W., Adler, A., Sturm, A. C., Tadros, R., Novelli, V., Owens, E., Bronicki, L., Jarinova, O., Callewaert, B. & Peters, S. & 15 others, Lumbers, T., Jordan, E., Asatryan, B., Krishnan, N., Hershberger, R. E., Chahal, C. A. A., Landstrom, A. P., James, C., McNally, E. M., Judge, D. P., van Tintelen, P., Wilde, A., Gollob, M., Ingles, J. & Ware, J. S., 3 Apr 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function

Jansen, S. A., Cutilli, A., de Koning, C., van Hoesel, M., Sierra, L. S., Nierkens, S., Mokry, M., Nieuwenhuis, E. E. S., Hanash, A. M., Mocholi, E., Coffer, P. J. & Lindemans, C. A., 30 Apr 2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

Colchicine promotes atherosclerotic plaque stability independently of inflammation

Li, W., Lin, A., Hutton, M., Dhaliwal, H., Nadel, J., Rodor, J., Tumanov, S., Örd, T., Hadden, M., Mokry, M., Mol, B. M., Pasterkamp, G., Padula, M. P., Geczy, C. L., Ramaswamy, Y., Sluimer, J. C., Kaikkonen, M. U., Stocker, R., Baker, A. H. & Fisher, E. A. & 2 others, Patel, S. & Misra, A., 3 Oct 2023, BioRxiv, 22 p. (bioRxiv).

Research output: Working paper › Preprint › Academic

EV-Elute: a universal platform for enrichment of functional surface marker-defined extracellular vesicle subpopulations

de Voogt, W., Frunt, R., Leandro, R., Triesscheijn, C., Monica, B., Paspali, I., Tielemans, M., Gitz-Francois, J. J. J. M., Seinen, C., de Jong, O. & Kooijmans, S., 29 Oct 2023, BioRxiv, 28 p.

Research output: Working paper › Preprint › Academic

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Evidence of survival bias in the association between APOE-ϵ4 and age of ischemic stroke onset.

SiGN, FinnGen, Women’s Health Initiative, 1 Dec 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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Female gene networks are expressed in myofibroblast-like smooth muscle cells in vulnerable atherosclerotic plaques

Benavente, E. D., Karnewar, S., Buono, M., Mili, E., Hartman, R. J. G., Kapteijn, D., Slenders, L., Daniels, M., Aherrahrou, R., Reinberger, T., Mol, B. M., de Borst, G. J., de Kleijn, D. P. V., Prange, K. H. M., Depuydt, M. A. C., de Winther, M. P. J., Kuiper, J., Bj Rkegren, J. L. M., Erdmann, J. & Civelek, M. & 4 others, Mokry, M., Owens, G. K., Pasterkamp, G. & den Ruijter, H. M., 9 Feb 2023, BioRxiv.

Research output: Working paper › Preprint › Academic

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20 Downloads (Pure)

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

Karnewar, S., Karnewar, V., Deaton, R., Shankman, L. S., Benavente, E. D., Williams, C. M., Bradley, X., Alencar, G. F., Bulut, G. B., Kirmani, S., Baylis, R. A., Zunder, E. R., den Ruijter, H. M., Pasterkamp, G. & Owens, G. K., 14 Oct 2023, BioRxiv.

Research output: Working paper › Preprint › Academic

Open Access

Integrative multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci

Hodonsky, C. J., Turner, A. W., Khan, M. D., Barrientos, N. B., Methorst, R., Ma, L., Lopez, N. G., Mosquera, J. V., Auguste, G., Farber, E., Ma, W. F., Wong, D., Onengut-Gumuscu, S., Kavousi, M., Peyser, P. A., van der Laan, S. W., Leeper, N. J., Kovacic, J. C., Björkegren, J. L. M. & Miller, C. L., 14 Feb 2023, medRxiv.

Research output: Working paper › Preprint › Academic

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Leukocytes carrying Clonal Hematopoiesis of Indeterminate Potential (CHIP) Mutations invade Human Atherosclerotic Plaques.

von Scheidt, M., Bauer, S., Ma, A., Hao, K., Kessler, T., Vilne, B., Wang, Y., Hodonsky, C. J., Ghosh, S. K. B., Mokry, M., Gao, H., Kawai, K., Sakamoto, A., Kaiser, J., Bongiovanni, D., Fleig, J., Oldenbuettel, L., Chen, Z., Moggio, A. & Sager, H. B. & 14 others, Hecker, J. S., Bassermann, F., Maegdefessel, L., Miller, C. L., Koenig, W., Zeiher, A. M., Dimmeler, S., Graw, M., Braun, C., Ruusalepp, A., Leeper, N. J., Kovacic, J. C., Björkegren, J. L. M. & Schunkert, H., 26 Jul 2023, medRxiv, 34 p.

Research output: Working paper › Preprint › Academic

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Microvascular Specificity of Spin Echo BOLD fMRI: Impact of EPI Echo Train Length

van Horen, T., Siero, J. C. W., Bhogal, A. A., Petridou, N. & Báez-Yáñez, M. G., 15 Sept 2023, BioRxiv, (bioRxiv).

Research output: Working paper › Preprint › Academic

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Proteogenomic integration reveals CXCL10 as a potentially downstream causal mediator for IL-6 signaling on atherosclerosis

Prapiadou, S., Živković, L., Thorand, B., George, M. J., van der Laan, S. W., Malik, R., Herder, C., Koenig, W., Ueland, T., Kleveland, O., Aukrust, P., Gullestad, L., Bernhagen, J., Pasterkamp, G., Peters, A., Hingorani, A. D., Rosand, J., Dichgans, M., Anderson, C. D. & Georgakis, M. K., 28 Mar 2023, (medRxiv).

Research output: Working paper › Preprint › Academic

Open Access

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2021

Sex-dependent gene regulation of human atherosclerotic plaques by DNA methylation and transcriptome integration points to smooth muscle cell involvement in women

Hartman, R., Siemelink, M., Haitjema, S., Dekkers, K. F., Slenders, L., Boltjes, A., Mokry, M., Timmerman, N., De Borst, G. J., Heijmans, B. T., Asselbergs, F. W., Pasterkamp, G., Van der Laan, S. W. & Den Ruijter, H. M., 29 Jan 2021, BioRxiv.

Research output: Working paper › Preprint › Academic

Circulatory Health

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